메뉴 건너뛰기




Volumn , Issue , 2003, Pages 175-188

Molecular Variations Based on Isosteric Replacements

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL PROPERTIES; ELECTRONIC STRUCTURE; QUANTUM THEORY;

EID: 84942926254     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012744481-9/50017-9     Document Type: Chapter
Times cited : (10)

References (139)
  • 1
    • 33947343510 scopus 로고
    • Isomorphism, isosterism and covalence
    • Langmuir I. Isomorphism, isosterism and covalence. J. Am. Chem. Soc. 1919, 41:1543-1559.
    • (1919) J. Am. Chem. Soc. , vol.41 , pp. 1543-1559
    • Langmuir, I.1
  • 2
    • 0003632308 scopus 로고
    • Influence of isosteric replacements upon biological activity
    • National Research Council Publication, New York
    • Friedman H.L. Influence of isosteric replacements upon biological activity. Symposium on Chemical-Biological Correlation 1951, National Research Council Publication, New York.
    • (1951) Symposium on Chemical-Biological Correlation
    • Friedman, H.L.1
  • 3
    • 0000821676 scopus 로고
    • Über bau und grösse der nichtmetallhydride
    • Grimm H.G. Über bau und grösse der nichtmetallhydride. Z. Elektrochem 1925, 31:474-480.
    • (1925) Z. Elektrochem , vol.31 , pp. 474-480
    • Grimm, H.G.1
  • 4
    • 11644292710 scopus 로고
    • The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part I
    • Grimm H.G. The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part I. Naturwissenschaften 1929, 17:535-540.
    • (1929) Naturwissenschaften , vol.17 , pp. 535-540
    • Grimm, H.G.1
  • 5
    • 34250969168 scopus 로고
    • The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part II
    • Grimm H.G. The system of chemical compounds from the viewpoint of atom research, several problems of experimental research. Part II. Naturwissenschaften 1929, 17:557-564.
    • (1929) Naturwissenschaften , vol.17 , pp. 557-564
    • Grimm, H.G.1
  • 7
    • 0342818561 scopus 로고
    • Les composés isostères et le problème de la resemblance en chimie
    • Erlenmeyer H. Les composés isostères et le problème de la resemblance en chimie. Bull. Soc. Chim. Biol. 1948, 30:792-805.
    • (1948) Bull. Soc. Chim. Biol. , vol.30 , pp. 792-805
    • Erlenmeyer, H.1
  • 8
    • 0006908514 scopus 로고
    • Isosterism and molecular modification in drug design
    • Thornber C.W. Isosterism and molecular modification in drug design. Chem. Soc. Rev. 1979, 8:563-580.
    • (1979) Chem. Soc. Rev. , vol.8 , pp. 563-580
    • Thornber, C.W.1
  • 9
    • 0001457952 scopus 로고
    • Recent advances in GABA agonists, antagonists and uptake inhibitors: structure-activity relationships and therapeutic potential
    • Academic Press, Washington, DC, B. Testa (Ed.)
    • Krogsgaard-Larsen P., Hjeds H., Falch E., Jørgensen F.S., Nielsen L. Recent advances in GABA agonists, antagonists and uptake inhibitors: structure-activity relationships and therapeutic potential. Advances in Drug Research 1988, 381-456. Academic Press, Washington, DC. B. Testa (Ed.).
    • (1988) Advances in Drug Research , pp. 381-456
    • Krogsgaard-Larsen, P.1    Hjeds, H.2    Falch, E.3    Jørgensen, F.S.4    Nielsen, L.5
  • 11
    • 0022485090 scopus 로고
    • 7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents
    • Boyle E.A., Mangan F.R., Markwell R.E., Smith S.A., Thomson M.J., et al. 7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents. J. Med. Chem. 1986, 29:894-898.
    • (1986) J. Med. Chem. , vol.29 , pp. 894-898
    • Boyle, E.A.1    Mangan, F.R.2    Markwell, R.E.3    Smith, S.A.4    Thomson, M.J.5
  • 12
    • 0026093346 scopus 로고
    • Differential binding energy: a detailed evaluation of the influence of hydrogen bonding and hydrophobic groups on the inhibition of thermolysin by phosphorous-containing inhibitors
    • Morgan B.P., Scholtz J.M., Ballinger M.D., Zipkin I.D., Bartlett P.A. Differential binding energy: a detailed evaluation of the influence of hydrogen bonding and hydrophobic groups on the inhibition of thermolysin by phosphorous-containing inhibitors. J. Am. Chem. Soc. 1991, 113:297-307.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 297-307
    • Morgan, B.P.1    Scholtz, J.M.2    Ballinger, M.D.3    Zipkin, I.D.4    Bartlett, P.A.5
  • 13
    • 0026720908 scopus 로고
    • Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 898-carbaphysostigmine analogues
    • Chen Y.L., Nielsen J., Hedberg K.D.A., Jones S., Russo L., et al. Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 898-carbaphysostigmine analogues. J. Med. Chem. 1992, 35:1429-1434.
    • (1992) J. Med. Chem. , vol.35 , pp. 1429-1434
    • Chen, Y.L.1    Nielsen, J.2    Hedberg, K.D.A.3    Jones, S.4    Russo, L.5
  • 14
    • 0000489340 scopus 로고    scopus 로고
    • Synthesis of new amino-acids mimicking sulfated and phosphorylated tyrosine residues.
    • Marseigne, I. and Roques, B.P. Synthesis of new amino-acids mimicking sulfated and phosphorylated tyrosine residues. J. Org. Chem.53: 3621-3624.
    • J. Org. Chem. , vol.53 , pp. 3621-3624
    • Marseigne, I.1    Roques, B.P.2
  • 15
    • 0027231381 scopus 로고
    • Preparation of fluoro- and hydroxy-4-phosphonomethyl-d,l-phenylalanine suitably protected for solid phase synthesis of peptides containing hydrolytically stable analogues of O-phosphotyrosine
    • Burke T.R., Smyth M., Nomizu M., Otaka A., Roller P.P. Preparation of fluoro- and hydroxy-4-phosphonomethyl-d,l-phenylalanine suitably protected for solid phase synthesis of peptides containing hydrolytically stable analogues of O-phosphotyrosine. J. Org. Chem. 1993, 58:1336-1340.
    • (1993) J. Org. Chem. , vol.58 , pp. 1336-1340
    • Burke, T.R.1    Smyth, M.2    Nomizu, M.3    Otaka, A.4    Roller, P.P.5
  • 16
    • 84982337464 scopus 로고
    • Zusammenhänge zwischen Konstitution und Wirkung bei Pyrazolonderivaten
    • Erlenmeyer H., Willi E. Zusammenhänge zwischen Konstitution und Wirkung bei Pyrazolonderivaten. Helv. Chim. Acta 1935, 18:740-743.
