-
1
-
-
33947343510
-
Isomorphism, isosterism and covalence
-
Langmuir I. Isomorphism, isosterism and covalence. J. Am. Chem. Soc. 1919, 41:1543-1559.
-
(1919)
J. Am. Chem. Soc.
, vol.41
, pp. 1543-1559
-
-
Langmuir, I.1
-
2
-
-
0003632308
-
Influence of isosteric replacements upon biological activity
-
National Research Council Publication, New York
-
Friedman H.L. Influence of isosteric replacements upon biological activity. Symposium on Chemical-Biological Correlation 1951, National Research Council Publication, New York.
-
(1951)
Symposium on Chemical-Biological Correlation
-
-
Friedman, H.L.1
-
3
-
-
0000821676
-
Über bau und grösse der nichtmetallhydride
-
Grimm H.G. Über bau und grösse der nichtmetallhydride. Z. Elektrochem 1925, 31:474-480.
-
(1925)
Z. Elektrochem
, vol.31
, pp. 474-480
-
-
Grimm, H.G.1
-
4
-
-
11644292710
-
The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part I
-
Grimm H.G. The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part I. Naturwissenschaften 1929, 17:535-540.
-
(1929)
Naturwissenschaften
, vol.17
, pp. 535-540
-
-
Grimm, H.G.1
-
5
-
-
34250969168
-
The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part II
-
Grimm H.G. The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part II. Naturwissenschaften 1929, 17:557-564.
-
(1929)
Naturwissenschaften
, vol.17
, pp. 557-564
-
-
Grimm, H.G.1
-
7
-
-
0342818561
-
Les composés isostères et le problème de la resemblance en chimie
-
Erlenmeyer H. Les composés isostères et le problème de la resemblance en chimie. Bull. Soc. Chim. Biol. 1948, 30:792-805.
-
(1948)
Bull. Soc. Chim. Biol.
, vol.30
, pp. 792-805
-
-
Erlenmeyer, H.1
-
8
-
-
0006908514
-
Isosterism and molecular modification in drug design
-
Thornber C.W. Isosterism and molecular modification in drug design. Chem. Soc. Rev. 1979, 8:563-580.
-
(1979)
Chem. Soc. Rev.
, vol.8
, pp. 563-580
-
-
Thornber, C.W.1
-
9
-
-
0001457952
-
Recent advances in GABA agonists, antagonists and uptake inhibitors: structure-activity relationships and therapeutic potential
-
Academic Press, Washington, DC, B. Testa (Ed.)
-
Krogsgaard-Larsen P., Hjeds H., Falch E., Jørgensen F.S., Nielsen L. Recent advances in GABA agonists, antagonists and uptake inhibitors: structure-activity relationships and therapeutic potential. Advances in Drug Research 1988, 381-456. Academic Press, Washington, DC. B. Testa (Ed.).
-
(1988)
Advances in Drug Research
, pp. 381-456
-
-
Krogsgaard-Larsen, P.1
Hjeds, H.2
Falch, E.3
Jørgensen, F.S.4
Nielsen, L.5
-
11
-
-
0022485090
-
7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents
-
Boyle E.A., Mangan F.R., Markwell R.E., Smith S.A., Thomson M.J., et al. 7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents. J. Med. Chem. 1986, 29:894-898.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 894-898
-
-
Boyle, E.A.1
Mangan, F.R.2
Markwell, R.E.3
Smith, S.A.4
Thomson, M.J.5
-
12
-
-
0026093346
-
Differential binding energy: a detailed evaluation of the influence of hydrogen bonding and hydrophobic groups on the inhibition of thermolysin by phosphorous-containing inhibitors
-
Morgan B.P., Scholtz J.M., Ballinger M.D., Zipkin I.D., Bartlett P.A. Differential binding energy: a detailed evaluation of the influence of hydrogen bonding and hydrophobic groups on the inhibition of thermolysin by phosphorous-containing inhibitors. J. Am. Chem. Soc. 1991, 113:297-307.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 297-307
-
-
Morgan, B.P.1
Scholtz, J.M.2
Ballinger, M.D.3
Zipkin, I.D.4
Bartlett, P.A.5
-
13
-
-
0026720908
-
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 898-carbaphysostigmine analogues
-
Chen Y.L., Nielsen J., Hedberg K.D.A., Jones S., Russo L., et al. Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 898-carbaphysostigmine analogues. J. Med. Chem. 1992, 35:1429-1434.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1429-1434
-
-
Chen, Y.L.1
Nielsen, J.2
Hedberg, K.D.A.3
Jones, S.4
Russo, L.5
-
14
-
-
0000489340
-
Synthesis of new amino-acids mimicking sulfated and phosphorylated tyrosine residues.
-
Marseigne, I. and Roques, B.P. Synthesis of new amino-acids mimicking sulfated and phosphorylated tyrosine residues. J. Org. Chem.53: 3621-3624.
-
J. Org. Chem.
, vol.53
, pp. 3621-3624
-
-
Marseigne, I.1
Roques, B.P.2
-
15
-
-
0027231381
-
Preparation of fluoro- and hydroxy-4-phosphonomethyl-d,l-phenylalanine suitably protected for solid phase synthesis of peptides containing hydrolytically stable analogues of O-phosphotyrosine
-
Burke T.R., Smyth M., Nomizu M., Otaka A., Roller P.P. Preparation of fluoro- and hydroxy-4-phosphonomethyl-d,l-phenylalanine suitably protected for solid phase synthesis of peptides containing hydrolytically stable analogues of O-phosphotyrosine. J. Org. Chem. 1993, 58:1336-1340.
-
(1993)
J. Org. Chem.
, vol.58
, pp. 1336-1340
-
-
Burke, T.R.1
Smyth, M.2
Nomizu, M.3
Otaka, A.4
Roller, P.P.5
-
16
-
-
84982337464
-
Zusammenhänge zwischen Konstitution und Wirkung bei Pyrazolonderivaten
-
Erlenmeyer H., Willi E. Zusammenhänge zwischen Konstitution und Wirkung bei Pyrazolonderivaten. Helv. Chim. Acta 1935, 18:740-743.
-
(1935)
Helv. Chim. Acta
, vol.18
, pp. 740-743
-
-
Erlenmeyer, H.1
Willi, E.2
-
17
-
-
15644384509
-
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme
-
Wallace E.M., Moliterni J.A., Moskal M.A., Neubert A.D., Marcopoulos N., et al. Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme. J. Med. Chem. 1998, 41:1513-1523.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1513-1523
-
-
Wallace, E.M.1
Moliterni, J.A.2
Moskal, M.A.3
Neubert, A.D.4
Marcopoulos, N.5
-
18
-
-
0030934793
-
Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase. 22.11
-
De Lombaert S., Stamford L.B., Blanchard L., Tan J., Hoyer D., et al. Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase. 22.11. Bioorg. Med. Chem. Lett. 1997, 8:1059-1064.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 1059-1064
-
-
De Lombaert, S.1
Stamford, L.B.2
Blanchard, L.3
Tan, J.4
Hoyer, D.5
-
19
-
-
0023410634
-
Thiophen als strukturelement physiologisch aktiver substanzen,16. Thienoisoxazole durch substitution am oximstickstoff
-
Binder D., Noe C.R., Holzer W., Baumann K. Thiophen als strukturelement physiologisch aktiver substanzen,16. Thienoisoxazole durch substitution am oximstickstoff. Arch. Pharm. 1987, 320:837-843.
