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Volumn 125, Issue , 2014, Pages 193-202

Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Author keywords

Apoptosis; Aquaporin 4; Bioflavonoid; GFAP; Neuroinflammation; Quercetin

Indexed keywords

AQUAPORIN 4; CASPASE 3; CATALASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; QUERCETIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84903848890     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.06.009     Document Type: Article
Times cited : (153)

References (64)
  • 1
    • 1942473768 scopus 로고    scopus 로고
    • Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats
    • Anjaneyulu M., Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin. Exp. Pharmacol. Physiol. 2004, 31:244-248.
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 244-248
    • Anjaneyulu, M.1    Chopra, K.2
  • 2
    • 0033771018 scopus 로고    scopus 로고
    • Altered expression of retinal occludin and glial fi{ligature}brillary acidic protein in experimental diabetes
    • Barber A.J., Antonetti D.A., Gardner T.W. Altered expression of retinal occludin and glial fi{ligature}brillary acidic protein in experimental diabetes. Invest. Ophthalmol.Vis. Sci. 2000, 41:3561-3568.
    • (2000) Invest. Ophthalmol.Vis. Sci. , vol.41 , pp. 3561-3568
    • Barber, A.J.1    Antonetti, D.A.2    Gardner, T.W.3
  • 3
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin
    • Barber A.J., Lieth E., Khin S.A., Antonetti D.A., Buchanan A.G., Gardner T.W. Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J.Clin. Invest. 1998, 102:783-791.
    • (1998) J.Clin. Invest. , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 4
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: a new perspective on an old paradigm
    • Baynes J.W., Thorpe S.R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 1999, 48:1-9.
    • (1999) Diabetes , vol.48 , pp. 1-9
    • Baynes, J.W.1    Thorpe, S.R.2
  • 7
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 8
    • 77649250409 scopus 로고    scopus 로고
    • Early detection of retinal thickness changes in diabetes using optical coherence tomography
    • Cabrera DeBuc D., Somfai G.M. Early detection of retinal thickness changes in diabetes using optical coherence tomography. Med. Sci. Monit. 2010, 16:MT15-21.
    • (2010) Med. Sci. Monit. , vol.16
    • Cabrera DeBuc, D.1    Somfai, G.M.2
  • 9
    • 77953356981 scopus 로고    scopus 로고
    • The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
    • Cao X., Liu M., Tuo J., Shen D., Chan C.C. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp. Eye Res. 2010, 91:15-25.
    • (2010) Exp. Eye Res. , vol.91 , pp. 15-25
    • Cao, X.1    Liu, M.2    Tuo, J.3    Shen, D.4    Chan, C.C.5
  • 10
    • 0032796794 scopus 로고    scopus 로고
    • L-arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1 beta and NO synthase activity
    • Carmo A., Cunha-Vaz J.G., Carvalho A.P., Lopes M.C. L-arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1 beta and NO synthase activity. Vision Res. 1999, 39:3817-3823.
    • (1999) Vision Res. , vol.39 , pp. 3817-3823
    • Carmo, A.1    Cunha-Vaz, J.G.2    Carvalho, A.P.3    Lopes, M.C.4
  • 13
    • 16244408972 scopus 로고    scopus 로고
    • (-) Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis
    • Choi Y.J., Jeong Y.J., Lee Y.J., Kwon H.M., Kang Y.H. (-) Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis. J.Nutr. 2005, 135:707-713.
    • (2005) J.Nutr. , vol.135 , pp. 707-713
    • Choi, Y.J.1    Jeong, Y.J.2    Lee, Y.J.3    Kwon, H.M.4    Kang, Y.H.5
  • 14
    • 0036628730 scopus 로고    scopus 로고
    • Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract
    • Cornish K.M., Williamson G., Sanderson J. Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free Radic. Biol. Med. 2002, 33:63-70.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 63-70
    • Cornish, K.M.1    Williamson, G.2    Sanderson, J.3
  • 15
    • 9444274146 scopus 로고    scopus 로고
    • Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia
    • Da T., Verkman A.S. Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Invest. Ophthalmol. Vis. Sci. 2004, 45:4477-4483.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 4477-4483
    • Da, T.1    Verkman, A.S.2
  • 16
    • 0027370108 scopus 로고
    • The effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus
    • DCCT Research Group
    • The effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus. N.Engl. J. Med. 1993, 329:977-986. DCCT Research Group.
    • (1993) N.Engl. J. Med. , vol.329 , pp. 977-986