    • (1935) Helv. Chim. Acta , vol.18 , pp. 740-743
    • Erlenmeyer, H.1    Willi, E.2
  • 17
    • 15644384509 scopus 로고    scopus 로고
    • Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme
    • Wallace E.M., Moliterni J.A., Moskal M.A., Neubert A.D., Marcopoulos N., et al. Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme. J. Med. Chem. 1998, 41:1513-1523.
    • (1998) J. Med. Chem. , vol.41 , pp. 1513-1523
    • Wallace, E.M.1    Moliterni, J.A.2    Moskal, M.A.3    Neubert, A.D.4    Marcopoulos, N.5
  • 18
    • 0030934793 scopus 로고    scopus 로고
    • Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase. 22.11
    • De Lombaert S., Stamford L.B., Blanchard L., Tan J., Hoyer D., et al. Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase. 22.11. Bioorg. Med. Chem. Lett. 1997, 8:1059-1064.
    • (1997) Bioorg. Med. Chem. Lett. , vol.8 , pp. 1059-1064
    • De Lombaert, S.1    Stamford, L.B.2    Blanchard, L.3    Tan, J.4    Hoyer, D.5
  • 19
    • 0023410634 scopus 로고
    • Thiophen als strukturelement physiologisch aktiver substanzen,16. Thienoisoxazole durch substitution am oximstickstoff
    • Binder D., Noe C.R., Holzer W., Baumann K. Thiophen als strukturelement physiologisch aktiver substanzen,16. Thienoisoxazole durch substitution am oximstickstoff. Arch. Pharm. 1987, 320:837-843.
    • (1987) Arch. Pharm. , vol.320 , pp. 837-843
    • Binder, D.1    Noe, C.R.2    Holzer, W.3    Baumann, K.4
  • 20
    • 0018345266 scopus 로고
    • Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anti-convulsant activities
    • Uno H., Kurokawa M., Masuda Y., Nishimura H. Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anti-convulsant activities. J. Med. Chem. 1979, 22:180-183.
    • (1979) J. Med. Chem. , vol.22 , pp. 180-183
    • Uno, H.1    Kurokawa, M.2    Masuda, Y.3    Nishimura, H.4
  • 21
    • 77951063711 scopus 로고
    • Synthèses de nouvelles phényl-1-triazoline-1,2,4-ones-5 substituées en 3 et 4
    • Gold-Aubert P., Melkonian D., Toribio L. Synthèses de nouvelles phényl-1-triazoline-1,2,4-ones-5 substituées en 3 et 4. Helv. Chim. Acta 1964, 47:2068-2071.
    • (1964) Helv. Chim. Acta , vol.47 , pp. 2068-2071
    • Gold-Aubert, P.1    Melkonian, D.2    Toribio, L.3
  • 23
    • 0028575501 scopus 로고
    • Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine
    • Garvey D.S., Wasicak J.T., Elliott R.L., Lebold S.A., Hettinger A.-M., et al. Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine. J. Med. Chem. 1994, 37:4455-4463.
    • (1994) J. Med. Chem. , vol.37 , pp. 4455-4463
    • Garvey, D.S.1    Wasicak, J.T.2    Elliott, R.L.3    Lebold, S.A.4    Hettinger, A.-M.5
  • 26
    • 0022474451 scopus 로고
    • Octahydroindolo[2,3-a]quinolizin-2-one, a novel structure for γ-aminobutyric acid (GABA) uptake inhibition
    • Kardos J., Blaskó G., Simonyi M., Szántay C. Octahydroindolo[2,3-a]quinolizin-2-one, a novel structure for γ-aminobutyric acid (GABA) uptake inhibition. Eur. J. Med. Chem. 1985, 21:151-154.
    • (1985) Eur. J. Med. Chem. , vol.21 , pp. 151-154
    • Kardos, J.1    Blaskó, G.2    Simonyi, M.3    Szántay, C.4
  • 27
    • 0026652403 scopus 로고
    • 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-d-aspartic receptor associated glycine binding site
    • Salituro F.G., Harrison B.L., Baron B.M., Nyce P.L., Stewart K.T., et al. 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-d-aspartic receptor associated glycine binding site. J. Med. Chem. 1992, 35:1791-1799.
    • (1992) J. Med. Chem. , vol.35 , pp. 1791-1799
    • Salituro, F.G.1    Harrison, B.L.2    Baron, B.M.3    Nyce, P.L.4    Stewart, K.T.5
  • 28
    • 0027298123 scopus 로고
    • Pharmacochemistry of the furoxan ring: recent developments
    • Calvino R., Stilo A.D., Fruttero R., Gasco A.M., Sorba G., et al. Pharmacochemistry of the furoxan ring: recent developments. Il Farmaco 1993, 48:321-334.
    • (1993) Il Farmaco , vol.48 , pp. 321-334
    • Calvino, R.1    Stilo, A.D.2    Fruttero, R.3    Gasco, A.M.4    Sorba, G.5
  • 29
    • 0026652442 scopus 로고
    • Hydantoin isosteres. In vivo active spiro hydroxy acetic aldose reductase inhibitors
    • Lipinski C.A., Aldinger C.E., Beyer T.A., Bordner J., Burdi D.F., et al. Hydantoin isosteres. In vivo active spiro hydroxy acetic aldose reductase inhibitors. J. Med. Chem. 1992, 35:2169-2177.
    • (1992) J. Med. Chem. , vol.35 , pp. 2169-2177
    • Lipinski, C.A.1    Aldinger, C.E.2    Beyer, T.A.3    Bordner, J.4    Burdi, D.F.5
  • 30
    • 0345650335 scopus 로고
    • Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists
    • Academic Press, London
    • Ganellin C.R. Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists. Medicinal Chemistry-The Role of Organic Chemistry in Drug Research 1993, 227-255. Academic Press, London.
    • (1993) Medicinal Chemistry-The Role of Organic Chemistry in Drug Research , pp. 227-255
    • Ganellin, C.R.1
  • 31
    • 84942873862 scopus 로고
    • 3-Aryl as-triazines: Bioisostérie avec les 6-aryl pyridazines
    • 17 January
    • Morin I. 3-Aryl as-triazines: Bioisostérie avec les 6-aryl pyridazines. Thesis, Université Louis Pasteur, Strasbourg 1991, 17 January.
    • (1991) Thesis, Université Louis Pasteur, Strasbourg
    • Morin, I.1
  • 32
    • 0026776278 scopus 로고
    • Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles
    • Mallamo J.P., Pilling G.M., Wetzel J.R., Kowalczik P.J., Bell M.R, et al. Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles. J. Med. Chem. 1992, 35:1663-1670.
    • (1992) J. Med. Chem. , vol.35 , pp. 1663-1670
    • Mallamo, J.P.1    Pilling, G.M.2    Wetzel, J.R.3    Kowalczik, P.J.4    Bell, M.R.5
  • 33
    • 0029922314 scopus 로고    scopus 로고
    • New set of principal properties for heteroaromatics obtained by grid
    • Clementi S., Cruciani G. New set of principal properties for heteroaromatics obtained by grid. Quant. Struct. Act. Rel. 1996, 15:108-120.