-
(1987)
Arch. Pharm.
, vol.320
, pp. 837-843
-
-
Binder, D.1
Noe, C.R.2
Holzer, W.3
Baumann, K.4
-
20
-
-
0018345266
-
Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anti-convulsant activities
-
Uno H., Kurokawa M., Masuda Y., Nishimura H. Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anti-convulsant activities. J. Med. Chem. 1979, 22:180-183.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 180-183
-
-
Uno, H.1
Kurokawa, M.2
Masuda, Y.3
Nishimura, H.4
-
21
-
-
77951063711
-
Synthèses de nouvelles phényl-1-triazoline-1,2,4-ones-5 substituées en 3 et 4
-
Gold-Aubert P., Melkonian D., Toribio L. Synthèses de nouvelles phényl-1-triazoline-1,2,4-ones-5 substituées en 3 et 4. Helv. Chim. Acta 1964, 47:2068-2071.
-
(1964)
Helv. Chim. Acta
, vol.47
, pp. 2068-2071
-
-
Gold-Aubert, P.1
Melkonian, D.2
Toribio, L.3
-
22
-
-
0021810255
-
Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide
-
Alonzo R., Andrès J.I., Garcia-Lopez M.-T., de las Heras F.G., Herranz R., et al. Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide. J. Med. Chem. 1985, 28:834-838.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 834-838
-
-
Alonzo, R.1
Andrès, J.I.2
Garcia-Lopez, M.-T.3
de las Heras, F.G.4
Herranz, R.5
-
23
-
-
0028575501
-
Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine
-
Garvey D.S., Wasicak J.T., Elliott R.L., Lebold S.A., Hettinger A.-M., et al. Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine. J. Med. Chem. 1994, 37:4455-4463.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4455-4463
-
-
Garvey, D.S.1
Wasicak, J.T.2
Elliott, R.L.3
Lebold, S.A.4
Hettinger, A.-M.5
-
25
-
-
0022483129
-
Pyrimido[1,6-a]pyrido[3,4-b] indoles as new platelet inhibiting agents
-
Blaskó G., Major E., Blaskó G., Rózsa I., Szántay C. Pyrimido[1,6-a]pyrido[3,4-b] indoles as new platelet inhibiting agents. Eur. J. Med. Chem. 1986, 21:91-95.
-
(1986)
Eur. J. Med. Chem.
, vol.21
, pp. 91-95
-
-
Blaskó, G.1
Major, E.2
Blaskó, G.3
Rózsa, I.4
Szántay, C.5
-
26
-
-
0022474451
-
Octahydroindolo[2,3-a]quinolizin-2-one, a novel structure for γ-aminobutyric acid (GABA) uptake inhibition
-
Kardos J., Blaskó G., Simonyi M., Szántay C. Octahydroindolo[2,3-a]quinolizin-2-one, a novel structure for γ-aminobutyric acid (GABA) uptake inhibition. Eur. J. Med. Chem. 1985, 21:151-154.
-
(1985)
Eur. J. Med. Chem.
, vol.21
, pp. 151-154
-
-
Kardos, J.1
Blaskó, G.2
Simonyi, M.3
Szántay, C.4
-
27
-
-
0026652403
-
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-d-aspartic receptor associated glycine binding site
-
Salituro F.G., Harrison B.L., Baron B.M., Nyce P.L., Stewart K.T., et al. 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-d-aspartic receptor associated glycine binding site. J. Med. Chem. 1992, 35:1791-1799.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1791-1799
-
-
Salituro, F.G.1
Harrison, B.L.2
Baron, B.M.3
Nyce, P.L.4
Stewart, K.T.5
-
28
-
-
0027298123
-
Pharmacochemistry of the furoxan ring: recent developments
-
Calvino R., Stilo A.D., Fruttero R., Gasco A.M., Sorba G., et al. Pharmacochemistry of the furoxan ring: recent developments. Il Farmaco 1993, 48:321-334.
-
(1993)
Il Farmaco
, vol.48
, pp. 321-334
-
-
Calvino, R.1
Stilo, A.D.2
Fruttero, R.3
Gasco, A.M.4
Sorba, G.5
-
29
-
-
0026652442
-
Hydantoin isosteres. In vivo active spiro hydroxy acetic aldose reductase inhibitors
-
Lipinski C.A., Aldinger C.E., Beyer T.A., Bordner J., Burdi D.F., et al. Hydantoin isosteres. In vivo active spiro hydroxy acetic aldose reductase inhibitors. J. Med. Chem. 1992, 35:2169-2177.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2169-2177
-
-
Lipinski, C.A.1
Aldinger, C.E.2
Beyer, T.A.3
Bordner, J.4
Burdi, D.F.5
-
30
-
-
0345650335
-
Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists
-
Academic Press, London
-
Ganellin C.R. Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists. Medicinal Chemistry-The Role of Organic Chemistry in Drug Research 1993, 227-255. Academic Press, London.
-
(1993)
Medicinal Chemistry-The Role of Organic Chemistry in Drug Research
, pp. 227-255
-
-
Ganellin, C.R.1
-
31
-
-
84942873862
-
3-Aryl as-triazines: Bioisostérie avec les 6-aryl pyridazines
-
17 January
-
Morin I. 3-Aryl as-triazines: Bioisostérie avec les 6-aryl pyridazines. Thesis, Université Louis Pasteur, Strasbourg 1991, 17 January.
-
(1991)
Thesis, Université Louis Pasteur, Strasbourg
-
-
Morin, I.1
-
32
-
-
0026776278
-
Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles
-
Mallamo J.P., Pilling G.M., Wetzel J.R., Kowalczik P.J., Bell M.R, et al. Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles. J. Med. Chem. 1992, 35:1663-1670.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1663-1670
-
-
Mallamo, J.P.1
Pilling, G.M.2
Wetzel, J.R.3
Kowalczik, P.J.4
Bell, M.R.5
-
33
-
-
0029922314
-
New set of principal properties for heteroaromatics obtained by grid
-
Clementi S., Cruciani G. New set of principal properties for heteroaromatics obtained by grid. Quant. Struct. Act. Rel. 1996, 15:108-120.
-
(1996)
Quant. Struct. Act. Rel.