  • 17
    • 33845546564 scopus 로고    scopus 로고
    • Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
    • Demircan N., Safran B.G., Soylu M., Ozcan A.A., Sizmaz S. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye (Lond) 2006, 20:1366-1369.
    • (2006) Eye (Lond) , vol.20 , pp. 1366-1369
    • Demircan, N.1    Safran, B.G.2    Soylu, M.3    Ozcan, A.A.4    Sizmaz, S.5
  • 18
    • 58149252632 scopus 로고    scopus 로고
    • Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trial
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trial. Arch. Ophthalmol. 2008, 126:1707-1715. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group.
    • (2008) Arch. Ophthalmol. , vol.126 , pp. 1707-1715
  • 19
    • 0034626921 scopus 로고    scopus 로고
    • VEGF release by retinal glia depends on both oxygen and glucose supply
    • Eichler W., Kuhrt H., Hoffmann S., Wiedemann P., Reichenbach A. VEGF release by retinal glia depends on both oxygen and glucose supply. Neuroreport 2000, 11:3533-3537.
    • (2000) Neuroreport , vol.11 , pp. 3533-3537
    • Eichler, W.1    Kuhrt, H.2    Hoffmann, S.3    Wiedemann, P.4    Reichenbach, A.5
  • 22
    • 29744458225 scopus 로고    scopus 로고
    • Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide
    • Gitika B., Sai Ram M., Sharma S.K., Ilavazhagan G., Banerjee P.K. Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide. Free Radic. Res. 2006, 40:95-102.
    • (2006) Free Radic. Res. , vol.40 , pp. 95-102
    • Gitika, B.1    Sai Ram, M.2    Sharma, S.K.3    Ilavazhagan, G.4    Banerjee, P.K.5
  • 23
    • 79955008744 scopus 로고    scopus 로고
    • Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms
    • Gupta S.K., Kumar B., Nag T.C., Agrawal S.S., Agrawal R., Agrawal P., Saxena R., Srivastava S. Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J.Ocul. Pharmacol. Ther. 2011, 27:123-130.
    • (2011) J.Ocul. Pharmacol. Ther. , vol.27 , pp. 123-130
    • Gupta, S.K.1    Kumar, B.2    Nag, T.C.3    Agrawal, S.S.4    Agrawal, R.5    Agrawal, P.6    Saxena, R.7    Srivastava, S.8
  • 24
    • 84880552383 scopus 로고    scopus 로고
    • Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats
    • Gupta S.K., Kumar B., Srinivasan B.P., Nag T.C., Srivastava S., Saxena R., Aggarwal A. Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats. J.Ocul. Pharmacol.Ther. 2013, 29:419-426.
    • (2013) J.Ocul. Pharmacol.Ther. , vol.29 , pp. 419-426
    • Gupta, S.K.1    Kumar, B.2    Srinivasan, B.P.3    Nag, T.C.4    Srivastava, S.5    Saxena, R.6    Aggarwal, A.7
  • 25
    • 84893825339 scopus 로고    scopus 로고
    • Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats
    • Gupta S.K., Kumar B., Nag T.C., Srinivasan B.P., Srivastava S., Gaur S., Saxena R. Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats. Mol. Cell. Biochem. 2014, 388:1-9.
    • (2014) Mol. Cell. Biochem. , vol.388 , pp. 1-9
    • Gupta, S.K.1    Kumar, B.2    Nag, T.C.3    Srinivasan, B.P.4    Srivastava, S.5    Gaur, S.6    Saxena, R.7
  • 26
    • 84865580448 scopus 로고    scopus 로고
    • Neuroprotection in diabetic retinopathy
    • Hernández C., Simó R. Neuroprotection in diabetic retinopathy. Curr. Diabetes Rep. 2012, 12:329-337.
    • (2012) Curr. Diabetes Rep. , vol.12 , pp. 329-337
    • Hernández, C.1    Simó, R.2
  • 27
    • 79955943133 scopus 로고    scopus 로고
    • TNF alpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis
    • Huang H., Gandhi J.K., Zhong X., Wei Y., Gong J., Duh E.J., Vinores S.A. TNF alpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest. Ophthalmol. Vis. Sci. 2011, 52:1336-1344.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 1336-1344
    • Huang, H.1    Gandhi, J.K.2    Zhong, X.3    Wei, Y.4    Gong, J.5    Duh, E.J.6    Vinores, S.A.7
  • 28
    • 0033861887 scopus 로고    scopus 로고
    • Anti-apoptotic effect of quercetin: intervention in the JNK-and ERK-mediated apoptotic pathways
    • Ishikawa Y., Kitamura M. Anti-apoptotic effect of quercetin: intervention in the JNK-and ERK-mediated apoptotic pathways. Kidney Int. 2000, 58:1078-1087.
    • (2000) Kidney Int. , vol.58 , pp. 1078-1087
    • Ishikawa, Y.1    Kitamura, M.2
  • 29
  • 30
    • 76849090223 scopus 로고    scopus 로고
    • Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia
    • Kao T.K., Ou Y.C., Raung S.L., Lai C.Y., Liao S.L., Chen C.J. Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life Sci. 2010, 86:315-321.
    • (2010) Life Sci. , vol.86 , pp. 315-321
    • Kao, T.K.1    Ou, Y.C.2    Raung, S.L.3    Lai, C.Y.4    Liao, S.L.5    Chen, C.J.6
