Antidepressant-like effects of the xanthine oxidase enzyme inhibitor allopurinol in rats. A comparison with fluoxetine

Pharmacology Biochemistry and Behavior

Volumn 138, Issue , 2015, Pages 91-95

  Gürbüz Özgür, Börte ^a   Aksu, Hatice ^a   Birincioʇlu, Mustafa ^a   Dost, Turhan ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

Allopurinol; Depression; Fluoxetine; Forced swimming test; Serotonin; Tryptophan 2,3 dioxygenase

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ALLOPURINOL; FLUOXETINE; SEROTONIN; TRYPTOPHAN; URIC ACID; ANTIDEPRESSANT AGENT; ENZYME INHIBITOR; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANTIDEPRESSANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFICACY; FORCED SWIM TEST; IMMOBILIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BLOOD LEVEL; URIC ACID BLOOD LEVEL; WISTAR RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; DRUG EFFECTS; MOTOR ACTIVITY; PSYCHOLOGY; SWIMMING;

ALLOPURINOL; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; FLUOXETINE; HYDROXYINDOLEACETIC ACID; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SEROTONIN; SWIMMING; URIC ACID; XANTHINE OXIDASE;

EID: 84942869113     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.09.016     Document Type: Article

References (34)

1. A.A. Badawy, and M. Evans The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (allopurinol) Biochem. J. 133 1973 585 591
2. G.C. Becking, and W.J. Johnson The inhibition of tryptophan pyrrolase by allopurinol, an inhibitor of xanthine oxidase Can. J. Biochem. 45 1967 1667 1672
3. K.A. Bradley, J.A. Case, O. Khan, T. Ricart, A. Hanna, C.M. Alonso, and et al. The role of the kynurenine pathway in suicidality in adolescent major depressive disorder Psychiatry Res. 227 2015 206 212
4. L.J. Brandes, R.J. Arron, R.P. Bogdanovic, J. Tong, C.L. Zaborniak, G.R. Hogg, and et al. Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses Cancer Res. 52 1992 3796 3800
5. S.L. Brown, A. Bleich, and H.M. van Praag The monoamine hypothesis of depression: the case for serotonin S.L. Brown, H.M. van Praag, The Role of Serotonin in Psychiatric Disorders 1990 Brunner/Mazel New York 91 128
6. L. Capuron, A. Ravaud, P.J. Neveu, A.H. Miller, M. Maes, and R. Dantzer Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy Mol. Psychiatry 7 2002 468 473
7. J.M. Carlin, E.C. Borden, P.M. Sondel, and G.I. Byrne Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes J. Leukoc. Biol. 45 1989 29 34
8. J.F. Cryan, A. Markou, and I. Lucki Assessing antidepressant activity in rodents: recent developments and future needs Trends Pharmacol. Sci. 23 2002 238 245
9. M.J. Detke, M. Rickels, and I. Lucki Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants Psychopharmacology 121 1995 66 72
10. F.B. Dickerson, C.R. Stallings, A.E. Origoni, A. Sullens, S. Khushalani, N. Sandson, and et al. A double-blind trial of adjunctive allopurinol for schizophrenia Schizophr. Res. 109 2009 66 69
11. V. Gabbay, R.G. Klein, Y. Katz, S. Mendoza, L.E. Guttman, C.M. Alonso, and et al. The possible role of the kynurenine pathway in adolescent depression with melancholic features J. Child Psychol. Psychiatry 51 2010 935 943
12. S.M. Gibney, E.M. Fagan, A.-M. Waldron, J. O'Byrne, T.J. Connor, and A. Harkin Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour Int. J. Neuropsychopharmacol. 1-12 2014
13. A.R. Green, and G. Curzon Effects of hydrocortisone and immobilization on tryptophan metabolism in brain and liver of rats of different ages Biochem. Pharmacol. 24 1975 713 716
14. N.E. Harto, K.F. Spera, and R.J. Branconnier Fluoxetine-induced reduction of body mass in patients with major depressive disorder Psychopharmacol. Bull. 24 1988 220 223
15. S.E. Hemby, I. Lucki, G. Gatto, A. Singh, C. Thornley, J. Matasi, and et al. Potential antidepressant effects of novel tropane compounds, selective for serotonin or dopamine transporters J. Pharmacol. Exp. Ther. 282 1997 727 733
16. H. Herken, O. Akyol, H.R. Yilmaz, H. Tutkun, H.A. Savas, M.E. Ozen, and et al. Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment Hum. Psychopharmacol. 21 2006 53 59
17. H. Herken, A. Gurel, S. Selek, F. Armutcu, M.E. Ozen, M. Bulut, and et al. Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment Arch. Med. Res. 38 2007 247 252
18. IBM C IBM SPSS Statistics for Windows 20.0 ed. 2011 Armonk, NY Corp, IBM
19. A.V. Karve, S.S. Jagtiani, and K.A. Chitnis Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice Indian J. Pharm. 45 2013 244 247
20. S. Lee, J. Jeong, Y. Kwak, and S.K. Park Depression research: where are we now? Mol. Brain 3 2010 8
21. D. Lindberg, D. Shan, J. Ayers-Ringler, A. Oliveros, J. Benitez, M. Prieto, and et al. Purinergic signaling and energy homeostasis in psychiatric disorders Curr. Mol. Med. 15 2015 275 295
22. I. Lucki The forced swimming test as a model for core and component behavioral effects of antidepressant drugs Behav. Pharmacol. 8 1997 523 532
23. R. Machado-Vieira, J.C. Soares, D.R. Lara, D.A. Luckenbaugh, J.V. Busnello, G. Marca, and et al. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania J. Clin. Psychiatry 69 2008 1237 1245
24. M. Maes, S. Bonaccorso, V. Marino, A. Puzella, M. Pasquini, M. Biondi, and et al. Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation Mol. Psychiatry 6 2001 475 480
25. M. Maes, B.E. Leonard, A.M. Myint, M. Kubera, and R. Verkerk The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression Prog. Neuro-Psychopharmacol. Biol. Psychiatry 35 2011 702 721
26. J. McGuirk, and T. Silverstone The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects Int. J. Obes. 14 1990 361 372
27. A.M. Myint, and Y.K. Kim Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis Prog. Neuro-Psychopharmacol. Biol. Psychiatry 48 2014 304 313
28. R.D. Porsolt, M. Le Pichon, and M. Jalfre Depression: a new animal model sensitive to antidepressant treatments Nature 266 1977 730 732
29. R.D. Porsolt, G. Anton, N. Blavet, and M. Jalfre Behavioural despair in rats: a new model sensitive to antidepressant treatments Eur. J. Pharmacol. 47 1978 379 391
30. J.P. Reneric, and I. Lucki Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test Psychopharmacology 136 1998 190 197
31. G.Z. Reus, K. Jansen, S. Titus, A.F. Carvalho, V. Gabbay, and J. Quevedo Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies J. Psychiatr. Res 2015
32. D. Rial, D.R. Lara, and R.A. Cunha The adenosine neuromodulation system in schizophrenia Int. Rev. Neurobiol. 119 2014 395 449
33. J. Savitz, W.C. Drevets, B.E. Wurfel, B.N. Ford, P.S. Bellgowan, T.A. Victor, and et al. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder Brain Behav. Immun. 46 2015 55 59
34. A.P. Schmidt, A.E. Bohmer, C. Antunes, C. Schallenberger, L.O. Porciuncula, E. Elisabetsky, and et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors Br. J. Pharmacol. 156 2009 163 172