Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation

Biotechnology Journal

Volumn 9, Issue 6, 2014, Pages 766-775

  Hammerschmidt, Nikolaus ^a,b   Tscheliessnig, Anne ^a   Sommer, Ralf ^a   Helk, Bernhard ^c   Jungbauer, Alois ^a,b  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b Austria Centre for Industrial Biotechnology   (Austria)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antibodies; Bioprocess engineering; Downstream processing; Process development

Indexed keywords

AFFINITY CHROMATOGRAPHY; BATCH DATA PROCESSING; COST BENEFIT ANALYSIS; ECONOMIC ANALYSIS; PRODUCTION ENGINEERING; PURIFICATION; RECOMBINANT PROTEINS;

BIOPROCESS ENGINEERING; CHROMATOGRAPHIC RESINS; CONTINUOUS PRECIPITATION; DOWNSTREAM-PROCESSING; PROCESS DEVELOPMENT; RECOMBINANT ANTIBODY PRODUCTION; SELECTIVE PRECIPITATION; SMALL-SCALE PRODUCTION;

ANTIBODIES;

RECOMBINANT ANTIBODY; ANTIBODIES; RECOMBINANT PROTEINS;

ANION EXCHANGE CHROMATOGRAPHY; ANTIBODY PRODUCTION; ARTICLE; BATCH PROCESS; CONTINUOUS PROCESS; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG COST; DRUG INDUSTRY; DRUG PURIFICATION; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR WEIGHT; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; CHROMATOGRAPHY; CLINICAL TRIALS AS TOPIC; COSTS AND COST ANALYSIS; ECONOMICS; ISOLATION AND PURIFICATION; METHODS; MODELS, ECONOMIC; SOFTWARE;

ANTIBODIES; CHROMATOGRAPHY; CLINICAL TRIALS AS TOPIC; COSTS AND COST ANALYSIS; MODELS, ECONOMIC; RECOMBINANT PROTEINS; SOFTWARE;

EID: 84901696090     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300480     Document Type: Article

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