The Risk of Metabolic Syndrome in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Zhang, Jianming ^a   Fu, Lingyu ^a   Shi, Jingpu ^a   Chen, Xin ^a   Li, Yongze ^a   Ma, Bing ^a   Zhang, Yao ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL EVALUATION; DISEASE ASSOCIATION; HUMAN; METABOLIC SYNDROME X; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREVALENCE; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; RISK FACTOR;

ARTHRITIS, RHEUMATOID; CROSS-SECTIONAL STUDIES; HUMANS; METABOLIC SYNDROME X; PREVALENCE;

EID: 84886410060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078151     Document Type: Article

References (60)

1. Reaven GM, (1997) Role of insulin resistance in human disease. Nutrition 13: 65-65. PubMed: 9058458.
2. Reilly MP, Rader DJ, (2003) The metabolic syndrome. Circulation 108: 1546-1551. doi:10.1161/01.CIR.0000088846.10655.E0. PubMed: 14517150.
3. Ford ES, (2005) Risks for All-Cause Mortality, Cardiovascular Disease, and Diabetes Associated With the Metabolic Syndrome A summary of the evidence. Diabetes Care 28: 1769-1778. doi:10.2337/diacare.28.7.1769. PubMed: 15983333.
4. Gabriel SE, (2001) The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27: 269-281. doi:10.1016/S0889-857X(05)70201-5. PubMed: 11396092.
5. Goshayeshi L, Saber HR, Sahebari M, Rezaieyazdi Z, Rafatpanah H, et al. (2012) Association between metabolic syndrome, BMI, and serum vitamin D concentrations in rheumatoid arthritis. Clin Rheumatol, 31: 1-7. PubMed: 22581277.
6. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283: 2008-2012. doi:10.1001/jama.283.15.2008. PubMed: 10789670.
7. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, et al. (2000) Meta-analysis of observational studies in epidemiology. J Am Med Assoc 283: 2008-2012. doi:10.1001/jama.283.15.2008.
8. Higgins JP, Thompson SG, Deeks JJ, Altman DG, (2003) Measuring inconsistency in meta-analyses. Bmj 327: 557-560. doi:10.1136/bmj.327.7414.557. PubMed: 12958120.
9. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188. doi:10.1016/0197-2456(86)90046-2. PubMed: 3802833.
10. Begg CB, Mazumdar M, (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics, 50: 1088-1101. PubMed: 7786990.
11. Egger M, Smith GD, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. Bmj 315: 629-634. doi:10.1136/bmj.315.7109.629. PubMed: 9310563.
12. Terrin N, Schmid CH, Lau J, Olkin I, (2003) Adjusting for publication bias in the presence of heterogeneity. Statist Med 22: 2113-2126. doi:10.1002/sim.1461. PubMed: 12820277.
13. Sahebari M, Goshayeshi L, Mirfeizi Z, Rezaieyazdi Z, Hatef MR, et al. (2011) Investigation of the Association between Metabolic Syndrome and Disease Activity in Rheumatoid Arthritis. TheScientificWorldJournal 11: 1195-1205. doi:10.1100/tsw.2011.111. PubMed: 21666989.
14. Toms TE, Panoulas VF, Douglas KMJ, Griffiths HR, Kitas GD, (2008) Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 10: 145. doi:10.1186/ar2578. PubMed: 19091101.
15. Dessein PH, Tobias M, Veller MG, (2006) Metabolic syndrome and subclinical atherosclerosis in rheumatoid arthritis. J Rheumatol 33: 2425-2432. PubMed: 17080519.
16. Toms TE, Panoulas VF, John H, Douglas KMJ, Kitas GD, (2009) Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60-More than just an anti-inflammatory effect? A cross sectional study. Arthritis Res Ther 11: 110. doi:10.1186/ar2653. PubMed: 19439055.
17. Zonana-Nacach A, Santana-Sahagún E, Jiménez-Balderas FJ, Camargo-Coronel A, (2008) Prevalence and factors associated with metabolic syndrome in patients with rheumatoid arthritis and systemic lupus erythematosus. JCR. J Clin Rheumatol 14: 74-77. doi:10.1097/RHU.0b013e31816b2faa. PubMed: 18391674.
18. Raterman HG, Van Eijk IC, Voskuyl AE, Peters MJ, Dijkmans BA, et al. (2010) The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional study. Ann Rheum Dis 69: 39-42. doi:10.1136/ard.2010.129627k. PubMed: 19103637.
19. Gonzalez-Gay M, Vazquez-Rodriguez T, Garcia-Unzueta M, Berja A, Miranda-Filloy J, et al. (2010) Visfatin is not associated with inflammation or metabolic syndrome in patients with severe rheumatoid arthritis undergoing anti-TNF-α therapy. Clin Exp Rheumatol 28: 56.
