Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

Journal of Medicinal Food

Volumn 18, Issue 10, 2015, Pages 1143-1149

  Nakahara, Takeshi ^a   Mitoma, Chikage ^a   Hashimoto Hachiya, Akiko ^a   Takahara, Masakazu ^a   Tsuji, Gaku ^a   Uchi, Hiroshi ^a   Yan, Xianghong ^b   Hachisuka, Junichi ^a   Chiba, Takahito ^a   Esaki, Hitokazu ^a   Kido Nakahara, Makiko ^a   Furue, Masutaka ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b P and G Innovation Godo Kaisha   (Japan)

Author keywords

antioxidant; aryl hydrocarbon receptor; filaggrin; NQO1; NRF2; Opuntia ficus indica extract

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; FILAGGRIN; LORICRIN; OPUNTIA EXTRACT; OPUNTIA FICUS-INDICA EXTRACT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; INTERMEDIATE FILAMENT PROTEIN; MEMBRANE PROTEIN; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; PLANT EXTRACT;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH2 CELL; UPREGULATION; CELL CULTURE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION; GENE SILENCING; GENETICS; METABOLISM; OPUNTIA; PHYSIOLOGY; SKIN DISEASES;

ANTIOXIDANTS; CELLS, CULTURED; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KERATINOCYTES; MEMBRANE PROTEINS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OPUNTIA; PLANT EXTRACTS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; SKIN DISEASES;

EID: 84942868091     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.3396     Document Type: Article

References (26)

1. Shetty AA, Rana MK, Preetham SP: Cactus: A medicinal food. J Food Sci Technol 2012;49:530-536.
2. Butera D, Tesoriere L, Di Gaudio F, et al.: Antioxidant activities of Sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: Betanin and indicaxanthin. J Agric Food Chem 2002;50:6895-6901.
3. Hfaiedh M, Brahmi D, Zourgui L: Protective role of cactus cladodes extract on sodium dichromate-induced testicular injury and oxidative stress in rats. Biol Trace Elem Res 2014;159:304-311.
4. Kuti JO: Antioxidant compounds from four Opuntia cactus pear fruit varieties. Food Chem 2004;85:527-533.
5. Morán-Ramos S, Avila-Nava A, Tovar AR, et al.: Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats. J Nutr 2012;142:1956-1963.
6. Brahmi D, Bouaziz C, Ayed Y, et al.: Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1. Nutr Metab (Lond) 2012;8:73.
7. Fischedick JT, Standiford M, Johnson DA, et al.: Activation of antioxidant response element in mouse primary cortical cultures with sesquiterpene lactones isolated from Tanacetum parthenium. Planta Med 2012;78:1725-1730.
8. Jaiswal AK: Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 2004;36:1199-1207.
9. Ma Q: Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 2013;53:401-426.
10. Tsuji G, Takahara M, Uchi H, et al.: Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: The basis of its anti-inflammatory effect. J Invest Dermatol 2012;132:59-68.
11. Ramyaa P, Krishnaswamy R, Padma VV: Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2. Biochim Biophys Acta 2014;1840:681-692.
12. Ikuta T, Namiki T, Fujii-Kuriyama Y, Kawajiri K: AhR protein trafficking and function in the skin. Biochem Pharmacol 2009;77:588-596.
13. Furue M, Takahara M, Nakahara T, Uchi H: Role of AhR/ARNT system in skin homeostasis. Arch Dermatol Res 2014:306:769-779.
14. Hayes JD, Kelleher MO, Eggleston IM: The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr 2008;47:73-88.
15. Kimura S, Warabi E, Yanagawa T, et al.: Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun 2009;387:109-114.
16. Tsuji G, Takahara M, Uchi H, et al.: An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. J Dermatol Sci 2011;62:42-49.
17. Wu Z, Uchi H, Morino-Koga S, et al.: Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. Exp Dermatol 2014;23:260-265.
18. Loertscher JA, Lin TM, Peterson RE, Allen-Hoffmann BL: In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes accelerated terminal differentiation in fetal mouse skin. Toxicol Sci 2002;68:465-472.
19. van den Bogaard EH, Bergboer JG, Vonk-Bergers M, et al.: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest 2013;123:917-927.
20. Howell MD, Kim BE, Gao P, et al.: Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol 2009;124:R7-R12.
21. Kerdel FA, Strober BE: Tumor necrosis factor inhibitors in psoriasis: An update. Semin Cutan Med Surg 2014;33:S31-S36.
22. Feng XX, Yu XT, Li WJ, et al.: Effects of topical application of patchouli alcohol on the UV-induced skin photoaging in mice. Eur J Pharm Sci 2014;63:113-123.
23. Niestroy J, Barbara A, Herbst K, et al.: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro 2011;25:671-683.
24. Kennedy LH, Sutter CH, Leon Carrion S, et al.: 2,3,7,8-Tetra-chlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation. Toxicol Sci 2013;132:235-249.
25. Elias PM, Steinhoff M: "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 2008;128:1067-1070.
26. Elias PM, Eichenfield LF, Fowler JF, Jr., Horowitz P, McLeod RP: Update on the structure and function of the skin barrier: Atopic dermatitis as an exemplar of clinical implications. Semin Cutan Med Surg 2013;32:S21-S24.