, vol.15
, pp. 108-120
-
-
Clementi, S.1
Cruciani, G.2
-
34
-
-
0029848429
-
Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments
-
Gibson S., McGuire R., Rees D.C. Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments. J. Med. Chem. 1996, 39:4065-4072.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4065-4072
-
-
Gibson, S.1
McGuire, R.2
Rees, D.C.3
-
35
-
-
0026489556
-
Synthesis and evaluation of 2-pyridone derivatives as HIV-1-specific everse transcriptase inhibitors. 2. Analogues of 3-aminopyridine-2-(1H)-one
-
Saari W.S., Wai J.S., Fisher T.E., Thomas C.M., Hoffman J.M., et al. Synthesis and evaluation of 2-pyridone derivatives as HIV-1-specific everse transcriptase inhibitors. 2. Analogues of 3-aminopyridine-2-(1H)-one. J. Med. Chem. 1992, 35:3792-3802.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3792-3802
-
-
Saari, W.S.1
Wai, J.S.2
Fisher, T.E.3
Thomas, C.M.4
Hoffman, J.M.5
-
36
-
-
0031832448
-
New principal components derived parameters describing molecular diversity of heteroaromatic residues
-
Langer T., Hoffmann R.D. New principal components derived parameters describing molecular diversity of heteroaromatic residues. Quant. Struct. Act. Rel. 1998, 17:211-223.
-
(1998)
Quant. Struct. Act. Rel.
, vol.17
, pp. 211-223
-
-
Langer, T.1
Hoffmann, R.D.2
-
37
-
-
0021793924
-
Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-l-proline
-
Almquist R.G., Chao W.R., Jennings-White C. Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-l-proline. J. Med. Chem. 1985, 28:1067-1071.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1067-1071
-
-
Almquist, R.G.1
Chao, W.R.2
Jennings-White, C.3
-
39
-
-
0022445756
-
Acyl, N-protected α-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol deterrent agent cyanamide
-
Kwon C.-H., Nagasawa H.T., DeMaster E.G., Shirota F.N. Acyl, N-protected α-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol deterrent agent cyanamide. J. Med. Chem. 1986, 29:1922-1929.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 1922-1929
-
-
Kwon, C.-H.1
Nagasawa, H.T.2
DeMaster, E.G.3
Shirota, F.N.4
-
40
-
-
0027392743
-
Nonpeptide angiotensin II antagonists: N-phenyl-1-H-pyrrole derivatives are angiotensin II receptor antagonists
-
Bovy P.R., Reitz D.B., Collins J.T., Chamberlain T.S., Olins G.M., et al. Nonpeptide angiotensin II antagonists: N-phenyl-1-H-pyrrole derivatives are angiotensin II receptor antagonists. J. Med. Chem. 1993, 36:101-110.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 101-110
-
-
Bovy, P.R.1
Reitz, D.B.2
Collins, J.T.3
Chamberlain, T.S.4
Olins, G.M.5
-
41
-
-
0023183449
-
Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives
-
Marshall W.S., Goodson T., Cullinan G.J., Swanson-Bean D., Haisch K.D., et al. Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives. J. Med. Chem. 1987, 30:682-689.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 682-689
-
-
Marshall, W.S.1
Goodson, T.2
Cullinan, G.J.3
Swanson-Bean, D.4
Haisch, K.D.5
-
42
-
-
0030480485
-
Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole nioisosteres
-
Kohara Y., Kuba K., Imamiya E., Wada T., Inada Y., et al. Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole nioisosteres. J. Med. Chem. 1996, 39:5228-5235.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 5228-5235
-
-
Kohara, Y.1
Kuba, K.2
Imamiya, E.3
Wada, T.4
Inada, Y.5
-
44
-
-
84939801615
-
Poster No. P-041.A. LY262466, dl-2-amino-3-(4-hydroxy-1,2,5-thiazol-3-yl) propanoic acid hydrochloride, a novel and selective agonist at the AMPA excitatory amino acid receptor
-
Basel: Switzerland, 13-17 September
-
Lunn W.H.W., Schoepp D.D., Lodge D., True R.A., Millar J.D Poster No. P-041.A. LY262466, dl-2-amino-3-(4-hydroxy-1,2,5-thiazol-3-yl) propanoic acid hydrochloride, a novel and selective agonist at the AMPA excitatory amino acid receptor. XIIth International Symposium on Medicinal Chemistry 1992, 133-137. Basel: Switzerland, 13-17 September.
-
(1992)
XIIth International Symposium on Medicinal Chemistry
, pp. 133-137
-
-
Lunn, W.H.W.1
Schoepp, D.D.2
Lodge, D.3
True, R.A.4
Millar, J.D.5
-
45
-
-
0018408898
-
Kojic amine-A novel γ-aminobutyric acid analogue
-
Atkinson J.G., Girard Y., Rokach J., Rooney C.S., McFarlane C.S., et al. Kojic amine-A novel γ-aminobutyric acid analogue. J. Med. Chem. 1979, 22:90-106.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 90-106
-
-
Atkinson, J.G.1
Girard, Y.2
Rokach, J.3
Rooney, C.S.4
McFarlane, C.S.5
-
47
-
-
0021339180
-
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by l-homocysteic acid and l-cysteic acid: effect on enzyme inhibition and antitumor activity
-
Rosowsky A., Forsch R.A., Freisheim J.H., Moran R.G., Wick M. Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by l-homocysteic acid and l-cysteic acid: effect on enzyme inhibition and antitumor activity. J. Med. Chem. 1984, 27:600-604.
-
(1984)
J. Med. Chem.
, vol.27
, pp. 600-604
-
-
Rosowsky, A.1
Forsch, R.A.2
Freisheim, J.H.3
Moran, R.G.4
Wick, M.5
-
48
-
-
0023893062
-
Convenient procedure for the preparation of alkyl and aryl substituted N-(aminoalkylacyl)sulfonamides
-
Drummond J.T., Johnson G. Convenient procedure for the preparation of alkyl and aryl substituted N-(aminoalkylacyl)sulfonamides. Tetrahedron Lett. 1988, 29:1653-1656.
-
(1988)
Tetrahedron Lett.
, vol.29
, pp. 1653-1656
-
-
Drummond, J.T.1
Johnson, G.2
-
49
-
-
0020557336
-
Potential antiatherosclerotic agents. 3. Substituted benzoic and non-benzoic analogues of cetabon
-
Albright J.D., DeVries V.G., Du M.D., Largis E.E., Miner T.G., et al. Potential antiatherosclerotic agents. 3. Substituted benzoic and non-benzoic analogues of cetabon. J. Med. Chem. 1983, 26:1393-1411.
-
(1983)
J. Med. Chem.
, vol.26
, pp. 1393-1411
-
-
Albright, J.D.1
DeVries, V.G.2
Du, M.D.3
Largis, E.E.4
Miner, T.G.5
-
50
-
-
0013846957
-
Un nouvel agent anti-inflammatoire de structure non stéroïdique: l'acide p-butoxyphénylacéthydroxamique
-
Buu-Hoï N.P., Lambelin G., Lepoivre C., Gillet C., Gautier M., et al. Un nouvel agent anti-inflammatoire de structure non stéroïdique: l'acide p-butoxyphénylacéthydroxamique. CR Acad. Sci. (Paris) 1965, 261:2259-2262.
