Subclinical hypothyroidism and type 2 diabetes: A systematic review and meta-analysis

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Han, Cheng ^a   He, Xue ^a   Xia, Xinghai ^a   Li, Yongze ^a   Shi, Xiaoguang ^a   Shan, Zhongyan ^a   Teng, Weiping ^a   Veves, Aristidis ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; EUTHYROIDISM; HUMAN; ISCHEMIC HEART DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PREVALENCE; SUBCLINICAL HYPOTHYROIDISM; SYSTEMATIC REVIEW; COMPLICATION; DIABETIC NEPHROPATHIES; DIABETIC NEUROPATHIES; HYPOTHYROIDISM; META ANALYSIS; ODDS RATIO; RISK FACTOR;

DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; HUMANS; HYPOTHYROIDISM; ODDS RATIO; PREVALENCE; RISK FACTORS;

EID: 84943175981     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135233     Document Type: Article

References (88)

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-53. Epub 2004/04/28. PMID: 15111519.
2. Klein R, Klein BE, Moss SE Visual impairment in diabetes. Ophthalmology. 1984; 91(1):1-9. Epub 1984/01/01. PMID: 6709312.
3. Perneger TV, Brancati FL, Whelton PK, Klag MJ. End-stage renal disease attributable to diabetes mellitus. Ann Intern Med. 1994; 121(12):912-8. Epub 1994/12/15. PMID: 7978716.
4. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998; 339(4):229-34. Epub 1998/07/23.doi: 10.1056/NEJM199807233390404 PMID: 9673301.
5. Surks MI, Ortiz E, Daniels G.H., Sawin CT, Col NF, Cobin RH, et al Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228-38. Epub 2004/01/15. doi:10.1001/jama.291.2.228291/2/228 [pii]. PMID: 14722150.
6. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362(12):1090-101. Epub 2010/03/26. doi:10.1056/NEJMoa0908292 362/12/1090 [pii]. PMID: 20335585.
7. Sawin CT, Castelli WP, Hershman J.M., McNamara P, Bacharach P. The aging thyroid. Thyroid deficiency in the Framingham Study. Arch Intern Med. 1985; 145(8):1386-8. Epub 1985/08/01. PMID: 4026469.
8. Distiller LA, Polakow ES, Joffe BI Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy. DiabetMed. 2014; 31(2): 172-5. Epub 2013/10/25. doi:10.1111/dme.12342 PMID: 24151823.
9. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T (4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002; 87(2):489-99. Epub 2002/02/12. doi:10.1210/jcem.87.2.8182 PMID: 11836274.
10. Tunbridge WM, Evered DC, Hall R, Appleton D., Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf). 1977; 7(6):481-93. Epub 1977/12/01. PMID: 598014.
11. Vanderpump MP, Tunbridge WM, French J.M., Appleton D., Bates D, Clark F, et al The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43(1):55-68. Epub 1995/07/01. PMID: 7641412.
12. Kabadi UM. 'Subclinical hypothyroidism'. Natural course of the syndrome during a prolonged follow-up study. Arch Intern Med. 1993; 153(8):957-61. Epub 1993/04/26. PMID: 8481068.
13. Tunbridge WM, Brewis M, French JM, Appleton D, Bird T, Clark F, et al. Natural history of autoimmune thyroiditis. Br Med J (Clin Res Ed). 1981; 282(6260):258-62. Epub 1981/01/24. PMID: 6779977; PubMed Central PMCID: PMC1504057.
14. Wang C, Crapo LM The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin North Am. 1997; 26(1):189-218. Epub 1997/03/01. PMID: 9074859.
15. Hak AE, Pols HA, Visser T.J., Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent riskfactorforatherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000; 132(4):270-8. Epub 2000/02/19. 200002150-00004 [pii]. PMID: 10681281.
16. Pearce SH, Brabant G, Duntas L.H., Monzani F., Peeters RP, Razvi S, et al. 2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J. 2013; 2(4):215-28. Epub 2014/05/02. doi:10.1159/000356507 etj-0002-0215 [pii]. PMID: 24783053; PubMed Central PMCID: PMC3923601.
17. Garber JR, Cobin RH, Gharib H, Hennessey J.V., Klein I., Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012; 22(12):1200-35. Epub 2012/09/08. doi:10.1089/thy.2012.0205 PMID: 22954017.
18. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. Epub 2009/07/22. doi:10.1371/journal. pmed.1000100 PMID: 19621070; PubMed Central PMCID: PMC2707010.
