Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function: A double-blind, placebo-controlled study

European Journal of Endocrinology

Volumn 160, Issue 3, 2009, Pages 409-415

  Nagasaki, Toshiki ^a   Inaba, Masaaki ^a   Yamada, Shinsuke ^a   Shirakawa, Kumi ^a   Nagata, Yuki ^a   Kumeda, Yasuro ^a   Hiura, Yoshikazu ^a   Tahara, Hideki ^a   Ishimura, Eiji ^a   Nishizawa, Yoshiki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; PLACEBO; THYROTROPIN; THYROXINE;

ABSENCE OF SIDE EFFECTS; ADULT; ANKLE BRACHIAL INDEX; ARTERIAL STIFFNESS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG RESPONSE; FEMALE; HASHIMOTO DISEASE; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PULSE PRESSURE; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION; AGED; ANKLE; AUTOIMMUNE THYROIDITIS; BLOOD; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; DRUG EFFECT; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PULSATILE FLOW; VASCULARIZATION;

AGED; ANKLE JOINT; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPOTHYROIDISM; MIDDLE AGED; PLACEBOS; PULSATILE FLOW; THYROIDITIS, AUTOIMMUNE; THYROTROPIN; THYROXINE;

EID: 62649109930     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-08-0742     Document Type: Article

References (33)