-
(1965)
CR Acad. Sci. (Paris)
, vol.261
, pp. 2259-2262
-
-
Buu-Hoï, N.P.1
Lambelin, G.2
Lepoivre, C.3
Gillet, C.4
Gautier, M.5
-
51
-
-
84906439301
-
Pharmaceutical 2-(4-isobutylphenyl) propionohydroxamic acid
-
(24 July 1974, to Societa Italo-Britannica L. Manetti & H. Roberts e C.)
-
Orzalesi G., Selleri R Pharmaceutical 2-(4-isobutylphenyl) propionohydroxamic acid. Chem. Abst. 1974, 81:120272i. German Patent 2 400 531 (24 July 1974, to Societa Italo-Britannica L. Manetti & H. Roberts e C.).
-
(1974)
Chem. Abst.
, vol.81
, pp. 120272i
-
-
Orzalesi, G.1
Selleri, R.2
-
52
-
-
0016778688
-
Valutazione farmaco-tossicologica di un nuovo agente antifiammatorio non-steroideo: l'acido indoxamico
-
De Martiis F., Corsico N., Franzone J.S., Tamietto T. Valutazione farmaco-tossicologica di un nuovo agente antifiammatorio non-steroideo: l'acido indoxamico. Boll. Chim. Farm. 1975, 114:319-333.
-
(1975)
Boll. Chim. Farm.
, vol.114
, pp. 319-333
-
-
De Martiis, F.1
Corsico, N.2
Franzone, J.S.3
Tamietto, T.4
-
53
-
-
0023152641
-
Hydroxamic acid inhibitors of 5-lipoxygenase
-
Summers J.B., Masdiyasni H., Holms J.H., Ratajczik J.D., Dyer R.D., et al. Hydroxamic acid inhibitors of 5-lipoxygenase. J. Med. Chem. 1987, 30:574-580.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 574-580
-
-
Summers, J.B.1
Masdiyasni, H.2
Holms, J.H.3
Ratajczik, J.D.4
Dyer, R.D.5
-
54
-
-
0027097495
-
Structural alterations in desferioxamine compatible with iron clearance in animals
-
Bergeron R.J., Liu Z.-R., McManis J.S., Wiegand J. Structural alterations in desferioxamine compatible with iron clearance in animals. J. Med. Chem. 1992, 35:4739-4744.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 4739-4744
-
-
Bergeron, R.J.1
Liu, Z.-R.2
McManis, J.S.3
Wiegand, J.4
-
55
-
-
0016797336
-
Sintesi e proprieta antiflogistiche di alcuni acidici indolil-acetoidrossammici
-
De Martiis F., Franzone J.S., Tamietto T. Sintesi e proprieta antiflogistiche di alcuni acidici indolil-acetoidrossammici. Bol. Chim. Farm. 1975, 114:309-318.
-
(1975)
Bol. Chim. Farm.
, vol.114
, pp. 309-318
-
-
De Martiis, F.1
Franzone, J.S.2
Tamietto, T.3
-
56
-
-
0018832689
-
Anti-inflammatory agents: determination of ibuproxam and its metabolite in humans
-
Orzalesi G., Mari F., Bertol E., Selleri R., Pisaturo G. Anti-inflammatory agents: determination of ibuproxam and its metabolite in humans. Arzneim.-Forsch. 1980, 30:1607-1609.
-
(1980)
Arzneim.-Forsch.
, vol.30
, pp. 1607-1609
-
-
Orzalesi, G.1
Mari, F.2
Bertol, E.3
Selleri, R.4
Pisaturo, G.5
-
57
-
-
0020086409
-
A new non-steroidal anti-inflammatory drug (NSAID) in current rheumatologic practice (oxamethacin)
-
Demay F., De Sy J. A new non-steroidal anti-inflammatory drug (NSAID) in current rheumatologic practice (oxamethacin). Curr. Ther. Res. 1982, 31:113-118.
-
(1982)
Curr. Ther. Res.
, vol.31
, pp. 113-118
-
-
Demay, F.1
De Sy, J.2
-
58
-
-
0019444360
-
Pharmakokinetik und biotransformation von Oxametacin bei gesunden probanden
-
Vergin H., Ferber H., Brunner F., Kukovetz W.R. Pharmakokinetik und biotransformation von Oxametacin bei gesunden probanden. Arzneim.-Forsch. 1981, 31:513-518.
-
(1981)
Arzneim.-Forsch.
, vol.31
, pp. 513-518
-
-
Vergin, H.1
Ferber, H.2
Brunner, F.3
Kukovetz, W.R.4
-
59
-
-
0019236427
-
Medicinal chemistry of tetrazoles
-
Elsevier, Weinheim, G.P. Ellis, G.B. West (Eds.)
-
Singh H., Chawla A.S., Kapoor V.K., Paul D., Malhotra R.K. Medicinal chemistry of tetrazoles. Progress in Medicinal Chemistry 1980, 151-183. Elsevier, Weinheim. G.P. Ellis, G.B. West (Eds.).
-
(1980)
Progress in Medicinal Chemistry
, pp. 151-183
-
-
Singh, H.1
Chawla, A.S.2
Kapoor, V.K.3
Paul, D.4
Malhotra, R.K.5
-
60
-
-
0027462923
-
Non-peptide angiotensin II antagonists derived from 4H-1, 2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles
-
Ashton W.T., Cantone C.L., Chang L.L., Hutchins S.M., Strelitz R., et al. Non-peptide angiotensin II antagonists derived from 4H-1, 2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. J. Med. Chem. 1993, 36:591-609.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 591-609
-
-
Ashton, W.T.1
Cantone, C.L.2
Chang, L.L.3
Hutchins, S.M.4
Strelitz, R.5
-
61
-
-
0020647262
-
Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system
-
Kraus J.L. Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system. Pharmacol. Res. Commun. 1983, 15:183-189.
-
(1983)
Pharmacol. Res. Commun.
, vol.15
, pp. 183-189
-
-
Kraus, J.L.1
-
63
-
-
0018773504
-
GABA agonists. Synthesis and structure-activity studies on analogues of isoguvacine and THIP
-
Krogsgaard-Larsen P., Rodolskov-Christiansen T. GABA agonists. Synthesis and structure-activity studies on analogues of isoguvacine and THIP. Eur. J. Med. Chem. 1979, 14:157-164.
-
(1979)
Eur. J. Med. Chem.
, vol.14
, pp. 157-164
-
-
Krogsgaard-Larsen, P.1
Rodolskov-Christiansen, T.2
-
64
-
-
0019839152
-
γ-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects
-
Krogsgaard-Larsen P. γ-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J. Med. Chem. 1981, 24:1377-1383.
