Positive and negative allosteric modulation of an α1 β3γ2 y-aminobutyric acid type a (GABAA) receptor by binding to a site in the transmembrane domain at the γ+-β-interface

Journal of Biological Chemistry

Volumn 290, Issue 38, 2015, Pages 23432-23446

  Jayakar, Selwyn S ^a   Zhou, Xiaojuan ^b   Savechenkov, Pavel Y ^c   Chiara, David C ^a   Desai, Rooma ^b   Bruzik, Karol S ^c   Miller, Keith W ^a,b   Cohen, Jonathan B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; ANESTHETICS; BINS; ISOMERS;

ALLOSTERIC MODULATION; ALLOSTERIC MODULATORS; AMINOBUTYRIC ACIDS; ENERGETIC COUPLING; EXTRACELLULAR DOMAINS; GAMMA-AMINOBUTYRIC ACIDS; POSITIVE ALLOSTERIC MODULATOR; TRANS-MEMBRANE DOMAINS;

BINDING SITES;

4 AMINOBUTYRIC ACID RECEPTOR; ALPHA1BETA3 GABA A RECEPTOR; ALPHA1BETA3GAMMA3 GABA A RECEPTOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR;

ALLOSTERISM; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CHIRALITY; CONTROLLED STUDY; EXTRACELLULAR SPACE; GAMMA SUBUNIT; PHOTOAFFINITY LABELING; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; GAMMA-AMINOBUTYRIC ACID; HEK293 CELLS; HUMANS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GABA-A;

EID: 84942944889     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.672006     Document Type: Article

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