    • (1996) Quant. Struct. Act. Rel. , vol.15 , pp. 108-120
    • Clementi, S.1    Cruciani, G.2
  • 34
    • 0029848429 scopus 로고    scopus 로고
    • Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments
    • Gibson S., McGuire R., Rees D.C. Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments. J. Med. Chem. 1996, 39:4065-4072.
    • (1996) J. Med. Chem. , vol.39 , pp. 4065-4072
    • Gibson, S.1    McGuire, R.2    Rees, D.C.3
  • 35
    • 0026489556 scopus 로고
    • Synthesis and evaluation of 2-pyridone derivatives as HIV-1-specific everse transcriptase inhibitors. 2. Analogues of 3-aminopyridine-2-(1H)-one
    • Saari W.S., Wai J.S., Fisher T.E., Thomas C.M., Hoffman J.M., et al. Synthesis and evaluation of 2-pyridone derivatives as HIV-1-specific everse transcriptase inhibitors. 2. Analogues of 3-aminopyridine-2-(1H)-one. J. Med. Chem. 1992, 35:3792-3802.
    • (1992) J. Med. Chem. , vol.35 , pp. 3792-3802
    • Saari, W.S.1    Wai, J.S.2    Fisher, T.E.3    Thomas, C.M.4    Hoffman, J.M.5
  • 36
    • 0031832448 scopus 로고    scopus 로고
    • New principal components derived parameters describing molecular diversity of heteroaromatic residues
    • Langer T., Hoffmann R.D. New principal components derived parameters describing molecular diversity of heteroaromatic residues. Quant. Struct. Act. Rel. 1998, 17:211-223.
    • (1998) Quant. Struct. Act. Rel. , vol.17 , pp. 211-223
    • Langer, T.1    Hoffmann, R.D.2
  • 37
    • 0021793924 scopus 로고
    • Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-l-proline
    • Almquist R.G., Chao W.R., Jennings-White C. Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-l-proline. J. Med. Chem. 1985, 28:1067-1071.
    • (1985) J. Med. Chem. , vol.28 , pp. 1067-1071
    • Almquist, R.G.1    Chao, W.R.2    Jennings-White, C.3
  • 39
    • 0022445756 scopus 로고
    • Acyl, N-protected α-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol deterrent agent cyanamide
    • Kwon C.-H., Nagasawa H.T., DeMaster E.G., Shirota F.N. Acyl, N-protected α-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol deterrent agent cyanamide. J. Med. Chem. 1986, 29:1922-1929.
    • (1986) J. Med. Chem. , vol.29 , pp. 1922-1929
    • Kwon, C.-H.1    Nagasawa, H.T.2    DeMaster, E.G.3    Shirota, F.N.4
  • 40
    • 0027392743 scopus 로고
    • Nonpeptide angiotensin II antagonists: N-phenyl-1-H-pyrrole derivatives are angiotensin II receptor antagonists
    • Bovy P.R., Reitz D.B., Collins J.T., Chamberlain T.S., Olins G.M., et al. Nonpeptide angiotensin II antagonists: N-phenyl-1-H-pyrrole derivatives are angiotensin II receptor antagonists. J. Med. Chem. 1993, 36:101-110.
    • (1993) J. Med. Chem. , vol.36 , pp. 101-110
    • Bovy, P.R.1    Reitz, D.B.2    Collins, J.T.3    Chamberlain, T.S.4    Olins, G.M.5
  • 41
    • 0023183449 scopus 로고
    • Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives
    • Marshall W.S., Goodson T., Cullinan G.J., Swanson-Bean D., Haisch K.D., et al. Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives. J. Med. Chem. 1987, 30:682-689.
    • (1987) J. Med. Chem. , vol.30 , pp. 682-689
    • Marshall, W.S.1    Goodson, T.2    Cullinan, G.J.3    Swanson-Bean, D.4    Haisch, K.D.5
  • 42
    • 0030480485 scopus 로고    scopus 로고
    • Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole nioisosteres
    • Kohara Y., Kuba K., Imamiya E., Wada T., Inada Y., et al. Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole nioisosteres. J. Med. Chem. 1996, 39:5228-5235.
    • (1996) J. Med. Chem. , vol.39 , pp. 5228-5235
    • Kohara, Y.1    Kuba, K.2    Imamiya, E.3    Wada, T.4    Inada, Y.5
  • 44
    • 84939801615 scopus 로고
    • Poster No. P-041.A. LY262466, dl-2-amino-3-(4-hydroxy-1,2,5-thiazol-3-yl) propanoic acid hydrochloride, a novel and selective agonist at the AMPA excitatory amino acid receptor
    • Basel: Switzerland, 13-17 September
    • Lunn W.H.W., Schoepp D.D., Lodge D., True R.A., Millar J.D Poster No. P-041.A. LY262466, dl-2-amino-3-(4-hydroxy-1,2,5-thiazol-3-yl) propanoic acid hydrochloride, a novel and selective agonist at the AMPA excitatory amino acid receptor. XIIth International Symposium on Medicinal Chemistry 1992, 133-137. Basel: Switzerland, 13-17 September.
    • (1992) XIIth International Symposium on Medicinal Chemistry , pp. 133-137
    • Lunn, W.H.W.1    Schoepp, D.D.2    Lodge, D.3    True, R.A.4    Millar, J.D.5
  • 47
    • 0021339180 scopus 로고
    • Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by l-homocysteic acid and l-cysteic acid: effect on enzyme inhibition and antitumor activity
    • Rosowsky A., Forsch R.A., Freisheim J.H., Moran R.G., Wick M. Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by l-homocysteic acid and l-cysteic acid: effect on enzyme inhibition and antitumor activity. J. Med. Chem. 1984, 27:600-604.
    • (1984) J. Med. Chem. , vol.27 , pp. 600-604
    • Rosowsky, A.1    Forsch, R.A.2    Freisheim, J.H.3    Moran, R.G.4    Wick, M.5
  • 48
    • 0023893062 scopus 로고
    • Convenient procedure for the preparation of alkyl and aryl substituted N-(aminoalkylacyl)sulfonamides
    • Drummond J.T., Johnson G. Convenient procedure for the preparation of alkyl and aryl substituted N-(aminoalkylacyl)sulfonamides. Tetrahedron Lett. 1988, 29:1653-1656.
    • (1988) Tetrahedron Lett. , vol.29 , pp. 1653-1656
    • Drummond, J.T.1    Johnson, G.2
  • 49
    • 0020557336 scopus 로고
    • Potential antiatherosclerotic agents. 3. Substituted benzoic and non-benzoic analogues of cetabon
    • Albright J.D., DeVries V.G., Du M.D., Largis E.E., Miner T.G., et al. Potential antiatherosclerotic agents. 3. Substituted benzoic and non-benzoic analogues of cetabon. J. Med. Chem. 1983, 26:1393-1411.