1. Evered DC, Tunbridge WM, Hall R, Appleton D, Brewis M, Clark F, Manuel P & Young E. Thyroid hormone concentrations in a large scale community survey. Effect of age, sex, illness and medication. Clinica Chimica Acta 1978 83 223-229.
2. Cappola AR, Fried LP, Arnold AM, Danese MD, Kuller LH, Burke GL, Tracy RP & Ladenson PW. Thyroid status, cardiovascular risk, and mortality in older adults. Journal of the American Medical Association 2006 295 1033-1041.
3. Singh S, Molnar J & Arora R. Association between subclinical hypothyroidism and coronary heart disease in 2006. International Journal of Cardiology 2008 125 41-48.
4. Luboshitzky R, Aviv A, Herer P & Lavie L. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid 2002 12 421-425.
5. Althaus BU, Staub JJ, Ryff-De Leche A, Oberhansli A & Stahelin HB. LDL/HDL-changes in subclinical hypothyroidism: possible risk factors for coronary heart disease. Clinical Endocrinology 1998 28 157-163.
6. Pearce EN. Hypothyroidism and dyslipidemia: modern concepts and approaches. Current Cardiology Reports 2004 6 451-456.
7. Monzani F, Caraccio N, Kozakowa M, Dardano A, Vittone F, Virdis A, Taddei S, Palombo C & Ferrannini E. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. Journal of Clinical Endocrinology and Metabolism 2004 89 2099-2106.
8. Monzani F, Di Bello V, Caraccio N, Bertini A, Giorgi D, Giusti C & Ferrannini EJ. Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebocontrolled study. Journal of Clinical Endocrinology and Metabolism 2001 86 1110-1115.
9. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S & Yamamoto Y. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertension Research 2002 25 359-364.
10. Measume S, Benetos A, Henry OF, Rundnichi A & Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arteriosclerosis, Thrombosis, and Vascular Biology 2001 21 2046-2050.
11. Nagasaki T, Inaba M, Kumeda Y, Hiura Y, Shirakawa K, Yamada S, Henmi Y, Ishimura E & Nishizawa Y. Increased pulse wave velocity in subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2005 91 154-158.
12. Nagasaki T, Inaba M, Yamada S, Kumeda Y, Hiura Y & Nishizawa Y. Changes in brachial-ankle pulse wave velocity in subclinical hypothyroidism during normalization of thyroid function. Biomedicine and Pharmacotherapy 2007 61 482-487.
13. Takami T & Shigemasa M. Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients. Hypertension Research 2003 26 609-614.
14. Miura S, Tanaka E, Mori A, Toya M, Takahashi K, Nakahara K, Ohmichi M & Kurachi H. Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women. Maturitas 2003 45 293-298.
15. Koshiyama H, Tanaka S & Minamikawa J. Effect of calcium channel blocker amlodipine on the intima-media thickness of carotid arterial wall in type 2 diabetes. Journal of Cardiovascular Pharmacology 1999 33 894-896.
16. Mercuri M, Bond MG, Sirtori CR, Veglia F, Crepaldi G, Feruglio FS, Descovich G, Ricci G, Rubba P, Mancini M, Gallus G, Bianchi G, D'Alò G & Ventura A. Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population:the carotid atherosclerosis Italian ultrasound study. American Journal of Medicine 1996 101 627-634.
17. Migdalis IN, Varvarigos N, Charalabides J, Leontiades E, Gerolimou B, Mantzara F & Karmaniolas K. Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients. International Angiology 2001 20 126-130.
18. Koshiyama H, Nakamura Y, Tanaka S & Minamikawa J. Decrease in carotid intima-media thickness after 1-year therapy with etidronate for osteopenia associated with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2000 85 2793-2796.
19. Friedewald WT, Levy RI & Fredrickson DS. Estimation of the concentration of low-density lipoprotein in plasma without use of preparative ultracentrifuge. Clinical Chemistry 1972 18 499.
20. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB & Maseri A. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. New England Journal of Medicine 1994 331 417-424.
21. Girgensohn S, Liedtke R, Balzer G, Castor S & Hauser M. Performance of the ACS: Centaur™ high-capacity, random-access immunoassay system. Clinical Laboratory 1997 43 975-983.
22. Arai T, Kurashima C, Utsuyama M, Sawabe M & Ito H. Measurement of anti-thyroglobulin and anti-thyroid peroxidase antibodies using highly sensitive radioimmunoassay: an effective method for detecting asymptomatic focal lymphocytic thyroiditis in the elderly. Endocrine Journal 2000 47 575-582.
23. Kelly R, Hayward C, Avolio A & O'Rourke M. Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989 80 1652-1659.
24. McDermott MT & Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated. Journal of Clinical Endocrinology and Metabolism 2001 86 4585-4590.
25. Meier C, Staub JJ, Roth CB, Gueglielmetti M, Kunz M, Miserez AR, Drewe J, Huber P, Herzog R & Muller B. TSH controlled L-thyroxine therapy reduces cholesterol levels. Journal of Clinical Endocrinology and Metabolism 2001 86 4860-4866.
26. Chu JW & Crapo LM. The treatment of subclinical hypothyroidism is seldom necessary. Journal of Clinical Endocrinology and Metabolism 2001 86 4591-4599.
27. Kahaly GJ. Cardiovascular and atherogenic aspects of subclinical hypothyroidism. Thyroid 2000 10 665-679.
28. Biondi B & Klein I. Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 2004 24 1-13.
29. Nagasaki T, Inaba M, Shirakawa K, Hiura Y, Tahara H, Kumeda Y, Ishikawa T, Ishimura E & Nishizawa Y. Increased levels of C-reactive protein in hypothyroid patients and its correlation with arterial stiffness in the common carotid artery. Biomedicine and Pharmacotherapy 2007 61 167-172.
30. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ & Müller B. Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A crosssectional and a double-blind, placebo-controlled trial. Atherosclerosis 2003 166 379-386.
31. Lee WY, Suh JY, Rhee EJ, Park JS, Sung KC & Kim SW. Plasma CRP, apolipoprotein A-1, apolipoproteinBand Lpa levels according to thyroid function status. Archives of Medical Research 2004 35 540-545.
32. Obuobie K, Smith J, Evans LM, John R, Davies JS & Lazarus JH. Increased central arterial stiffness in hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2002 87 4662-4666.
33. Shinohara K, Shoji T, Kimoto E, Yokoyama H, Fujiwara S, Hatsuda S, Maeno T, Shoji T, Fukumoto S, Emoto M, Koyama H & Nishizawa Y. Effect of atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus. Journal of Atherosclerosis and Thrombosis 2005 12 205-210.