19. Monami M, Cremasco F, Lamanna C, Marchionni N, Mannucci E. Predictors of response to dipeptidyl peptidase-4 inhibitors: evidence from randomized clinical trials. Diabetes Metab Res Rev. 2011; 27 (4):362-72. Epub 2011/02/11. doi:10.1002/dmrr.1184 PMID: 21309062.
20. Wei M, He Y, Wang J., Chen N, Zhou Z, Wang Z. Laparoscopic versus open hepatectomywith or without synchronous colectomy for colorectal liver metastasis: a meta-analysis. PLoSOne. 2014; 9(1): e87461. Epub 2014/02/04. doi:10.1371/journal.pone.0087461 PONE-D-13-43969 [pii]. PMID: 24489916; PubMed Central PMCID: PMC3906170.
21. Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, et al. The methodological quality assessment tools for pre-clinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: asystematic review. J Evid Based Med. 2015; 8(1):2-10. Epub2015/01/17. doi:10.1111/jebm.12141 PMID: 25594108.
22. Zhao W, Han C, Shi X., Xiong C, Sun J, Shan Z., et al. Prevalence of goiter and thyroid nodules before and after implementation of the universal salt iodization program in mainland China from 1985 to 2014: asystematic review and meta-analysis. PLoSOne. 2014; 9(10):e109549. Epub 2014/10/15. doi:10.1371/journal.pone.0109549 PONE-D-14-20444 [pii]. PMID: 25313993; PubMed Central PMCID: PMC4196906.
23. Zhang J, Fu L, Shi J., Chen X, Li Y, Ma B, et al. The risk of metabolic syndrome in patients with rheumatoid arthritis: a meta-analysis of observational studies. PLoSOne. 2013; 8(10):e78151. Epub 2013/11/10 doi: 10.1371/journal.pone.0078151 PONE-D-13-19561 [pii]. PMID: 24205134; PubMed Central PMCID: PMC3808281.
24. Higgins JP, Thompson SG, Deeks J.J., Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414):557-60. Epub 2003/09/06. doi:10.1136/bmj.327.7414.557 327/7414/557 [pii]. PMID: 12958120; PubMed Central PMCID: PMC192859.
25. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088-101. Epub 1994/12/01. PMID: 7786990.
26. Liu W, Yang J, Yu M., Pan S. Screening for subclinical hypothyroidism in type 2 diabetes mellitus patients in Beijing (Article in Chinese). Clinical Focus. 2007; 22(21):1558-60.
27. Zhang N, Tang W, Lu W., Xu K, Bo L, Liu C., et al. Study on type 2 diabetes mellitus with subclinical hypothyroidism in Jiangsu(Article in Chinese). Chinese Journal of Practical Internal Medicine. 2009; 29 (12):1106-8.
28. Ghazali SM, Abbiyesuku FM Thyroid dysfunction in type 2 diabetics seen at the University College Hospital, Ibadan, Nigeria. Niger J Physiol Sci. 2010; 25(2):173-9. Epub 2010/01/01. PMID: 22314957.
29. Diez JJ, Sanchez P, Iglesias P. Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2011; 119(4):201-7. Epub 2011/04/06. doi:10.1055/s-0031-1271691 PMID: 21465427.
30. Deng X. Clinical analysis on incidence of subclinical hypothyroidism in type 2 diabetes mellitus in wujiaqu(Article in Chinese). Chinese Community Doctors. 2011; 13(247):124-5.
31. Zang S, Ning L, Yang L., Shou L. The prevalence of thyroid disease in geriatric type 2 diabetes(Article in Chinese). Journal of Medical Research. 2011; 40(4):114-6.
32. Diez JJ, Iglesias P. An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. DiabetMed. 2012; 29(12):1510-4. Epub 2012/04/18. doi:10.1111/j.1464-5491.2012.03687.x PMID: 22507223.
33. Zhang M, Qin S, Yang Y., Xiong Y, Cai X, Lai X. Thyroid function in patients with type 2 diabetes(Article in Chinese). Journal of Nanchang University(Medical Science). 2012; 52(12):42-3.
34. Shi Y, Zhao X. The prevalence of thyroid disease in type 2 diabetes(Article in Chinese). Guide of China Medicine. 2012; 10(22):25-6.
35. Wang Y, Li X, Wang S. Thyroid function investigation and analysis of patients with type 2 diabetes(Article in Chinese). Journal of Modern Laboratory Medicine. 2012; 27(2):132-3.
36. Liu X. Analysis of thyroid function state in type 2 diabetes patients(Article in Chinese). Guide of China Medicine. 2012; 10(33):55-6.
