Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion

Neurobiology of Learning and Memory

Volumn 101, Issue , 2013, Pages 46-54

  Zhang, Xu ^a   Yeung, Patrick K K ^a   McAlonan, Grainne M ^c   Chung, Stephen S M ^d   Chung, Sookja K ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d BNU HKBU UNITED INTERNATIONAL COLLEGE   (China)

Author keywords

Anxiety; BBB breakdown; Cognitive deficit; Endothelin 1 transgenic mice; Ischemia reperfusion brain injury

Indexed keywords

CASPASE 3; ENDOTHELIN 1; PEROXIREDOXIN 6;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BEHAVIOR CHANGE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN DAMAGE; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; ENDOTHELIUM CELL; GENOTYPE; HYPERTENSION; LOCOMOTION; MAZE TEST; MOLECULAR PATHOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PROTEIN EXPRESSION; REFERENCE MEMORY; REPERFUSION INJURY; SENSORIMOTOR FUNCTION; SPATIAL LEARNING; TRANSGENIC MOUSE; TRANSIENT ISCHEMIC ATTACK; UPREGULATION;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CASPASE 3; COGNITION DISORDERS; ENDOTHELIN-1; HIPPOCAMPUS; INFARCTION, MIDDLE CEREBRAL ARTERY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; PEROXIREDOXIN VI; REPERFUSION INJURY;

EID: 84873274538     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2013.01.002     Document Type: Article

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