The cancer chemotherapeutic paclitaxel increases human and rodent sensory neuron responses to TRPV1 by activation of TLR4

Journal of Neuroscience

Volumn 35, Issue 39, 2015, Pages 13487-13500

  Li, Yan ^a   Adamek, Pavel ^b   Zhang, Haijun ^c   Tatsui, Claudio Esteves ^a   Rhines, Laurence D ^a   Mrozkova, Petra ^b   Li, Qin ^a   Kosturakis, Alyssa K ^d   Cassidy, Ryan M ^e   Harrison, Daniel S ^f   Cata, Juan P ^a   Sapire, Kenneth ^a   Zhang, Hongmei ^a   Kennamer Chapman, Ross M ^e   Jawad, Abdul Basit ^e   Ghetti, Andre ^g   Yan, Jiusheng ^a   Palecek, Jiri ^b   Dougherty, Patrick M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF TEXAS   (United States)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g ANABIOS CORPORATION   (United States)

Author keywords

Cancer; Dorsal horn; DRG; Neuropathy

Indexed keywords

4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; CAPSAICIN; LIPOPOLYSACCHARIDE; N (1,4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL)ACRYLAMIDE; PACLITAXEL; TOLL LIKE RECEPTOR 4; VANILLOID RECEPTOR 1; ANTINEOPLASTIC AGENT; CALCIUM; TRPV1 RECEPTOR; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CANCER CHEMOTHERAPY; CELL ACTIVATION; CONTROLLED STUDY; ELECTROPHYSIOLOGICAL PROCEDURES; HUMAN; HUMAN CELL; HYPERALGESIA; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; HEK293 CELL LINE; METABOLISM; MOUSE; PAIN MEASUREMENT; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; SENSORY NERVE CELL; SPINAL CORD; SPINAL GANGLION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALCIUM; EXCITATORY POSTSYNAPTIC POTENTIALS; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; PACLITAXEL; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; SPINAL CORD; TOLL-LIKE RECEPTOR 4; TRPV CATION CHANNELS;

EID: 84942929378     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1956-15.2015     Document Type: Article

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