메뉴 건너뛰기




Volumn 106, Issue 9, 2011, Pages 1310-1316

Lactate and the GPR81 receptor in metabolic regulation: Implications for adipose tissue function and fatty acid utilisation by muscle during exercise

Author keywords

Adipose tissue; GPR81 lactate receptor; Lactate; Lipolysis; Muscle

Indexed keywords

CARBOHYDRATE; FATTY ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 81; GLUCOSE; INSULIN; LACTIC ACID; LIPID; UNCLASSIFIED DRUG;

EID: 80055032631     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511004673     Document Type: Article
Times cited : (48)

References (50)
  • 2
    • 34547790342 scopus 로고    scopus 로고
    • Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis
    • DOI 10.1096/fj.07-8174com
    • Hashimoto T, Hussien R, Oommen S, et al. (2007) Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis. FASEB J 21, 2602-2612. (Pubitemid 47230688)
    • (2007) FASEB Journal , vol.21 , Issue.10 , pp. 2602-2612
    • Hashimoto, T.1    Hussien, R.2    Oommen, S.3    Gohil, K.4    Brooks, G.A.5
  • 3
    • 59149094602 scopus 로고    scopus 로고
    • Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
    • Liu C, Wu J, Zhu J, et al. (2009) Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. J Biol Chem 284, 2811-2822.
    • (2009) J Biol Chem , vol.284 , pp. 2811-2822
    • Liu, C.1    Wu, J.2    Zhu, J.3
  • 4
    • 77950261397 scopus 로고    scopus 로고
    • An autocrine lac-tate loop mediates insulin-dependent inhibition of lipolysis through GPR81
    • Ahmed K, Tunaru S, Tang C, et al. (2010) An autocrine lac-tate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab 11, 311-319.
    • (2010) Cell Metab , vol.11 , pp. 311-319
    • Ahmed, K.1    Tunaru, S.2    Tang, C.3
  • 5
    • 70350346153 scopus 로고    scopus 로고
    • GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
    • Ahmed K, Tunaru S & Offermanns S (2009) GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci 30, 557-562.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 557-562
    • Ahmed, K.1    Tunaru, S.2    Offermanns, S.3
  • 6
    • 70349565510 scopus 로고    scopus 로고
    • Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipo-cytes by macrophage-conditioned medium
    • O'Hara A, Lim F-L, Mazzatti D, et al. (2009) Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipo-cytes by macrophage-conditioned medium. Pflügers Archiv Eur J Physiol 458, 1103-1114.
    • (2009) Pflügers Archiv Eur J Physiol , vol.458 , pp. 1103-1114
    • O'Hara, A.1    Lim, F.-L.2    Mazzatti, D.3
  • 7
    • 0016152186 scopus 로고
    • Lactate inhibition of lipolysis in exercising man
    • Boyd AEI, Giamber SR, Mager M, et al. (1974) Lactate inhibition of lipolysis in exercising man. Metabolism 23, 532-542.
    • (1974) Metabolism , vol.23 , pp. 532-542
    • Boyd, A.E.I.1    Giamber, S.R.2    Mager, M.3
  • 8
    • 77954338705 scopus 로고    scopus 로고
    • Fat as a fuel: Emerging understanding of the adipose tissue-skeletal muscle axis
    • Frayn KN (2010) Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis. Acta Physiol 199, 509-518.
    • (2010) Acta Physiol , vol.199 , pp. 509-518
    • Frayn, K.N.1
  • 12
    • 0020504817 scopus 로고
    • Lactate release from isolated rat adipocytes: Influence of cell size, glucose concentration, insulin and epinephrine
    • Crandall DL, Fried SK, Francendese AA, et al. (1983) Lactate release from isolated rat adipocytes: influence of cell size, glucose concentration, insulin and epinephrine. Horm Metab Res 15, 326-329. (Pubitemid 13070201)
    • (1983) Hormone and Metabolic Research , vol.15 , Issue.7 , pp. 326-329
    • Crandall, D.L.1    Fried, S.K.2    Francendese, A.A.3
  • 13
    • 0026770646 scopus 로고
    • Lactate production in adipose tissue: A regulated function with extra-adipose implications