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1377-1383
-
-
Krogsgaard-Larsen, P.1
-
65
-
-
0025970909
-
Novel class of amino acid antagonists at non-N-methyl-d-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection
-
Krogsgaard-Larsen P., Ferkany J.W., Nielsen E.O., Madsen U., Ebert B., et al. Novel class of amino acid antagonists at non-N-methyl-d-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection. J. Med. Chem. 1991, 34:123-130.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 123-130
-
-
Krogsgaard-Larsen, P.1
Ferkany, J.W.2
Nielsen, E.O.3
Madsen, U.4
Ebert, B.5
-
66
-
-
0020692273
-
Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase
-
Kraus J.L. Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase. Pharmacol Res. Commun. 1983, 15:119-129.
-
(1983)
Pharmacol Res. Commun.
, vol.15
, pp. 119-129
-
-
Kraus, J.L.1
-
67
-
-
84981769033
-
Intermediates in the formation of γ-pyrones from hexose derivatives: a simple synthesis of Kojic acid and hydroxymaltol
-
Lichtenthaler F.W., Heidel P. Intermediates in the formation of γ-pyrones from hexose derivatives: a simple synthesis of Kojic acid and hydroxymaltol. Angew. Chem. Int. Ed. 1969, 8:978-979.
-
(1969)
Angew. Chem. Int. Ed.
, vol.8
, pp. 978-979
-
-
Lichtenthaler, F.W.1
Heidel, P.2
-
68
-
-
0025191432
-
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists
-
Watkins J.C., Krogsgaard-Larsen P., Honoré T. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharm. Sci. 1990, 11:25-33.
-
(1990)
Trends Pharm. Sci.
, vol.11
, pp. 25-33
-
-
Watkins, J.C.1
Krogsgaard-Larsen, P.2
Honoré, T.3
-
69
-
-
0026684706
-
Rationally designed 'dipeptoid' analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988
-
Drysdale M.J., Pritchard M.C., Horwell D.C. Rationally designed 'dipeptoid' analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988. J. Med. Chem. 1992, 35:2573-2581.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2573-2581
-
-
Drysdale, M.J.1
Pritchard, M.C.2
Horwell, D.C.3
-
70
-
-
0027097494
-
Bioisosteric replacement of the α-amino carboxylic functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists
-
Kinney W.A., Lee N.E., Garrison D.T., Podlesny E.J., Simmonds J.T., et al. Bioisosteric replacement of the α-amino carboxylic functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists. J. Med. Chem. 1992, 35:4720-4726.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 4720-4726
-
-
Kinney, W.A.1
Lee, N.E.2
Garrison, D.T.3
Podlesny, E.J.4
Simmonds, J.T.5
-
71
-
-
0034624812
-
Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic
-
Gao Y., Luo J., Yao Z.J., Guo R., Zou H., et al. Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J. Med. Chem. 2000, 43:911-920.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 911-920
-
-
Gao, Y.1
Luo, J.2
Yao, Z.J.3
Guo, R.4
Zou, H.5
-
73
-
-
0016758084
-
Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylsalicylic acid)
-
Thompkins L., Lee K.H. Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylsalicylic acid). J. Pharm. Sci. 1975, 64:760-763.
-
(1975)
J. Pharm. Sci.
, vol.64
, pp. 760-763
-
-
Thompkins, L.1
Lee, K.H.2
-
75
-
-
0025237210
-
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor
-
Saunders J., Cassidy M., Freedman S.B., Harley E.A., Iversen L.L., et al. Novel quinuclidine-based ligands for the muscarinic cholinergic receptor. J. Med. Chem. 1990, 33:1128-1138.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 1128-1138
-
-
Saunders, J.1
Cassidy, M.2
Freedman, S.B.3
Harley, E.A.4
Iversen, L.L.5
-
76
-
-
0026062275
-
Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships
-
Sauerberg P., Kindtler J.W., Nielsen L., Sheardown M.J., Honoré T. Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships. J. Med. Chem. 1991, 34:687-692.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 687-692
-
-
Sauerberg, P.1
Kindtler, J.W.2
Nielsen, L.3
Sheardown, M.J.4
Honoré, T.5
-
77
-
-
0026611521
-
1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines
-
1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines. J. Med. Chem. 1992, 35:2263-2274.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2263-2274
-
-
Sauerberg, P.1
Olesen, P.H.2
Nielsen, S.3
Treppendahl, S.4
Sheardown, M.J.5
-
78
-
-
0026776275
-
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives
-
Wadsworth H.J., Jenkins S.M., Orlek B.S., Cassidy F., Clark M.S., et al. Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J. Med. Chem. 1992, 35:1280-1290.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1280-1290
-
-
Wadsworth, H.J.1
Jenkins, S.M.2
Orlek, B.S.3
Cassidy, F.4
Clark, M.S.5
-
79
-
-
0026542113
-
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives
-
Street L.J., Baker R., Book T., Reeve A.J., Saunders J., et al. Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives. J. Med. Chem. 1992, 35:295-305.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 295-305
-
-
Street, L.J.1
Baker, R.2
Book, T.3
Reeve, A.J.4
Saunders, J.5
-
80
-
-
0027064877
-
Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue
-
Kozikowski A.P., Roberti M., Xiang L., Bergmann J.S., Callahan P.M., et al. Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. J. Med. Chem. 1992, 35:4764-4766.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 4764-4766
-
-
Kozikowski, A.P.1
Roberti, M.2
Xiang, L.3
Bergmann, J.S.4
Callahan, P.M.5
-
81
-
-
77956715838
-
Bioisosterism in drug design
-
Academic Press, Amsterdam, D.M. Bailey (Ed.)
-
Lipinski C.A. Bioisosterism in drug design. Annual Reports in Medicinal Chemistry 1986, 283-291. Academic Press, Amsterdam. D.M. Bailey (Ed.).
-
(1986)
Annual Reports in Medicinal Chemistry
, pp. 283-291
-
-
Lipinski, C.A.1
-
82
-
-
0027273657
-
Aminopyridazines-an alternate route to potent muscarinic agonists with no cholinergic syndrome
-
Wermuth C.G. Aminopyridazines-an alternate route to potent muscarinic agonists with no cholinergic syndrome. Il Farmaco 1993, 48:253-274.
-
(1993)
Il Farmaco
, vol.48
, pp. 253-274
-
-
Wermuth, C.G.1
-
84
-
-
0020075860
-
Synthèse et propriétés pharmacologiques de sulfonylurées isostères du glibenclamide
-
Fournier J.-P., Moreau R.C., Narcisse G., Choay P. Synthèse et propriétés pharmacologiques de sulfonylurées isostères du glibenclamide. Eur. J. Med. Chem. 1982, 17:81-84.
-
(1982)
Eur. J. Med. Chem.
, vol.17
, pp. 81-84
-
-
Fournier, J.-P.1
Moreau, R.C.2
Narcisse, G.3
Choay, P.4
-
85
-
-
0000788606
-
Peptide backbone modifications: structure-activity analysis of peptides containing amide bond surrogates
-
Marcel Dekker, San Diego, B. Weinstein (Ed.)
