PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Guo, Jihua ^a   Jia, Jun ^a   Jia, Rong ^a  

^a Wuhan University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA; NERVE PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN BINDING; PTBP1 PROTEIN, HUMAN; PTBP2 PROTEIN, HUMAN; RNA BINDING PROTEIN; RNA PRECURSOR; SERINE ARGININE RICH SPLICING FACTOR; SRSF3 PROTEIN, HUMAN; STOP CODON;

ALTERNATIVE RNA SPLICING; BINDING SITE; EXON; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUTH TUMOR; NUCLEOTIDE SEQUENCE; PATHOLOGY; RNA STABILITY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STOP CODON; TISSUE MICROARRAY; TUMOR CELL CULTURE;

ALTERNATIVE SPLICING; BASE SEQUENCE; BINDING SITES; CARCINOMA, SQUAMOUS CELL; CODON, TERMINATOR; EXONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MOUTH NEOPLASMS; NERVE TISSUE PROTEINS; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BINDING; RNA PRECURSORS; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; SERINE-ARGININE SPLICING FACTORS; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED;

EID: 84942863103     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14548     Document Type: Article

References (32)

1. Zhang, J., Manley, J. L. Misregulation of pre-mRNA Alternative Splicing in Cancer. Cancer Discov. 3, 1228-1237 (2013).
2. Karni, R. et al. The Gene Encoding the Splicing Factor SF2/ASF is a Proto-Oncogene. Nat. Struct. Mol. Biol. 14, 185-193 (2007).
3. Cohen-Eliav, M. et al. The Splicing Factor SRSF6 is Amplified and is an Oncoprotein in Lung and Colon Cancers. J. Pathol. 229, 630-639 (2013).
4. Jensen, M. A., Wilkinson, J. E., Krainer, A. R. Splicing Factor SRSF6 Promotes Hyperplasia of Sensitized Skin. Nat. Struct. Mol. Biol. 21, 189-197 (2014).
5. Jia, R., Li, C., McCoy, J. P., Deng, C. X., Zheng, Z. M. SRp20 is a Proto-Oncogene Critical for Cell Proliferation and Tumor Induction and Maintenance. Int. J. Biol. Sci. 6, 806-826 (2010).
6. Zahler, A. M., Lane, W. S., Stolk, J. A., Roth, M. B. SR Proteins: A Conserved Family of pre-mRNA Splicing Factors. Genes Dev. 6, 837-847 (1992).
7. Cavaloc, Y., Bourgeois, C. F., Kister, L., Stevenin, J. The Splicing Factors 9G8 and SRp20 Transactivate Splicing through Different and Specific Enhancers. RNA. 5, 468-483 (1999).
8. Cui, M. et al. Genes Involved in pre-mRNA 3?-End Formation and Transcription Termination Revealed by a Lin-15 Operon Muv Suppressor Screen. Proc. Natl. Acad. Sci. USA. 105, 16665-16670 (2008).
9. Lou, H., Neugebauer, K. M., Gagel, R. F., Berget, S. M. Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20. Mol. Cell. Biol. 18, 4977-4985 (1998).
10. Bedard, K. M., Daijogo, S., Semler, B. L. A Nucleo-Cytoplasmic SR Protein Functions in Viral IRES-mediated Translation Initiation. Embo J. 26, 459-467 (2007).
11. Huang, Y., Gattoni, R., Stevenin, J., Steitz, J. A. SR Splicing Factors Serve as Adapter Proteins for TAP-dependent mRNA Export. Mo.l Cell. 11, 837-843 (2003).
12. Hautbergue, G. M., Hung, M. L., Golovanov, A. P., Lian, L. Y., Wilson, S. A. Mutually Exclusive Interactions Drive Handover of mRNA From Export Adaptors to TAP. Proc. Natl. Acad. Sci. USA. 105, 5154-5159 (2008).
13. Loomis, R. J. et al. Chromatin Binding of SRp20 and ASF/SF2 and Dissociation From Mitotic Chromosomes is Modulated by Histone H3 Serine 10 Phosphorylation. Mol. Cell. 33, 450-461 (2009).
