Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2635-2647

  Liu, Juan ^a   Zhang, Cen ^a   Lin, Meihua ^a   Zhu, Wei ^a   Liang, Yingjian ^a   Hong, Xuehui ^a   Zhao, Yuhan ^a   Young, Ken H ^b   Hu, Wenwei ^a   Feng, Zhaohui ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

GLS2; Hepatocellular carcinoma; p53; PI3K AKT; Tumor suppression

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN KINASE B; GLS2 PROTEIN, HUMAN; GLUTAMINASE; MESSENGER RNA;

ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; GLS2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; PROMOTER REGION; PROTEIN BLOOD LEVEL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL ADHESION; CELL MOTION; CELL PROLIFERATION; DRUG SCREENING; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GLUTAMINASE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901218395     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1862     Document Type: Article

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