Correlation between density of CD8+ T-cell infiltrate in microsatellite unstable colorectal cancers and frameshift mutations: A rationale for personalized immunotherapy

Cancer Research

Volumn 75, Issue 17, 2015, Pages 3446-3455

  Maby, Pauline ^a   Tougeron, David ^a,b,c   Hamieh, Mohamad ^a   Mlecnik, Bernhard ^d,e   Kora, Hafid ^a   Bindea, Gabriela ^d,e   Angell, Helen K ^d,e,f   Fredriksen, Tessa ^d,e   Elie, Nicolas ^g   Fauquembergue, Emilie ^a   Drouet, Aurélie ^a   Leprince, Jérôme ^a   Benichou, Jacques ^h   Mauillon, Jacques ^h,i   Pessot, Florence Le ^h   Sesboüé, Richard ^a   Tuech, Jean Jacques ^h   Sabourin, Jean Christophe ^a,h   Michel, Pierre ^h   Frébourg, Thierry ^a,h   Galon, Jérôme ^d,e   Latouche, Jean Baptiste ^a,h   more..

^a UNIVERSITY OF ROUEN   (France)

^b POITIERS UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE POITIERS   (France)

^d CENTRE DE RECHERCHE DES CORDELIERS   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f ASTRAZENECA   (United Kingdom)

^g CAEN UNIVERSITY HOSPITAL   (France)

^h ROUEN UNIVERSITY HOSPITAL   (France)

ⁱ LE HAVRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTING CELL; ARTICLE; ASTE1 GENE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL DENSITY; CELL INFILTRATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FIBROBLAST; FRAMESHIFT MUTATION; GENE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HNF1A GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MULTIPLEX POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TCF7L2 GENE; TISSUE MICROARRAY; TUMOR ASSOCIATED LEUKOCYTE; COLORECTAL TUMOR; FEMALE; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; MALE; PATHOLOGY; PERSONALIZED MEDICINE;

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; FRAMESHIFT MUTATION; HUMANS; IMMUNOTHERAPY; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICROSATELLITE INSTABILITY; PRECISION MEDICINE;

EID: 84942922149     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-3051     Document Type: Article

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