Pancreatic stellate cells: A dynamic player of the intercellular communication in pancreatic cancer

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue , 2015, Pages S98-S103

  Masamune, Atsushi ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

CANCER CELL; CARCINOGENESIS; CELL COMMUNICATION; CELL FUNCTION; CELL INTERACTION; DRUG TARGETING; ENDOTHELIUM CELL; HUMAN; IMMUNOCOMPETENT CELL; NERVE CELL; NONHUMAN; PANCREAS CANCER; PANCREAS ISLET CELL; PANCREATIC STELLATE CELL; PHASE 2 CLINICAL TRIAL (TOPIC); SHORT SURVEY; STROMA CELL; TUMOR MICROENVIRONMENT; CELL DIFFERENTIATION; DISEASE COURSE; EPITHELIAL MESENCHYMAL TRANSITION; FIBROSIS; LEUKOCYTE; NERVOUS SYSTEM DEVELOPMENT; PANCREAS; PANCREAS ISLET; PANCREAS TUMOR; PATHOLOGY;

CELL COMMUNICATION; CELL DIFFERENTIATION; DISEASE PROGRESSION; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; HUMANS; ISLETS OF LANGERHANS; LEUKOCYTES; NEUROGENESIS; PANCREAS; PANCREATIC NEOPLASMS; PANCREATIC STELLATE CELLS; TUMOR MICROENVIRONMENT;

EID: 84942816173     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2015.05.018     Document Type: Short Survey

References (50)