    • (1983) J. Med. Chem. , vol.26 , pp. 1393-1411
    • Albright, J.D.1    DeVries, V.G.2    Du, M.D.3    Largis, E.E.4    Miner, T.G.5
  • 50
    • 0013846957 scopus 로고
    • Un nouvel agent anti-inflammatoire de structure non stéroïdique: l'acide p-butoxyphénylacéthydroxamique
    • Buu-Hoï N.P., Lambelin G., Lepoivre C., Gillet C., Gautier M., et al. Un nouvel agent anti-inflammatoire de structure non stéroïdique: l'acide p-butoxyphénylacéthydroxamique. CR Acad. Sci. (Paris) 1965, 261:2259-2262.
    • (1965) CR Acad. Sci. (Paris) , vol.261 , pp. 2259-2262
    • Buu-Hoï, N.P.1    Lambelin, G.2    Lepoivre, C.3    Gillet, C.4    Gautier, M.5
  • 51
    • 84906439301 scopus 로고
    • Pharmaceutical 2-(4-isobutylphenyl) propionohydroxamic acid
    • (24 July 1974, to Societa Italo-Britannica L. Manetti & H. Roberts e C.)
    • Orzalesi G., Selleri R Pharmaceutical 2-(4-isobutylphenyl) propionohydroxamic acid. Chem. Abst. 1974, 81:120272i. German Patent 2 400 531 (24 July 1974, to Societa Italo-Britannica L. Manetti & H. Roberts e C.).
    • (1974) Chem. Abst. , vol.81 , pp. 120272i
    • Orzalesi, G.1    Selleri, R.2
  • 52
    • 0016778688 scopus 로고
    • Valutazione farmaco-tossicologica di un nuovo agente antifiammatorio non-steroideo: l'acido indoxamico
    • De Martiis F., Corsico N., Franzone J.S., Tamietto T. Valutazione farmaco-tossicologica di un nuovo agente antifiammatorio non-steroideo: l'acido indoxamico. Boll. Chim. Farm. 1975, 114:319-333.
    • (1975) Boll. Chim. Farm. , vol.114 , pp. 319-333
    • De Martiis, F.1    Corsico, N.2    Franzone, J.S.3    Tamietto, T.4
  • 54
    • 0027097495 scopus 로고
    • Structural alterations in desferioxamine compatible with iron clearance in animals
    • Bergeron R.J., Liu Z.-R., McManis J.S., Wiegand J. Structural alterations in desferioxamine compatible with iron clearance in animals. J. Med. Chem. 1992, 35:4739-4744.
    • (1992) J. Med. Chem. , vol.35 , pp. 4739-4744
    • Bergeron, R.J.1    Liu, Z.-R.2    McManis, J.S.3    Wiegand, J.4
  • 55
    • 0016797336 scopus 로고
    • Sintesi e proprieta antiflogistiche di alcuni acidici indolil-acetoidrossammici
    • De Martiis F., Franzone J.S., Tamietto T. Sintesi e proprieta antiflogistiche di alcuni acidici indolil-acetoidrossammici. Bol. Chim. Farm. 1975, 114:309-318.
    • (1975) Bol. Chim. Farm. , vol.114 , pp. 309-318
    • De Martiis, F.1    Franzone, J.S.2    Tamietto, T.3
  • 56
    • 0018832689 scopus 로고
    • Anti-inflammatory agents: determination of ibuproxam and its metabolite in humans
    • Orzalesi G., Mari F., Bertol E., Selleri R., Pisaturo G. Anti-inflammatory agents: determination of ibuproxam and its metabolite in humans. Arzneim.-Forsch. 1980, 30:1607-1609.
    • (1980) Arzneim.-Forsch. , vol.30 , pp. 1607-1609
    • Orzalesi, G.1    Mari, F.2    Bertol, E.3    Selleri, R.4    Pisaturo, G.5
  • 57
    • 0020086409 scopus 로고
    • A new non-steroidal anti-inflammatory drug (NSAID) in current rheumatologic practice (oxamethacin)
    • Demay F., De Sy J. A new non-steroidal anti-inflammatory drug (NSAID) in current rheumatologic practice (oxamethacin). Curr. Ther. Res. 1982, 31:113-118.
    • (1982) Curr. Ther. Res. , vol.31 , pp. 113-118
    • Demay, F.1    De Sy, J.2
  • 58
    • 0019444360 scopus 로고
    • Pharmakokinetik und biotransformation von Oxametacin bei gesunden probanden
    • Vergin H., Ferber H., Brunner F., Kukovetz W.R. Pharmakokinetik und biotransformation von Oxametacin bei gesunden probanden. Arzneim.-Forsch. 1981, 31:513-518.
    • (1981) Arzneim.-Forsch. , vol.31 , pp. 513-518
    • Vergin, H.1    Ferber, H.2    Brunner, F.3    Kukovetz, W.R.4
  • 60
    • 0027462923 scopus 로고
    • Non-peptide angiotensin II antagonists derived from 4H-1, 2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles
    • Ashton W.T., Cantone C.L., Chang L.L., Hutchins S.M., Strelitz R., et al. Non-peptide angiotensin II antagonists derived from 4H-1, 2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. J. Med. Chem. 1993, 36:591-609.
    • (1993) J. Med. Chem. , vol.36 , pp. 591-609
    • Ashton, W.T.1    Cantone, C.L.2    Chang, L.L.3    Hutchins, S.M.4    Strelitz, R.5
  • 61
    • 0020647262 scopus 로고
    • Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system
    • Kraus J.L. Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system. Pharmacol. Res. Commun. 1983, 15:183-189.
    • (1983) Pharmacol. Res. Commun. , vol.15 , pp. 183-189
    • Kraus, J.L.1
  • 63
    • 0018773504 scopus 로고
    • GABA agonists. Synthesis and structure-activity studies on analogues of isoguvacine and THIP
    • Krogsgaard-Larsen P., Rodolskov-Christiansen T. GABA agonists. Synthesis and structure-activity studies on analogues of isoguvacine and THIP. Eur. J. Med. Chem. 1979, 14:157-164.
    • (1979) Eur. J. Med. Chem. , vol.14 , pp. 157-164
    • Krogsgaard-Larsen, P.1    Rodolskov-Christiansen, T.2
  • 64
    • 0019839152 scopus 로고
    • γ-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects
    • Krogsgaard-Larsen P. γ-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J. Med. Chem. 1981, 24:1377-1383.
    • (1981) J. Med. Chem. , vol.24 , pp. 1377-1383
    • Krogsgaard-Larsen, P.1
  • 65
    • 0025970909 scopus 로고
    • Novel class of amino acid antagonists at non-N-methyl-d-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection
    • Krogsgaard-Larsen P., Ferkany J.W., Nielsen E.O., Madsen U., Ebert B., et al. Novel class of amino acid antagonists at non-N-methyl-d-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection. J. Med. Chem. 1991, 34:123-130.