14. Sen, S., Jumaa, H., Webster, N. J. Splicing Factor SRSF3 is Crucial for Hepatocyte Differentiation and Metabolic Function. Nat. Commun. 4, 1336 (2013).
15. Majerciak, V., Lu, M., Li, X., Zheng, Z. M. Attenuation of the Suppressive Activity of Cellular Splicing Factor SRSF3 by Kaposi Sarcoma-Associated Herpesvirus ORF57 Protein is Required for RNA Splicing. RNA. 20, 1747-1758 (2014).
16. Jia, R. et al. Control of the Papillomavirus Early-To-Late Switch by Differentially Expressed SRp20. J. Virol. 83, 167-180 (2009).
17. Corbo, C., Orru, S., Salvatore, F. SRp20: An Overview of its Role in Human Diseases. Biochem. Biophys. Res. Commun. 436, 1-5 (2013).
18. He, X. et al. Knockdown of Splicing Factor SRp20 Causes Apoptosis in Ovarian Cancer Cells and its Expression is Associated with Malignancy of Epithelial Ovarian Cancer. Oncogene. 30, 356-365 (2011).
19. Iborra, S. et al. Alterations in Expression Pattern of Splicing Factors in Epithelial Ovarian Cancer and its Clinical Impact. Int. J. Gynecol. Cancer. 23, 990-996 (2013).
20. Jumaa, H., Nielsen, P. J. The Splicing Factor SRp20 Modifies Splicing of its Own mRNA and ASF/SF2 Antagonizes this Regulation. Embo J. 16, 5077-5085 (1997).
21. Jumaa, H., Nielsen, P. J. Regulation of SRp20 Exon 4 Splicing. Biochim. Biophys. Acta. 1494, 137-143 (2000).
22. Spellman, R., Smith, C. W. Novel Modes of Splicing Repression by PTB. Trends. Biochem. Sci. 31, 73-76 (2006).
23. Cheung, H. C. et al. Splicing Factors PTBP1 and PTBP2 Promote Proliferation and Migration of Glioma Cell Lines. Brain. 132, 2277-2288 (2009).
24. Spellman, R., Llorian, M., Smith, C. W. Crossregulation and Functional Redundancy Between the Splicing Regulator PTB and its Paralogs nPTB and ROD1. Mol. Cell. 27, 420-434 (2007).
25. Boutz, P. L. et al. A Post-Transcriptional Regulatory Switch in Polypyrimidine Tract-Binding Proteins Reprograms Alternative Splicing in Developing Neurons. Genes Dev. 21, 1636-1652 (2007).
26. Sun, S., Zhang, Z., Sinha, R., Karni, R., Krainer, A. R. SF2/ASF Autoregulation Involves Multiple Layers of Post-Transcriptional and Translational Control. Nat. Struct. Mol. Biol. 17, 306-312 (2010).
27. Sureau, A., Gattoni, R., Dooghe, Y., Stevenin, J., Soret, J. SC35 Autoregulates its Expression by Promoting Splicing Events that Destabilize its mRNAs. Embo J. 20, 1785-1796 (2001).
28. Zheng, Z. M., Huynen, M., Baker, C. C. A Pyrimidine-Rich Exonic Splicing Suppressor Binds Multiple RNA Splicing Factors and Inhibits Spliceosome Assembly. Proc. Natl. Acad. Sci. USA. 95, 14088-14093 (1998).
29. Jumaa, H., Wei, G., Nielsen, P. J. Blastocyst Formation is Blocked in Mouse Embryos Lacking the Splicing Factor SRp20. Curr. Biol. 9, 899-902 (1999).
30. Sen, S., Langiewicz, M., Jumaa, H., Webster, N. J. Deletion of Splicing Factor SRSF3 in Hepatocytes Predisposes to Hepatocellular Carcinoma in Mice. Hepatology. 61, 171-183 (2014).
31. Wang, C., Politz, J. C., Pederson, T., Huang, S. RNA Polymerase III Transcripts and the PTB Protein are Essential for the Integrity of the Perinucleolar Compartment. Mol. Biol. Cell. 14, 2425-2435 (2003).
32. Mendell, J. T., Ap, R. C., Dietz, H. C. Separable Roles for rent1/hUpf1 in Altered Splicing and Decay of Nonsense Transcripts. Science. 298, 419-422 (2002).