Comorbid rat model of ischemia and β-Amyloid toxicity: Striatal and cortical degeneration

Brain Pathology

Volumn 25, Issue 1, 2015, Pages 24-32

  Amtul, Zareen ^a   Whitehead, Shawn N ^a   Keeley, Robin J ^b   Bechberger, John ^c   Fisher, Alicia L ^b   McDonald, Robert J ^b   Naus, Christian C ^c   Munoz, David G ^d   Cechetto, David F ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF LETHBRIDGE   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

axonal retraction; beta Amyloid; cellular degeneration; infarct; microgliosis

Indexed keywords

AMYLOID BETA PROTEIN; CONNEXIN 43; ENDOTHELIN 1; PROTEIN KINASE FER; PROTEIN TYROSINE KINASE; PROTO-ONCOGENE PROTEIN C-FES-FPS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; BRAIN CORTEX; BRAIN DEGENERATION; BRAIN ISCHEMIA; CLINICAL STUDY; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; CORTICAL THICKNESS (BRAIN); DEMENTIA; FUNCTIONAL DISEASE; IMMUNOHISTOCHEMISTRY; LEARNING; MALE; MEMORY; MICROGLIA; NERVE CELL; NEUROTOXICITY; NONHUMAN; RADIAL ARM MAZE TEST; RAT; RISK FACTOR; VISUAL DISCRIMINATION; AMYLOIDOSIS; ANIMAL; CEREBROVASCULAR ACCIDENT; COMORBIDITY; DISEASE MODEL; MAZE TEST; METABOLISM; NERVE DEGENERATION; NEURITE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; VISION; WISTAR RAT;

AMYLOID BETA-PEPTIDES; AMYLOIDOSIS; ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; COMORBIDITY; CONNEXIN 43; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; MALE; MAZE LEARNING; MICROGLIA; NERVE DEGENERATION; NEURITES; NEURONS; PROTEIN-TYROSINE KINASES; RANDOM ALLOCATION; RATS, WISTAR; STROKE; VISUAL PERCEPTION;

EID: 84923547216     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12149     Document Type: Article

References (57)