37. Sun L, Fei Y. Analysis of thyroid function state in type 2 diabetes patients(Article in Chinese). Zhejiang Practical Medicine 2013; 17(5):342-3.
38. Zhao R, Xie X. A preliminary study on the function of thyroid in patients with type 2 diabetes(Article in Chinese). Ningxia Med J. 2013; 35(9):810-2.
39. Xu X, Zhong X, Du Y., Pan T. Analysis of the clinical characteristics of newly diagnosed type 2 diabetic patients under different thyroid function(Article in Chinese). Acta Universitis Medicinalis Anhui. 2013; 48(6):675-7.
40. Xi W, Wang X. Retrospective study of thyroid disease of the inpatients with type 2 diabetes(Article in Chinese). Inner Mongolia Med. 2014; (6):686-9.
41. Zhang D, Zhang L, Zhang Y., Zeng Y, Li L, Lei M. Association of subclinical hypothyroidism with diabetic chronic complications in type 2 diabetic patients(Article in Chinese). Chin J Diabetes. 2014; 22(1):25-9.
42. Zhu Y, Zheng D. Clinical screening analysis of type 2 diabetes patients with thyroid disease(Article in Chinese). Zhejiang Clinical Medical Journal. 2014; 16(9):1451-2.
43. Gopinath B, Wang JJ, Kifley A, Wall JR, Leeder SR, Mitchell P. Type 2 diabetes does not predict incident thyroid dysfunction in the elderly. Diabetes Res Clin Pract. 2008; 82(3):e11-3. Epub 2008/10/08. doi:10.1016/j.diabres.2008.08.017 PMID: 18838187.
44. Zhang H, li J, Ji Q. The association between type 2 diabetes and thyroid disease(Article in Chinese). Shandong Medical Journal. 2012; 52(17):52-3.
45. Zhao F, Zhang L, Dong Y., Qian W. Prevalence of subclinical hypothyroidism in patients with type 2 diabetes mellitus(Article in Chinese). Chin J Diabetes. 2012; 11(4):417-8.
46. Liu C, Zheng T, Yang L., Du W, PENG S. Changes of serum thyroid hormone levels in elderly type 2 diabetes patients and clinical significance(Article in Chinese). Journal of Clinical Research. 2014; 31 (002):323-5.
47. Chen HS, Wu TE, Jap TS, Lu RA, Wang ML, Chen RL, et al. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabet Med. 2007; 24 (12):1336-44. Epub 2007/10/19. doi:10.1111/j.1464-5491.2007.02270.x PMID: 17941864.
48. Wang M, Ren A, Wang D. Study on the correlation between type 2 diabetes complicating subclinical hypothyroidism and diabetic vascular complications(Article in Chinese). China Journal of Modern Medicine. 2012; 22(36):66-70.
49. Tang J, Kang Z, Li Q, Lei L, He L, Luo F. Clinical parameters analysis of type 2 diabetes mellitus patients with subclinical hypothyroidism(Article in Chinese). Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases. 2012; 20(5):591-2.
50. Shen Y, Bi H. Impact of subclinical hypothyroidism on chronic complications of type 2 diabetes(Article in Chinese). Wuhan University Journal. 2012; 33(3):415-9.
51. Zhou J, Wang H. The correlation between the symptoms of hypothyroidism and vascular complications in type 2 diabetes patients(Article in Chinese). Medical Recapitulate. 2013; 19(23):4383-4.
52. Furukawa S, Yamamoto S, Todo Y., Maruyama K, Miyake T, Ueda T, et al. Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. Endocr J. 2014; 61(10):1011-8. Epub 2014/08/08. PMID: 25100149.
53. Lv B, Liu H. Clinical analysis of type 2 diabetes patients with subclinical hypothyroidism(Article in Chinese). Guide of China Medicine. 2014; 12(5):135-6.
54. Lu L, Wang Y. The correlation between subclinical hypothyroidism and diabetic microvascular complication in type 2 diabetic patients(Article in Chinese). Shanxi Medical Journal. 2014; 43(20):2374-7.
55. Shao F, Li X, Zhang Z., Luo Y. Study of the impact of subclinical hypothyroidism on chronic complications of type 2 diabetes mellitus(Article in Chinese). Journal of Clinical Research. 2014; 31(007):1291-3.
56. Chen Y. Comments on the impact that subclinical hypothyroidism makes on diabetic retinopathy in the elderly patients with type 2 diabetes mellitus (Article in Chinese). Medical Information. 2014; 27(3):169-70.
57. Liu W, Hua L, Yu M., Xie R, Pan S, Yang J. Research on association between diabetic macrovascular complications and subclinical hypothyroidism(Article in Chinese). Clinical Focus. 2009; 24(23):2063-6.