1. Hidalgo M. Pancreatic cancer. N Engl J Med 2010, 362:1605-1617.
2. Erkan M., Michalski C.W., Rieder S., Reiser-Erkan C., Abiatari I., Kolb A., et al. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol 2008, 6:1155-1161.
3. Neesse A., Michl P., Frese K.K., Feig C., Cook N., Jacobetz M.A., et al. Stromal biology and therapy in pancreatic cancer. Gut 2011, 60:861-868.
4. Gore J., Korc M. Pancreatic cancer stroma: friend or foe?. Cancer Cell 2014, 25:711-712.
5. Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation and culture. Gut 1998, 43:128-133.
6. Bachem M.G., Schneider E., Gross H., Weidenbach H., Schmid R.M., Menke A., et al. Identification, culture, and characterization of pancreas stellate cells in rats and humans. Gastroenterology 1998, 115:421-432.
7. Masamune A., Shimosegawa T. Signal transduction in pancreatic stellate cells. J Gastroenterol 2009, 44:249-260.
8. Masamune A., Watanabe T., Kikuta K., Shimosegawa T. Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis. Clin Gastroenterol Hepatol 2009, 7:S48-S54.
9. Erkan M., Adler G., Apte M.V., Bachem M.G., Buchholz M., Detlefsen S., et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 2012, 61:172-178.
10. Apte M.V., Wilson J.S., Lugea A., Pandol S.J. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 2013, 144:1210-1219.
11. Masamune A., Shimosegawa T. Pancreatic stellate cells - multi-functional cells in the pancreas. Pancreatology 2013, 13:102-105.
12. Mantoni T.S., Schendel R.R., Rödel F., Niedobitek G., Al-Assar O., Masamune A., et al. Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther 2008, 7:1806-1815.
13. Erkan M., Kleeff J., Gorbachevski A., Reiser C., Mitkus T., Esposito I., et al. Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 2007, 132:1447-1464.
14. Provenzano P.P., Hingorani S.R. Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br J Cancer 2013, 108:1-8.
15. Masamune A., Satoh M., Kikuta K., Sakai Y., Satoh A., Shimosegawa T. Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells. J Pharmacol Exp Ther 2003, 304:8-14.
16. Masamune A., Nakano E., Hamada S., Takikawa T., Yoshida N., Shimosegawa T. Alteration of the microRNA expression profile during the activation of pancreatic stellate cells. Scand J Gastroenterol 2014, 49:323-331.
17. Hwang R.F., Moore T., Arumugam T., Ramachandran V., Amos K.D., Rivera A., et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 2008, 68:918-926.
18. Bachem M.G., Schünemann M., Ramadani M., Siech M., Beger H., Buck A., et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 2005, 128:907-921.
19. Vonlaufen A., Phillips P.A., Xu Z., Goldstein D., Pirola R.C., Wilson J.S., et al. Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. Cancer Res 2008, 68:7707-7710.
20. Kikuta K., Masamune A., Watanabe T., Ariga H., Itoh H., Hamada S., et al. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun 2010, 403:380-384.
21. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
22. Takikawa T., Masamune A., Hamada S., Nakano E., Yoshida N., Shimosegawa T. miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem Biophys Res Commun 2013, 437:433-439.
23. Xu Z., Vonlaufen A., Phillips P.A., Fiala-Beer E., Zhang X., Yang L., et al. Role of pancreatic stellate cells in pancreatic cancer metastasis. Am J Pathol 2010, 177:2585-2596.
24. Mantoni T.S., Lunardi S., Al-Assar O., Masamune A., Brunner T.B. Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling. Cancer Res 2011, 71:3453-3458.
25. Brabletz S., Schmalhofer O., Brabletz T. Gastrointestinal stem cells in development and cancer. J Pathol 2009, 217:307-317.
26. Hamada S., Masamune A., Takikawa T., Suzuki N., Kikuta K., Hirota M., et al. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Biochem Biophys Res Commun 2012, 421:349-354.
27. Masamune A., Kikuta K., Watanabe T., Satoh K., Hirota M., Shimosegawa T. Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol 2008, 295:G709-G717.
28. Patel M.B., Pothula S.P., Xu Z., Lee A.K., Goldstein D., Pirola R.C., et al. The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer. Carcinogenesis 2014, 35:1891-1900.
29. Brammer R.D., Bramhall S.R., Eggo M.C. Endostatin expression in pancreatic tissue is modulated by elastase. Br J Cancer 2005, 92:89-93.
30. Ceyhan G.O., Demir I.E., Rauch U., Bergmann F., Müller M.W., Büchler M.W., et al. Pancreatic neuropathy results in "neural remodeling" and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer. Am J Gastroenterol 2009, 104:2555-2565.
31. Gritsenko P.G., Ilina O., Friedl P. Interstitial guidance of cancer invasion. J Pathol 2012, 226:185-199.
32. Omary M.B., Lugea A., Lowe A.W., Pandol S.J. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest 2007, 117:50-59.
33. Haas S.L., Fitzner B., Jaster R., Wiercinska E., Gaitantzi H., Jesnowski R., et al. Transforming growth factor-beta induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway. Growth Factors 2009, 27:289-299.
34. Li X., Wang Z., Ma Q., Xu Q., Liu H., Duan W., et al. Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clin Cancer Res 2014, 20:4326-4338.
35. Mace T.A., Ameen Z., Collins A., Wojcik S., Mair M., Young G.S., et al. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res 2013, 73:3007-3018.
36. Ene-Obong A., Clear A.J., Watt J., Wang J., Fatah R., Riches J.C., et al. Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology 2013, 145:1121-1132.
37. Ma Y., Hwang R.F., Logsdon C.D., Ullrich S.E. Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Cancer Res 2013, 73:3927-3937.
38. Tang D., Yuan Z., Xue X., Lu Z., Zhang Y., Wang H., et al. High expression of galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer. Int J Cancer 2012, 130:2337-2348.
39. Masamune A., Satoh M., Hirabayashi J., Kasai K., Satoh K., Shimosegawa T. Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2006, 290:G729-G736.
40. Chen N., Unnikrishnan I.R., Anjana R.M., Mohan V., Pitchumoni C.S. The complex exocrine-endocrine relationship and secondary diabetes in exocrine pancreatic disorders. J Clin Gastroenterol 2011, 45:850-861.
41. Kikuta K., Masamune A., Hamada S., Takikawa T., Nakano E., Shimosegawa T. Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells. Biochem Biophys Res Commun 2013, 433:292-297.
42. Stromnes I.M., DelGiorno K.E., Greenberg P.D., Hingorani S.R. Stromal reengineering to treat pancreas cancer. Carcinogenesis 2014, 35:1451-1460.
43. Olive K.P., Jacobetz M.A., Davidson C.J., Gopinathan A., McIntyre D., Honess D., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009, 324:1457-1461.
44. Von Hoff D.D., Ramanathan R.K., Borad M.J., Laheru D.A., Smith L.S., Wood T.E., et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011, 29:4548-4554.
45. Froeling F.E., Feig C., Chelala C., Dobson R., Mein C.E., Tuveson D.A., et al. Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology 2011, 141:1486-1497.
46. Provenzano P.P., Cuevas C., Chang A.E., Goel V.K., Von Hoff D.D., Hingorani S.R. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012, 21:418-429.
47. Gonzalez-Villasana V., Rodriguez-Aguayo C., Arumugam T., Cruz-Monserrate Z., Fuentes-Mattei E., Deng D., et al. Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma. Mol Cancer Ther 2014, 13:2583-2594.
48. Sherman M.H., Yu R.T., Engle D.D., Ding N., Atkins A.R., Tiriac H., et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 2014, 159:80-93.
49. Ozdemir B.C., Pentcheva-Hoang T., Carstens J.L., Zheng X., Wu C.C., Simpson T.R., et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014, 25:719-734.
50. Rhim A.D., Oberstein P.E., Thomas D.H., Mirek E.T., Palermo C.F., Sastra S.A., et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014, 25:735-747.