    • (1991) J. Med. Chem. , vol.34 , pp. 123-130
    • Krogsgaard-Larsen, P.1    Ferkany, J.W.2    Nielsen, E.O.3    Madsen, U.4    Ebert, B.5
  • 66
    • 0020692273 scopus 로고
    • Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase
    • Kraus J.L. Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase. Pharmacol Res. Commun. 1983, 15:119-129.
    • (1983) Pharmacol Res. Commun. , vol.15 , pp. 119-129
    • Kraus, J.L.1
  • 67
    • 84981769033 scopus 로고
    • Intermediates in the formation of γ-pyrones from hexose derivatives: a simple synthesis of Kojic acid and hydroxymaltol
    • Lichtenthaler F.W., Heidel P. Intermediates in the formation of γ-pyrones from hexose derivatives: a simple synthesis of Kojic acid and hydroxymaltol. Angew. Chem. Int. Ed. 1969, 8:978-979.
    • (1969) Angew. Chem. Int. Ed. , vol.8 , pp. 978-979
    • Lichtenthaler, F.W.1    Heidel, P.2
  • 68
    • 0025191432 scopus 로고
    • Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists
    • Watkins J.C., Krogsgaard-Larsen P., Honoré T. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharm. Sci. 1990, 11:25-33.
    • (1990) Trends Pharm. Sci. , vol.11 , pp. 25-33
    • Watkins, J.C.1    Krogsgaard-Larsen, P.2    Honoré, T.3
  • 69
    • 0026684706 scopus 로고
    • Rationally designed 'dipeptoid' analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988
    • Drysdale M.J., Pritchard M.C., Horwell D.C. Rationally designed 'dipeptoid' analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988. J. Med. Chem. 1992, 35:2573-2581.
    • (1992) J. Med. Chem. , vol.35 , pp. 2573-2581
    • Drysdale, M.J.1    Pritchard, M.C.2    Horwell, D.C.3
  • 70
    • 0027097494 scopus 로고
    • Bioisosteric replacement of the α-amino carboxylic functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists
    • Kinney W.A., Lee N.E., Garrison D.T., Podlesny E.J., Simmonds J.T., et al. Bioisosteric replacement of the α-amino carboxylic functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists. J. Med. Chem. 1992, 35:4720-4726.
    • (1992) J. Med. Chem. , vol.35 , pp. 4720-4726
    • Kinney, W.A.1    Lee, N.E.2    Garrison, D.T.3    Podlesny, E.J.4    Simmonds, J.T.5
  • 71
    • 0034624812 scopus 로고    scopus 로고
    • Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic
    • Gao Y., Luo J., Yao Z.J., Guo R., Zou H., et al. Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J. Med. Chem. 2000, 43:911-920.
    • (2000) J. Med. Chem. , vol.43 , pp. 911-920
    • Gao, Y.1    Luo, J.2    Yao, Z.J.3    Guo, R.4    Zou, H.5
  • 73
    • 0016758084 scopus 로고
    • Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylsalicylic acid)
    • Thompkins L., Lee K.H. Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylsalicylic acid). J. Pharm. Sci. 1975, 64:760-763.
    • (1975) J. Pharm. Sci. , vol.64 , pp. 760-763
    • Thompkins, L.1    Lee, K.H.2
  • 75
    • 0025237210 scopus 로고
    • Novel quinuclidine-based ligands for the muscarinic cholinergic receptor
    • Saunders J., Cassidy M., Freedman S.B., Harley E.A., Iversen L.L., et al. Novel quinuclidine-based ligands for the muscarinic cholinergic receptor. J. Med. Chem. 1990, 33:1128-1138.
    • (1990) J. Med. Chem. , vol.33 , pp. 1128-1138
    • Saunders, J.1    Cassidy, M.2    Freedman, S.B.3    Harley, E.A.4    Iversen, L.L.5
  • 76
    • 0026062275 scopus 로고
    • Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships
    • Sauerberg P., Kindtler J.W., Nielsen L., Sheardown M.J., Honoré T. Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships. J. Med. Chem. 1991, 34:687-692.
    • (1991) J. Med. Chem. , vol.34 , pp. 687-692
    • Sauerberg, P.1    Kindtler, J.W.2    Nielsen, L.3    Sheardown, M.J.4    Honoré, T.5
  • 77
    • 0026611521 scopus 로고
    • 1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines
    • 1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines. J. Med. Chem. 1992, 35:2263-2274.
    • (1992) J. Med. Chem. , vol.35 , pp. 2263-2274
    • Sauerberg, P.1    Olesen, P.H.2    Nielsen, S.3    Treppendahl, S.4    Sheardown, M.J.5
  • 78
    • 0026776275 scopus 로고
    • Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives
    • Wadsworth H.J., Jenkins S.M., Orlek B.S., Cassidy F., Clark M.S., et al. Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J. Med. Chem. 1992, 35:1280-1290.
    • (1992) J. Med. Chem. , vol.35 , pp. 1280-1290
    • Wadsworth, H.J.1    Jenkins, S.M.2    Orlek, B.S.3    Cassidy, F.4    Clark, M.S.5
  • 79
    • 0026542113 scopus 로고
    • Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives
    • Street L.J., Baker R., Book T., Reeve A.J., Saunders J., et al. Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives. J. Med. Chem. 1992, 35:295-305.
    • (1992) J. Med. Chem. , vol.35 , pp. 295-305
    • Street, L.J.1    Baker, R.2    Book, T.3    Reeve, A.J.4    Saunders, J.5
  • 80
    • 0027064877 scopus 로고
    • Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue
    • Kozikowski A.P., Roberti M., Xiang L., Bergmann J.S., Callahan P.M., et al. Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. J. Med. Chem. 1992, 35:4764-4766.
    • (1992) J. Med. Chem. , vol.35 , pp. 4764-4766
    • Kozikowski, A.P.1    Roberti, M.2    Xiang, L.3    Bergmann, J.S.4    Callahan, P.M.5
  • 81
    • 77956715838 scopus 로고
    • Bioisosterism in drug design
    • Academic Press, Amsterdam, D.M. Bailey (Ed.)
    • Lipinski C.A. Bioisosterism in drug design. Annual Reports in Medicinal Chemistry 1986, 283-291. Academic Press, Amsterdam. D.M. Bailey (Ed.).
    • (1986) Annual Reports in Medicinal Chemistry , pp. 283-291
    • Lipinski, C.A.1
  • 82
    • 0027273657 scopus 로고
    • Aminopyridazines-an alternate route to potent muscarinic agonists with no cholinergic syndrome
    • Wermuth C.G. Aminopyridazines-an alternate route to potent muscarinic agonists with no cholinergic syndrome. Il Farmaco 1993, 48:253-274.