20. Baker JF, Mehta NN, Baker DG, Toedter G, Shults J, et al. (2012) Vitamin D, Metabolic Dyslipidemia, and Metabolic Syndrome in Rheumatoid Arthritis. Am J Med, 125: 1036.e9-1036.e15. PubMed: 22800875.
21. Ferraccioli G, Gremese E, (2011) Adiposity, joint and systemic inflammation: the additional risk of having a metabolic syndrome in rheumatoid arthritis. Swiss Med Wkly 141: w13211. PubMed: 21618146.
22. Raterman HG, Voskuyl AE, Dijkmans BAC, Nurmohamed MT, (2009) Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome. Arthritis Res Ther 11: R110. doi:10.1186/ar2653. PubMed: 19607680.
23. Dessein PH, Stanwix AE, Joffe BI, (2002) Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis. Arthritis Res 4: R5. doi:10.1186/ar428. PubMed: 12223108.
24. Channual J, Wu JJ, Dann FJ, (2009) Effects of tumor necrosis factor-α blockade on metabolic syndrome components in psoriasis and psoriatic arthritis and additional lessons learned from rheumatoid arthritis. Dermatol Therapy 22: 61-73. doi:10.1111/j.1529-8019.2008.01217.x.
25. Santos MJ, Vinagre F, Silva JJ, Gil V, Fonseca JE, (2010) Cardiovascular risk profile in systemic lupus erythematosus and rheumatoid arthritis: a comparative study of female patients. PubMed: 20975635.
26. Dao HH, Do QT, Sakamoto J, (2010) Increased frequency of metabolic syndrome among Vietnamese women with early rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 12: R218. doi:10.1186/ar3203. PubMed: 21182767.
27. Crowson CS, Myasoedova E, Davis JM III, Matteson EL, Roger VL, et al. (2011) Increased prevalence of metabolic syndrome associated with rheumatoid arthritis in patients without clinical cardiovascular disease. J Rheumatol 38: 29-35. doi:10.3899/jrheum.100346. PubMed: 20952464.
28. Karvounaris SA, Sidiropoulos PI, Papadakis JA, Spanakis EK, Bertsias GK, et al. (2007) Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study. Ann Rheum Dis 66: 28-33. PubMed: 16793841.
29. da Cunha VR, Brenol CV, Brenol JC, Fuchs SC, Arlindo EM, et al. (2012) Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity. Scand J Rheumatol 41: 186-191. doi:10.3109/03009742.2011.626443. PubMed: 22416768.
30. Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, et al. (2008) Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis 196: 756-763. doi:10.1016/j.atherosclerosis.2007.01.004. PubMed: 17266963.
31. Mok CC, Ko GTC, Ho LY, Yu KL, Chan PT, et al. (2011) Prevalence of atherosclerotic risk factors and the metabolic syndrome in patients with chronic inflammatory arthritis. Arthritis Care Res 63: 195-202. doi:10.1002/acr.20363. PubMed: 20890981.
32. Karimi M, MAZLOOMZADEH S, KAFAN S, AMIRMOGHADAMI H, (2011) The frequency of metabolic syndrome in women with rheumatoid arthritis and in controls. Int J Rheumatic Dis 14: 248-254. doi:10.1111/j.1756-185X.2011.01595.x. PubMed: 21816020.
33. Karakoc M, Batmaz I, Sariyildiz MA, Tahtasiz M, Cevik R, et al. (2012) The Relationship of Metabolic Syndrome With Disease Activity and the Functional Status in Patients With Rheumatoid Arthritis. Clin Med Res 4: 279-285. PubMed: 22870176.
34. Sahebari M, Goshayeshi L, Mirfeizi Z, Rezaieyazdi Z, Hatef MR, et al. (2011) Investigation of the association between metabolic syndrome and disease activity in rheumatoid arthritis. The Scientific. World J 11: 1195-1205. doi:10.1100/tsw.2011.111.
35. Ormseth MJ, Lipson A, Alexopoulos N, Hartlage GR, Oeser AM, et al. (2013) Epicardial adipose tissue is associated with cardiometabolic risk and the metabolic syndrome in patients with rheumatoid arthritis. Arthritis Care Res.
36. Lee S-G, Kim J-M, Lee S-H, Kim K-H, Kim J-H, et al. (2013) Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects? Korean J Intern Med 28: 206-215. doi:10.3904/kjim.2013.28.2.206. PubMed: 23526131.
37. Meigs JB, (2004) Metabolic Syndrome In search of a clinical role. Diabetes Care 27: 2761-2763. doi:10.2337/diacare.27.11.2761. PubMed: 15505020.
