-
1
-
-
70349442548
-
The first 30 years of p53: Growing ever more complex
-
Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009; 9: 749-758.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 749-758
-
-
Levine, A.J.1
Oren, M.2
-
3
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004; 119: 861-872.
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.A.3
Liu, G.4
Rao, V.A.5
Parant, J.M.6
-
4
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004; 119: 847-860.
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
-
5
-
-
84890695935
-
Tumour-associated mutant p53 drives the Warburg effect
-
Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun 2013; 4: 2935.
-
(2013)
Nat Commun
, vol.4
, pp. 2935
-
-
Zhang, C.1
Liu, J.2
Liang, Y.3
Wu, R.4
Zhao, Y.5
Hong, X.6
-
6
-
-
44149124776
-
Chaperone-dependent stabilization and degradation of p53 mutants
-
Muller P, Hrstka R, Coomber D, Lane DP, Vojtesek B. Chaperone-dependent stabilization and degradation of p53 mutants. Oncogene 2008; 27: 3371-3383.
-
(2008)
Oncogene
, vol.27
, pp. 3371-3383
-
-
Muller, P.1
Hrstka, R.2
Coomber, D.3
Lane, D.P.4
Vojtesek, B.5
-
7
-
-
84890950891
-
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
-
Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X et al. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun 2013; 4: 2996.
-
(2013)
Nat Commun
, vol.4
, pp. 2996
-
-
Zheng, T.1
Wang, J.2
Zhao, Y.3
Zhang, C.4
Lin, M.5
Wang, X.6
-
8
-
-
84862636275
-
Mutant p53: One name, many proteins
-
Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev 2012; 26: 1268-1286.
-
(2012)
Genes Dev
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
9
-
-
0035131701
-
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
-
Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001; 21: 1874-1887.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1874-1887
-
-
Gaiddon, C.1
Lokshin, M.2
Ahn, J.3
Zhang, T.4
Prives, C.5
-
10
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 2012; 148: 244-258.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerod, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
-
11
-
-
77649298024
-
Modulation of the vitamin D3 response by cancer-associated mutant p53
-
Stambolsky P, Tabach Y, Fontemaggi G,Weisz L, Maor-Aloni R, Siegfried Z et al. Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 2010; 17: 273-285.
-
(2010)
Cancer Cell
, vol.17
, pp. 273-285
-
-
Stambolsky, P.1
Tabach, Y.2
Fontemaggi, G.3
Weisz, L.4
Maor-Aloni, R.5
Siegfried, Z.6
-
12
-
-
34247329362
-
P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
-
Song H, Hollstein M, Xu Y. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 2007; 9: 573-580.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 573-580
-
-
Song, H.1
Hollstein, M.2
Xu, Y.3
-
13
-
-
66349134417
-
Promyelocytic leukemia protein is required for gain of function by mutant p53
-
Haupt S, di Agostino S, Mizrahi I, Alsheich-Bartok O, Voorhoeve M, Damalas A et al. Promyelocytic leukemia protein is required for gain of function by mutant p53. Cancer Res 2009; 69: 4818-4826.
-
(2009)
Cancer Res
, vol.69
, pp. 4818-4826
-
-
Haupt, S.1
Di Agostino, S.2
Mizrahi, I.3
Alsheich-Bartok, O.4
Voorhoeve, M.5
Damalas, A.6
-
14
-
-
79960039752
-
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
-
Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell 2011; 20: 79-91.
-
(2011)
Cancer Cell
, vol.20
, pp. 79-91
-
-
Girardini, J.E.1
Napoli, M.2
Piazza, S.3
Rustighi, A.4
Marotta, C.5
Radaelli, E.6
-
15
-
-
28144460300
-
A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex
-
Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK et al. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J Biol Chem 2005; 280: 41207-41212.