-
Spatola A.F. Peptide backbone modifications: structure-activity analysis of peptides containing amide bond surrogates. Chemistry and Biochemistry of Amino Acids, Peptides and Proteins 1983, 267-357. Marcel Dekker, San Diego. B. Weinstein (Ed.).
-
(1983)
Chemistry and Biochemistry of Amino Acids, Peptides and Proteins
, pp. 267-357
-
-
Spatola, A.F.1
-
86
-
-
0002961632
-
Elements for the rational design of peptide drugs
-
Academic Press, New York, B. Testa (Ed.)
-
Fauchère J.-L. Elements for the rational design of peptide drugs. Advances in Drug Research 1986, 29-69. Academic Press, New York. B. Testa (Ed.).
-
(1986)
Advances in Drug Research
, pp. 29-69
-
-
Fauchère, J.-L.1
-
87
-
-
0027081659
-
Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a β-strand: potential application to the design of novel inhibitors of proteolytic enzymes
-
Smith A.B., Keenan T.P., Holcomb R.C., Sprengeler P.A., Guzman M.C., et al. Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a β-strand: potential application to the design of novel inhibitors of proteolytic enzymes. J. Am. Chem. Soc. 1992, 114:10672-10674.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10672-10674
-
-
Smith, A.B.1
Keenan, T.P.2
Holcomb, R.C.3
Sprengeler, P.A.4
Guzman, M.C.5
-
88
-
-
0027511186
-
An effective synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones
-
Smith A.B., Holcomb R.C., Guzman M.C., Keenan T.P., Sprengeler P.A., et al. An effective synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones. Tetrahedron Lett. 1993, 34:63-66.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 63-66
-
-
Smith, A.B.1
Holcomb, R.C.2
Guzman, M.C.3
Keenan, T.P.4
Sprengeler, P.A.5
-
89
-
-
0002485698
-
Fluoroolefin dipeptide isosteres
-
American Chemical Society, London, J.T. Weldi (Ed.)
-
Allmendinger T., Felder E., Hungerbuehler E. Fluoroolefin dipeptide isosteres. Selective Fluorination in Organic and Bioorganic Chemistry 1991, 186-195. American Chemical Society, London. J.T. Weldi (Ed.).
-
(1991)
Selective Fluorination in Organic and Bioorganic Chemistry
, pp. 186-195
-
-
Allmendinger, T.1
Felder, E.2
Hungerbuehler, E.3
-
90
-
-
0026602250
-
Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-l-tyrosyl-N-(3-phenylpropyl)-d-alanylamide
-
Chandrakumar N.S., Yonan P.K., Stapelfeld A., Svage M., Rorbacher E., et al. Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-l-tyrosyl-N-(3-phenylpropyl)-d-alanylamide. J. Med. Chem. 1992, 35:223-233.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 223-233
-
-
Chandrakumar, N.S.1
Yonan, P.K.2
Stapelfeld, A.3
Svage, M.4
Rorbacher, E.5
-
91
-
-
0021287857
-
2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities
-
2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities. J. Med. Chem. 1984, 27:849-857.
-
(1984)
J. Med. Chem.
, vol.27
, pp. 849-857
-
-
Yanagisawa, I.1
Hirata, Y.2
Ishii, Y.3
-
94
-
-
0000262436
-
The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in aqueous solution
-
Young R.C., Ganellin C.R., Graham M.J., Grant E.H. The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in aqueous solution. Tetrahedron 1982, 38:1493-1497.
-
(1982)
Tetrahedron
, vol.38
, pp. 1493-1497
-
-
Young, R.C.1
Ganellin, C.R.2
Graham, M.J.3
Grant, E.H.4
-
95
-
-
46549104536
-
The dielectric properties of seven polar amidinecontaining compounds of biological interest
-
Young R.C., Ganellin C.R., Graham M.J., Roantree M.J., Grant E.H. The dielectric properties of seven polar amidinecontaining compounds of biological interest. Tetrahedron Lett. 1985, 26:1897-1900.
-
(1985)
Tetrahedron Lett.
, vol.26
, pp. 1897-1900
-
-
Young, R.C.1
Ganellin, C.R.2
Graham, M.J.3
Roantree, M.J.4
Grant, E.H.5
-
96
-
-
0034618553
-
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines
-
Wright J.L., Gregory T.F., Kesten S.R., Boxer P.A., Serpa K.A., et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J. Med. Chem. 2000, 43:3408-3419.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3408-3419
-
-
Wright, J.L.1
Gregory, T.F.2
Kesten, S.R.3
Boxer, P.A.4
Serpa, K.A.5
-
97
-
-
0001159494
-
A new bio-isostere: alkylsulphonamidophenethanolamines
-
Larson A.A., Lish P.M. A new bio-isostere: alkylsulphonamidophenethanolamines. Nature (London) 1964, 203:1283-1285.
-
(1964)
Nature (London)
, vol.203
, pp. 1283-1285
-
-
Larson, A.A.1
Lish, P.M.2
-
98
-
-
0024580983
-
Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
-
Roderick S.L., Fournié-Zaluski M.C., Roques B.P., Matthews B.W. Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin. Biochemistry 1989, 28:1493-1497.
-
(1989)
Biochemistry
, vol.28
, pp. 1493-1497
-
-
Roderick, S.L.1
Fournié-Zaluski, M.C.2
Roques, B.P.3
Matthews, B.W.4
-
99
-
-
84882500012
-
Über lokalanästhetisch wirksame basische ester und amide verschiedener alkoxy-amino-benzoesäuren
-
Büchi J., Stünzi E., Flury M., Hirt R., Labhart P., et al. Über lokalanästhetisch wirksame basische ester und amide verschiedener alkoxy-amino-benzoesäuren. Helv. Chim. Acta 1951, 34:1002-1013.
-
(1951)
Helv. Chim. Acta
, vol.34
, pp. 1002-1013
-
-
Büchi, J.1
Stünzi, E.2
Flury, M.3
Hirt, R.4
Labhart, P.5
-
100
-
-
0030610606
-
Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder
-
Bös M., Jenck F., Martin J.R., Moreau J.L., Sleight A.J., et al. Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder. J. Med. Chem. 1997, 40:2762-2769.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2762-2769
-
-
Bös, M.1
Jenck, F.2
Martin, J.R.3
Moreau, J.L.4
Sleight, A.J.5
-
101
-
-
0345526665
-
The chemistry of polycyclic psycho-active drugs: serendipity or systematic investigation?
-
Wilhelm M. The chemistry of polycyclic psycho-active drugs: serendipity or systematic investigation?. Pharm. J. 1975, 214:414-416.
-
(1975)
Pharm. J.
, vol.214
, pp. 414-416
-
-
Wilhelm, M.1
-
102
-
-
18244424282
-
Discovery of novel and potent retinoic acid receptor α agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole
-
Yoshimura H., Kikuchi K., Hibi S., Tagami K., Satoh T., et al. Discovery of novel and potent retinoic acid receptor α agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole. J. Med. Chem. 2000, 43:2929-2937.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2929-2937
-
-
Yoshimura, H.1
Kikuchi, K.2
Hibi, S.3
Tagami, K.4
Satoh, T.5
-
103
-
-
0037725951
-
On the mechanism of the pharmacophoric effect of halogenation
-
Chenoweth M.B., McCarthy L.P. On the mechanism of the pharmacophoric effect of halogenation. Pharmacol. Rev. 1963, 15:673-707.
