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Volumn 10, Issue 8, 2015, Pages

Biochemical and immunological characterization of truncated fragments of the receptor-binding domains of C. difficile Toxin A

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL TOXIN; BACTERIAL TOXIN A; HEMAGGLUTININ; LECTIN; TCDA TOXIN; TCDB TOXIN; UNCLASSIFIED DRUG; BACTERIAL VACCINE; ENTEROTOXIN; PEPTIDE FRAGMENT; PROTEIN BINDING; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

EID: 84942869305     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135045     Document Type: Article
Times cited : (7)

References (55)
  • 1
    • 0027228486 scopus 로고
    • Clostridium difficile: Clinical disease and diagnosis
    • PMID: 8358706
    • Knoop FC, Owens M, Crocker IC (1993) Clostridium difficile: clinical disease and diagnosis. Clin Microbiol Rev 6: 251-265. PMID: 8358706
    • (1993) Clin Microbiol Rev , vol.6 , pp. 251-265
    • Knoop, F.C.1    Owens, M.2    Crocker, I.C.3
  • 2
    • 0023748735 scopus 로고
    • Clostridium difficile: Its disease and toxins
    • PMID: 3144429
    • Lyerly DM, Krivan HC, Wilkins TD (1988) Clostridium difficile: its disease and toxins. Clin Microbiol Rev 1: 1-18. PMID: 3144429
    • (1988) Clin Microbiol Rev , vol.1 , pp. 1-18
    • Lyerly, D.M.1    Krivan, H.C.2    Wilkins, T.D.3
  • 3
    • 55249105923 scopus 로고    scopus 로고
    • Clostridium difficile - More difficult than ever
    • PMID: 18971494
    • Kelly CP, LaMont JT (2008) Clostridium difficile - more difficult than ever. N Engl J Med 359: 1932-1940. doi: 10.1056/NEJMra0707500 PMID: 18971494
    • (2008) N Engl J Med , vol.359 , pp. 1932-1940
    • Kelly, C.P.1    LaMont, J.T.2
  • 5
    • 84871990888 scopus 로고    scopus 로고
    • Emergence and global spread of epidemic healthcare-associated Clostridium difficile
    • PMID: 23222960
    • He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, et al. (2013) Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet 45: 109-113 doi: 10.1038/ng.2478 PMID: 23222960
    • (2013) Nat Genet , vol.45 , pp. 109-113
    • He, M.1    Miyajima, F.2    Roberts, P.3    Ellison, L.4    Pickard, D.J.5    Martin, M.J.6
  • 6
    • 79851470700 scopus 로고    scopus 로고
    • The enterotoxicity of Clostridium difficile toxins
    • PMID: 22069662
    • Sun X, Savidge T, Feng H (2010) The enterotoxicity of Clostridium difficile toxins. Toxins 2: 1848-1880. doi: 10.3390/toxins2071848 PMID: 22069662
    • (2010) Toxins , vol.2 , pp. 1848-1880
    • Sun, X.1    Savidge, T.2    Feng, H.3
  • 8
    • 79957761288 scopus 로고    scopus 로고
    • Super toxins from a super bug: Structure and function of Clostridium difficile toxins
    • PMID: 21615333
    • Davies AH, Roberts AK, Shone CC, Acharya KR (2011) Super toxins from a super bug: structure and function of Clostridium difficile toxins. Biochem J 436: 517-526. doi: 10.1042/BJ20110106 PMID: 21615333
    • (2011) Biochem J , vol.436 , pp. 517-526
    • Davies, A.H.1    Roberts, A.K.2    Shone, C.C.3    Acharya, K.R.4
  • 9
    • 77955782233 scopus 로고    scopus 로고
    • Strcutural organization of the functional domains of C. Difficile toxins A and B
    • PMID: 20624955
    • Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB (2010) Strcutural organization of the functional domains of C. difficile toxins A and B. Proc Natl Acad Sci USA 107: 13467-72. doi: 10.1073/pnas.1002199107 PMID: 20624955
