A new, integrated, continuous purification process template for monoclonal antibodies: Process modeling and cost of goods studies

Journal of Biotechnology

Volumn 213, Issue , 2015, Pages 42-53

  Xenopoulos, Alex ^a  

^a MILLIPORE CORPORATION   (United States)

Author keywords

Antibodies; Connected; Continuous; Cost of goods; Modeling; Process integration; Purification

Indexed keywords

CLARIFIERS; COLUMN CHROMATOGRAPHY; COSTS; MODELS; MONOCLONAL ANTIBODIES; POLISHING; PROCESS ENGINEERING; PURIFICATION;

BIOPHARMACEUTICAL INDUSTRY; CONNECTED; CONTINUOUS; COST-OF-GOODS; MANUFACTURING SOLUTIONS; MONOCLONAL ANTIBODY PURIFICATION; PROCESS INTEGRATION; PROTEIN A CHROMATOGRAPHY;

ANTIBODIES;

ACTIVATED CARBON; MONOCLONAL ANTIBODY; RESIN;

ARTICLE; BATCH PROCESS; BIOREACTOR; CENTRIFUGATION; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONTINUOUS PROCESS; CONTROLLED STUDY; COST; DIAFILTRATION; DILUTION; ELUTION; FLOCCULATION; ION EXCHANGE CHROMATOGRAPHY; MODEL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN PURIFICATION; ULTRAFILTRATION; VIRUS INACTIVATION; ANIMAL; BIOSYNTHESIS; BIOTECHNOLOGY; CHO CELL LINE; CRICETULUS; DRUG INDUSTRY; ECONOMICS; HAMSTER; ISOLATION AND PURIFICATION; PROCEDURES; THEORETICAL MODEL;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; BIOTECHNOLOGY; CHO CELLS; CHROMATOGRAPHY; COSTS AND COST ANALYSIS; CRICETINAE; CRICETULUS; DRUG INDUSTRY; MODELS, THEORETICAL;

EID: 84942817041     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2015.04.020     Document Type: Article

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