-
(2005)
J Biol Chem
, vol.280
, pp. 41207-41212
-
-
Jin, J.1
Cai, Y.2
Yao, T.3
Gottschalk, A.J.4
Florens, L.5
Swanson, S.K.6
-
16
-
-
42149162883
-
Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage
-
Jha S, Shibata E, Dutta A. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol 2008; 28: 2690-2700.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2690-2700
-
-
Jha, S.1
Shibata, E.2
Dutta, A.3
-
17
-
-
40749135820
-
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
-
Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell 2008; 132: 945-957.
-
(2008)
Cell
, vol.132
, pp. 945-957
-
-
Venteicher, A.S.1
Meng, Z.2
Mason, P.J.3
Veenstra, T.D.4
Artandi, S.E.5
-
18
-
-
0033859666
-
An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc
-
Wood MA, McMahon SB, Cole MD. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell 2000; 5: 321-330.
-
(2000)
Mol Cell
, vol.5
, pp. 321-330
-
-
Wood, M.A.1
McMahon, S.B.2
Cole, M.D.3
-
19
-
-
0346690269
-
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling
-
Feng Y, Lee N, Fearon ER. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. Cancer Res 2003; 63: 8726-8734.
-
(2003)
Cancer Res
, vol.63
, pp. 8726-8734
-
-
Feng, Y.1
Lee, N.2
Fearon, E.R.3
-
20
-
-
84872842559
-
Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative earlystage breast cancers
-
Lacombe J, Mange A, Jarlier M, Bascoul-Mollevi C, Rouanet P, Lamy PJ et al. Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative earlystage breast cancers. Int J Cancer 2013; 132: 1105-1113.
-
(2013)
Int J Cancer
, vol.132
, pp. 1105-1113
-
-
Lacombe, J.1
Mange, A.2
Jarlier, M.3
Bascoul-Mollevi, C.4
Rouanet, P.5
Lamy, P.J.6
-
21
-
-
84866447658
-
Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma
-
Lauscher JC, Elezkurtaj S, Dullat S, Lipka S, Grone J, Buhr HJ et al. Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma. Oncol Rep 2012; 28: 1619-1624.
-
(2012)
Oncol Rep
, vol.28
, pp. 1619-1624
-
-
Lauscher, J.C.1
Elezkurtaj, S.2
Dullat, S.3
Lipka, S.4
Grone, J.5
Buhr, H.J.6
-
22
-
-
79960002978
-
A member of the ETS family EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis
-
Taniue K, Oda T, Hayashi T, Okuno M, Akiyama T. A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO Rep 2011; 12: 682-689.
-
(2011)
EMBO Rep
, vol.12
, pp. 682-689
-
-
Taniue, K.1
Oda, T.2
Hayashi, T.3
Okuno, M.4
Akiyama, T.5
-
23
-
-
36549048006
-
The AAA+ superfamily - A myriad of motions
-
Tucker PA, Sallai L. The AAA+ superfamily-a myriad of motions. Curr Opin Struct Biol 2007; 17: 641-652.
-
(2007)
Curr Opin Struct Biol
, vol.17
, pp. 641-652
-
-
Tucker, P.A.1
Sallai, L.2
-
24
-
-
0031554722
-
Biochemical properties of RuvBD113N: A mutation in helicase motif II of the RuvB hexamer affects DNA binding and ATPase activities
-
Mezard C, Davies AA, Stasiak A, West SC. Biochemical properties of RuvBD113N: a mutation in helicase motif II of the RuvB hexamer affects DNA binding and ATPase activities. J Mol Biol 1997; 271: 704-717.
-
(1997)
J Mol Biol
, vol.271
, pp. 704-717
-
-
Mezard, C.1
Davies, A.A.2
Stasiak, A.3
West, S.C.4
-
25
-
-
84859466247
-
First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay
-
Elkaim J, Castroviejo M, Bennani D, Taouji S, Allain N, Laguerre M et al. First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay. Biochem J 2012; 443: 549-559.