    • DiGirolamo M, Newby FD & Lovejoy J (1992) Lactate production in adipose tissue: a regulated function with extra-adipose implications. FASEB J 6, 2405-2412.
    • (1992) FASEB J , vol.6 , pp. 2405-2412
    • Digirolamo, M.1    Newby, F.D.2    Lovejoy, J.3
  • 14
    • 0020576117 scopus 로고
    • In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus
    • Kashiwagi A, Verso MA, Andrews J, et al. (1983) In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus. J Clin Invest 72, 1246-1254. (Pubitemid 13013757)
    • (1983) Journal of Clinical Investigation , vol.72 , Issue.4 , pp. 1246-1254
    • Kashiwagi, A.1    Verso, M.A.2    Andrews, J.3
  • 15
    • 0023473755 scopus 로고
    • Glucose uptake in human adipose tissue
    • Marin P, Rebuffé-Scrive M, Smith U, et al. (1987) Glucose uptake in human adipose tissue. Metabolism 36, 1154-1160.
    • (1987) Metabolism , vol.36 , pp. 1154-1160
    • Marin, P.1    Rebuffé-Scrive, M.2    Smith, U.3
  • 17
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • DOI 10.1152/ajpendo.00435.2007
    • Ye J, Gao Z, Yin J, et al. (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293, E1118-E1128. (Pubitemid 47535846)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.4
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 18
    • 62749167010 scopus 로고    scopus 로고
    • Reduced adipose tissue oxygenation in human obesity: Evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response
    • Pasarica M, Sereda OR, Redman LM, et al. (2009) Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58, 718-725.
    • (2009) Diabetes , vol.58 , pp. 718-725
    • Pasarica, M.1    Sereda, O.R.2    Redman, L.M.3
  • 19
    • 77955404793 scopus 로고    scopus 로고
    • Reduced oxy-genation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis
    • Pasarica M, Rood J, Ravussin E, et al. (2010) Reduced oxy-genation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis. J Clin Endocrinol Metab 95, 4052-4055.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4052-4055
    • Pasarica, M.1    Rood, J.2    Ravussin, E.3
  • 20
    • 79960359853 scopus 로고    scopus 로고
    • Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation
    • Goossens GH, Bizzarri A, Venteclef N, et al. (2011) Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 124, 67-76.
    • (2011) Circulation , vol.124 , pp. 67-76
    • Goossens, G.H.1    Bizzarri, A.2    Venteclef, N.3
  • 21
    • 34547583651 scopus 로고    scopus 로고
    • Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-d-glucose uptake in human adipocytes
    • DOI 10.1016/j.bbrc.2007.07.032, PII S0006291X07015045
    • Wood IS, Wang B, Lorente-Cebrián S, et al. (2007) Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes. Biochem Biophys Res Commun 361, 468-473. (Pubitemid 47193119)
    • (2007) Biochemical and Biophysical Research Communications , vol.361 , Issue.2 , pp. 468-473
    • Wood, I.S.1    Wang, B.2    Lorente-Cebrian, S.3    Trayhurn, P.4
  • 22
    • 63249093556 scopus 로고    scopus 로고
    • Hypoxia decreases insulin signaling pathways in adipocytes
    • Regazzetti C, Peraldi P, Gremeaux T, et al. (2009) Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 58, 95-103.
    • (2009) Diabetes , vol.58 , pp. 95-103
    • Regazzetti, C.1    Peraldi, P.2    Gremeaux, T.3
  • 24
    • 35448934913 scopus 로고    scopus 로고
    • Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    • DOI 10.1007/s00424-007-0301-8
    • Wang B, Wood IS & Trayhurn P (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflügers Archiv Eur J Physiol 455, 479-492. (Pubitemid 47624196)
    • (2007) Pflugers Archiv European Journal of Physiology , vol.455 , Issue.3 , pp. 479-492
    • Wang, B.1    Wood, I.S.2    Trayhurn, P.3