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13467-13472
    • Pruitt, R.N.1    Chambers, M.G.2    Ng, K.K.3    Ohi, M.D.4    Lacy, D.B.5
  • 10
    • 77649270019 scopus 로고    scopus 로고
    • Four distinct structural domains in C. Difficile toxin B visualized using SAXA
    • PMID: 20070948
    • Albesa-Jove D, Bertrand T, Carpenter EP, Swain GV, Lim J, Zhang J, et al. (2010) Four distinct structural domains in C. difficile toxin B visualized using SAXA. J Mol Biol 396: 1260-70. doi: 10.1016/j.jmb.2010.01.012 PMID: 20070948
    • (2010) J Mol Biol , vol.396 , pp. 1260-1270
    • Albesa-Jove, D.1    Bertrand, T.2    Carpenter, E.P.3    Swain, G.V.4    Lim, J.5    Zhang, J.6
  • 11
    • 84904467481 scopus 로고    scopus 로고
    • Antibodies for treatment of Clostridium difficile infection
    • PMID: 24789799
    • Humphreys DP, Wilcox MH (2014) Antibodies for treatment of Clostridium difficile infection. Clin Vaccine Immunol 21: 913-923. doi: 10.1128/CVI.00116-14 PMID: 24789799
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 913-923
    • Humphreys, D.P.1    Wilcox, M.H.2
  • 12
    • 84865966570 scopus 로고    scopus 로고
    • IgG antibody response to toxins A and B in patients with Clostridium difficile infection
    • PMID: 22787196
    • Wult M, Noren T, Ljungh A, Akerlund T (2012) IgG antibody response to toxins A and B in patients with Clostridium difficile infection. Clin Vaccine Immunol 19: 1552-1554. doi: 10.1128/CVI.00210-12 PMID: 22787196
    • (2012) Clin Vaccine Immunol , vol.19 , pp. 1552-1554
    • Wult, M.1    Noren, T.2    Ljungh, A.3    Akerlund, T.4
  • 13
    • 0021836686 scopus 로고
    • Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea
    • Aronsson B, Granstrom M, Molby R, Nord CE (1985) Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea. Infection 3: 97-101.
    • (1985) Infection , vol.3 , pp. 97-101
    • Aronsson, B.1    Granstrom, M.2    Molby, R.3    Nord, C.E.4
  • 14
    • 0035915688 scopus 로고    scopus 로고
    • Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea
    • PMID: 11213096
    • Kyne L, Warny M, Qamar A, Kelly CP (2001) Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 357: 189-193. PMID: 11213096
    • (2001) Lancet , vol.357 , pp. 189-193
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 15
    • 84883779131 scopus 로고    scopus 로고
    • Circulating antibody and memory B-cell responses to C. Difficile toxins A and B in patients with C. Difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis
    • PMID: 24058568
    • Monaghan T, Robins A, Knox A, Sewell HF, Mahida YR (2013) Circulating antibody and memory B-cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis. PLoSOne 8: e74452. doi: 10.1371/journal.pone.0074452 PMID: 24058568
    • (2013) PLoSOne , vol.8
    • Monaghan, T.1    Robins, A.2    Knox, A.3    Sewell, H.F.4    Mahida, Y.R.5
  • 16
    • 0020650849 scopus 로고
    • Active and passive immunization to protect against antibiotic associated caecitis in hamsters
    • PMID: 6873474
    • Fernie DS, Thomson RO, Batty I, Walker PD (1983) Active and passive immunization to protect against antibiotic associated caecitis in hamsters. Dev Biol Stand 53: 325-332. PMID: 6873474
    • (1983) Dev Biol Stand , vol.53 , pp. 325-332