58. Hong T, Zhao S, Mao H., Wang Z. Effects of type 2 diabetes mellitus coexisted with subclinical hypothyroidism on the incidence of diabeticfoot(Article in Chinese). Chinese Journal of Gerontology. 2012; 32 (18):3909-11.
59. Fu X, Zhao S, Mao H., Wang Z. Researches on factors affecting vasodilation function of elderly type 2 diabetes mellitus patients with subclinical hypothyroidism(Article in Chinese). Chinese General Practice. 2013; 16(23):2674-6.
60. Liu H, Lin X. The influence of subclinical hypothyroidism on serum high sensitivity C-reactive protien and macrovascular disease in type 2 diabetic patients(Article in Chinese). Chinese Journal of Diabetes. 2014; 22(006):511-3.
61. Duan Q, Chi X, Du S, Wang L, Hua B, Yin J, et al. The impact of subclinical hypothyroidism on lower extremity arterial disease of type 2 diabetes mellitus patients(Article in Chinese). Acta Academiae Medicinae Neimongol. 2014; 36(5):439-41.
62. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC The Colorado thyroid disease prevalence study. Arch Intern Med. 2000; 160(4):526-34. Epub 2000/03/01. PMID: 10695693.
63. Rivolta G, Cerutti R, Colombo R., Miano G, Dionisio P, Grossi E. Prevalence of subclinical hypothyroidism in a population living in the Milan metropolitan area. J Endocrinol Invest. 1999; 22(9):693-7. Epub 1999/12/14. PMID: 10595833.
64. Meng F, Zhao R, Liu P., Liu L, Liu S. Assessment of iodine status in children, adults, pregnant women and lactating women in iodine-replete areas of China. PLoSOne. 2013; 8(11):e81294. Epub 2013/11/28. doi:10.1371/journal.pone.0081294 PONE-D-13-25552 [pii]. PMID: 24282581; PubMed Central PMCID: PMC3840003.
65. Zou S, Wu F, Guo C, Song J, Huang C, Zhu Z, et al. Iodine nutrition and the prevalence of thyroid disease after salt iodization: a cross-sectional survey in Shanghai, a coastal area in China. PLoS One. 2012; 7(7):e40718. Epub 2012/08/23. doi:10.1371/journal.pone.0040718 PONE-D-11-08927 [pii]. PMID: 22911705; PubMed Central PMCID: PMC3414375.
66. Taylor PN, Porcu E, Chew S., Campbell PJ, Traglia M, Brown SJ, et al Whole-genome sequence-based analysis of thyroid function. Nat Commun. 2015; 6:5681. Epub 2015/03/07. doi:10.1038/ncomms6681 ncomms6681 [pii]. PMID: 25743335; PubMed Central PMCID: PMC4366514.
67. Tamez-Perez H.E., Martinez E, Quintanilla-Flores DL, Tamez-Pena AL, Gutierrez-Hermosillo H, Diaz de Leon-Gonzalez E. The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study. Med Clin (Barc). 2012; 138(11):475-7. Epub 2011/12/30. doi:10.1016/j.medcli.2011.08.009 PMID: 22204860.
68. Al-Hamodi Z., Al-Habori M, Al-Meeri A, Saif-Ali R. Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetol Metab Syndr. 2014; 6(1):99-106. Epub 2014/10/03. doi:10.1186/1758-5996-6-99362 [pii]. PMID: 25276234; PubMed Central PMCID: PMC4177707.
69. Xu J, Zhao YH, Chen YP, Yuan XL, Wang J, Zhu H, et al. Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis. The Scientific World Journal. 2014; 2014:926-932. Epub 2014/09/10. doi:10.1155/2014/926932 PMID: 25202741; PubMed Central PMCID: PMC4151523.
70. Ortiga-Carvalho T.M., Oliveira KJ, Soares B.A., Pazos-Moura CC. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J Endocrinol. 2002; 174(1):121-5. Epub 2002/07/06. doi:JOE04754 [pii]. PMID: 12098670.
71. Reusch CE, Tomsa K. Serum fructosamine concentration in cats with overt hyperthyroidism. J Am Vet Med Assoc. 1999; 215(9):1297-300. Epub 1999/12/20. PMID: 10553441.
72. Ripoli A, Pingitore A, Favilli B., Bottoni A, Turchi S, Osman N.F., et al. Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study. J Am Coll Cardiol. 2005; 45(3):439-45. Epub 2005/02/01. doi:S0735-1097(04)02156-4 [pii] doi: 10.1016/j.jacc.2004.10.044 PMID: 15680725.