  • 25
    • 47849121225 scopus 로고    scopus 로고
    • Hypoxia in adipose tissue: A basis for the dysregulation of tissue function in obesity?
    • Trayhurn P, Wang B & Wood IS (2008) Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100, 227-235.
    • (2008) Br J Nutr , vol.100 , pp. 227-235
    • Trayhurn, P.1    Wang, B.2    Wood, I.S.3
  • 26
    • 79959562708 scopus 로고    scopus 로고
    • Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor) by human adipocytes
    • Gonzalez-Muniesa P, de Oliveira CJ, Perez de Heredia F, et al. (2011) Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor) by human adipocytes. J Nutrigenet Nutrigenomics 4, 146-153.
    • (2011) J Nutrigenet Nutrigenomics , vol.4 , pp. 146-153
    • Gonzalez-Muniesa, P.1    De Oliveira, C.J.2    Perez De Heredia, F.3
  • 27
    • 77949884840 scopus 로고    scopus 로고
    • Hypoxia stimulates lactate release and modulates monocar-boxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes
    • Pérez de Heredia F, Wood IS & Trayhurn P (2010) Hypoxia stimulates lactate release and modulates monocar-boxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. Pflügers Arch Eur J Physiol 459, 509-518.
    • (2010) Pflügers Arch Eur J Physiol , vol.459 , pp. 509-518
    • Pérez De Heredia, F.1    Wood, I.S.2    Trayhurn, P.3
  • 28
    • 60849121937 scopus 로고    scopus 로고
    • Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
    • Yin J, Gao Z, He Q, et al. (2009) Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 296, E333-E342.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Yin, J.1    Gao, Z.2    He, Q.3
  • 29
    • 0028334748 scopus 로고
    • Balance of carbohydrate and lipid utilization during exercise: The 'crossover' concept
    • Brooks GA & Mercier J (1994) The balance of carbohydrate and lipid utilization during exercise: the 'crossover' concept (Brief Review). J Appl Physiol 76, 2253-2261. (Pubitemid 24184739)
    • (1994) Journal of Applied Physiology , vol.76 , Issue.6 , pp. 2253-2261
    • Brooks, G.A.1    Mercier, J.2
  • 30
    • 0028917083 scopus 로고
    • Glucose kinetics during high-intensity exercise in endurance-trained and untrained humans
    • Coggan AR, Raguso CA, Williams BD, et al. (1995) Glucose kinetics during high-intensity exercise in endurance-trained and untrained humans. J Appl Physiol 78, 1203-1207.
    • (1995) J Appl Physiol , vol.78 , pp. 1203-1207
    • Coggan, A.R.1    Raguso, C.A.2    Williams, B.D.3
  • 31
    • 0030095997 scopus 로고    scopus 로고
    • Glucose kinetics during high-intensity exercise and the crossover concept
    • Brooks GA & Trimmer JK (1996) Glucose kinetics during high-intensity exercise and the crossover concept. J Appl Physiol 80, 1073-1075.
    • (1996) J Appl Physiol , vol.80 , pp. 1073-1075
    • Brooks, G.A.1    Trimmer, J.K.2
  • 33
    • 0013772629 scopus 로고
    • Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles
    • Randle PJ, Newsholme EA & Garland PB (1964) Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J 93, 652-665.
    • (1964) Biochem J , vol.93 , pp. 652-665
    • Randle, P.J.1    Newsholme, E.A.2    Garland, P.B.3
  • 34
    • 0026007729 scopus 로고
    • Effect of increased plasma free fatty acid concentrations on muscle metabolism in exercising men
    • Hargreaves M, Kiens B & Richter EA (1991) Effect of increased plasma free fatty acid concentrations on muscle metabolism in exercising men. J Appl Physiol 70, 194-201.
    • (1991) J Appl Physiol , vol.70 , pp. 194-201
    • Hargreaves, M.1    Kiens, B.2    Richter, E.A.3
  • 38
    • 0029980385 scopus 로고    scopus 로고
    • Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise
    • Odland LM, Heigenhauser GJ, Lopaschuk GD, et al. (1996) Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise. Am J Physiol 270, E541-E544.