    • Fernie, D.S.1    Thomson, R.O.2    Batty, I.3    Walker, P.D.4
  • 17
    • 0032962874 scopus 로고    scopus 로고
    • Serum antitoxin antibodies mediate systemic and mucosal protection from Clostridium difficile disease in hamsters
    • PMID: 9916055
    • Giannasca PJ, Zhang Z-x, Lei W-d, Boden JA, Giel MA, Monath TP, et al. (1999) Serum antitoxin antibodies mediate systemic and mucosal protection from Clostridium difficile disease in hamsters. Infect Immun 67: 527-538. PMID: 9916055
    • (1999) Infect Immun , vol.67 , pp. 527-538
    • Giannasca, P.J.1    Zhang, Z.-X.2    Lei, W.-D.3    Boden, J.A.4    Giel, M.A.5    Monath, T.P.6
  • 18
    • 44749091706 scopus 로고    scopus 로고
    • Open-label, doseescalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A
    • PMID: 18502001
    • Taylor CP, Tummala S, Molrine D, Davidson L, Farrell RJ, Lembo A, et al. (2008) Open-label, doseescalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A. Vaccine 26: 3404-3409. doi: 10.1016/j.vaccine.2008.04.042 PMID: 18502001
    • (2008) Vaccine , vol.26 , pp. 3404-3409
    • Taylor, C.P.1    Tummala, S.2    Molrine, D.3    Davidson, L.4    Farrell, R.J.5    Lembo, A.6
  • 19
    • 74849098405 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against Clostridium difficile toxin
    • PMID: 20089970
    • Lowy IMD, Molrine D, Leav BA, Blair BM, Baxter R, Gerding DN, et al. (2010) Treatment with monoclonal antibodies against Clostridium difficile toxin. N Engl J Med 362: 197-205. doi: 10.1056/NEJMoa0907635 PMID: 20089970
    • (2010) N Engl J Med , vol.362 , pp. 197-205
    • Lowy, I.M.D.1    Molrine, D.2    Leav, B.A.3    Blair, B.M.4    Baxter, R.5    Gerding, D.N.6
  • 20
    • 0028818809 scopus 로고
    • Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters
    • PMID: 7591115
    • Torres JF, Lyerly DM, Hill JE, Monath TP (1995) Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters. Infect Immun 63: 4619-4627. PMID: 7591115
    • (1995) Infect Immun , vol.63 , pp. 4619-4627
    • Torres, J.F.1    Lyerly, D.M.2    Hill, J.E.3    Monath, T.P.4
  • 21
    • 0031948840 scopus 로고    scopus 로고
    • Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. Difficile-associated disease in a hamster model of infection
    • PMID: 9573084
    • Kink JA, Williams JA (1998) Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection. Infect Immun 66: 2018-2025. PMID: 9573084
    • (1998) Infect Immun , vol.66 , pp. 2018-2025
    • Kink, J.A.1    Williams, J.A.2
  • 22
    • 0031446325 scopus 로고    scopus 로고
    • The C-terminal ligand-binding domain of Clostridium difficile toxin A (TcdA) abrogates TcdA-specific binding to cells and prevents mouse lethality
    • PMID: 9345763
    • Sauerborn M, Leukel P, von Eichel-Streiber C (1997) The C-terminal ligand-binding domain of Clostridium difficile toxin A (TcdA) abrogates TcdA-specific binding to cells and prevents mouse lethality. FEMS Microbiol Lett 155: 45-54. PMID: 9345763
    • (1997) FEMS Microbiol Lett , vol.155 , pp. 45-54
    • Sauerborn, M.1    Leukel, P.2    Von Eichel-Streiber, C.3
  • 23
    • 84856570281 scopus 로고    scopus 로고
    • Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice
    • PMID: 22200503
    • Seregin SS, Aldhamen YA, Rastall DP, Godbehere S, Amalfitano A (2012) Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice. Vaccine 30: 1492-1501. doi: 10.1016/j.vaccine.2011.12.064 PMID: 22200503