    • (1993) Il Farmaco , vol.48 , pp. 253-274
    • Wermuth, C.G.1
  • 84
    • 0020075860 scopus 로고
    • Synthèse et propriétés pharmacologiques de sulfonylurées isostères du glibenclamide
    • Fournier J.-P., Moreau R.C., Narcisse G., Choay P. Synthèse et propriétés pharmacologiques de sulfonylurées isostères du glibenclamide. Eur. J. Med. Chem. 1982, 17:81-84.
    • (1982) Eur. J. Med. Chem. , vol.17 , pp. 81-84
    • Fournier, J.-P.1    Moreau, R.C.2    Narcisse, G.3    Choay, P.4
  • 85
    • 0000788606 scopus 로고
    • Peptide backbone modifications: structure-activity analysis of peptides containing amide bond surrogates
    • Marcel Dekker, San Diego, B. Weinstein (Ed.)
    • Spatola A.F. Peptide backbone modifications: structure-activity analysis of peptides containing amide bond surrogates. Chemistry and Biochemistry of Amino Acids, Peptides and Proteins 1983, 267-357. Marcel Dekker, San Diego. B. Weinstein (Ed.).
    • (1983) Chemistry and Biochemistry of Amino Acids, Peptides and Proteins , pp. 267-357
    • Spatola, A.F.1
  • 86
    • 0002961632 scopus 로고
    • Elements for the rational design of peptide drugs
    • Academic Press, New York, B. Testa (Ed.)
    • Fauchère J.-L. Elements for the rational design of peptide drugs. Advances in Drug Research 1986, 29-69. Academic Press, New York. B. Testa (Ed.).
    • (1986) Advances in Drug Research , pp. 29-69
    • Fauchère, J.-L.1
  • 87
    • 0027081659 scopus 로고
    • Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a β-strand: potential application to the design of novel inhibitors of proteolytic enzymes
    • Smith A.B., Keenan T.P., Holcomb R.C., Sprengeler P.A., Guzman M.C., et al. Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a β-strand: potential application to the design of novel inhibitors of proteolytic enzymes. J. Am. Chem. Soc. 1992, 114:10672-10674.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 10672-10674
    • Smith, A.B.1    Keenan, T.P.2    Holcomb, R.C.3    Sprengeler, P.A.4    Guzman, M.C.5
  • 90
    • 0026602250 scopus 로고
    • Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-l-tyrosyl-N-(3-phenylpropyl)-d-alanylamide
    • Chandrakumar N.S., Yonan P.K., Stapelfeld A., Svage M., Rorbacher E., et al. Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-l-tyrosyl-N-(3-phenylpropyl)-d-alanylamide. J. Med. Chem. 1992, 35:223-233.
    • (1992) J. Med. Chem. , vol.35 , pp. 223-233
    • Chandrakumar, N.S.1    Yonan, P.K.2    Stapelfeld, A.3    Svage, M.4    Rorbacher, E.5
  • 91
    • 0021287857 scopus 로고
    • 2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities
    • 2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities. J. Med. Chem. 1984, 27:849-857.
    • (1984) J. Med. Chem. , vol.27 , pp. 849-857
    • Yanagisawa, I.1    Hirata, Y.2    Ishii, Y.3
  • 94
    • 0000262436 scopus 로고
    • The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in aqueous solution
    • Young R.C., Ganellin C.R., Graham M.J., Grant E.H. The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in aqueous solution. Tetrahedron 1982, 38:1493-1497.
    • (1982) Tetrahedron , vol.38 , pp. 1493-1497
    • Young, R.C.1    Ganellin, C.R.2    Graham, M.J.3    Grant, E.H.4
  • 95
    • 46549104536 scopus 로고
    • The dielectric properties of seven polar amidinecontaining compounds of biological interest
    • Young R.C., Ganellin C.R., Graham M.J., Roantree M.J., Grant E.H. The dielectric properties of seven polar amidinecontaining compounds of biological interest. Tetrahedron Lett. 1985, 26:1897-1900.
    • (1985) Tetrahedron Lett. , vol.26 , pp. 1897-1900
    • Young, R.C.1    Ganellin, C.R.2    Graham, M.J.3    Roantree, M.J.4    Grant, E.H.5
  • 96
    • 0034618553 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines
    • Wright J.L., Gregory T.F., Kesten S.R., Boxer P.A., Serpa K.A., et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J. Med. Chem. 2000, 43:3408-3419.
    • (2000) J. Med. Chem. , vol.43 , pp. 3408-3419
    • Wright, J.L.1    Gregory, T.F.2    Kesten, S.R.3    Boxer, P.A.4    Serpa, K.A.5
  • 97
    • 0001159494 scopus 로고
    • A new bio-isostere: alkylsulphonamidophenethanolamines
    • Larson A.A., Lish P.M. A new bio-isostere: alkylsulphonamidophenethanolamines. Nature (London) 1964, 203:1283-1285.
    • (1964) Nature (London) , vol.203 , pp. 1283-1285
    • Larson, A.A.1    Lish, P.M.2
  • 98
    • 0024580983 scopus 로고
    • Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
    • Roderick S.L., Fournié-Zaluski M.C., Roques B.P., Matthews B.W. Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin. Biochemistry 1989, 28:1493-1497.
    • (1989) Biochemistry , vol.28 , pp. 1493-1497
    • Roderick, S.L.1    Fournié-Zaluski, M.C.2    Roques, B.P.3    Matthews, B.W.4
  • 99
    • 84882500012 scopus 로고
    • Über lokalanästhetisch wirksame basische ester und amide verschiedener alkoxy-amino-benzoesäuren
    • Büchi J., Stünzi E., Flury M., Hirt R., Labhart P., et al. Über lokalanästhetisch wirksame basische ester und amide verschiedener alkoxy-amino-benzoesäuren. Helv. Chim. Acta 1951, 34:1002-1013.
    • (1951) Helv. Chim. Acta , vol.34 , pp. 1002-1013
    • Büchi, J.1    Stünzi, E.2    Flury, M.3    Hirt, R.4    Labhart, P.5
  • 100
    • 0030610606 scopus 로고    scopus 로고
    • Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder
    • Bös M., Jenck F., Martin J.R., Moreau J.L., Sleight A.J., et al. Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder. J. Med. Chem. 1997, 40:2762-2769.
    • (1997) J. Med. Chem. , vol.40 , pp. 2762-2769
    • Bös, M.1    Jenck, F.2    Martin, J.R.3    Moreau, J.L.4    Sleight, A.J.5
  • 101
    • 0345526665 scopus 로고
    • The chemistry of polycyclic psycho-active drugs: serendipity or systematic investigation?
    • Wilhelm M. The chemistry of polycyclic psycho-active drugs: serendipity or systematic investigation?. Pharm. J. 1975, 214:414-416.
    • (1975) Pharm. J. , vol.214 , pp. 414-416
    • Wilhelm, M.1
  • 102
    • 18244424282 scopus 로고    scopus 로고
    • Discovery of novel and potent retinoic acid receptor α agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole
    • Yoshimura H., Kikuchi K., Hibi S., Tagami K., Satoh T., et al. Discovery of novel and potent retinoic acid receptor α agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole. J. Med. Chem. 2000, 43:2929-2937.