    • (1996) Am J Physiol , vol.270
    • Odland, L.M.1    Heigenhauser, G.J.2    Lopaschuk, G.D.3
  • 42
    • 23944440358 scopus 로고    scopus 로고
    • Lactic acid still remains the real cause of exercise-induced metabolic acido-sis
    • author reply R904-R910
    • Boning D, Strobel G, Beneke R, et al. (2005) Lactic acid still remains the real cause of exercise-induced metabolic acido-sis. Am J Physiol Regul Integr Comp Physiol 289, R902-R903; author reply R904-R910.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Boning, D.1    Strobel, G.2    Beneke, R.3
  • 43
    • 77953174044 scopus 로고    scopus 로고
    • What does glycolysis make and why is it important?
    • Brooks GA (2010) What does glycolysis make and why is it important? J Appl Physiol 108, 1450-1451.
    • (2010) J Appl Physiol , vol.108 , pp. 1450-1451
    • Brooks, G.A.1
  • 44
    • 77953162251 scopus 로고    scopus 로고
    • Lactic acidosis in vivo: Testing the link between lactate generation and H\+ accumulation in ischemic mouse muscle
    • Marcinek DJ, Kushmerick MJ & Conley KE (2010) Lactic acidosis in vivo: testing the link between lactate generation and H\+ accumulation in ischemic mouse muscle. J Appl Physiol 108, 1479-1486.
    • (2010) J Appl Physiol , vol.108 , pp. 1479-1486
    • Marcinek, D.J.1    Kushmerick, M.J.2    Conley, K.E.3
  • 45
    • 0017074260 scopus 로고
    • Adipose tissue blood flow during prolonged, heavy exercise
    • Bulow J & Madsen J (1976) Adipose tissue blood flow during prolonged, heavy exercise. Pflü gers Archiv Eur J Physiol 363, 231-234.
    • (1976) Pflügers Archiv Eur J Physiol , vol.363 , pp. 231-234
    • Bulow, J.1    Madsen, J.2
  • 46
    • 0017867111 scopus 로고
    • Human adipose tissue blood flow during prolonged exercise. II
    • Bulow J & Madsen J (1978) Human adipose tissue blood flow during prolonged exercise II. Pflügers Archiv Eur J Phy-siol 376, 41-45. (Pubitemid 8390067)
    • (1978) Pflugers Archiv European Journal of Physiology , vol.376 , Issue.1 , pp. 41-45
    • Bulow, J.1    Madsen, J.2
  • 47
    • 0019814816 scopus 로고
    • Subcutaneous adipose tissue blood flow and triacylglycerol-mobilization during prolonged exercise in dogs
    • Bulow J (1982) Subcutaneous adipose tissue blood flow and triacylglycerol-mobilization during prolonged exercise in dogs. Pflügers Archiv Eur J Physiol 392, 230-234.
    • (1982) Pflügers Archiv Eur J Physiol , vol.392 , pp. 230-234
    • Bulow, J.1
  • 48
    • 0016152186 scopus 로고
    • Lactate inhibition of lipolysis in exercising man
    • Boyd AE 3rd, Giamber SR, Mager M, et al. (1974) Lactate inhibition of lipolysis in exercising man. Metabolism 23, 531-542.
    • (1974) Metabolism , vol.23 , pp. 531-542
    • Boyd Iii, A.E.1    Giamber, S.R.2    Mager, M.3
  • 49
    • 0016774607 scopus 로고
    • Effect of lactate on FFA and glycerol turnover in resting and exercising dogs
    • Issekutz B, Shaw WAS & Issekutz TB (1975) Effect of lactate on FFA and glycerol turnover in resting and exercising dogs. J Appl Physiol 39, 349-353.
    • (1975) J Appl Physiol , vol.39 , pp. 349-353
    • Issekutz, B.1    Shaw, W.A.S.2    Issekutz, T.B.3
  • 50
    • 1142309525 scopus 로고    scopus 로고
    • Relation between Plasma Lactate Concentration and Fat Oxidation Rates over a Wide Range of Exercise Intensities
    • DOI 10.1055/s-2003-45231
    • Achten J & Jeukendrup AE (2004) Relation between plasma lactate concentration and fat oxidation rates over a wide range of exercise intensities. Int J Sports Med 25, 32-37. (Pubitemid 38210475)
    • (2004) International Journal of Sports Medicine , vol.25 , Issue.1 , pp. 32-37
    • Achten, J.1    Jeukendrup, A.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.