    • (2012) Vaccine , vol.30 , pp. 1492-1501
    • Seregin, S.S.1    Aldhamen, Y.A.2    Rastall, D.P.3    Godbehere, S.4    Amalfitano, A.5
  • 24
    • 84861661669 scopus 로고    scopus 로고
    • A novel fusion protein containing the receptor binding domains of C. Difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models
    • PMID: 22537987
    • Tian JH, Fuhrmann SR, Kluepfel-Stahl S, Carman RJ, Ellingsworth L, Flyer DC (2012). A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models. Vaccine 30: 4249-4258. doi: 10.1016/j.vaccine.2012.04.045 PMID: 22537987
    • (2012) Vaccine , vol.30 , pp. 4249-4258
    • Tian, J.H.1    Fuhrmann, S.R.2    Kluepfel-Stahl, S.3    Carman, R.J.4    Ellingsworth, L.5    Flyer, D.C.6
  • 25
    • 0030987748 scopus 로고    scopus 로고
    • Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain
    • PMID: 9199470
    • Ryan ET, Butterton JR, Smith RN, Carroll PA, Crean TI, Calderwood SB (1997) Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain. Infect Immun 65: 2941-2949. PMID: 9199470
    • (1997) Infect Immun , vol.65 , pp. 2941-2949
    • Ryan, E.T.1    Butterton, J.R.2    Smith, R.N.3    Carroll, P.A.4    Crean, T.I.5    Calderwood, S.B.6
  • 26
    • 0032900382 scopus 로고    scopus 로고
    • Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A
    • PMID: 10225867
    • Ward SJ, Douce G, Figueiredo D, Dougan G, Wren BW (1999) Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A. Infect Immun 67: 2145-2152. PMID: 10225867
    • (1999) Infect Immun , vol.67 , pp. 2145-2152
    • Ward, S.J.1    Douce, G.2    Figueiredo, D.3    Dougan, G.4    Wren, B.W.5
  • 27
    • 67349187243 scopus 로고    scopus 로고
    • A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A
    • PMID: 19464540
    • Gardiner DF, Rosenberg T, Zaharatos J, Franco D, Ho DD (2009) A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A. Vaccine 27: 3598-3604. doi: 10.1016/j.vaccine.2009.03.058 PMID: 19464540
    • (2009) Vaccine , vol.27 , pp. 3598-3604
    • Gardiner, D.F.1    Rosenberg, T.2    Zaharatos, J.3    Franco, D.4    Ho, D.D.5
  • 28
    • 79959449569 scopus 로고    scopus 로고
    • Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B
    • PMID: 21482682
    • Permpoonpattana P, Hong HA, Phetcharaburanin J, Huang JM, Cook J, Fairweather NF, et al. (2011) Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B. Infect Immun 79: 2295-2302. doi: 10.1128/IAI.00130-11 PMID: 21482682
    • (2011) Infect Immun , vol.79 , pp. 2295-2302
    • Permpoonpattana, P.1    Hong, H.A.2    Phetcharaburanin, J.3    Huang, J.M.4    Cook, J.5    Fairweather, N.F.6
  • 29
    • 84880837675 scopus 로고    scopus 로고
    • Protective efficacy induced by recombinant Clostridium difficile toxin fragments
    • PMID: 23716610
    • Leuzzi R, Spencer J, Buckley A, Brettoni C, Martinelli M, Tulli L, et al. (2013) Protective efficacy induced by recombinant Clostridium difficile toxin fragments. Infect Immun 81: 2851-2860. doi: 10.1128/IAI.01341-12 PMID: 23716610
    • (2013) Infect Immun , vol.81 , pp. 2851-2860
    • Leuzzi, R.1    Spencer, J.2    Buckley, A.3    Brettoni, C.4    Martinelli, M.5    Tulli, L.6
  • 31
    • 29444439842 scopus 로고    scopus 로고
    • Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A
    • PMID: 16344467