    • (2000) J. Med. Chem. , vol.43 , pp. 2929-2937
    • Yoshimura, H.1    Kikuchi, K.2    Hibi, S.3    Tagami, K.4    Satoh, T.5
  • 103
    • 0037725951 scopus 로고
    • On the mechanism of the pharmacophoric effect of halogenation
    • Chenoweth M.B., McCarthy L.P. On the mechanism of the pharmacophoric effect of halogenation. Pharmacol. Rev. 1963, 15:673-707.
    • (1963) Pharmacol. Rev. , vol.15 , pp. 673-707
    • Chenoweth, M.B.1    McCarthy, L.P.2
  • 104
    • 0014665768 scopus 로고
    • The carbon-florine bond in compounds of biological interest
    • Goldman P. The carbon-florine bond in compounds of biological interest. Science 1969, 164:1123-1130.
    • (1969) Science , vol.164 , pp. 1123-1130
    • Goldman, P.1
  • 106
    • 84882559115 scopus 로고
    • Chemical reactivity and pharmacological activity among 2-haloethylamine derivatives with a naphtylmethyl group
    • Chapman N.B., James J.W., Graham J.D.P., Lewis G.P. Chemical reactivity and pharmacological activity among 2-haloethylamine derivatives with a naphtylmethyl group. Chem. Ind (London) 1952, 805-807.
    • (1952) Chem. Ind (London) , pp. 805-807
    • Chapman, N.B.1    James, J.W.2    Graham, J.D.P.3    Lewis, G.P.4
  • 107
    • 0348047879 scopus 로고
    • Antihistamine agents. IV. Halogenated N,N-dimethyl-N'-benzyl-N-(2-pyridyl)-ethylenediamines
    • Vaughan J.R.J., Anderson G.W., Clapp R.C., Clark J.H., English J.P., et al. Antihistamine agents. IV. Halogenated N,N-dimethyl-N'-benzyl-N-(2-pyridyl)-ethylenediamines. J. Org. Chem. 1949, 14:228-234.
    • (1949) J. Org. Chem. , vol.14 , pp. 228-234
    • Vaughan, J.R.J.1    Anderson, G.W.2    Clapp, R.C.3    Clark, J.H.4    English, J.P.5
  • 108
    • 84982415227 scopus 로고
    • Isosterism and bioisosterism
    • Interscience Publishers, Oxford, A. Burger (Ed.)
    • Schatz V.B. Isosterism and bioisosterism. Medicinal Chemistry 1963, 72-88. Interscience Publishers, Oxford. A. Burger (Ed.).
    • (1963) Medicinal Chemistry , pp. 72-88
    • Schatz, V.B.1
  • 109
    • 0014176249 scopus 로고
    • The biological properties of silicon compounds
    • Academic Press, New York, N.J. Harper, A.B. Simmonds (Eds.)
    • Fessenden R.J., Fessenden J.S. The biological properties of silicon compounds. Advances in Drug Research 1967, 95-132. Academic Press, New York. N.J. Harper, A.B. Simmonds (Eds.).
    • (1967) Advances in Drug Research , pp. 95-132
    • Fessenden, R.J.1    Fessenden, J.S.2
  • 110
    • 0022854753 scopus 로고
    • Sila-substitution-a useful strategy for drug design?
    • Tacke R., Zilch H. Sila-substitution-a useful strategy for drug design?. Endeavour, New Series 1986, 10:191-197.
    • (1986) Endeavour, New Series , vol.10 , pp. 191-197
    • Tacke, R.1    Zilch, H.2
  • 111
    • 1542415822 scopus 로고
    • Drug-design by sila-substitution and microbial transformations of organosilicon compounds: some recent results
    • Tacke R., Zilch H. Drug-design by sila-substitution and microbial transformations of organosilicon compounds: some recent results. L'Actualité Chimique 1986, 75-82.
    • (1986) L'Actualité Chimique , pp. 75-82
    • Tacke, R.1    Zilch, H.2
  • 113
    • 0013833680 scopus 로고
    • Silicon-containing carbamate insecticides
    • Metcalf R.L., Fukuto T.R. Silicon-containing carbamate insecticides. J. Econ. Entomol. 1965, 58:1151.
    • (1965) J. Econ. Entomol. , vol.58 , pp. 1151
    • Metcalf, R.L.1    Fukuto, T.R.2
  • 114
    • 0027970147 scopus 로고
    • Zifrosilone
    • Anonymous Zifrosilone. Drugs Fut. 1994, 19:854-855.
    • (1994) Drugs Fut. , vol.19 , pp. 854-855
  • 115
    • 0027933449 scopus 로고
    • Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745
    • Hornsperger J.M., Collard J.N., Heydt J.G., Giacobini E., Funes S., et al. Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745. Biochem. Soc. Trans. 1994, 22:758-763.
    • (1994) Biochem. Soc. Trans. , vol.22 , pp. 758-763
    • Hornsperger, J.M.1    Collard, J.N.2    Heydt, J.G.3    Giacobini, E.4    Funes, S.5
  • 116
    • 0013798155 scopus 로고
    • Silicon-substituted medicinal agents. Silacarbamates related to meprobamate
    • Fessenden R.J., Coon M.D. Silicon-substituted medicinal agents. Silacarbamates related to meprobamate. J. Med. Chem. 1965, 8:604-608.
    • (1965) J. Med. Chem. , vol.8 , pp. 604-608
    • Fessenden, R.J.1    Coon, M.D.2
  • 117
    • 0018879522 scopus 로고
    • Sila-pharmaka XIX. Sila-pridinol und pridinol: darstellung und eigenschaften sowie strukturen im kristallinen und gelösten Zustand
    • Tacke R. Sila-pharmaka XIX. Sila-pridinol und pridinol: darstellung und eigenschaften sowie strukturen im kristallinen und gelösten Zustand. Chem. Ber. 1980, 113:1962-1980.
    • (1980) Chem. Ber. , vol.113 , pp. 1962-1980
    • Tacke, R.1
  • 120
    • 0029149283 scopus 로고
    • (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors
    • Gotteland J.-P., Brunel I., Gendre F., Désiré J., Delhon A., et al. (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors. J. Med. Chem. 1995, 38:3207-3216.
