Multiple propofol-binding sites in a γ-aminobutyric acid type a receptor (GABAAR) identified using a photoreactive propofol analog

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 27456-27468

  Jayakar, Selwyn S ^a   Zhou, Xiaojuan ^b   Chiara, David C ^a   Dostalova, Zuzana ^b   Savechenkov, Pavel Y ^c   Bruzik, Karol S ^c   Dailey, William P ^d   Miller, Keith W ^a,b   Eckenhoff, Roderic G ^e   Cohen, Jonathan B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; ANESTHETICS; CARBOXYLATION; MODULATORS; PHOTOREACTIVITY;

CONCENTRATION DEPENDENCE; GAMMA-AMINOBUTYRIC ACIDS; MICROSEQUENCING; PHOTOINCORPORATION; POSITIVE ALLOSTERIC MODULATOR; SUBUNIT INTERFACES; TRANS-MEMBRANE DOMAINS; TRIFLUOROMETHYL;

BINDING SITES;

2 ISOPROPYL 5 [3 [TRIFLUOROMETHYL] 3H DIAZIRIN 3 YL]PHENOL; 2 PROPOFOL DIAZIRINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 5 ALLYL 1 METHYL 5 (3 TRIFLUOROMETHYL DIAZIRYNYLPHENYL)BARBITURIC ACID; AMINO ACID; ANESTHETIC AGENT; AZIETOMIDATE; BARBITURIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ETOMIDATE; ETOMIDATE DERIVATIVE; METHIONINE; METHYLPHENOBARBITAL; METHYLPHENOBARBITAL DERIVATIVE; PHENOL DERIVATIVE; PROPOFOL; PROPOFOL DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; GABRA1 PROTEIN, HUMAN; GABRB3 PROTEIN, HUMAN; PHOTOAFFINITY LABELING;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENERAL ANESTHESIA; HETEROLOGOUS EXPRESSION; IN VIVO STUDY; PHOTOAFFINITY LABELING; PHOTOREACTIVITY; PROTEIN DOMAIN; SEQUENCE ANALYSIS; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; HUMAN; KINETICS; METABOLISM;

BINDING SITES; HUMANS; KINETICS; PHOTOAFFINITY LABELS; PROPOFOL; RECEPTORS, GABA-A;

EID: 84907487802     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.581728     Document Type: Article

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