    • Ho JG, Greco A, Rupnik M, Ng KK (2005) Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci USA 102: 18373-18378. PMID: 16344467
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18373-18378
    • Ho, J.G.1    Greco, A.2    Rupnik, M.3    Ng, K.K.4
  • 33
    • 84878486491 scopus 로고    scopus 로고
    • Toward a structural understanding of Clostridium difficile toxins A and B
    • PMID: 22919620
    • Pruitt RN, Lacy DB (2012) Toward a structural understanding of Clostridium difficile toxins A and B. Front Cell Infect Microbiol 2: 28. doi: 10.3389/fcimb.2012.00028 PMID: 22919620
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 28
    • Pruitt, R.N.1    Lacy, D.B.2
  • 34
    • 0022525082 scopus 로고
    • Cell surface binding site for Clostridium difficile enterotoxin: Evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta1-4GlcNAc
    • PMID: 3744552
    • Krivan HC, Clark GF, Smith DF, Wilkins TD (1986) Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta1-4GlcNAc. Infect Immun 53: 573-581. PMID: 3744552
    • (1986) Infect Immun , vol.53 , pp. 573-581
    • Krivan, H.C.1    Clark, G.F.2    Smith, D.F.3    Wilkins, T.D.4
  • 35
    • 58149115498 scopus 로고    scopus 로고
    • Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and Tcd B, expressed by Clostridium difficile
    • PMID: 18509107
    • Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, et al. (2008). Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and Tcd B, expressed by Clostridium difficile. Glycobiology 18: 698-706. doi: 10.1093/glycob/cwn048 PMID: 18509107
    • (2008) Glycobiology , vol.18 , pp. 698-706
    • Dingle, T.1    Wee, S.2    Mulvey, G.L.3    Greco, A.4    Kitova, E.N.5    Sun, J.6
  • 36
    • 84938812752 scopus 로고    scopus 로고
    • Biochemical and immunological characterizations of the receptor binding domain of C. Difficile toxin B
    • Huang JH, Wu CW, Lien SP, Hsiao KN, Leng CH, Lin YH, et al. (2015) Biochemical and immunological characterizations of the receptor binding domain of C. difficile toxin B. J Vaccines Vaccin 6: 276-284.
    • (2015) J Vaccines Vaccin , vol.6 , pp. 276-284
    • Huang, J.H.1    Wu, C.W.2    Lien, S.P.3    Hsiao, K.N.4    Leng, C.H.5    Lin, Y.H.6
  • 37
    • 0025785879 scopus 로고
    • Antigenic cross-reactivity and functional inhibition by antibodies to Clostridium difficile toxin A, Streptococcus mutans glucan-binding protein, and a synthetic peptide
    • PMID: 1715320
    • Wren BW, Russell RR, Tabaqchali S (1991) Antigenic cross-reactivity and functional inhibition by antibodies to Clostridium difficile toxin A, Streptococcus mutans glucan-binding protein, and a synthetic peptide. Infect Immun 59: 3151-3155. PMID: 1715320
    • (1991) Infect Immun , vol.59 , pp. 3151-3155
    • Wren, B.W.1    Russell, R.R.2    Tabaqchali, S.3
  • 38
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • PMID: 10037236
    • Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223: 77-92. PMID: 10037236
    • (1999) J Immunol Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rossner, S.4    Koch, F.5    Romani, N.6
  • 39
    • 0041670743 scopus 로고    scopus 로고
    • Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system
    • Burger S, Tatge H, Hofmann F, Genth H, Just I, Gerhard R (2003) Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system. Biochem Bioph Res Co 307: 584-588.
