Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

Brain, Behavior, and Immunity

Volumn 48, Issue , 2015, Pages 313-325

  Zeis, T ^a   Allaman, I ^b   Gentner, M ^a   Schroder, K ^c,f   Tschopp, J ^c   Magistretti, P J ^b,d,e   Schaeren Wiemers, N ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d DEPT UNIV DE PSYCHIATRIE ADULTE   (Switzerland)

^e KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Astrocyte neuron lactate shuttle; Brain energy homeostasis; Cerebral cortex; Gray matter pathology; Inflammasomes; Multiple Sclerosis; Normal appearing gray matter

Indexed keywords

ADENOSINE TRIPHOSPHATE; CX43 PROTEIN; GAP JUNCTION PROTEIN; GLUTAMIC ACID; GLUTAMINE; IMMUNOLOGICAL ADJUVANT; INFLAMMASOME; INTERLEUKIN 1BETA; LACTIC ACID; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; ASTROCYTE NEURON LACTATE SHUTTLE; BRAIN CORTEX; C57BL 6 MOUSE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS PRESENTATION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLUTAMATE GLUTAMINE CYCLE; GRAY MATTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM PARAMETERS; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; YOUNG ADULT; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM; NERVE CELL; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ASTROCYTES; CEREBRAL CORTEX; FEMALE; GENE EXPRESSION; HUMANS; MALE; MICE; MIDDLE AGED; MULTIPLE SCLEROSIS; NEURONS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84942990219     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.04.013     Document Type: Article

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