Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 10, 2015, Pages 1687-1696

  Hung, Victor K L ^a   Yeung, Patrick K K ^a   Lai, Angela K W ^a   Ho, Maggie C Y ^a   Lo, Amy C Y ^a   Chan, Kevin C ^a   Wu, Ed X K ^a   Chung, Stephen S M ^a   Cheung, Chi W ^a   Chung, Sookja K ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b State Key Laboratory of Bioelectronics   (China)

Author keywords

Alzheimer's disease; amyloidosis; astrocytes; endothelin 1; ischemic stroke

Indexed keywords

AMYLOID; CASPASE 3; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AGGREGATE; PROTEIN KINASE B; THIOFLAVINE; TUMOR NECROSIS FACTOR ALPHA; AMYLOID PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DISEASE SEVERITY; ENDOTHELIUM CELL; GLIA; HEMISPHERE; HIPPOCAMPAL CA2 REGION; LEARNING DISORDER; MALE; MEMORY DISORDER; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SENSORIMOTOR FUNCTION; SPATIAL LEARNING; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; BIOSYNTHESIS; BRAIN HYPOXIA; CEREBRAL ARTERY DISEASE; COGNITION; COMPLICATION; HIPPOCAMPUS; HUMAN; MAZE TEST; MEMORY DISORDERS; METABOLISM; NERVOUS SYSTEM DISEASES; PATHOLOGY; PSYCHOLOGY; TRANSIENT ISCHEMIC ATTACK;

AMYLOIDOGENIC PROTEINS; ANIMALS; ASTROCYTES; BRAIN EDEMA; BRAIN ISCHEMIA; COGNITION; DEMENTIA; ENDOTHELIN-1; HIPPOCAMPUS; HUMANS; HYPOXIA, BRAIN; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NERVOUS SYSTEM DISEASES;

EID: 84942983582     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.109     Document Type: Article

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