메뉴 건너뛰기




Volumn 110, Issue 51, 2013, Pages 20593-20598

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors

Author keywords

Cancer; Membrane protein; Oncogene

Indexed keywords

GUANOSINE TRIPHOSPHATE; INOSITOL TRISPHOSPHATE; INOSITOL TRISPHOSPHATE RECEPTOR; K RAS PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; PROTEIN KINASE C; SERINE; UNCLASSIFIED DRUG;

EID: 84890835716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306431110     Document Type: Article
Times cited : (72)

References (38)
  • 1
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL (1989) ras oncogenes in human cancer: A review. Cancer Res 49(17):4682-4689.
    • (1989) Cancer Res , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 2
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • Prior IA, Lewis PD, Mattos C (2012) A comprehensive survey of Ras mutations in cancer. Cancer Res 72(10):2457-2467.
    • (2012) Cancer Res , vol.72 , Issue.10 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 3
    • 33646777423 scopus 로고    scopus 로고
    • Thematic review series: Lipid posttranslational modifications. CAAX modification and membrane targeting of Ras
    • Wright LP, Philips MR (2006) Thematic review series: Lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J Lipid Res 47(5): 883-891.
    • (2006) J Lipid Res , vol.47 , Issue.5 , pp. 883-891
    • Wright, L.P.1    Philips, M.R.2
  • 4
    • 0033538559 scopus 로고    scopus 로고
    • Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi
    • Choy E, et al. (1999) Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi. Cell 98(1):69-80.
    • (1999) Cell , vol.98 , Issue.1 , pp. 69-80
    • Choy, E.1
  • 5
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
    • Hancock JF, Paterson H, Marshall CJ (1990) A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63(1):133-139.
    • (1990) Cell , vol.63 , Issue.1 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, C.J.3
  • 6
    • 32444441115 scopus 로고    scopus 로고
    • PKC regulates a farnesyl-Electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
    • Bivona TG, et al. (2006) PKC regulates a farnesyl-Electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell 21(4):481-493.
    • (2006) Mol Cell , vol.21 , Issue.4 , pp. 481-493
    • Bivona, T.G.1
  • 7
    • 0029058605 scopus 로고
    • The myristoyl-Electrostatic switch: A modulator of reversible protein-Membrane interactions
    • McLaughlin S, Aderem A (1995) The myristoyl-Electrostatic switch: A modulator of reversible protein-Membrane interactions. Trends Biochem Sci 20(7):272-276.
    • (1995) Trends Biochem Sci , vol.20 , Issue.7 , pp. 272-276
    • McLaughlin, S.1    Aderem, A.2
  • 8
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, et al. (2001) Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292(5517):727-730.
    • (2001) Science , vol.292 , Issue.5517 , pp. 727-730
    • Wei, M.C.1
  • 9
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-Ras
    • Shirasawa S, Furuse M, Yokoyama N, Sasazuki T (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-Ras. Science 260(5104):85-88.
    • (1993) Science , vol.260 , Issue.5104 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 10
    • 0036091925 scopus 로고    scopus 로고
    • Ras signalling on the endoplasmic reticulum and the Golgi
    • Chiu VK, et al. (2002) Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 4(5):343-350.
    • (2002) Nat Cell Biol , vol.4 , Issue.5 , pp. 343-350
    • Chiu, V.K.1
  • 11
    • 0035344460 scopus 로고    scopus 로고
    • Versatility of the mitochondrial protein import machinery
    • Pfanner N, Geissler A (2001) Versatility of the mitochondrial protein import machinery. Nat Rev Mol Cell Biol 2(5):339-349.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.5 , pp. 339-349
    • Pfanner, N.1    Geissler, A.2
  • 13
    • 27144487808 scopus 로고    scopus 로고
    • The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R
    • White C, et al. (2005) The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol 7(10):1021-1028.
    • (2005) Nat Cell Biol , vol.7 , Issue.10 , pp. 1021-1028
    • White, C.1
  • 14
    • 77955041880 scopus 로고    scopus 로고
    • Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria
    • Cárdenas C, et al. (2010) Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142(2):270-283.
