-
1
-
-
33750379420
-
Polycomb silencers control cell fate, development and cancer
-
Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6: 846-856.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 846-856
-
-
Sparmann, A.1
van Lohuizen, M.2
-
2
-
-
67649397334
-
Epigenetic gene regulation in stem cells and correlation to cancer
-
Mathews LA, Crea F, Farrar WL. Epigenetic gene regulation in stem cells and correlation to cancer. Differentiation 2009; 78: 1-17.
-
(2009)
Differentiation
, vol.78
, pp. 1-17
-
-
Mathews, L.A.1
Crea, F.2
Farrar, W.L.3
-
3
-
-
84868016543
-
EZH2: a pivotal regulator in controlling cell differentiation
-
Chen YH, Hung MC, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res 2012; 4: 364-375.
-
(2012)
Am J Transl Res
, vol.4
, pp. 364-375
-
-
Chen, Y.H.1
Hung, M.C.2
Li, L.Y.3
-
4
-
-
79955513100
-
Aberrations of EZH2 in cancer
-
Chase A, Cross NC. Aberrations of EZH2 in cancer. Clin Cancer Res 2011; 17: 2613-2618.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2613-2618
-
-
Chase, A.1
Cross, N.C.2
-
5
-
-
0035877978
-
Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
-
van Kemenade FJ, Raaphorst FM, Blokzijl T etal. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 2001; 97: 3896-3901.
-
(2001)
Blood
, vol.97
, pp. 3896-3901
-
-
van Kemenade, F.J.1
Raaphorst, F.M.2
Blokzijl, T.3
-
6
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer CG, Cao Q, Varambally S etal. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003; 100: 11606-11611.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
-
7
-
-
9144226103
-
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
-
Raaphorst FM, Meijer CJ, Fieret E etal. Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Neoplasia 2003; 5: 481-488.
-
(2003)
Neoplasia
, vol.5
, pp. 481-488
-
-
Raaphorst, F.M.1
Meijer, C.J.2
Fieret, E.3
-
8
-
-
34250706864
-
Polycomb-group oncogenes EZH2, BMI1,and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
-
van Leenders GJ, Dukers D, Hessels D etal. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. Eur Urol 2007; 52: 455-463.
-
(2007)
Eur Urol
, vol.52
, pp. 455-463
-
-
van Leenders, G.J.1
Dukers, D.2
Hessels, D.3
-
9
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally S, Dhanasekaran SM, Zhou M etal. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-629.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
-
10
-
-
26444477288
-
Increased expression of EZH2, a polycomb group protein, in bladder carcinoma
-
Arisan S, Buyuktuncer ED, Palavan-Unsal N, Caşkurlu T, Cakir OO, Ergenekon E. Increased expression of EZH2, a polycomb group protein, in bladder carcinoma. Urol Int 2005; 75: 252-257.
-
(2005)
Urol Int
, vol.75
, pp. 252-257
-
-
Arisan, S.1
Buyuktuncer, E.D.2
Palavan-Unsal, N.3
Caşkurlu, T.4
Cakir, O.O.5
Ergenekon, E.6
-
11
-
-
29344445843
-
Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder
-
Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res 2005; 11: 8570-8576.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8570-8576
-
-
Raman, J.D.1
Mongan, N.P.2
Tickoo, S.K.3
Boorjian, S.A.4
Scherr, D.S.5
Gudas, L.J.6
-
12
-
-
29344439946
-
Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
-
Weikert S, Christoph F, Köllermann J etal. Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 2005; 16: 349-353.
-
(2005)
Int J Mol Med
, vol.16
, pp. 349-353
-
-
Weikert, S.1
Christoph, F.2
Köllermann, J.3
-
13
-
-
33744519651
-
Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer
-
Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K, Yokozaki H. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci 2006; 97: 484-491.
-
(2006)
Cancer Sci
, vol.97
, pp. 484-491
-
-
Matsukawa, Y.1
Semba, S.2
Kato, H.3
Ito, A.4
Yanagihara, K.5
Yokozaki, H.6
-
14
-
-
56649103900
-
Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
-
Watanabe H, Soejima K, Yasuda H etal. Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells. Cancer Cell Int 2008; 8: 15. doi: 10.1186/1475-2867-8-15.
-
(2008)
Cancer Cell Int
, vol.8
, pp. 15
-
-
Watanabe, H.1
Soejima, K.2
Yasuda, H.3
-
15
-
-
19944397508
-
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
-
Sudo T, Utsunomiya T, Mimori K etal. Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma. Br J Cancer 2005; 92: 1754-1758.