-
(1963)
Pharmacol. Rev.
, vol.15
, pp. 673-707
-
-
Chenoweth, M.B.1
McCarthy, L.P.2
-
104
-
-
0014665768
-
The carbon-florine bond in compounds of biological interest
-
Goldman P. The carbon-florine bond in compounds of biological interest. Science 1969, 164:1123-1130.
-
(1969)
Science
, vol.164
, pp. 1123-1130
-
-
Goldman, P.1
-
106
-
-
84882559115
-
Chemical reactivity and pharmacological activity among 2-haloethylamine derivatives with a naphtylmethyl group
-
Chapman N.B., James J.W., Graham J.D.P., Lewis G.P. Chemical reactivity and pharmacological activity among 2-haloethylamine derivatives with a naphtylmethyl group. Chem. Ind (London) 1952, 805-807.
-
(1952)
Chem. Ind (London)
, pp. 805-807
-
-
Chapman, N.B.1
James, J.W.2
Graham, J.D.P.3
Lewis, G.P.4
-
107
-
-
0348047879
-
Antihistamine agents. IV. Halogenated N,N-dimethyl-N'-benzyl-N-(2-pyridyl)-ethylenediamines
-
Vaughan J.R.J., Anderson G.W., Clapp R.C., Clark J.H., English J.P., et al. Antihistamine agents. IV. Halogenated N,N-dimethyl-N'-benzyl-N-(2-pyridyl)-ethylenediamines. J. Org. Chem. 1949, 14:228-234.
-
(1949)
J. Org. Chem.
, vol.14
, pp. 228-234
-
-
Vaughan, J.R.J.1
Anderson, G.W.2
Clapp, R.C.3
Clark, J.H.4
English, J.P.5
-
108
-
-
84982415227
-
Isosterism and bioisosterism
-
Interscience Publishers, Oxford, A. Burger (Ed.)
-
Schatz V.B. Isosterism and bioisosterism. Medicinal Chemistry 1963, 72-88. Interscience Publishers, Oxford. A. Burger (Ed.).
-
(1963)
Medicinal Chemistry
, pp. 72-88
-
-
Schatz, V.B.1
-
109
-
-
0014176249
-
The biological properties of silicon compounds
-
Academic Press, New York, N.J. Harper, A.B. Simmonds (Eds.)
-
Fessenden R.J., Fessenden J.S. The biological properties of silicon compounds. Advances in Drug Research 1967, 95-132. Academic Press, New York. N.J. Harper, A.B. Simmonds (Eds.).
-
(1967)
Advances in Drug Research
, pp. 95-132
-
-
Fessenden, R.J.1
Fessenden, J.S.2
-
110
-
-
0022854753
-
Sila-substitution-a useful strategy for drug design?
-
Tacke R., Zilch H. Sila-substitution-a useful strategy for drug design?. Endeavour, New Series 1986, 10:191-197.
-
(1986)
Endeavour, New Series
, vol.10
, pp. 191-197
-
-
Tacke, R.1
Zilch, H.2
-
111
-
-
1542415822
-
Drug-design by sila-substitution and microbial transformations of organosilicon compounds: some recent results
-
Tacke R., Zilch H. Drug-design by sila-substitution and microbial transformations of organosilicon compounds: some recent results. L'Actualité Chimique 1986, 75-82.
-
(1986)
L'Actualité Chimique
, pp. 75-82
-
-
Tacke, R.1
Zilch, H.2
-
113
-
-
0013833680
-
Silicon-containing carbamate insecticides
-
Metcalf R.L., Fukuto T.R. Silicon-containing carbamate insecticides. J. Econ. Entomol. 1965, 58:1151.
-
(1965)
J. Econ. Entomol.
, vol.58
, pp. 1151
-
-
Metcalf, R.L.1
Fukuto, T.R.2
-
114
-
-
0027970147
-
Zifrosilone
-
Anonymous Zifrosilone. Drugs Fut. 1994, 19:854-855.
-
(1994)
Drugs Fut.
, vol.19
, pp. 854-855
-
-
-
115
-
-
0027933449
-
Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745
-
Hornsperger J.M., Collard J.N., Heydt J.G., Giacobini E., Funes S., et al. Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745. Biochem. Soc. Trans. 1994, 22:758-763.
-
(1994)
Biochem. Soc. Trans.
, vol.22
, pp. 758-763
-
-
Hornsperger, J.M.1
Collard, J.N.2
Heydt, J.G.3
Giacobini, E.4
Funes, S.5
-
116
-
-
0013798155
-
Silicon-substituted medicinal agents. Silacarbamates related to meprobamate
-
Fessenden R.J., Coon M.D. Silicon-substituted medicinal agents. Silacarbamates related to meprobamate. J. Med. Chem. 1965, 8:604-608.
-
(1965)
J. Med. Chem.
, vol.8
, pp. 604-608
-
-
Fessenden, R.J.1
Coon, M.D.2
-
117
-
-
0018879522
-
Sila-pharmaka XIX. Sila-pridinol und pridinol: darstellung und eigenschaften sowie strukturen im kristallinen und gelösten Zustand
-
Tacke R. Sila-pharmaka XIX. Sila-pridinol und pridinol: darstellung und eigenschaften sowie strukturen im kristallinen und gelösten Zustand. Chem. Ber. 1980, 113:1962-1980.
-
(1980)
Chem. Ber.
, vol.113
, pp. 1962-1980
-
-
Tacke, R.1
-
120
-
-
0029149283
-
(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors
-
Gotteland J.-P., Brunel I., Gendre F., Désiré J., Delhon A., et al. (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors. J. Med. Chem. 1995, 38:3207-3216.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3207-3216
-
-
Gotteland, J.-P.1
Brunel, I.2
Gendre, F.3
Désiré, J.4
Delhon, A.5
-
121
-
-
0029972476
-
Design and synthesis of new hypocholesteremic organosilanes with antioxidant properties
-
Gotteland J.-P., Delhon A., Junquéro D., Oms P., Halazy S. Design and synthesis of new hypocholesteremic organosilanes with antioxidant properties. Bioorg. Med. Chem. Lett. 1996, 6:533-538.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 533-538
-
-
Gotteland, J.-P.1
Delhon, A.2
Junquéro, D.3
Oms, P.4
Halazy, S.5
-
122
-
-
0029810006
-
Synthesis and pharmacological properties of 4(5)-(2-ethyl-2,3-dihydro-2-silainden-2-yl)imidazole, a silicon analogue of atipamezole
-
Heinonen P., Sipilä H., Neuvonen K., Lönnberg H., Cockroft V.B., et al. Synthesis and pharmacological properties of 4(5)-(2-ethyl-2,3-dihydro-2-silainden-2-yl)imidazole, a silicon analogue of atipamezole. Eur. J. Med. Chem. 1996, 31:725-729.