-
(2012)
Biochem J
, vol.443
, pp. 549-559
-
-
Elkaim, J.1
Castroviejo, M.2
Bennani, D.3
Taouji, S.4
Allain, N.5
Laguerre, M.6
-
26
-
-
58149104029
-
Gap junctions and cancer: New functions for an old story
-
Cronier L, Crespin S, Strale PO, Defamie N, Mesnil M. Gap junctions and cancer: new functions for an old story. Antioxid Redox Signal 2009; 11: 323-338.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 323-338
-
-
Cronier, L.1
Crespin, S.2
Strale, P.O.3
Defamie, N.4
Mesnil, M.5
-
27
-
-
77954310492
-
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
-
Feng Z, Levine AJ. The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol 2010; 20: 427-434.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 427-434
-
-
Feng, Z.1
Levine, A.J.2
-
28
-
-
84890862301
-
EGF receptor trafficking: Consequences for signaling and cancer
-
Tomas A, Futter CE, Eden ER. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol 2014; 24: 26-34.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 26-34
-
-
Tomas, A.1
Futter, C.E.2
Eden, E.R.3
-
29
-
-
67651177622
-
Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardiomyocytes
-
Xia Y, Gong KZ, Xu M, Zhang YY, Guo JH, Song Y et al. Regulation of gap-junction protein connexin 43 by beta-adrenergic receptor stimulation in rat cardiomyocytes. Acta Pharmacologica Sinica 2009; 30: 928-934.
-
(2009)
Acta Pharmacologica Sinica
, vol.30
, pp. 928-934
-
-
Xia, Y.1
Gong, K.Z.2
Xu, M.3
Zhang, Y.Y.4
Guo, J.H.5
Song, Y.6
-
30
-
-
70350418226
-
Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol
-
Guo K, Ma Q, Wang L, Hu H, Li J, Zhang D et al. Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol. Oncol Rep 2009; 22: 825-830.
-
(2009)
Oncol Rep
, vol.22
, pp. 825-830
-
-
Guo, K.1
Ma, Q.2
Wang, L.3
Hu, H.4
Li, J.5
Zhang, D.6
-
31
-
-
79960348853
-
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: Implication in breast cancer metastasis
-
Bist P, Leow SC, Phua QH, Shu S, Zhuang Q, Loh WT et al. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 2011; 30: 3174-3185.
-
(2011)
Oncogene
, vol.30
, pp. 3174-3185
-
-
Bist, P.1
Leow, S.C.2
Phua, Q.H.3
Shu, S.4
Zhuang, Q.5
Loh, W.T.6
-
32
-
-
84897069469
-
Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells
-
Masciarelli S, Fontemaggi G, Di Agostino S, Donzelli S, Carcarino E, Strano S et al. Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells. Oncogene 2014; 33: 1601-1608.
-
(2014)
Oncogene
, vol.33
, pp. 1601-1608
-
-
Masciarelli, S.1
Fontemaggi, G.2
Di Agostino, S.3
Donzelli, S.4
Carcarino, E.5
Strano, S.6
-
33
-
-
33748211158
-
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
-
Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A et al. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 2006; 10: 191-202.
-
(2006)
Cancer Cell
, vol.10
, pp. 191-202
-
-
Di Agostino, S.1
Strano, S.2
Emiliozzi, V.3
Zerbini, V.4
Mottolese, M.5
Sacchi, A.6
-
34
-
-
84877823153
-
Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer
-
Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S et al. Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell 2013; 23: 634-646.
-
(2013)
Cancer Cell
, vol.23
, pp. 634-646
-
-
Cooks, T.1
Pateras, I.S.2
Tarcic, O.3
Solomon, H.4
Schetter, A.J.5
Wilder, S.6
-
35
-
-
84894064647
-
RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model
-
Byrne FL, Yang L, Phillips PA, Hansford LM, Fletcher JI, Ormandy CJ et al. RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model. Oncogene 2014; 33: 882-890.
-
(2014)
Oncogene
, vol.33
, pp. 882-890
-
-
Byrne, F.L.1
Yang, L.2
Phillips, P.A.3
Hansford, L.M.4
Fletcher, J.I.5
Ormandy, C.J.6
-
36
-
-
79151483638
-
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
-
Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat 2010; 123: 725-731.