    • (1995) J. Med. Chem. , vol.38 , pp. 3207-3216
    • Gotteland, J.-P.1    Brunel, I.2    Gendre, F.3    Désiré, J.4    Delhon, A.5
  • 121
    • 0029972476 scopus 로고    scopus 로고
    • Design and synthesis of new hypocholesteremic organosilanes with antioxidant properties
    • Gotteland J.-P., Delhon A., Junquéro D., Oms P., Halazy S. Design and synthesis of new hypocholesteremic organosilanes with antioxidant properties. Bioorg. Med. Chem. Lett. 1996, 6:533-538.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 533-538
    • Gotteland, J.-P.1    Delhon, A.2    Junquéro, D.3    Oms, P.4    Halazy, S.5
  • 122
    • 0029810006 scopus 로고    scopus 로고
    • Synthesis and pharmacological properties of 4(5)-(2-ethyl-2,3-dihydro-2-silainden-2-yl)imidazole, a silicon analogue of atipamezole
    • Heinonen P., Sipilä H., Neuvonen K., Lönnberg H., Cockroft V.B., et al. Synthesis and pharmacological properties of 4(5)-(2-ethyl-2,3-dihydro-2-silainden-2-yl)imidazole, a silicon analogue of atipamezole. Eur. J. Med. Chem. 1996, 31:725-729.
    • (1996) Eur. J. Med. Chem. , vol.31 , pp. 725-729
    • Heinonen, P.1    Sipilä, H.2    Neuvonen, K.3    Lönnberg, H.4    Cockroft, V.B.5
  • 123
    • 0034687233 scopus 로고    scopus 로고
    • The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity
    • Bom D., Curran D.P., Kruszewski S., Zimmer S.G., Strode J.T., et al. The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity. J. Med. Chem. 2000, 43:3970-3980.
    • (2000) J. Med. Chem. , vol.43 , pp. 3970-3980
    • Bom, D.1    Curran, D.P.2    Kruszewski, S.3    Zimmer, S.G.4    Strode, J.T.5
  • 124
    • 33947469585 scopus 로고
    • Stereochemistry of hydride ion displacement from silicon. Enhanced rates at Bridgehead and 4-ring silicon atoms
    • Sommer L.H., Bennet O.F., Campbell P.G., Weyenberg D.R. Stereochemistry of hydride ion displacement from silicon. Enhanced rates at Bridgehead and 4-ring silicon atoms. J. Am. Chem. Soc. 1957, 79:3295-3296.
    • (1957) J. Am. Chem. Soc. , vol.79 , pp. 3295-3296
    • Sommer, L.H.1    Bennet, O.F.2    Campbell, P.G.3    Weyenberg, D.R.4
  • 125
    • 0014127511 scopus 로고
    • The metabolic fate of some silicon-containing carbamates
    • Fessenden R.J., Ahlfors C. The metabolic fate of some silicon-containing carbamates. J. Med. Chem. 1967, 10:810-812.
    • (1967) J. Med. Chem. , vol.10 , pp. 810-812
    • Fessenden, R.J.1    Ahlfors, C.2
  • 126
    • 84965190026 scopus 로고
    • On the chemical production of developmental abnormalities and of phenocopies in chicken embryos
    • Landauer W. On the chemical production of developmental abnormalities and of phenocopies in chicken embryos. J. Cell. Comp. Physiol. 1954, 43:261-305.
    • (1954) J. Cell. Comp. Physiol. , vol.43 , pp. 261-305
    • Landauer, W.1
  • 127
    • 0343190418 scopus 로고
    • On the role of riboflavin in the teratogenic activity of boric acid
    • Landauer W., Clark E.M. On the role of riboflavin in the teratogenic activity of boric acid. J. Exp. Zool. 1964, 156:307-312.
    • (1964) J. Exp. Zool. , vol.156 , pp. 307-312
    • Landauer, W.1    Clark, E.M.2
  • 128
    • 0004288073 scopus 로고
    • Appleton-Century-Crofts, London second edn.
    • Browning E. Toxicity of Industrial Metals 1969, 90-97. Appleton-Century-Crofts, London. second edn.
    • (1969) Toxicity of Industrial Metals , pp. 90-97
    • Browning, E.1
  • 129
    • 0014272171 scopus 로고
    • Structure chimique et activité spasmolytique des organoboriques
    • Caujolle P.H.C. Structure chimique et activité spasmolytique des organoboriques. Arch. Int. Pharmacodyn. Ther. 1968, 172:467-474.
    • (1968) Arch. Int. Pharmacodyn. Ther. , vol.172 , pp. 467-474
    • Caujolle, P.H.C.1
  • 130
    • 0021734983 scopus 로고
    • Some aspects of the antimicrobial and chemical properties of phenyl boronate esters of chloramphenicol
    • Mubarak S.I.M., Stanford J.B., Sugden J.K. Some aspects of the antimicrobial and chemical properties of phenyl boronate esters of chloramphenicol. Drug Dev. Ind. Pharm. 1984, 10:1131-1160.
    • (1984) Drug Dev. Ind. Pharm. , vol.10 , pp. 1131-1160
    • Mubarak, S.I.M.1    Stanford, J.B.2    Sugden, J.K.3
  • 132
    • 0022356416 scopus 로고
    • Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsine and elastase
    • Kinder D.H., Katzenellenbogen J.A. Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsine and elastase. J. Med. Chem. 1985, 28:1917-1925.
    • (1985) J. Med. Chem. , vol.28 , pp. 1917-1925
    • Kinder, D.H.1    Katzenellenbogen, J.A.2
  • 134
    • 0024488447 scopus 로고
    • A carboranyl porphyrin for boron neutron capture therapy of brain tumors
    • Kahl S.B., Joel D.D., Finkel G.C., Micca P.L., Nawrocky M.M., et al. A carboranyl porphyrin for boron neutron capture therapy of brain tumors. Basic Life Sci. 1989, 50:193-203.
    • (1989) Basic Life Sci. , vol.50 , pp. 193-203
    • Kahl, S.B.1    Joel, D.D.2    Finkel, G.C.3    Micca, P.L.4    Nawrocky, M.M.5
  • 135
    • 0024488448 scopus 로고
    • Tumor-seeking for boron neutron capture therapy: synthesis and biodistribution
    • Gabel D. Tumor-seeking for boron neutron capture therapy: synthesis and biodistribution. Basic Life Sci. 1989, 50:233-241.
    • (1989) Basic Life Sci. , vol.50 , pp. 233-241
    • Gabel, D.1
  • 137
    • 0023236184 scopus 로고
    • Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(-chloroethyl) selenides
    • Kang S.I., Spears C.P. Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(-chloroethyl) selenides. J. Med. Chem. 1987, 30:597-602.
    • (1987) J. Med. Chem. , vol.30 , pp. 597-602
    • Kang, S.I.1    Spears, C.P.2
  • 138
    • 0024239935 scopus 로고
    • A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen
    • Fischer H., Terlinden R., Löhr J.P., Römer A. A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen. Xenobiotica 1988, 18:1347-1359.
    • (1988) Xenobiotica , vol.18 , pp. 1347-1359
    • Fischer, H.1    Terlinden, R.2    Löhr, J.P.3    Römer, A.4
  • 139
    • 0023638093 scopus 로고
    • Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
    • Parnham M.J., Graf E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem. Pharmacol. 1987, 36:3095-3102.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3095-3102
    • Parnham, M.J.1    Graf, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.