-
(1996)
Eur. J. Med. Chem.
, vol.31
, pp. 725-729
-
-
Heinonen, P.1
Sipilä, H.2
Neuvonen, K.3
Lönnberg, H.4
Cockroft, V.B.5
-
123
-
-
0034687233
-
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity
-
Bom D., Curran D.P., Kruszewski S., Zimmer S.G., Strode J.T., et al. The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity. J. Med. Chem. 2000, 43:3970-3980.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3970-3980
-
-
Bom, D.1
Curran, D.P.2
Kruszewski, S.3
Zimmer, S.G.4
Strode, J.T.5
-
124
-
-
33947469585
-
Stereochemistry of hydride ion displacement from silicon. Enhanced rates at Bridgehead and 4-ring silicon atoms
-
Sommer L.H., Bennet O.F., Campbell P.G., Weyenberg D.R. Stereochemistry of hydride ion displacement from silicon. Enhanced rates at Bridgehead and 4-ring silicon atoms. J. Am. Chem. Soc. 1957, 79:3295-3296.
-
(1957)
J. Am. Chem. Soc.
, vol.79
, pp. 3295-3296
-
-
Sommer, L.H.1
Bennet, O.F.2
Campbell, P.G.3
Weyenberg, D.R.4
-
125
-
-
0014127511
-
The metabolic fate of some silicon-containing carbamates
-
Fessenden R.J., Ahlfors C. The metabolic fate of some silicon-containing carbamates. J. Med. Chem. 1967, 10:810-812.
-
(1967)
J. Med. Chem.
, vol.10
, pp. 810-812
-
-
Fessenden, R.J.1
Ahlfors, C.2
-
126
-
-
84965190026
-
On the chemical production of developmental abnormalities and of phenocopies in chicken embryos
-
Landauer W. On the chemical production of developmental abnormalities and of phenocopies in chicken embryos. J. Cell. Comp. Physiol. 1954, 43:261-305.
-
(1954)
J. Cell. Comp. Physiol.
, vol.43
, pp. 261-305
-
-
Landauer, W.1
-
127
-
-
0343190418
-
On the role of riboflavin in the teratogenic activity of boric acid
-
Landauer W., Clark E.M. On the role of riboflavin in the teratogenic activity of boric acid. J. Exp. Zool. 1964, 156:307-312.
-
(1964)
J. Exp. Zool.
, vol.156
, pp. 307-312
-
-
Landauer, W.1
Clark, E.M.2
-
128
-
-
0004288073
-
-
Appleton-Century-Crofts, London second edn.
-
Browning E. Toxicity of Industrial Metals 1969, 90-97. Appleton-Century-Crofts, London. second edn.
-
(1969)
Toxicity of Industrial Metals
, pp. 90-97
-
-
Browning, E.1
-
129
-
-
0014272171
-
Structure chimique et activité spasmolytique des organoboriques
-
Caujolle P.H.C. Structure chimique et activité spasmolytique des organoboriques. Arch. Int. Pharmacodyn. Ther. 1968, 172:467-474.
-
(1968)
Arch. Int. Pharmacodyn. Ther.
, vol.172
, pp. 467-474
-
-
Caujolle, P.H.C.1
-
130
-
-
0021734983
-
Some aspects of the antimicrobial and chemical properties of phenyl boronate esters of chloramphenicol
-
Mubarak S.I.M., Stanford J.B., Sugden J.K. Some aspects of the antimicrobial and chemical properties of phenyl boronate esters of chloramphenicol. Drug Dev. Ind. Pharm. 1984, 10:1131-1160.
-
(1984)
Drug Dev. Ind. Pharm.
, vol.10
, pp. 1131-1160
-
-
Mubarak, S.I.M.1
Stanford, J.B.2
Sugden, J.K.3
-
131
-
-
0015187424
-
Structure of boromycin
-
Dünitz J.D., Hawley D.M., Miklos D., White D.N.J., Berlin Y., et al. Structure of boromycin. Helv. Chim. Acta 1971, 54:1709-1713.
-
(1971)
Helv. Chim. Acta
, vol.54
, pp. 1709-1713
-
-
Dünitz, J.D.1
Hawley, D.M.2
Miklos, D.3
White, D.N.J.4
Berlin, Y.5
-
132
-
-
0022356416
-
Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsine and elastase
-
Kinder D.H., Katzenellenbogen J.A. Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsine and elastase. J. Med. Chem. 1985, 28:1917-1925.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1917-1925
-
-
Kinder, D.H.1
Katzenellenbogen, J.A.2
-
133
-
-
0024533882
-
Boron compounds for neutron capture therapy
-
Alam F., Soloway A.H., Bapat B.V., Barth R.F., Adams D.M. Boron compounds for neutron capture therapy. Basic Life Sci. 1989, 50:107-111.
-
(1989)
Basic Life Sci.
, vol.50
, pp. 107-111
-
-
Alam, F.1
Soloway, A.H.2
Bapat, B.V.3
Barth, R.F.4
Adams, D.M.5
-
134
-
-
0024488447
-
A carboranyl porphyrin for boron neutron capture therapy of brain tumors
-
Kahl S.B., Joel D.D., Finkel G.C., Micca P.L., Nawrocky M.M., et al. A carboranyl porphyrin for boron neutron capture therapy of brain tumors. Basic Life Sci. 1989, 50:193-203.
-
(1989)
Basic Life Sci.
, vol.50
, pp. 193-203
-
-
Kahl, S.B.1
Joel, D.D.2
Finkel, G.C.3
Micca, P.L.4
Nawrocky, M.M.5
-
135
-
-
0024488448
-
Tumor-seeking for boron neutron capture therapy: synthesis and biodistribution
-
Gabel D. Tumor-seeking for boron neutron capture therapy: synthesis and biodistribution. Basic Life Sci. 1989, 50:233-241.
-
(1989)
Basic Life Sci.
, vol.50
, pp. 233-241
-
-
Gabel, D.1
-
137
-
-
0023236184
-
Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(-chloroethyl) selenides
-
Kang S.I., Spears C.P. Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(-chloroethyl) selenides. J. Med. Chem. 1987, 30:597-602.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 597-602
-
-
Kang, S.I.1
Spears, C.P.2
-
138
-
-
0024239935
-
A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen
-
Fischer H., Terlinden R., Löhr J.P., Römer A. A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen. Xenobiotica 1988, 18:1347-1359.
-
(1988)
Xenobiotica
, vol.18
, pp. 1347-1359
-
-
Fischer, H.1
Terlinden, R.2
Löhr, J.P.3
Römer, A.4
-
139
-
-
0023638093
-
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
-
Parnham M.J., Graf E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem. Pharmacol. 1987, 36:3095-3102.
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 3095-3102
-
-
Parnham, M.J.1
Graf, E.2
|