Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway

Brazilian Journal of Medical and Biological Research

Volumn 46, Issue 10, 2013, Pages 861-867

  Wang, Y ^a   Zhang, Z Z ^a   Wu, Y ^a   Ke, J J ^a   He, X H ^a   Wang, Y L ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Ischemia and reperfusion; PI3K Akt; Postconditioning; Quercetin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CREATINE KINASE; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; ISCHEMIC POSTCONDITIONING; MALE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; MYOCARDIAL REPERFUSION INJURY; PHYSIOLOGY; RANDOMIZATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUNEL ASSAY;

RATTUS;

ANIMALS; APOPTOSIS; IN SITU NICK-END LABELING; MALE; MYOCARDIAL REPERFUSION INJURY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84886933048     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20133036     Document Type: Article

References (40)

1. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. NEngl J Med 2007; 357: 1121-1135, doi: 10.1056/NEJMra071667.
2. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 2013; 123: 92-100, doi: 10.1172/JCI62874.
3. Penna C, Mancardi D, Raimondo S, Geuna S, Pagliaro P. The paradigm of postconditioning to protect the heart. J Cell Mol Med 2008; 12: 435-458, doi: 10.1111/j.1582-4934.2007. 00210.x.
4. Tamareille S, Ghaboura N, Treguer F, Khachman D, Croue A, Henrion D, et al. Myocardial reperfusion injury management: erythropoietin compared with postconditioning. Am J Physiol Heart Circ Physiol 2009; 297: H2035-H2043, doi: 10.1152/ajpheart.00472.2009.
5. Ke JJ, Yu FX, Rao Y, Wang YL. Adenosine postconditioning protects against myocardial ischemia-reperfusion injury though modulate production of TNF-alpha and prevents activation of transcription factor NF-kappaB. Mol Biol Rep 2011; 38: 531-538, doi: 10.1007/s11033-010-0137-8.
6. Ji Y, Pang QF, Xu G, Wang L, Wang JK, Zeng YM. Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury. Eur J Pharmacol 2008; 587: 1-7, doi: 10.1016/j.ejphar. 2008.03.044.
7. Smith AJ, Kavuru P, Wojtas L, Zaworotko MJ, Shytle RD. Cocrystals of quercetin with improved solubility and oral bioavailability. Mol Pharm 2011; 8: 1867-1876, doi: 10.1021/ mp200209j.
8. Staedler D, Idrizi E, Kenzaoui BH, Juillerat-Jeanneret L. Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Cancer Chemother Pharmacol 2011; 68: 1161-1172, doi: 10.1007/s00280-011-1596-x.
9. Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z, et al. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clin Cancer Res 2010; 16: 5679-5691, doi: 10.1158/1078-0432.CCR-10-1565.
10. Noori-Daloii MR, Momeny M, Yousefi M, Shirazi FG, Yaseri M, Motamed N, et al. Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol 2011; 28: 1395-1404, doi: 10.1007/s12032-010-9603-3.
11. Dodson HC, Lyda TA, Chambers JW, MorrisMT, Christensen KA, Morris JC. Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1. Exp Parasitol 2011; 127: 423-428, doi: 10.1016/j.exppara.2010.10.011.
12. Jin HB, Yang YB, Song YL, Zhang YC, Li YR. Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats. Mol Biol Rep 2012; 39: 11005-11009, doi: 10.1007/s11033-012-2002-4.
13. Wan LL, Xia J, Ye D, Liu J, Chen J, Wang G. Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. Cardiovasc Ther 2009; 27: 28-33, doi: 10.1111/j.1755-5922. 2009.00071.x.
14. Bartekova M, Carnicka S, Pancza D, Ondrejcakova M, Breier A, Ravingerova T. Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia. Can J Physiol Pharmacol 2010; 88: 465-471, doi: 10.1139/Y10-025.
15. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657, doi: 10.1126/science.296. 5573.1655.
16. Xu X, Cao Z, Cao B, Li J, Guo L, Que L, et al. Carbamylated erythropoietin protects the myocardium from acute ischemia/ reperfusion injury through a PI3K/Akt-dependent mechanism. Surgery 2009; 146: 506-514, doi: 10.1016/ j.surg.2009.03.022.
17. Wu QL, Shen T, Ma H, Wang JK. Sufentanil postconditioning protects the myocardium from ischemia-reperfusion via PI3K/Akt-GSK-3beta pathway. J Surg Res 2012; 178: 563-570, doi: 10.1016/j.jss.2012.05.081.