1. Abe K, Tanzi RE, Kogure K, (1991) Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 125: 172-174.
2. Akama KT, Albanese C, Pestell RG, Van Eldik LJ, (1998) Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc Natl Acad Sci U S A 95: 5795-5800.
3. Akundi RS, Candelario-Jalil E, Hess S, Hull M, Lieb K, Gebicke-Haerter PJ, Fiebich BL, (2005) Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-Activated primary rat microglia. Glia 51: 199-208.
4. Amtul Z, Hepburn JD, (2014) Protein markers to cerebrovascular disruption of neurovascular unit: immunohistochemical and imaging approaches. Rev Neurosci doi: 10.1515/revneuro-2013-0041. [Epub ahead of print].
5. Amtul Z, Nikolova S, Gao L, Keeley RJ, Bechberger JF, Fisher AL, et al (2014) Comorbid Abeta toxicity and stroke: hippocampal atrophy, pathology, and cognitive deficit. Neurobiol Aging 35: 1605-1614.
6. Bitting L, Naidu A, Cordell B, Murphy GM Jr, (1996) Beta-Amyloid peptide secretion by a microglial cell line is induced by beta-Amyloid-(25-35) and lipopolysaccharide. J Biol Chem 271: 16084-16089.
7. Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG, (2006) The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Curr Top Med Chem 6: 597-608.
8. Cechetto DF, Hachinski V, Whitehead SN, (2008) Vascular risk factors and Alzheimer's disease. Expert Rev Neurother 8: 743-750.
9. Centonze D, Finazzi-Agro A, Bernardi G, Maccarrone M, (2007) The endocannabinoid system in targeting inflammatory neurodegenerative diseases. Trends Pharmacol Sci 28: 180-187.
10. Cheng G, Whitehead SN, Hachinski V, Cechetto DF, (2006) Effects of pyrrolidine dithiocarbamate on beta-Amyloid (25-35)-induced inflammatory responses and memory deficits in the rat. Neurobiol Dis 23: 140-151.
11. Damjanac M, Rioux BA, Barrier L, Pontcharraud R, Anne C, Hugon J, et al (2007) Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease. Brain Res 1128: 40-49.
12. Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD, (1999) Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 354: 919-920.
13. Geerts H, (2004) NC-531 (Neurochem). Curr Opin Investig Drugs 5: 95-100.
14. Guirland C, Suzuki S, Kojima M, Lu B, Zheng JQ, (2004) Lipid rafts mediate chemotropic guidance of nerve growth cones. Neuron 42: 51-62.
15. Hachinski V, Munoz D, (2000) Vascular factors in cognitive impairment-where are we now? Ann N Y Acad Sci 903: 1-5.
16. Heyman A, Fillenbaum GG, Welsh-Bohmer KA, Gearing M, Mirra SS, Mohs RC, et al (1998) Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to establish a registry for Alzheimer's disease. Neurology 51: 159-162.
17. Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, et al (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 165: 347-356.
18. Honig LS, Tang MX, Albert S, Costa R, Luchsinger J, Manly J, et al (2003) Stroke and the risk of Alzheimer disease. Arch Neurol 60: 1707-1712.
19. Hu J, Van Eldik LJ, (1999) Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain Res 842: 46-54.
20. Kaminsky YG, Marlatt MW, Smith MA, Kosenko EA, (2010) Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Exp Neurol 221: 26-37.
21. Kaneko I, Morimoto K, Kubo T, (2001) Drastic neuronal loss in vivo by beta-Amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-Amyloid 1-40 to toxic and proteinase-resistant fragments. Neuroscience 104: 1003-1011.
22. Klunk WE, Price JC, Mathis CA, Tsopelas ND, Lopresti BJ, Ziolko SK, et al (2007) Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci 27: 6174-6184.
23. Koistinaho J, Pyykonen I, Keinanen R, Hokfelt T, (1996) Expression of beta-Amyloid precursor protein mRNAs following transient focal ischaemia. Neuroreport 7: 2727-2731.
24. Kubo T, Nishimura S, Kumagae Y, Kaneko I, (2002) In vivo conversion of racemized beta-Amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients. J Neurosci Res 70: 474-483.
25. Levin ER, (1995) Endothelins. N Engl J Med 333: 356-363.
26. McDonald RJ, Hong NS, Devan BD, (2004) The challenges of understanding mammalian cognition and memory-based behaviours: an interactive learning and memory systems approach. Neurosci Biobehav Rev 28: 719-745.
27. McDonald RJ, White NM, (1993) A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci 107: 3-22.
28. Mei X, Ezan P, Giaume C, Koulakoff A, (2010) Astroglial connexin immunoreactivity is specifically altered at beta-Amyloid plaques in beta-Amyloid precursor protein/presenilin1 mice. Neuroscience 171: 92-105.
29. Nagy JI, Li W, Hertzberg EL, Marotta CA, (1996) Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer's disease. Brain Res 717: 173-178.
30. Nicolas O, Gavin R, Braun N, Urena JM, Fontana X, Soriano E, et al (2007) Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. FASEB J 21: 3107-3117.
31. Orellana JA, Shoji KF, Abudara V, Ezan P, Amigou E, Saez PJ, et al (2011) Amyloid beta-induced death in neurons involves glial and neuronal hemichannels. J Neurosci 31: 4962-4977.
32. Packard MG, Hirsh R, White NM, (1989) Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems. J Neurosci 9: 1465-1472.
33. Packard MG, McGaugh JL, (1996) Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem 65: 65-72.
34. Paxinos G, Watson C, (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, Inc.: San Diego.
35. Pearson RC, Esiri MM, Hiorns RW, Wilcock GK, Powell TP, (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci U S A 82: 4531-4534.
36. Pluta R, Ulamek M, Januszewski S, (2006) Micro-blood-brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long-lived rats. Acta Neurochir Suppl 96: 267-271.
37. Pooler AM, Arjona AA, Lee RK, Wurtman RJ, (2004) Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia. Neurosci Lett 362: 127-130.
38. Rosslenbroich V, Dai L, Franken S, Gehrke M, Junghans U, Gieselmann V, Kappler J, (2003) Subcellular localization of collapsin response mediator proteins to lipid rafts. Biochem Biophys Res Commun 305: 392-399.
39. Schmued LC, Albertson C, Slikker W Jr, (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 751: 37-46.
40. Shapovalova Z, Tabunshchyk K, Greer PA, (2007) The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons. BMC Dev Biol 7: 133.
41. Sigurdsson EM, Lee JM, Dong XW, Hejna MJ, Lorens SA, (1997) Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects. Neurobiol Aging 18: 591-608.
42. Silbert LC, Quinn JF, Moore MM, Corbridge E, Ball MJ, Murdoch G, et al (2003) Changes in premorbid brain volume predict Alzheimer's disease pathology. Neurology 61: 487-492.
43. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR, (1997) Brain infarction and the clinical expression of Alzheimer disease. The nun study. JAMA 277: 813-817.
44. Streit WJ, Graeber MB, Kreutzberg GW, (1988) Functional plasticity of microglia: a review. Glia 1: 301-307.
45. Thiel A, Radlinska BA, Paquette C, Sidel M, Soucy JP, Schirrmacher R, Minuk J, (2010) The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. J Nucl Med 51: 1404-1412.
46. Thompson PM, Hayashi KM, De Zubicaray GI, Janke AL, Rose SE, Semple J, et al (2004) Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage 22: 1754-1766.
47. Tsai J, Grutzendler J, Duff K, Gan WB, (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7: 1181-1183.
48. Vanlangenakker N, Vanden BT, Krysko DV, Festjens N, Vandenabeele P, (2008) Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med 8: 207-220.
49. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM, (2003) Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 348: 1215-1222.
50. Whitehead S, Cheng G, Hachinski V, Cechetto DF, (2005) Interaction between a rat model of cerebral ischemia and beta-Amyloid toxicity: II. Effects of triflusal. Stroke 36: 1782-1789.
51. Whitehead SN, Bayona NA, Cheng G, Allen GV, Hachinski VC, Cechetto DF, (2007) Effects of triflusal and aspirin in a rat model of cerebral ischemia. Stroke 38: 381-387.
52. Whitehead SN, Cheng G, Hachinski VC, Cechetto DF, (2007) Progressive increase in infarct size, neuroinflammation, and cognitive deficits in the presence of high levels of amyloid. Stroke 38: 3245-3250.
53. Whitehead SN, Massoni E, Cheng G, Hachinski VC, Cimino M, Balduini W, Cechetto DF, (2010) Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke. Brain Res 1366: 246-256.
54. Zelinski EL, Hong NS, Tyndall AV, Halsall B, McDonald RJ, (2010) Prefrontal cortical contributions during discriminative fear conditioning, extinction, and spontaneous recovery in rats. Exp Brain Res 203: 285-297.
55. Zipp F, Aktas O, (2006) The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci 29: 518-527.
56. Zlokovic BV, (2002) Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev 54: 1553-1559.
57. Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al (2013) Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-beta peptide injection in rats. PLoS ONE 8: e53117.