Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity

Journal of Cell Science

Volumn 112, Issue 20, 1999, Pages 3569-3578

  Arellano, Manuel ^a,b   Valdivieso, M Henar ^a   Calonge, Teresa M ^a   Coll, Pedro M ^a   Duran, Angel ^a   Perez, Pilar ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cell wall; Fission yeast; Glucan synthase; Morphogenesis; PKC; Rho

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; PROTEIN KINASE C;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ANALYSIS; ENZYME STABILITY; NONHUMAN; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE;

AMINO ACID SEQUENCE; CELL POLARITY; CELL SIZE; CONSERVED SEQUENCE; FUNGAL PROTEINS; GENE DELETION; GENOTYPE; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; PROTEIN KINASE C; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCES POMBE; SCHIZOSACCHAROMYCES POMBE;

EID: 0032754298     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Arellano, M., Duran, A. and Perez, P. (1996). Rho1 GTPase activates the (1-3)β-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis. EMBO J. 15, 4584-4591.
2. Arellano, M., Duran, A. and Perez, P. (1997). Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton. J. Cell Sci. 110, 2547-2555.
3. Arellano M., Coll, P. M., Duran A., Yang, W., Tamanoi F. and Perez P. (1998). Characterization of the geranylgeranyltranferase type I activity in Schizosaccharomyces pombe. Mol. Microbiol. 29, 1357-1367.
4. Bähler, J., Wu, J.-Q., Longtine, M. S., Shah, N. G., MckenzieIII, A., Steever, A. B., Wach, A., Philippsen, P. and Pringle, J. R. (1998). Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14, 943-951.
5. Banuett, F. (1998). Signalling in the yeast: An informational cascade with links to the filamentous fungi. Microbiol. Mol. Rev. 62, 249-274
6. ruml CDK inhibitor. EMBO J. 17, 482-497.
7. Cabib, E, Drgonovâ, J. and Drgon, T. (1998). Role of small G proteins in yeast cell polarization and wall biosynthesis. Annu. Rev. Biochem. 67, 307-333.
8. Drgonovâ, J., Drgon, T., Tanaka, K., Kollâr, R., Chen, G-Ch., Ford, R. A., Chan, C. S. M., Takai, Y. and Cabib E. (1996). Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science 272, 277-279.
9. Durfee, T., Becherer, K., Chen, P.-L., Yeh, S.-H., Yang, Y., Kilburn, A. E., Lee, W.-H. and Elledge, S. J. (1993). The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569.
10. Flynn, P., Mellor, H., Palmer, R., Panayotou, G. and Parker, P. J. (1998). Multiple interactions of PRK1 with RhoA. J. Biol. Chem. 273, 2698-2705.
11. Forsburg, S. L. (1993). Comparison of S. pombe expression systems. Nucl. Acids Res. 21, 2955-2956.
12. Fukui, Y. and Kaziro, Y. (1985). Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe. EMBO J. 4, 687-691.
13. -. Mol. Gen. Genet. 15, 26-31.
14. + is defective in metaphase to anaphase transition. J. Biol. Chem. 271, 5704-5711.
15. Guarente, L. (1983). Yeast promoters and LacZ fusions designed to study expression of cloned genes in yeast. Meth. Enzymol. 101, 181-191.
16. Gustin, M. C., Albertyn, J., Alexander, M. and Davenport, K. (1998). MAP Kinase pathways in the Yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62, 1264-1300.
17. - cells of Schizosaccharomyces pombe. Folia Microbiol. 40, 519-27.
18. Helliwell, S. B., Schmidt, A., Ohya, Y. and Hall, M. N. (1998). The Rho1 effector Pkc 1, but not Bni1, mediates signalling from Tor2 to actin cytoskeleton. Curr. Biol. 8, 1211-1214.
19. Hirata, D., Nakano, K., Fukui, M., Takenaka, H., Miyakawa, T. and Mabuchi, I. (1998). Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis. J. Cell Sci. 111, 149-159.
20. Hochstenbach, F., Klis, F. M., van den Ende, E., van Donselar, P. J. P. and Klausner, R. D. (1998). Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast. Proc. Nat. Acad. Sci. USA 95, 9161-9166.
21. Igual, J. C., Johnson, A. L. and Johnston, L. H. (1996). Coordinated regulation of gene expression by the cell cycle transcription factor SW14 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J. 15, 5001-5013.
22. +, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersesensitivity to cyclosporin A and Papulacandin B. J. Bacteriol. 179, 7653-7662.