-
(2005)
Br J Cancer
, vol.92
, pp. 1754-1758
-
-
Sudo, T.1
Utsunomiya, T.2
Mimori, K.3
-
16
-
-
24744464786
-
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
-
Takeshita F, Minakuchi Y, Nagahara S etal. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A 2005; 102: 12177-12182.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 12177-12182
-
-
Takeshita, F.1
Minakuchi, Y.2
Nagahara, S.3
-
17
-
-
35748937338
-
Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
-
Yu J, Cao Q, Mehra R etal. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 2007; 12: 419-431.
-
(2007)
Cancer Cell
, vol.12
, pp. 419-431
-
-
Yu, J.1
Cao, Q.2
Mehra, R.3
-
18
-
-
79957568143
-
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
-
Smits M, Nilsson J, Mir SE etal. miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget 2010; 1: 710-720.
-
(2010)
Oncotarget
, vol.1
, pp. 710-720
-
-
Smits, M.1
Nilsson, J.2
Mir, S.E.3
-
19
-
-
84867509134
-
Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase
-
Ott M, Litzenburger UM, Sahm F etal. Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase. PLoS ONE 2012; 7: e47663.
-
(2012)
PLoS ONE
, vol.7
, pp. e47663
-
-
Ott, M.1
Litzenburger, U.M.2
Sahm, F.3
-
20
-
-
84856466661
-
The role of EZH2 in tumour progression
-
Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012; 106: 243-247.
-
(2012)
Br J Cancer
, vol.106
, pp. 243-247
-
-
Chang, C.J.1
Hung, M.C.2
-
21
-
-
0028986612
-
Loss of P16INK4 expression is frequent in high grade gliomas
-
Nishikawa R, Furnari FB, Lin H etal. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res 1995; 55: 1941-1945.
-
(1995)
Cancer Res
, vol.55
, pp. 1941-1945
-
-
Nishikawa, R.1
Furnari, F.B.2
Lin, H.3
-
22
-
-
0029823960
-
Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices
-
Ono Y, Tamiya T, Ichikawa T etal. Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices. J Neuropathol Exp Neurol 1996; 55: 1026-1031.
-
(1996)
J Neuropathol Exp Neurol
, vol.55
, pp. 1026-1031
-
-
Ono, Y.1
Tamiya, T.2
Ichikawa, T.3
-
23
-
-
0032947770
-
CDKN2/p16 predicts survival in oligodendrogliomas: comparison with astrocytomas
-
Miettinen H, Kononen J, Sallinen P etal. CDKN2/p16 predicts survival in oligodendrogliomas: comparison with astrocytomas. J Neurooncol 1999; 41: 205-211.
-
(1999)
J Neurooncol
, vol.41
, pp. 205-211
-
-
Miettinen, H.1
Kononen, J.2
Sallinen, P.3
-
24
-
-
84877107135
-
EZH2 regulates the expression of p16 in the nasopharyngeal cancer cells
-
Zhong J, Min L, Huang H etal. EZH2 regulates the expression of p16 in the nasopharyngeal cancer cells. Technol Cancer Res Treat 2013; 12: 269-274.
-
(2013)
Technol Cancer Res Treat
, vol.12
, pp. 269-274
-
-
Zhong, J.1
Min, L.2
Huang, H.3
-
25
-
-
69349093771
-
Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin
-
Yamaguchi J, Sasaki M, Harada K etal. Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin. Lab Invest 2009; 89: 1018-1031.
-
(2009)
Lab Invest
, vol.89
, pp. 1018-1031
-
-
Yamaguchi, J.1
Sasaki, M.2
Harada, K.3
-
26
-
-
33846148370
-
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene
-
Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 2007; 21: 49-54.
-
(2007)
Genes Dev
, vol.21
, pp. 49-54
-
-
Kotake, Y.1
Cao, R.2
Viatour, P.3
Sage, J.4
Zhang, Y.5
Xiong, Y.6
-
27
-
-
0030929534
-
Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR
-
Perry A, Nobori T, Ru N etal. Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR. J Neuropathol Exp Neurol 1997; 56: 999-1008.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 999-1008
-
-
Perry, A.1
Nobori, T.2
Ru, N.3
-
28
-
-
80755159100
-
Molecular profile of oligodendrogliomas in young patients
-
Suri V, Jha P, Agarwal S etal. Molecular profile of oligodendrogliomas in young patients. Neuro Oncol 2011; 13: 1099-1106.
-
(2011)
Neuro Oncol
, vol.13
, pp. 1099-1106
-
-
Suri, V.1
Jha, P.2
Agarwal, S.3
-
29
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
30
-
-
0035013213
-
The INK4A/ARF locus: role in cellcycle control and apoptosis and implications for glioma growth
-
Ivanchuk SM, Mondal S, Dirks PB, Rutka JT. The INK4A/ARF locus: role in cellcycle control and apoptosis and implications for glioma growth. J Neurooncol 2001; 51: 219-229.
