Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives

Archiv der Pharmazie

Volumn 348, Issue 10, 2015, Pages 743-756

  Evranos Aksöz, Begüm ^a   Baysal, Ipek ^b   Yabanoʇlu Çiftçi, Samiye ^b   Djikic, Teodora ^c   Yelekçi, Kemal ^c   Uçar, Gülberk ^b   Ertan, Rahmiye ^d  

^a MINISTRY OF HEALTH   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c KADIR HAS UNIVERSITY   (Turkey)

^d ANKARA UNIVERSITY   (Turkey)

Author keywords

2 Pyrazoline; Hydrazone; MAO inhibitors; Molecular docking

Indexed keywords

1 (2 HYDROXY 4 METHOXYPHENYL) 3 (2 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2 HYDROXY 4 METHOXYPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2,4 DIMETHOXYPHENYL) 3 P TOLYLPROP 2 EN 1 ONE; 1 (4 BROMOPHENYL) 3 M TOLYLPROP 2 EN 1 ONE; 1 (4 BROMOPHENYL) 3 P TOLYLPROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 M TOLYLPROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 P TOLYLPROP 2 EN 1 ONE; 1 (5 BROMO 2 HYDROXYPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; HYDRAZONE DERIVATIVE; MONOAMINE OXIDASE A INHIBITOR; N' [1 (2,4 DIMETHOXYPHENYL) 3 P TOLYLALLYLIDENE)FURANE 2 CARBOHYDRAZIDE; N' [1 (2,4 DIMETHOXYPHENYL) 3 P TOLYLALLYLIDENE]THIOPHENE 2 CARBOHYDRAZIDE; N' [1 (4 FLUOROPHENYL) 3 (4 METHOXYPHENYL)ALLYLIDENE] 4 METHYL 1,2,3 THIADIAZOLE 5 CARBOHYDRAZIDE; N' [1 (4 FLUOROPHENYL) 3 (4 METHOXYPHENYL)ALLYLIDENE]THIOPHENE 2 CARBOHYDRAZIDE; N' [1 (4 FLUOROPHENYL) 3 M TOLYLALLYLIDENE)THIOPHENE 2 CARBOHYDRAZIDE; N' [1 (4 FLUOROPHENYL) 3 P TOLYLALLYLIDENE]THIOPHENE 2 CARBOHYDRAZIDE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 (2 HYDROXY 4 METHOXYPHENYL) 5 (2 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE 1 YL](PHENYL)METHANONE; [3 (2 HYDROXY 4 METHOXYPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE 1 YL](4 5 DIHYDROPYRAZOLE 1 YL)(4 METHOXYPHENYL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 M TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](4 METHOXYPHENYL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 M TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](4 METHYL 1,2,3 THIADIAZOLE 5 YL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 M TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](FURANE 2 YL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 M TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](PHENYL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 P TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](4 METHOXYPHENYL)METHANONE; [3 (3,5 DICHLORO 2 HYDROXYPHENYL) 5 P TOLYL 4,5 DIHYDROPYRAZOLE 1 YL](PYRIDINE 4 YL)METHANONE; [3 (5 BROMO 2 HYDROXYPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE 1 YL](4 METHOXYPHENYL)METHANONE; [3 (5 CHLORO 2 HYDROXYPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDROPYRAZOLE 1 YL](THIOPHENE 2 YL)METHANONE; AMINE OXIDASE (FLAVIN CONTAINING); MOCLOBEMIDE; MONOAMINE OXIDASE A, HUMAN; MONOAMINE OXIDASE INHIBITOR; PYRAZOLE DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MELTING POINT; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; THIN LAYER CHROMATOGRAPHY; CHEMISTRY; COMPARATIVE STUDY; DRUG DESIGN; HUMAN; KINETICS; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DRUG DESIGN; HUMANS; HYDRAZONES; KINETICS; MOCLOBEMIDE; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN CONFORMATION; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84942987491     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201500212     Document Type: Article

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