73. Asvold BO, Bjoro T, Vatten LJ Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study. Eur J Endocrinol. 2011; 164(1):101-5. Epub 2010/10/12. doi:10.1530/EJE-10-0705EJE-10-0705 [pii]. PMID: 20930062.
74. Owen PJ, Rajiv C, Vinereanu D., Mathew T, Fraser AG, Lazarus JH. Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab. 2006; 91(6):2126-32. Epub 2006/03/16. doi:jc.2005-2108 [pii] doi: 10.1210/jc.2005-2108 PMID: 16537677.
75. Kotsis V, Alevizaki M, Stabouli S., Pitiriga V, Rizos Z, Sion M, et al. Hypertension and hypothyroidism: results from an ambulatory blood pressure monitoring study. J Hypertens. 2007; 25(5):993-9. Epub 2007/04/07. doi:10.1097/H JH.0b013e328082e2ff 00004872-200705000-00016 [pii]. PMID: 17414663.
76. Hellstrom A, Carlsson B, Niklasson A., Segnestam K, Boguszewski M, de Lacerda L, et al. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002; 87(7):3413-6. Epub 2002/07/11. doi:10.1210/jcem.87.7.8629 PMID: 12107259.
77. Sevilla-Romero E., Munoz A, Pinazo-Duran MD. Low thyroid hormone levels impairthe perinatal development of the rat retina. Ophthalmic Res. 2002; 34(4):181-91. Epub 2002/09/26. doi:63885 [pii] 63885. PMID: 12297689.
78. Navegantes LC, Silveira LC, Santos GL Effect of congenital hypothyroidism on cell density in the ganglion cell layer of the rat retina. Braz J Med Biol Res. 1996; 29(5):665-8. Epub 1996/05/01. PMID: 9033820.
79. Monzani F, Caraccio N, Kozakowa M., Dardano A, Vittone F, Virdis A., et al. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2004; 89(5):2099-106. Epub 2004/05/06. doi:10.1210/jc.2003-031669 PMID: 15126526.
80. Nagasaki T, Inaba M, Yamada S, Shirakawa K, Nagata Y, Kumeda Y, et al. Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function: a double-blind, placebo-controlled study. Eur J Endocrinol. 2009; 160(3):409-15. Epub 2008/12/31. doi:10.1530/EJE-08-0742EJ E-08-0742 [pii]. PMID: 19114542.
81. Kim SK, Kim SH, Park K.S., Park SW, Cho YW. Regression of the increased common carotid artery-intima media thickness in subclinical hypothyroidism after thyroid hormone replacement. Endocr J. 2009; 56(6):753-8. Epub 2009/06/10. doi:JST.JSTAGE/endocrj/K09E-049 [pii]. PMID: 19506325.
82. Turemen EE, Cetinarslan B, Sahin T., Canturk Z, Tarkun I. Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr J. 2011; 58 (5):349-54. Epub 2011/04/15. doi:JST.JSTAGE/endocrj/K10E-333 [pii]. PMID: 21490407.
83. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab. 2007; 92(5):1715-23. Epub 2007/02/15. doi: jc.2006-1869 [pii] doi: 10.1210/jc.2006-1869 PMID: 17299073.
84. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab. 2008; 93(8):2998-3007. Epub 2008/05/29. doi:10.1210/jc.2008-0167jc.2008-0167 [pii]. PMID: 18505765.
85. Yerdelen D, Ertorer E, Koc F. The effects of hypothyroidism on strength-duration properties of peripheral nerve. J Neurol Sci. 2010; 294(1-2):89-91. Epub 2010/05/11. doi:10.1016/j.jns.2010.03.026 S0022-510X(10)00152-8 [pii]. PMID: 20452625.
86. Shirabe T, Tawara S, Terao A., Araki S. Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle. J Neurol Neurosurg Psychiatry. 1975; 38(3):241-7. Epub 1975/03/01. PMID: 168317; PubMed Central PMCID: PMC491903.
87. Kadiyala R, Peter R, Okosieme OE Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int J Clin Pract. 2010; 64(8):1130-9. Epub 2010/07/21. doi:10.1111/j.1742-1241.2010.02376.x PMID: 20642711.
88. Cappelli C, Rotondi M, Pirola I, Agosti B, Gandossi E, Valentini U, et al. TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients. Diabetes Care. 2009; 32(9):1589-90. Epub 2009/06/09. doi:10.2337/dc09-0273dc09-0273 [pii]. PMID: 19502536; PubMed Central PMCID: PMC2732148.