    • (2010) Cell , vol.142 , Issue.2 , pp. 270-283
    • Cárdenas, C.1
  • 15
    • 34248584090 scopus 로고    scopus 로고
    • Inositol trisphosphate receptor Ca2+ release channels
    • Foskett JK, White C, Cheung KH, Mak DO (2007) Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 87(2):593-658.
    • (2007) Physiol Rev , vol.87 , Issue.2 , pp. 593-658
    • Foskett, J.K.1    White, C.2    Cheung, K.H.3    Mak, D.O.4
  • 16
    • 34547617018 scopus 로고    scopus 로고
    • Apoptosis regulation by Bcl-X(L) modulation of mammalian inositol 1,4,5-Trisphosphate receptor channel isoform gating
    • Li C, et al. (2007) Apoptosis regulation by Bcl-X(L) modulation of mammalian inositol 1,4,5-Trisphosphate receptor channel isoform gating. Proc Natl Acad Sci USA 104(30): 12565-12570.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.30 , pp. 12565-12570
    • Li, C.1
  • 17
    • 0035853040 scopus 로고    scopus 로고
    • Circularly permuted green fluorescent proteins engineered to sense Ca2+
    • Nagai T, Sawano A, Park ES, Miyawaki A (2001) Circularly permuted green fluorescent proteins engineered to sense Ca2+. Proc Natl Acad Sci USA 98(6):3197-3202.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.6 , pp. 3197-3202
    • Nagai, T.1    Sawano, A.2    Park, E.S.3    Miyawaki, A.4
  • 18
    • 67650558672 scopus 로고    scopus 로고
    • A simple analogue of tumor-Promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-Like activity
    • Nakagawa Y, et al. (2009) A simple analogue of tumor-Promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-Like activity. J Am Chem Soc 131(22):7573-7579.
    • (2009) J Am Chem Soc , vol.131 , Issue.22 , pp. 7573-7579
    • Nakagawa, Y.1
  • 19
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, et al. (2004) The role of autophagy during the early neonatal starvation period. Nature 432(7020):1032-1036.
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1032-1036
    • Kuma, A.1
  • 20
    • 0034682560 scopus 로고    scopus 로고
    • Mutational and biochemical analysis of plasma membrane targeting mediated by the farnesylated, polybasic carboxy terminus of K-Ras4B
    • Roy MO, Leventis R, Silvius JR (2000) Mutational and biochemical analysis of plasma membrane targeting mediated by the farnesylated, polybasic carboxy terminus of K-Ras4B. Biochemistry 39(28):8298-8307.
    • (2000) Biochemistry , vol.39 , Issue.28 , pp. 8298-8307
    • Roy, M.O.1    Leventis, R.2    Silvius, J.R.3
  • 21
    • 38149094836 scopus 로고    scopus 로고
    • Membrane phosphatidylserine regulates surface charge and protein localization
    • Yeung T, et al. (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science 319(5860):210-213.
    • (2008) Science , vol.319 , Issue.5860 , pp. 210-213
    • Yeung, T.1
  • 22
    • 80052514798 scopus 로고    scopus 로고
    • RALA and RALBP1 regulate mitochondrial fission at mitosis
    • Kashatus DF, et al. (2011) RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol 13(9):1108-1115.
    • (2011) Nat Cell Biol , vol.13 , Issue.9 , pp. 1108-1115
    • Kashatus, D.F.1
  • 23
    • 70350695998 scopus 로고    scopus 로고
    • Regulation of Rnd3 localization and function by protein kinase C alpha-Mediated phosphorylation
    • Madigan JP, et al. (2009) Regulation of Rnd3 localization and function by protein kinase C alpha-Mediated phosphorylation. Biochem J 424(1):153-161.
    • (2009) Biochem J , vol.424 , Issue.1 , pp. 153-161
    • Madigan, J.P.1
  • 24
    • 0036732940 scopus 로고    scopus 로고
    • Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi
    • Michaelson D, Ahearn I, Bergo M, Young S, Philips M (2002) Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Mol Biol Cell 13(9):3294-3302.
    • (2002) Mol Biol Cell , vol.13 , Issue.9 , pp. 3294-3302
    • Michaelson, D.1    Ahearn, I.2    Bergo, M.3    Young, S.4    Philips, M.5
  • 25
    • 33746503286 scopus 로고    scopus 로고
    • Receptor activation alters inner surface potential during phagocytosis
    • Yeung T, et al. (2006) Receptor activation alters inner surface potential during phagocytosis. Science 313(5785):347-351.
    • (2006) Science , vol.313 , Issue.5785 , pp. 347-351
    • Yeung, T.1
  • 26
    • 7944238453 scopus 로고    scopus 로고
    • Cell signalling: IP3 receptors channel calcium into cell death