-
(2001)
J Neurooncol
, vol.51
, pp. 219-229
-
-
Ivanchuk, S.M.1
Mondal, S.2
Dirks, P.B.3
Rutka, J.T.4
-
31
-
-
0034649787
-
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
-
Ichimura K, Bolin MB, Goike HM, Schmidt EE, Moshref A, Collins VP. Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res 2000; 60: 417-424.
-
(2000)
Cancer Res
, vol.60
, pp. 417-424
-
-
Ichimura, K.1
Bolin, M.B.2
Goike, H.M.3
Schmidt, E.E.4
Moshref, A.5
Collins, V.P.6
-
32
-
-
0029884472
-
Infrequent alterations of the p15,p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors
-
Sato K, Schäuble B, Kleihues P, Ohgaki H. Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors. Int J Cancer 1996; 66: 305-308.
-
(1996)
Int J Cancer
, vol.66
, pp. 305-308
-
-
Sato, K.1
Schäuble, B.2
Kleihues, P.3
Ohgaki, H.4
-
33
-
-
0032801035
-
Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization
-
Bigner SH, Matthews MR, Rasheed BK etal. Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. Am J Pathol 1999; 155: 375-386.
-
(1999)
Am J Pathol
, vol.155
, pp. 375-386
-
-
Bigner, S.H.1
Matthews, M.R.2
Rasheed, B.K.3
-
34
-
-
0033767164
-
CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas
-
Bortolotto S, Chiadò-Piat L, Cavalla P etal. CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas. Int J Cancer 2000; 88: 554-557.
-
(2000)
Int J Cancer
, vol.88
, pp. 554-557
-
-
Bortolotto, S.1
Chiadò-Piat, L.2
Cavalla, P.3
-
35
-
-
84881312974
-
CDKN2A deletion in pediatric versus adult glioblastomas and predictive value of p16 immunohistochemistry
-
Purkait S, Jha P, Sharma MC etal. CDKN2A deletion in pediatric versus adult glioblastomas and predictive value of p16 immunohistochemistry. Neuropathology 2013; 33: 405-412.
-
(2013)
Neuropathology
, vol.33
, pp. 405-412
-
-
Purkait, S.1
Jha, P.2
Sharma, M.C.3
-
36
-
-
0031906358
-
Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas
-
Burns KL, Ueki K, Jhung SL, Koh J, Louis DN. Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. J Neuropathol Exp Neurol 1998; 57: 122-130.
-
(1998)
J Neuropathol Exp Neurol
, vol.57
, pp. 122-130
-
-
Burns, K.L.1
Ueki, K.2
Jhung, S.L.3
Koh, J.4
Louis, D.N.5
-
37
-
-
77956222562
-
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer
-
Sauvageau M, Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell 2010; 7: 299-313.
-
(2010)
Cell
, vol.7
, pp. 299-313
-
-
Sauvageau, M.1
Sauvageau, G.2
-
38
-
-
0028034775
-
Transcriptional repression of the d-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
-
Li Y, Nichols MA, Shay JW, Xiong Y. Transcriptional repression of the d-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res 1994; 54: 6078-6082.
-
(1994)
Cancer Res
, vol.54
, pp. 6078-6082
-
-
Li, Y.1
Nichols, M.A.2
Shay, J.W.3
Xiong, Y.4
-
39
-
-
0032541623
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
-
Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 1998; 395: 237-243.
-
(1998)
Nature
, vol.395
, pp. 237-243
-
-
Russo, A.A.1
Tong, L.2
Lee, J.O.3
Jeffrey, P.D.4
Pavletich, N.P.5
-
40
-
-
84892426861
-
Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells
-
Nakagawa S, Sakamoto Y, Okabe H etal. Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells. Oncol Rep 2014; 31: 983-988.
-
(2014)
Oncol Rep
, vol.31
, pp. 983-988
-
-
Nakagawa, S.1
Sakamoto, Y.2
Okabe, H.3
-
41
-
-
84871841675
-
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
-
Qi W, Chan H, Teng L etal. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012; 109: 21360-21365.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 21360-21365
-
-
Qi, W.1
Chan, H.2
Teng, L.3
-
42
-
-
84867401194
-
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
-
Kikuchi J, Takashina T, Kinoshita I etal. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer 2012; 78: 138-143.
-
(2012)
Lung Cancer
, vol.78
, pp. 138-143
-
-
Kikuchi, J.1
Takashina, T.2
Kinoshita, I.3
|