Synthesis and antiinflammatory activity of heterocyclic indole derivatives

European Journal of Medicinal Chemistry

Volumn 39, Issue 5, 2004, Pages 449-452

  Rani, Preeti ^a   Srivastava, V K ^a   Kumar, Ashok ^a  

^a LLRM MEDICAL COLLEGE   (India)

Author keywords

Acute toxicity; Albino rates; Antiinflammatory activity; Azo derivatives; Chalcones; Pyrazolines; Synthesis; Ulcerogenic activity

Indexed keywords

3 [1 ACETYL 5 (4 HYDROXYPHENYL) 2 PYRAZOLIN 3 YL]INDOLE; ANTIINFLAMMATORY AGENT; AZO COMPOUND; CARRAGEENAN; CHALCONE; INDOLE DERIVATIVE; PHENYLBUTAZONE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; EDEMA; INFRARED RADIATION; LD 50; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ULCEROGENESIS;

ACUTE TOXICITY TESTS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EDEMA; HETEROCYCLIC COMPOUNDS; INDOLES; LETHAL DOSE 50; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 1942519876     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2003.11.002     Document Type: Article

References (15)

1. Flower R.J., Moncada S., Vane J.R. Goodman and Gilman's the Pharmacological Basis of Therapeutics. seventh ed:1985;695 MacMillan, New-York.
2. Moore P.F., Larson D.L., Otterness I.G., Weissman A., Kadin S.B., Sweeney F.J., Eskara J.D., Nagahisa A., Sakakibara M., Carty T.J. Inflamm. Res. 45:1996;54-61.
3. Misra U., Hitkari A., Saxena A.K., Gurtu S., Shanker K. Eur. J. Med. Chem. 31:1996;629-634.
4. Andreani A., Rambaldi M., Locatelli A., Pifferi G. Eur. J. Med. Chem. 29:1994;903-906.
5. Ebeid Mohamad Y., Lashine Sayed M., El-Adl Sobhy M., Abou Kull Mansour E. Zagazig J. Pharm. Sci. 3:1994;40-48.
6. El-Gendy Adel A., Abdou Naida A., Sarhan El-Taher Z., El-Banna Hosny A. Alexandria J. Pharm. Sci. 7:1993;99-103.
7. Kumar A., Saxena K.K., Gurtu S., Sinha J.N., Shanker K. Indian Drugs. 24:1986;1-5.
8. Dandia A., Sehgal V., Singh P. Indian J. Chem. 32B:1993;1288-1291.
9. Verma M., Tripathi M., Saxena A.K., Shanker K. Eur. J. Med. Chem. 29:1994;941-946.
10. Bansal E., Srivastava V.K., Kumar A. Eur. J. Med. Chem. 36:2001;81-92.
11. Bansal E., Srivastava V.K., Kumar A. Indian J. Chem. 39B:2000;357-362.
12. Winter C.A., Risley E.A., Nuss C.W. Proc. Soc. Exp. Biol. Med. 111:1962;544-547.
13. Buttle C.A.N., Arcy P.F.W., Howard E.M., Kettel D.M. Nature (London). 176:1957;926-937.
14. Djahanjuiri B. J. Pharm. Pharmacol. 21:1969;341-345.
15. Smith Q.E. Pharmacological Screening Tests Progress in Medicinal Chemistry. 1:1960;1-33 Butterworths, London.