    • (2003) Biochem Bioph Res Co , vol.307 , pp. 584-588
    • Burger, S.1    Tatge, H.2    Hofmann, F.3    Genth, H.4    Just, I.5    Gerhard, R.6
  • 40
    • 77956461530 scopus 로고    scopus 로고
    • Clostridial glucosylating toxins enter cells viaclathrin-mediated endocytosis
    • PMID: 20498856
    • Papatheodorou P, Zamboglou C, Genisyuerek S, Guttenberg G, Aktories K (2010) Clostridial glucosylating toxins enter cells viaclathrin-mediated endocytosis. PLOS ONE 5: e10673. doi: 10.1371/journal.pone.0010673 PMID: 20498856
    • (2010) PLOS ONE , vol.5
    • Papatheodorou, P.1    Zamboglou, C.2    Genisyuerek, S.3    Guttenberg, G.4    Aktories, K.5
  • 41
    • 79952803707 scopus 로고    scopus 로고
    • The repetitive oligopeptide sequences modulate cytopathic Potency but are not crucial for cellular uptake of Clostridium difficile toxin A
    • PMID: 21445253
    • Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R (2011) The repetitive oligopeptide sequences modulate cytopathic Potency but are not crucial for cellular uptake of Clostridium difficile toxin A. PLoS ONE 6: e17623. doi: 10.1371/journal.pone.0017623 PMID: 21445253
    • (2011) PLoS ONE , vol.6
    • Olling, A.1    Goy, S.2    Hoffmann, F.3    Tatge, H.4    Just, I.5    Gerhard, R.6
  • 42
    • 58549112757 scopus 로고    scopus 로고
    • Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappaB signaling pathway
    • Lee JY, Kim H, Cha MY, Park HG, Kim YJ, Kim IY, et al. (2009) Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappaB signaling pathway. J Mol Med (Berl) 87: 169-180.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 169-180
    • Lee, J.Y.1    Kim, H.2    Cha, M.Y.3    Park, H.G.4    Kim, Y.J.5    Kim, I.Y.6
  • 43
    • 2142761566 scopus 로고    scopus 로고
    • Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant
    • PMID: 15102793
    • Castagliuolo I, Sardina M, Brun P, DeRos C, Mastroto C, Lovato L, et al. (2004) Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant. Infect Immun 72: 2827-2836. PMID: 15102793
    • (2004) Infect Immun , vol.72 , pp. 2827-2836
    • Castagliuolo, I.1    Sardina, M.2    Brun, P.3    DeRos, C.4    Mastroto, C.5    Lovato, L.6
  • 44
    • 45249119262 scopus 로고    scopus 로고
    • Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen
    • PMID: 18480329
    • Brun P, Scarpa M, Grillo A, Palu G, Mengoli C, Zecconi A, et al. (2008) Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen. J Med Microbiol 57: 725-31 doi: 10.1099/jmm.0.47736-0 PMID: 18480329
    • (2008) J Med Microbiol , vol.57 , pp. 725-731
    • Brun, P.1    Scarpa, M.2    Grillo, A.3    Palu, G.4    Mengoli, C.5    Zecconi, A.6
  • 45
    • 79953206941 scopus 로고    scopus 로고
    • Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain
    • PMID: 21216961
    • Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, et al. (2011) Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain. J Biol Chem 286: 8961-8976. doi: 10.1074/jbc.M110.198754 PMID: 21216961
    • (2011) J Biol Chem , vol.286 , pp. 8961-8976
    • Hussack, G.1    Arbabi-Ghahroudi, M.2    Van Faassen, H.3    Songer, J.G.4    Ng, K.K.5    MacKenzie, R.6
  • 46
    • 84857763473 scopus 로고    scopus 로고
    • Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations
    • PMID: 22396735
    • Stabler RA, Dawson LF, Valiente E, Cairns MD, Martin MJ, Donahue EH, et al. (2012) Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations. PLOS ONE 7: e31559. doi: 10.1371/journal.pone.0031559 PMID: 22396735
    • (2012) PLOS ONE , vol.7
    • Stabler, R.A.1    Dawson, L.F.2    Valiente, E.3    Cairns, M.D.4    Martin, M.J.5    Donahue, E.H.6
  • 47
    • 0032829877 scopus 로고    scopus 로고