23. Kang, M. S. and Cabib, E. (1986). Regulation of fungal cell wall growth: A guanine nucleotide-binding, proteinaceous component required for activity of (1-3)-β-D-glucan synthase. Proc. Nat. Acad. Sci. USA 83, 5808-5812.
24. Kamada, Y., Qadota, H., Python, C. P., Anraku, Y., Ohya, Y. and Levin, D. E. (1996). Activation of yeast protein kinase C by Rho1p GTPase. J. Biol. Chem. 271, 9193-9196.
25. Katayama, S., Hirata, D., Arellano, M., Perez, P. and Toda, T. (1999). Fission yeast α-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function. J. Cell Biol. 144, 1173-1186.
26. Kobori, H., Toda, T., Yaguchi, H., Toya, M., Yanagida, M. and Osumi, M. (1994). Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control. J. Cell Sci. 107, 1131-1136.
27. Leung, T., Manser, E., Tan, L. and Lim, L. (1995) A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 270, 29051-29054.
28. Mazur, P., Morin, N., Baginsky, W., El-Sherbeini, M., Clemas, J. A., Nielsen, J. B. and Foor, F. (1995). Differential expression and function of two homologous subunits of yeast 1, 3-beta-D-glucan synthase. Mol. Cell. Biol. 15, 5671-5681.
29. +-independent protein kinase C from fission yeast. J. Biol. chem. 268, 7401-7406.
30. Mellor H. and Parker, P. J. (1998). The extended protein kinase C superfamily. Biochem. J. 332, 281-292.
31. Miller, P. J. and Johnson D. I. (1994). Cdc42p GTPase is involved in controlling polarized growth in Schizosaccharomyces pombe. Mol. Cell. Biol. 14, 1075-1083.
32. Moreno, S., Klar, A. and Nurse, P. (1991). Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Meth. Enzymol. 194, 795-823.
33. Nakano, K., Arai, R. and Mabuchi, I. (1997). The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe. Genes to Cells 2, 679-694.
34. Nonaka, H., Tanaka, K., Hirano, H., Fujiwara, T., Kohno, H., Umikawa, M., Mino, A. and Takai, Y. (1995). A downstream target of RHO1 small GTP-binding protein is PKC1P, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J. 14, 5931-5938.
35. Ottilie, S., Chernoff, J., Hannig, G., Hoffman, C. S. and Erikson, R. L. (1991). A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proc. Nat. Acad. Sci. USA 88, 3455-3459.
36. Prentice, H. L. (1992). High efficiency transformation of Schizosaccharomyces pombe by electroporation. Nucl. Acids Res. 20, 621.
37. Qadota, H., Python, Ch. P., Inoue, S. B., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. and Ohya, Y. (1996). Identification of yeast Rho1p GTPase as a regulatory subunit of 1, 3-β-Glucan synthase. Science 272, 279-281.
38. Ribas, J. C., Díaz, M., Duran, A. and Perez, P. (1991). Isolation and characterization of Schizosaccharomyces pombe mutants defective in cell wall (1-3)β-D-glucan. J. Bacteriol. 173, 3456-3462.
39. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
40. Schmidt, A. and Hall, A. (1998). Signalling to the actin cytoskeleton. Annu. Rev. Cell Dev. Biol. 14, 305-338.
41. Sengar, A. S., Markley, N. A., Marini, N. J. and Young, D. (1997). Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 3508-3519.
42. + involved in cell shape control and mitosis. Mol. Biol. Cell 4, 303-313.
43. Shiozaki, K. and Russell, P. (1995a). Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J. 14, 492-502.
44. Shiozaki, K. and Russell, P. (1995b). Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378, 739-743.
45. Tanaka, K. and Takai, Y. (1998). Control of reorganization of the actin cytoskeleton by Rho family small GTP binding proteins in yeast. Curr. Opin. Cell Biol. 10, 112-116.
46. Toda, T., Shimanuki, M. and Yanagida, M. (1991). Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev. 5, 60-73.
47. Toda, T., Shimanuki, M. and Yanagida, M. (1993). Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. EMBO J. 12, 1987-1995.
48. + is required for establishment of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway. J. Cell Sci. 109, 2331-2342.
49. + gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the Protein Kinase C pathway, Mol. Cell. Biol. 16, 6752-6764.
50. + in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. J. Cell Sci. 107, 1725-1735.
51. Zaitsevskaya-Carter, T. and Cooper, J. A. (1997). Spm1, a stress-activated MAP kinase that regulates morphogenesis in S. pombe. EMBO J. 16, 1318-31.