18. Yao RQ, Qi DS, Yu HL, Liu J, Yang LH, Wu XX. Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res 2012; 37: 2777-2786, doi: 10.1007/s11064-012-0871-5.
19. Annapurna A, Reddy CS, Akondi RB, Rao SR. Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 2009; 61: 1365-1374, doi: 10.1211/ jpp.61.10.0014.
20. Zhang JY, Chen ZW, Yao H. Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphatidylinositol 39-kinase-Akt pathway. Can J Physiol Pharmacol 2012; 90: 637-645, doi: 10.1139/y2012-048.
21. Ha T, Hua F, Liu X, Ma J, McMullen JR, Shioi T, et al. Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/ Akt-dependent mechanism. Cardiovasc Res 2008; 78: 546-553, doi: 10.1093/cvr/cvn037.
22. Zhang S, Li H, Yang SJ. Tribulosin protects rat hearts from ischemia/reperfusion injury. Acta Pharmacol Sin 2010; 31: 671-678, doi: 10.1038/aps.2010.45.
23. Perez-Vizcaino F, Duarte J. Flavonols and cardiovascular disease. Mol Aspects Med 2010; 31: 478-494, doi: 10.1016/ j.mam.2010.09.002.
24. Punithavathi VR, Prince PS. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci 2010; 86: 178-184, doi: 10.1016/ j.lfs.2009.11.021.
25. Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. Mitochondrial function in response to cardiac ischemiareperfusion after oral treatment with quercetin. Free Radic Biol Med 2002; 32: 1220-1228, doi: 10.1016/S0891-5849(02)00839-0.
26. Punithavathi VR, Stanely Mainzen Prince P. The cardioprotective effects of a combination of quercetin and alphatocopherol on isoproterenol-induced myocardial infarcted rats. J Biochem Mol Toxicol 2011; 25: 28-40, doi: 10.1002/ jbt.20357.
27. Punithavathi VR, Prince PS. Combined effects of quercetin and alpha-tocopherol on lipids and glycoprotein components in isoproterenol induced myocardial infarcted Wistar rats. Chem Biol Interact 2009; 181: 322-327, doi: 10.1016/ j.cbi.2009.07.002.
28. Song JQ, Teng X, Cai Y, Tang CS, Qi YF. Activation of Akt/ GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis 2009; 14: 1061-1069, doi: 10.1007/s10495-009-0382-2.
29. Sun H, Guo T, Liu L, Yu Z, Xu W, Chen W, et al. Ischemic postconditioning inhibits apoptosis after acute myocardial infarction in pigs. Heart Surg Forum 2010; 13: E305-E310, doi: 10.1532/HSF98.20101013.
30. Valen G. The basic biology of apoptosis and its implications for cardiac function and viability. Ann Thorac Surg 2003; 75: S656-S660, doi: 10.1016/S0003-4975(02)04687-8.
31. Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, Ronson RS, et al. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res 2000; 45: 651-660, doi: 10.1016/ S0008-6363(99)00354-5.
32. Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, et al. Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol 2003; 66: 1287-1295, doi: 10.1016/S0006-2952(03)00478-7.
33. Jeong JJ, Ha YM, Jin YC, Lee EJ, Kim JS, Kim HJ, et al. Rutin from Lonicera japonica inhibits myocardial ischemia/ reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Food Chem Toxicol 2009; 47: 1569-1576, doi: 10.1016/j.fct.2009.03.044.
34. Luan HF, Zhao ZB, Zhao QH, Zhu P, Xiu MY, Ji Y. Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway. Braz J Med Biol Res 2012; 45: 898-905.
35. Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, et al. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med 2005; 201: 1217-1228, doi: 10.1084/jem.20040995.
36. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 2004; 95: 230-232, doi: 10.1161/01.RES.0000138303.76488.fe.
37. Ren Y, Cai Y, Jia D. Comparative antiapoptotic effects of KB-R7943 and ischemic postconditioning during myocardial ischemia reperfusion. Cell Biochem Biophys 2012; 64: 137-145, doi: 10.1007/s12013-012-9382-x.
38. Uchiyama T, Engelman RM, Maulik N, Das DK. Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation 2004; 109: 3042-3049, doi: 10.1161/01.CIR.0000130647.29030.90.
39. Guo JY, Yang T, Sun XG, Zhou NY, Li FS, Long D, et al. Ischemic postconditioning attenuates liver warm ischemiareperfusion injury through Akt-eNOS-NO-HIF pathway. J Biomed Sci 2011; 18: 79, doi: 10.1186/1423-0127-18-79.
40. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 2008; 88: 581-609, doi: 10.1152/physrev.00024.2007.