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 725-731
-
-
Gyorffy, B.1
Lanczky, A.2
Eklund, A.C.3
Denkert, C.4
Budczies, J.5
Li, Q.6
-
37
-
-
26444546442
-
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
-
Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 2005; 102: 13550-13555.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13550-13555
-
-
Miller, L.D.1
Smeds, J.2
George, J.3
Vega, V.B.4
Vergara, L.5
Ploner, A.6
-
38
-
-
84917705638
-
ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy
-
Messai Y, Noman MZ, Hasmim M, Janji B, Tittarelli A, Boutet M et al. ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy. Cancer Res 2014; 74: 6820-6832.
-
(2014)
Cancer Res
, vol.74
, pp. 6820-6832
-
-
Messai, Y.1
Noman, M.Z.2
Hasmim, M.3
Janji, B.4
Tittarelli, A.5
Boutet, M.6
-
39
-
-
39049124311
-
P19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein
-
Chen YW, Paliwal S, Draheim K, Grossman SR, Lewis BC. p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. Cancer Res 2008; 68: 476-482.
-
(2008)
Cancer Res
, vol.68
, pp. 476-482
-
-
Chen, Y.W.1
Paliwal, S.2
Draheim, K.3
Grossman, S.R.4
Lewis, B.C.5
-
40
-
-
84900413202
-
Tumoursuppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer
-
Goto Y, Nishikawa R, Kojima S, Chiyomaru T, Enokida H, Inoguchi S et al. Tumoursuppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer. FEBS Lett 2014; 588: 1973-1982.
-
(2014)
FEBS Lett
, vol.588
, pp. 1973-1982
-
-
Goto, Y.1
Nishikawa, R.2
Kojima, S.3
Chiyomaru, T.4
Enokida, H.5
Inoguchi, S.6
-
41
-
-
84877786902
-
TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness
-
Shan J, Dsouza SP, Bakhru S, Al-Azwani EK, Ascierto ML, Sastry KS et al. TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness. Cancer Res 2013; 73: 2840-2849.
-
(2013)
Cancer Res
, vol.73
, pp. 2840-2849
-
-
Shan, J.1
Dsouza, S.P.2
Bakhru, S.3
Al-Azwani, E.K.4
Ascierto, M.L.5
Sastry, K.S.6
-
42
-
-
84896886438
-
LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway
-
Li X, Yang Q, Yu H, Wu L, Zhao Y, Zhang C et al. LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget 2014; 5: 788-801.
-
(2014)
Oncotarget
, vol.5
, pp. 788-801
-
-
Li, X.1
Yang, Q.2
Yu, H.3
Wu, L.4
Zhao, Y.5
Zhang, C.6
-
43
-
-
84901218395
-
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma
-
Liu J, Zhang C, Lin M, Zhu W, Liang Y, Hong X et al. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget 2014; 5: 2635-2647.
-
(2014)
Oncotarget
, vol.5
, pp. 2635-2647
-
-
Liu, J.1
Zhang, C.2
Lin, M.3
Zhu, W.4
Liang, Y.5
Hong, X.6
-
44
-
-
84924252176
-
LIF negatively regulates tumoursuppressor p53 through Stat3/ID1/MDM2 in colorectal cancers
-
Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C et al. LIF negatively regulates tumoursuppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun 2014; 5: 5218.
-
(2014)
Nat Commun
, vol.5
, pp. 5218
-
-
Yu, H.1
Yue, X.2
Zhao, Y.3
Li, X.4
Wu, L.5
Zhang, C.6
-
45
-
-
77953096272
-
Negative regulation of tumor suppressor p53 by microRNA miR-504
-
Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell 2010; 38: 689-699.
-
(2010)
Mol Cell
, vol.38
, pp. 689-699
-
-
Hu, W.1
Chan, C.S.2
Wu, R.3
Zhang, C.4
Sun, Y.5
Song, J.S.6
|