38. Del Rincón ID, Williams K, Stern MP, Freeman GL, Escalante A, (2001) High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum 44: 2737-2745. doi:10.1002/1529-0131(200112)44:12. PubMed: 11762933.
39. Maradit-Kremers H, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE, (2005) Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 52: 722-732. doi:10.1002/art.20878. PubMed: 15751097.
40. Neuschwander-Tetri BA, Caldwell SH, (2003) Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37: 1202-1219. doi:10.1053/jhep.2003.50193. PubMed: 12717402.
41. Eckel RH, Grundy SM, Zimmet PZ, (2005) The metabolic syndrome. Lancet 365: 1415-1428. doi:10.1016/S0140-6736(05)66378-7. PubMed: 15836891.
42. La Montagna G, Cacciapuoti F, Buono R, Manzella D, Mennillo GA, et al. (2007) Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis. Diabetes Vasc Dis Res 4: 130-135. PubMed: 17654447.
43. Dessein PH, Norton GR, Woodiwiss AJ, Joffe BI, Solomon A, (2007) Independent role of conventional cardiovascular risk factors as predictors of C-reactive protein concentrations in rheumatoid arthritis. J Rheumatol 34: 681-688. PubMed: 17299845.
44. Pamuk ON, Unlü E, Cakir N, (2006) Role of insulin resistance in increased frequency of atherosclerosis detected by carotid ultrasonography in rheumatoid arthritis. J Rheumatol 33: 2447-2452. PubMed: 17143979.
45. Dessein PH, Joffe BI, Stanwix A, Botha AS, Moomal Z, (2002) The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis. J Rheumatol 29: 462-466. PubMed: 11908557.
46. Romeo GR, Lee J, Shoelson SE, (2012) Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32: 1771-1776. doi:10.1161/ATVBAHA.111.241869. PubMed: 22815343.
47. Trayhurn P, Wood IS, (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355. doi:10.1079/BJN20041213. PubMed: 15469638.
48. Gualillo O, González-Juanatey JR, Lago F, (2007) The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trends Cardiovasc Med 17: 275-283. doi:10.1016/j.tcm.2007.09.005. PubMed: 18021938.
49. Wulan SN, Westerterp KR, Plasqui G, (2010) Ethnic differences in body composition and the associated metabolic profile: a comparative study between Asians and Caucasians. Maturitas 65: 315-319. doi:10.1016/j.maturitas.2009.12.012. PubMed: 20079586.
50. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645. doi:10.1161/CIRCULATIONAHA.109.192644. PubMed: 19805654.
51. Alberti KG, Zimmet P, Shaw J, (2005) The metabolic syndrome--a new worldwide definition. Lancet 366: 1059-1062. doi:10.1016/S0140-6736(05)67402-8. PubMed: 16182882.
52. Grundy SM, Cleeman JI, Merz CNB, Brewer HB, Clark LT, et al. (2004) Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. J Am Coll Cardiol 44: 720-732. doi:10.1016/j.jacc.2004.07.001. PubMed: 15358046.
53. Panel Expert, DetectionEvaluation on, THBCA (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). J-Am Med Assoc 285: 2486-2497. doi:10.1001/jama.285.19.2486.
54. Balkau B, Charles M, (1999) Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med J Br Diabet Assoc 16: 442. doi:10.1046/j.1464-5491.1999.00059.x.
55. Alberti KG, Zimmet PZ, (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15: 539-553. doi:10.1002/(SICI)1096-9136(199807)15:7. PubMed: 9686693.
56. Altman DG, (2001) Systematic reviews of evaluations of prognostic variables. Bmj 323: 224-228. doi:10.1136/bmj.323.7306.224. PubMed: 11473921.
57. Svenson KL, Lundqvist G, Wide L, Hällgren R, (1987) Impaired glucose handling in active rheumatoid arthritis: effects of corticosteroids and antirheumatic treatment. Metabolism 36: 944-948. doi:10.1016/0026-0495(87)90129-6. PubMed: 3309546.
58. Park Y-B, Choi HK, Kim M-Y, Lee W-K, Song J, et al. (2002) Effects of antirheumatic therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study. Am J Med 113: 188-193. doi:10.1016/S0002-9343(02)01186-5. PubMed: 12208376.
59. Choi HK, Seeger JD, (2005) Lipid profiles among US elderly with untreated rheumatoid arthritis--the Third National Health and Nutrition Examination Survey. J Rheumatol 32: 2311-2316. PubMed: 16331755.
60. Bocharov AV, Huang W, Vishniakova TG, Zaitseva EV, Frolova EG, et al. (1995) Glucocorticoids upregulate high-affinity, high-density lipoprotein binding sites in rat hepatocytes. Metabolism 44: 730-738. doi:10.1016/0026-0495(95)90185-X. PubMed: 7783657.