Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

Arquivos Brasileiros de Oftalmologia

Volumn 78, Issue 2, 2015, Pages 100-104

  Arikan, Sedat ^a   Ersan, Ismail ^a   Karaca, Turan ^b   Kara, Selcuk ^a   Gencer, Baran ^a   Karaboga, Ihsan ^b   Tufan, Hasan Ali ^a  

^a ÇANAKKALE ONSEKIZ MART UNIVERSITY   (Turkey)

^b TRAKYA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Apoptosis; Disease models; Ischemia; Quercetin; Rats; Reperfusion injury; Retina drug effects

Indexed keywords

ANTIOXIDANT; CASPASE 3; DIMETHYL SULFOXIDE; QUERCETIN; SOLVENT;

ANIMAL; APOPTOSIS; CELL COUNT; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EVALUATION STUDY; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MALE; PATHOLOGY; REPERFUSION INJURY; REPRODUCIBILITY; RETINA; RETINAL DISEASES; TREATMENT OUTCOME; TUNEL ASSAY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL COUNT; DIMETHYL SULFOXIDE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTRAOCULAR PRESSURE; MALE; QUERCETIN; RATS, WISTAR; REPERFUSION INJURY; REPRODUCIBILITY OF RESULTS; RETINA; RETINAL DISEASES; SOLVENTS; TREATMENT OUTCOME;

EID: 84942693943     PISSN: 00042749     EISSN: 16782925     Source Type: Journal    
DOI: 10.5935/0004-2749.20150026     Document Type: Article

References (39)

1. Zimmerman BJ, Granger DN. Oxygen free radicals and the gastrointestinal tract: role in ischemia-reperfusion injury. Hepatogastroenterology 1994;41(1):337-42.
2. Bresnick GH. Excitotoxins: a possible new mechanism for the pathogenesis of ischemic retinal damage. Arch Ophthalmol.1989;107(3):339-41.
3. Qu J, Wang D, Grosskreutz CL. Mechanisms of retinal ganglion cell injury and defense in glaucoma. Exp Eye Res. 2010;91(1):48-53.
4. Ryan SJ (ed). Retina. 5th ed. Philadelphia (PA): Elsevier/Mosby; 2013. Vol. 1, p.537
5. Büchi ER. Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study. I. Ganglion cell layer and inner nuclear layer. Exp Eye Res. 1992;55(4):605-13.
6. Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol. 1996;114(4):488-91.
7. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res. 2004;23(1):91-147.
8. Chen WJ, Sun SF, Cao W, Liang Y, Song JR. Antioxidant property of quercetin-Cr(III) complex: The role of Cr(III) ion. J Mol Struct. 2009;918:194-7.
9. Chao CL, Hou YC, Chao PD, Weng CS, Ho FM. The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells. Br J Nutr. 2009;101(8):1165-70.
10. Chang HC, Yang YR, Wang PS, Wang RY. Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats. Med Sci Sports Exerc. 2014;46(10):1908-16.
11. Sekaran S, Kandaswamy S, Gunasekaran K, Perumal E, Afsar Basha FY, Madhan Mohan BJ, et al. Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. J Biochem Mol Toxicol. 2012;26(12):522-32.
12. Büchi ER, Suivaizdis I, Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica. 1991;203(3):138-47.
13. Woo TT, Li SY, Lai WW, Wong D, Lo AC. Neuroprotective effects of lutein in a rat model of retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2013;251(1):41-51.
14. Sayhan MB, Kanter M, Oguz S, Erboga M. Protective effect of Urtica dioica L. on renal ischemia/reperfusion injury in rat. J Mol Hist. 2012;43(6):691-8.
15. Rodriguez RJ, Miranda CL, Stevens JF, Deinzer ML, Buhler DR. Influence of phenylated and non-phenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes. Food Chem Toxicol. 2001;39(5):437-45.
16. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;13;585(2-3):325-37.
17. Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LF, Lemos-Senna E, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res. 2010;61(4):288-97.
18. Ghosh A, Sarkar S, Mandal AK, Das N. Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged rats. PLoS One 2013;19;8(4):e57735.
19. Chen YW, Chou HC, Lin ST, Chen YH, Chang YJ, Chen L, et al. Cardioprotective effects of quercetin in cardiomyocyte under ischemia/reperfusion injury. Evid Based Complement Alternat Med. 2013;2013:364519.
20. Maher P, Hanneken A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci. 2005;46(12):4796-803.
21. Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res. 2009;28(5):348-68.
22. Jarrett SG, Lin H, Godley BF, Boulton ME. Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res. 2008;27(6):596-607.
23. Meldrum B, Garthwaite J. Excitatory amino acids in neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci. 1990;11(9):379-87.
24. Osborne NN, Ugarte M, Chao M, Childlow G, Wood JP, et al. Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv Ophthalmol. 1999;43 Suppl 1:S102-28.
25. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 2002;13(10):572-84.
26. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001;30(4):433-46.
27. Nakayama M, Aihara M, Chen YN, Araie M, Tomita-Yokotani K, Iwashina T. Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death. Mol Vis. 2011;17:1784-93.
28. Kook D, Wolf AH, Yu AL, Neubauer AS, Priglinger SG, Kampik A, et al. The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci. 2008;49(4):1712-20.
29. Wang Y, Zhang ZZ, Wu Y, Ke JJ, He XH, Wang YL. Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway. Braz J Med Biol Res. 2013;46(10):861-7.
30. Hughes WF. Quantation of ischemic damage in the rat retina. Exp Eye Res. 1991;53(5): 573-82.
31. Zhao Y, Niu YJ, Zhou ZY, Gao YX, Wang HY. Expression of Fas/Fas L and the apoptosis in rat ischemia/reperfusion-induced retinal injury and effects of bFGF. Int J Opthalmol. 2008;1:226-9.
32. Zheng GY, Zhang C, Li ZG. Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice. Chin Med J (Engl). 2004;117(5):717-21.
33. Ju WK, Kim KY, Hofmann HD, Kim IB, Lee MY, Oh SJ, et al. Selective neuronal survival and upregulation of PCNA in the rat inner retina following transient ischemia. J Neuropathol Exp Neurol. 2000;59(3):241-50.
34. Massey SC. Cell types using glutamate as a neurotransmitter in the vertebrate retina. In: Osborne NN, Chader GJ, editors. Progress in retinal research, Oxford: Pergamon Press;
35. Brandstätter JH, Koulen P, Wässle H. Diversity of glutamate receptors in the mammalian retina. Vision Res. 1998;38(10):1385-97.
36. Kim IB, Kim KY, Joo CK, Lee MY, Oh SJ, Chung JW, et al. Reaction of Müller cells after increased intraocular pressure in the rat retina. Exp Brain Res. 1998;121(4):419-24.
37. Abu-El-Asrar AM, Dralands L, Missotten L, Al-Jadaan IA, Geboes K. Expression of apoptosis markers in the retinas of human subjects with diabetes. Invest Ophthalmol Vis Sci. 2004;45(8):2760-6.
38. Mansoorali KP, Prakash T, Kotresha D, Prabhu K, Rama Rao N. Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats. Phytomedicine 2012;15;19(12):1108-16.
39. Kumar B, Gupta SK, Nag TC, Srivastava S, Saxena R, Jha KA, et al. Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats. Exp Eye Res. 2014;125:193-202.