    • Hanson CJ, Bootman MD, Roderick HL (2004) Cell signalling: IP3 receptors channel calcium into cell death. Curr Biol 14(21):R933-R935.
    • (2004) Curr Biol , vol.14 , Issue.21 , pp. 933-935
    • Hanson, C.J.1    Bootman, M.D.2    Roderick, H.L.3
  • 27
    • 0346880483 scopus 로고    scopus 로고
    • Calcium and apoptosis: Facts and hypotheses
    • Rizzuto R, et al. (2003) Calcium and apoptosis: Facts and hypotheses. Oncogene 22(53):8619-8627.
    • (2003) Oncogene , vol.22 , Issue.53 , pp. 8619-8627
    • Rizzuto, R.1
  • 28
    • 77952700862 scopus 로고    scopus 로고
    • Apoptotic cell death nixed by an er-Mitochondrial necrotic pathway
    • Kitsis RN, Molkentin JD (2010) Apoptotic cell death Nixed by an ER-Mitochondrial necrotic pathway. Proc Natl Acad Sci USA 107(20):9031-9032.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.20 , pp. 9031-9032
    • Kitsis, R.N.1    Molkentin, J.D.2
  • 29
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong WX, Thompson CB (2006) Necrotic death as a cell fate. Genes Dev 20(1):1-15.
    • (2006) Genes Dev , vol.20 , Issue.1 , pp. 1-15
    • Zong, W.X.1    Thompson, C.B.2
  • 30
    • 3342984659 scopus 로고    scopus 로고
    • Bcl-2 functionally interacts with inositol 1,4,5-Trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-Trisphosphate
    • Chen R, et al. (2004) Bcl-2 functionally interacts with inositol 1,4,5-Trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-Trisphosphate. J Cell Biol 166(2):193-203.
    • (2004) J Cell Biol , vol.166 , Issue.2 , pp. 193-203
    • Chen, R.1
  • 31
    • 70149105706 scopus 로고    scopus 로고
    • The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
    • Rong YP, et al. (2009) The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci USA 106(34):14397-14402.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.34 , pp. 14397-14402
    • Rong, Y.P.1
  • 32
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-Like systems
    • Ohsumi Y (2001) Molecular dissection of autophagy: Two ubiquitin-Like systems. Nat Rev Mol Cell Biol 2(3):211-216.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.3 , pp. 211-216
    • Ohsumi, Y.1
  • 33
    • 79952196841 scopus 로고    scopus 로고
    • Apoptosis and autophagy: Decoding calcium signals that mediate life or death
    • Harr MW, Distelhorst CW (2010) Apoptosis and autophagy: Decoding calcium signals that mediate life or death. Cold Spring Harb Perspect Biol 2(10):a005579.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.10
    • Harr, M.W.1    Distelhorst, C.W.2
  • 34
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death
    • Baehrecke EH (2005) Autophagy: Dual roles in life and death Nat Rev Mol Cell Biol 6(6):505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 35
    • 27144503701 scopus 로고    scopus 로고
    • Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-Mediated autophagic cell death
    • Høyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jäättelä M (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-Mediated autophagic cell death. Cell Death Differ 12(10):1297-1309.
    • (2005) Cell Death Differ , vol.12 , Issue.10 , pp. 1297-1309
    • Høyer-Hansen, M.1    Bastholm, L.2    Mathiasen, I.S.3    Elling, F.4    Jäättelä, M.5
  • 36
    • 67949088074 scopus 로고    scopus 로고
    • Ras/MAPK signaling from endomembranes
    • Fehrenbacher N, Bar-Sagi D, Philips M (2009) Ras/MAPK signaling from endomembranes. Mol Oncol 3(4):297-307.
    • (2009) Mol Oncol , vol.3 , Issue.4 , pp. 297-307
    • Fehrenbacher, N.1    Bar-Sagi, D.2    Philips, M.3
  • 37
    • 1642553461 scopus 로고    scopus 로고
    • The dark side of Ras: Regulation of apoptosis
    • Cox AD, Der CJ (2003) The dark side of Ras: Regulation of apoptosis. Oncogene 22(56): 8999-9006.
    • (2003) Oncogene , vol.22 , Issue.56 , pp. 8999-9006
    • Cox, A.D.1    Der, C.J.2
  • 38
    • 0037177350 scopus 로고    scopus 로고
    • Confocal imaging of subcellular Ca2+ concentrations using a dual-Excitation ratiometric indicator based on green fluorescent protein
    • Shimozono S, et al. (2002) Confocal imaging of subcellular Ca2+ concentrations using a dual-Excitation ratiometric indicator based on green fluorescent protein. Sci STKE 2002(125):pl4.
    • (2002) Sci STKE , vol.2002
    • Shimozono, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.