Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain

Neuroscience Bulletin

Volumn 28, Issue 2, 2012, Pages 165-172

  Han, Ying ^a   Li, Yan ^a   Xiao, Xing ^a   Liu, Jia ^a   Meng, Xiang Ling ^a   Liu, Feng Yu ^a   Xing, Guo Gang ^a   Wan, You ^a,b,c  

^a Neuroscience Research Institute   (China)

^b Neuroscience Research Institute   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Cancer pain; Formaldehyde; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase; TRPV1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BISINDOLYLMALEIMIDE; FORMALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CANCER; CANCER PAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BONE NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; FORMALDEHYDE; GANGLIA, SPINAL; MAP KINASE SIGNALING SYSTEM; NOCICEPTORS; PAIN, INTRACTABLE; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS; UP-REGULATION;

EID: 84862776626     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-012-1211-0     Document Type: Article

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