Metastatic competence can emerge with selection of preexisting oncogenic alleles without a need of new mutations

Cancer Research

Volumn 75, Issue 18, 2015, Pages 3713-3719

  Jacob, Leni S ^a   Vanharanta, Sakari ^a,b   Obenauf, Anna C ^a   Pirun, Mono ^a   Viale, Agnes ^a   Socci, Nicholas D ^a   Massagué, Joan ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; VON HIPPEL LINDAU PROTEIN; BRAF PROTEIN, HUMAN; DNA; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASE PAIRING; BIOLUMINESCENCE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL POPULATION; CONTROLLED STUDY; COPY NUMBER VARIATION; EXOME; EXON; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC SELECTION; GENETIC VARIABILITY; HIGH THROUGHPUT SEQUENCING; KIDNEY ADENOMA; METASTASIS POTENTIAL; MISSENSE MUTATION; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE K RAS; PHENOTYPE; PHYLOGENY; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; ALLELE; ANIMAL; ANTIBODY SPECIFICITY; BREAST TUMOR; CANCER TRANSPLANTATION; CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; DNA SEQUENCE; GENE DOSAGE; GENETICS; HUMAN; KIDNEY TUMOR; LUNG TUMOR; METASTASIS; NUDE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; SECONDARY; TUMOR CELL LINE; XENOGRAFT;

ALLELES; ANIMALS; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; COMPARATIVE GENOMIC HYBRIDIZATION; DNA, NEOPLASM; EXOME; FEMALE; GENE DOSAGE; HETEROGRAFTS; HUMANS; KIDNEY NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; ONCOGENES; ORGAN SPECIFICITY; PHENOTYPE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84942872720     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0562     Document Type: Article

References (33)

1. Nguyen DX, Bos PD, Massagué J.Metastasis: from dissemination to organspecific colonization. Nat Rev Cancer 2009;9:274-84.
2. Bos PD, Nguyen DX, Massagué J. Modeling metastasis in the mouse. Curr Opin Pharmacol 2010;10:571-7.
3. Vanharanta S, Massagué J.Origins of metastatic traits. Cancer Cell 2013;24: 410-21.
4. Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977;197:893-5.
5. Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-8.
6. Jones S, Chen W-D, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 2008;105:4283-8.
7. Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings La, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 2010;467:1109-13.
8. Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 2010;464:999-1005.
9. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010;467:1114-7.
10. Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed bymultiregion sequencing. New Engl J Med 2012;366:883-92.
11. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz La, Kinzler KW. Cancer genome landscapes. Science 2013;339:1546-58.
12. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009;459:1005-9.
13. Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
14. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
15. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 2009;138:51-62.
16. Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med 2013;19:50-6.
17. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007;446: 153-8.
18. Landau Da, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013;152:714-26.
19. Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 2013;155:948-62.
20. Won HH, Scott SN, Brannon AR, Shah RH, Berger MF. Detecting somatic genetic alterations in tumor specimens by exon capture and massively parallel sequencing. J Vis Exp 2013:e50710.
21. Satya-Prakash KL, Pathak S, Hsu TC, Olive M, Cailleau R. Cytogenetic analysis on eighthuman breast tumor cell lines: high frequencies of 1q, 11q and HeLa-like marker chromosomes. Cancer Genet and Cytogenet 1981;3: 61-73.
22. Young A, Lou D, McCormick F. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov 2012;3:112-23.
23. Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet 2001;29:25-33.
24. Staffas A, Karlsson C, Persson M, Palmqvist L, Bergo MO. Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice. Leukemia 2015;29: 1032-40.
25. Vartanian S, Bentley C, Brauer MJ, Li L, Shirasawa S, Sasazuki T, et al. Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem 2013;288:2403-13.
26. Chen Q, Zhang XH, Massagué J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.Cancer Cell 2011;20:538-49.
27. Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med 2011;17:867-74.
28. Zhang XHF, Jin X, Malladi S, Zou Y,WenYH, Brogi E, et al. Selection of bone metastasis seeds bymesenchymal signals in the primary tumor stroma.Cell 2013;154:1060-73.
29. Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011;19:192-205.
30. Yaeger R, Cowell E, Chou JF, Gewirtz AN, Borsu L, Vakiani E, et al. RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer. Cancer 2015;121:1195-203.
31. Yaeger R, Cercek A, Chou JF, Sylvester BE, Kemeny NE, Hechtman JF, et al. BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer. Cancer 2014;120:2316-24.
32. Tran B, Kopetz S, Tie J, Gibbs P, Jiang ZQ, Lieu CH, et al. Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer 2011;117:4623-32.
33. Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S, et al. Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A 2010;107:18545-50.