The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury

Fundamental and Clinical Pharmacology

Volumn 18, Issue 4, 2004, Pages 423-430

  Hernandez, Maria Rosa ^a   Alvarez Guerra, Miriam ^b   Escolar, Ginés ^a   Chiavaroli, Carlo ^c   Hannaert, Patrick ^b   Garay, Ricardo P ^b  

^a HOSPITAL CLÍNIC   (Spain)

^b INSERM   (France)

^c Vifor (International) Inc   (Switzerland)

Author keywords

Ethamsylate; Hemostasis; Leukocyte; P selectin; P selectin glycoprotein ligand 1; Platelet

Indexed keywords

ANTIBODY; CARBON 14; CD11B ANTIGEN; ETAMSYLATE; HEMOSTATIC AGENT; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL INJURY; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; LEUKOCYTE AGGREGATION; LEUKOCYTE MEMBRANE; MEMBRANE BINDING; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

EID: 4544259754     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2004.00256.x     Document Type: Article

References (25)

1. Symes D.M., Offen D.N., Lyttle J.A., Blandy J.P. The effect of dicynene on blood loss during and after transurethral resection of the prostate. Br. J. Urol. (1975) 47 203-207.
2. Vinazzer H. Clinical and experimental studies on the action of ethamsylate on haemostasis and on platelet functions. Thromb. Res. (1980) 19 783-791.
3. Hutton R.A., Wickham E.A., Reed J.V., Tuddenham E.G. Studies on the action of ethamsylate (Dicynene) on haemostasis. Thromb. Haemost. (1986) 56 6-8.
4. Sack E.S., Cerutti N. Effects of cyclonamine on blood platelets. II. Changes in the surface charge and inhibition of the release reaction. Medicina (B Aires) (1973) 3 685-694.
5. Okuma M., Takayama H., Sugiyama T., Sensaki S., Uchino H. Effects of etamsylate on platelet functions and arachidonic acid metabolism. Thromb. Haemost. (1982) 48 330-333.
6. Sack E.S., Dujovne I. Effects of cyclonamine on blood platelets. I. Turbidimetric and electronmicroscopic studies. Medicina (B Aires) (1973) 33 525-535.
7. Alvarez-Guerra M., Hernandez M.R., Escolar G., Chiavaroli C., Garay R.P., Hannaert P. The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Thromb. Res. (2002) 107 329-335.
8. Furie B., Furie B.C., Flaumenhaft R. A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion. Thromb. Haemost. (2001) 86 214-221.
9. Li N., Hu H., Lindqvist M., Wikstrom-Jonsson E., Goodall A.H., Hjemdahl P. Platelet-leukocyte cross talk in whole blood. Arterioscler. Thromb. Vasc. Biol. (2000) 20 2702-2708.
10. Shebuski R.J., Kilgore K.S. Role of inflammatory mediators in thrombogenesis. J. Pharmacol. Exp. Ther. (2002) 300 729-735.
11. McEver R.P., Cummings R.D. Role of PSGL-1 binding to selectins in leukocyte recruitment. J. Clin. Invest. (1997) 100 S97-S103.
12. Evangelista V., Manarini S., Sideri R. et al. Platelet/polymorphonuclear leukocyte interaction: P-selectin triggers protein-tyrosine phosphorylation- dependent CD11b/CD18 adhesion: role of PSGL-1 as a signaling molecule. Blood (1999) 93 876-885.
13. Baumgartner H.R. Platelet interaction with collagen fibrils in flowing blood. I. Reaction of human platelets with alpha chymotrypsin-digested subendothelium. Thromb. Haemost. (1977) 37 1-16.
14. Baumgartner H.R., Tschopp T.B., Weiss H.J. Platelet interaction with collagen fibrils in flowing blood. II. Impaired adhesion-aggregation in bleeding disorders. A comparison with subendothelium. Thromb. Haemost. (1977) 37 17-28.
15. Zwaginga J.J., Sixma J.J., de Groot P.G. Activation of endothelial cells induces platelet thrombus formation on their matrix. Studies of new in vitro thrombosis model with low molecular weight heparin as anticoagulant. Arteriosclerosis (1990) 10 49-61.
16. Buchanan M.R., Vazquez M.J., Gimbrone M.A. Jr. Arachidonic acid metabolism and the adhesion of human polymorphonuclear leukocytes to cultured vascular endothelial cells. Blood (1983) 62 889-895.
17. Hernandez M.R., Bozzo J., Mazzara R., Ordinas A., Escolar G. Platelet concentrates promote procoagulant activity: evidence from experimental studies using a perfusion technique. Transfusion (1995) 35 660-665.
18. Yeo E.L., Gemmell C.H., Sutherland D.R., Sefton M.V. Characterization of canine platelet P-selectin (CD 62) and its utility in flow cytometry platelet studies. Comp. Biochem. Physiol. (1993) 105 625-636.
19. Stenberg P.E., McEver R.P., Shuman M.A., Jacques Y.V., Bainton D.F. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J. Cell. Biol. (1985) 101 880-886.
20. Dore M., Burns A.R., Hughes B.J., Entman M.L., Smith C.W. Chemoattractant-induced changes in surface expression and redistribution of a functional ligand for P-selectin on neutrophils. Blood (1996) 87 2029-2037.
21. Dayrens P., Ivanoff B., Cussac M., Fontanges R. Antiinflammatory and immunostimulant activities of six sulphur compounds - four benzenesulphonates, levamisole, and pyritinol hydrochloride - assayed in mouse cell activation studies. Arzneimittelforschung (1983) 33 372-377.
22. Walcheck B., Moore K.L., McEver R.P., Kishimoto T.K. Neutrophil- neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation on P-selectin in vitro. J. Clin. Invest. (1996) 98 1081-1087.
23. Konstantopoulos K., McIntire L.V. Effects of fluid dynamic forces on vascular cell adhesion. J. Clin. Invest. (1996) 98 2661-2665.
24. Falati S., Liu Q., Gross P. et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J. Exp. Med. (2003) 197 1585-1598.
25. Hrachovinova I., Cambien B., Hafezi-Moghadam A. et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat. Med. (2003) 9 1020-1025.