Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen

Journal of Medical Microbiology

Volumn 57, Issue 6, 2008, Pages 725-731

  Brun, Paola ^a   Scarpa, Melania ^a   Grillo, Alessia ^a   Palù, Giorgio ^a   Mengoli, Carlo ^a   Zecconi, Alfonso ^b   Spigaglia, Patrizia ^c   Mastrantonio, Paola ^c   Castagliuolo, Ignazio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

36 KDA SURFACE LAYER PROTEIN; BACTERIAL ANTIGEN; CLOSTRIDIUM DIFFICILE TOXIN A; FIBRONECTIN BINDING PROTEIN; FIBRONECTIN BINDING PROTEIN A; FREUND ADJUVANT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; STAPHYLOCOCCUS VACCINE; ADHESIN; BACTERIAL PROTEIN; BACTERIAL TOXIN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; ENTEROTOXIN; FIBRONECTIN BINDING PROTEIN, BACTERIA; FIBRONECTIN-BINDING PROTEIN, BACTERIA; MEMBRANE PROTEIN; RECOMBINANT VACCINE; S LAYER PROTEINS; S-LAYER PROTEINS; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; CELLULAR IMMUNITY; CLOSTRIDIUM DIFFICILE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; GASTROINTESTINAL TRACT; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; MALE; MONOTHERAPY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; STAPHYLOCOCCUS AUREUS; TH1 CELL; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; IMMUNOLOGY; PHYSIOLOGY;

ADHESINS, BACTERIAL; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL TOXINS; BACTERIAL VACCINES; CLOSTRIDIUM DIFFICILE; ENTEROTOXINS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; VACCINES, SYNTHETIC;

EID: 45249119262     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.47736-0     Document Type: Article

References (30)