    • Local and systemic neutralizing antibody responses induced by intranasal immunization with the nontoxic binding domain of toxin A from Clostridium difficile
    • PMID: 10496886
    • Ward SJ, Douce G, Dougan G, Wren BW (1999) Local and systemic neutralizing antibody responses induced by intranasal immunization with the nontoxic binding domain of toxin A from Clostridium difficile. Infect Immun 67: 5124-5132. PMID: 10496886
    • (1999) Infect Immun , vol.67 , pp. 5124-5132
    • Ward, S.J.1    Douce, G.2    Dougan, G.3    Wren, B.W.4
  • 48
    • 84881571463 scopus 로고    scopus 로고
    • Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain
    • PMID: 23558138
    • Gerhard R, Frenzel E, Goy S, Olling A (2013) Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain. J Med Microbiol 62: 1414-1422. doi: 10.1099/jmm.0.057828-0 PMID: 23558138
    • (2013) J Med Microbiol , vol.62 , pp. 1414-1422
    • Gerhard, R.1    Frenzel, E.2    Goy, S.3    Olling, A.4
  • 49
    • 40749124456 scopus 로고    scopus 로고
    • C-terminal repeats of Clostridium difficile toxin A induce production of chemokine and adhesion molecules in endothelial cells and promote migration of leukocytes
    • PMID: 18160482
    • Yeh CY, Lin CN, Chang CF, Lin CH, Lien HT, Chen JY, et al. (2008) C-terminal repeats of Clostridium difficile toxin A induce production of chemokine and adhesion molecules in endothelial cells and promote migration of leukocytes. Infect Immun 76: 1170-1178. PMID: 18160482
    • (2008) Infect Immun , vol.76 , pp. 1170-1178
    • Yeh, C.Y.1    Lin, C.N.2    Chang, C.F.3    Lin, C.H.4    Lien, H.T.5    Chen, J.Y.6
  • 50
    • 0026764540 scopus 로고
    • Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A
    • PMID: 1375199
    • Frey SM, Wilkins TD (1992) Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A. Infect Immun 60: 2488-2493. PMID: 1375199
    • (1992) Infect Immun , vol.60 , pp. 2488-2493
    • Frey, S.M.1    Wilkins, T.D.2
  • 52
    • 0035130389 scopus 로고    scopus 로고
    • The identification of plant lectins with mucosal adjuvant activity
    • PMID: 11168640
    • Lavelle EC, Grant G, Pusztai A, Pfuller U, O'Hagan DT (2001) The identification of plant lectins with mucosal adjuvant activity. Immunology 102: 77-86. PMID: 11168640
    • (2001) Immunology , vol.102 , pp. 77-86
    • Lavelle, E.C.1    Grant, G.2    Pusztai, A.3    Pfuller, U.4    O'Hagan, D.T.5
  • 53
    • 84857790535 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mediators of inflammation
    • PMID: 22237401
    • Shen A (2012) Clostridium difficile toxins: mediators of inflammation. J Innate Immun 4: 149-158. doi: 10.1159/000332946 PMID: 22237401
    • (2012) J Innate Immun , vol.4 , pp. 149-158
    • Shen, A.1
  • 54
    • 33745536745 scopus 로고    scopus 로고
    • NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
    • PMID: 16764699
    • Kim JM, Lee JY, Yoon YM, Oh YK, Youn J, Kim YJ (2006) NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A. Scand J Immunol 63: 453-460. PMID: 16764699
    • (2006) Scand J Immunol , vol.63 , pp. 453-460
    • Kim, J.M.1    Lee, J.Y.2    Yoon, Y.M.3    Oh, Y.K.4    Youn, J.5    Kim, Y.J.6
  • 55
    • 0026047280 scopus 로고
    • Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B
    • PMID: 1910012
    • Flegel WA, Muller F, Daubener W, Fischer HG, Hadding U, Northoff H (1991) Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun 59: 3659-3666. PMID: 1910012
    • (1991) Infect Immun , vol.59 , pp. 3659-3666
    • Flegel, W.A.1    Muller, F.2    Daubener, W.3    Fischer, H.G.4    Hadding, U.5    Northoff, H.6


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