1. Aizpurua, H. J. & Russell-Jones, G. J. (1988). Identification of classes of proteins that provoke an immune response upon oral feeding. J Exp Med 167, 440-451.
2. Ausiello, C. M., Cerquetti, M., Fedele, G., Spensieri, F., Palazzo, R., Nasso, M., Frezza, S. & Mastrantonio, P. (2006). Surface layer proteins from Clostridium difficile induce inflammatory and regulatory cytokines in human monocytes and dendritic cells. Microbes Infect 8, 2640-2646.
3. Cario, E. (2005). Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut 54, 1182-1193.
4. Castagliuolo, I. & LaMont, J. T. (1999). Pathophysiology, diagnosis and treatment of Clostridium difficile infection. Keio J Med 48, 169-174.
5. Castagliuolo, I., Sardina, M., Brun, P., DeRos, C., Mastrotto, C., Lovato, L. & Palù, G. (2004). Clostridium difficile toxin A carboxylterminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant. Infect Immun 72, 2827-2836.
6. Castagliuolo, I., Piccinini, R., Beggiao, E., Paid, G., Mengoli, C., Ditadi, F., Vicenzoni, G. & Zecconi, A. (2006). Mucosal genetic immunization against four adhesins protects against Staphylococcus aureus-induced mastitis in mice. Vaccine 24, 4393-4402.
7. Cerquetti, M., Molinari, A., Serafino, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C. & Mastrantonio, P. (2000). Characterization of surface layer proteins from different Clostridium difficile clinical isolates. Microb Pathog 28, 363-372.
8. Cerquetti, M., Serafino, A., Sebastianelli, A. & Mastrantonio, P. (2002). Binding of Clostridium difficile to Caco-2 epithelial cell line and to extracellular matrix proteins. FEMS Immunol Med Microbiol 32, 211-218.
9. De Magistris, M. T. (2006). Mucosal delivery of vaccine antigens and its advantages in pediatrics. Adv Drug Deliv Rev 58, 52-67.
10. Eveillard, M., Fourel, V., Barc, M. C., Kernels, S., Coconnier, M. H., Karjalainen, T., Bourlioux, P. & Servin, A. L. (1993). Identification and characterization of adhesive factors of Clostridium difficile involved in adhesion to human colonic enterocyte-like Caco-2 and mucus-secreting HT-29 cells in culture. Mol Microbiol 7, 371-381.
11. Fallon, P. G. & Alcami, A. (2006). Pathogen-derived immunomodulatory molecules: future immunotherapeutics? Trends Immunol 27, 470-476.
12. Flegel, W. A., Muller, F., Daubener, W., Fischer, H. G., Hadding, U. & Northoff, H. (1991). Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun 59, 3659-3666.
13. Heyman, A., Levy, I., Altman, A. & Shoseyov, O. (2007). SP1 as a novel scaffold building block for self-assembly nanofabrication of submicron enzymatic structures. Nano Lett 7, 1575-1579.
14. Holmgren, J., Czerkinsky, C., Eriksson, K & Mharandi, A. (2003). Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges. Vaccine 21 (Suppl. 2), S89-S95.
15. Jones, H. P., Hodge, L. M., Fujihashi, K., Kiyono, H., McGhee, J. R. & Simecka, J. W. (2001). The pulmonary environment promotes Th2 responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol 167, 4518-4525.
16. Kyne, L., Warny, M., Qamar, A. & Kelly, C. P. (2000). Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 342, 390-397.
17. Lammers, A., Nuijten, J. M. & Smith, H. E. (1999). The fibronectin binding proteins of Staphylococcus aureus are required for adhesion to and invasion of bovine mammary gland cells. FEMS Microbiol Lett 180, 103-109.
18. Mamo, W., Boden, M. & Flock, J. I. (1994). Vaccination with Staphylococcus aureus fibrinogen-binding proteins (FgBPs) reduces colonisation of Staphylococcus aureus in a mouse mastitis model. FEMS Immunol Med Microbiol 10, 47-53.
19. McKenzie, B. S., Brady, J. L. & Lew, A. M. (2004). Mucosal immunity: overcoming the barrier for induction of proximal responses. Immunol Res 30, 35-71.
20. Moser, M. (2001). Regulation of Th1/Th2 development by antigen-presenting cells in vivo. Immunobiology 204, 551-557.
21. Mukherjee, K., Karlsson, S., Burman, L. G. & Akerlund, T. (2002). Proteins released during high toxin production in Clostridium difficile. Microbiology 148, 2245-2253.
22. Nakagawa, I., Takahashi, I., Kiyono, H., McGhee, J. R. & Hamada, S. (1996). Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches. J Infect Dis 173, 1428-1436.
23. Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G. & Schadendorf, D. (1998). Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med 4, 328.
24. Pizza, M. G., Giuliani, M. M., Fontana, M. R., Monaci, E., Douce, G., Dougan, G., Mills, K. H., Rappuoli, R. & Del Giudice, G. (2001). Mucosal vaccines: nontoxic derivatives of LT and CT as mucosal adjuvants. Vaccine 19, 2534-2541.
25. Rappuoli, R. & Pizza, M. G. (2000). Bacterial toxins. In Cellular Microbiology, pp. 193-220. Edited by P. Cossart, P. Boquet, S. Normark & R. Rappuoli. Washington, DC: American Society for Microbiology.
26. Svensson, M. & Kaye, P. M. (2006). Stromal-cell regulation of dendritic-cell differentiation and function. Trends Immunol 27, 580-587.
27. Svensson, M., Maroof, A., Ato, M. & Kaye, P. M. (2004). Stromal cells direct local differentiation of regulatory dendritic cells. Immunity 21, 805-816.
28. Uddowla, S., Freytag, L. C. & Clements, J. D. (2007). Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens. Vaccine 25, 7984-7993.
29. Warny, M. & Kelly, C. P. (1999). Monocyte cell necrosis is mediated by potassium depletion and caspase-like proteases. Am J Physiol 276, C717-C724.
30. Zecconi, A., Binda, E., Borromeo, V. & Piccinini, R. (2005). Relationship between some Staphylococcus aureus pathogenic factors and growth rates or somatic cell counts. J Dairy Res 72, 203-208.