  • 31
    • 33746727000 scopus 로고    scopus 로고
    • Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy
    • Kizawa J., Machida S., Kobayashi T., Gotoh Y., Kurosaka D. Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathy. Jpn. J. Ophthalmol. 2006, 50:367-373.
    • (2006) Jpn. J. Ophthalmol. , vol.50 , pp. 367-373
    • Kizawa, J.1    Machida, S.2    Kobayashi, T.3    Gotoh, Y.4    Kurosaka, D.5
  • 32
    • 12944302088 scopus 로고    scopus 로고
    • Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kappaB) in the retina
    • Kowluru R.A., Chakrabarti S., Chen S. Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kappaB) in the retina. Acta Diabetol. 2004, 41:194-199.
    • (2004) Acta Diabetol. , vol.41 , pp. 194-199
    • Kowluru, R.A.1    Chakrabarti, S.2    Chen, S.3
  • 33
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru R.A., Chan P.S. Oxidative stress and diabetic retinopathy. Exp. Diabetes. Res. 2007, 2007:43603.
    • (2007) Exp. Diabetes. Res. , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 34
    • 0036023314 scopus 로고    scopus 로고
    • Diabetes-induced activation of Caspase-3 in retina: effect of antioxidant therapy
    • Kowluru R.A., Koppolu P. Diabetes-induced activation of Caspase-3 in retina: effect of antioxidant therapy. Free Radic. Res. 2002, 36:993-999.
    • (2002) Free Radic. Res. , vol.36 , pp. 993-999
    • Kowluru, R.A.1    Koppolu, P.2
  • 35
    • 4744347272 scopus 로고    scopus 로고
    • Role of interleukin-1beta in the pathogenesis of diabetic retinopathy
    • Kowluru R.A., Odenbach S. Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. Br. J. Ophthalmol. 2004, 88:1343-1347.
    • (2004) Br. J. Ophthalmol. , vol.88 , pp. 1343-1347
    • Kowluru, R.A.1    Odenbach, S.2
  • 36
    • 77951224619 scopus 로고    scopus 로고
    • Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes
    • Kowluru R.A., Zhong Q., Kanwar M. Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes. Exp. Eye Res. 2010, 90:617-623.
    • (2010) Exp. Eye Res. , vol.90 , pp. 617-623
    • Kowluru, R.A.1    Zhong, Q.2    Kanwar, M.3
  • 37
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady J.K., Basu A., Allen C.M., Xu Y., LaNoue K.F., Gardner T.W., Levison S.W. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005, 54:1559-1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3    Xu, Y.4    LaNoue, K.F.5    Gardner, T.W.6    Levison, S.W.7
  • 38
    • 80053901365 scopus 로고    scopus 로고
    • Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats
    • Kumar B., Gupta S.K., Nag T.C., Srivastava S., Saxena R. Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats. Ophthalmic Res. 2012, 47:103-108.
    • (2012) Ophthalmic Res. , vol.47 , pp. 103-108
    • Kumar, B.1    Gupta, S.K.2    Nag, T.C.3    Srivastava, S.4    Saxena, R.5
  • 41
    • 84878417151 scopus 로고    scopus 로고
    • Quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside inhibits TNF-α-activated NF-κB-induced inflammatory mediator production by suppressing ERK activation
    • Lee C.S., Jeong E.B., Kim Y.J., Lee M.S., Seo S.J., Park K.H., Lee M.W. Quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside inhibits TNF-α-activated NF-κB-induced inflammatory mediator production by suppressing ERK activation. Int. Immunopharmacol. 2013, 16:481-487.
    • (2013) Int. Immunopharmacol. , vol.16 , pp. 481-487
    • Lee, C.S.1    Jeong, E.B.2    Kim, Y.J.3    Lee, M.S.4    Seo, S.J.5    Park, K.H.6    Lee, M.W.7
  • 42
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy
    • Lieth E., Barber A., Xu B., Dice C., Ratz M.J., Tanase D., Strother J.M. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Diabetes 1998, 47:815-820.
    • (1998) Diabetes , vol.47 , pp. 815-820
    • Lieth, E.1    Barber, A.2    Xu, B.3    Dice, C.4    Ratz, M.J.5    Tanase, D.6    Strother, J.M.7
  • 44
    • 0033566784 scopus 로고    scopus 로고
    • Active role of glutamate uptake in the synaptic transmission from retinal nonspiking neurons
    • Matsui K., Hosoi N., Tachibana M. Active role of glutamate uptake in the synaptic transmission from retinal nonspiking neurons. J.Neurosci. 1999, 19:6755-6766.
    • (1999) J.Neurosci. , vol.19 , pp. 6755-6766
    • Matsui, K.1    Hosoi, N.2    Tachibana, M.3
  • 45
    • 0031594369 scopus 로고    scopus 로고
    • Müller cell changes in human diabetic retinopathy
    • Mizutani M., Gerhardinger C., Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes 1998, 47:445-449.
    • (1998) Diabetes , vol.47 , pp. 445-449
    • Mizutani, M.1    Gerhardinger, C.2    Lorenzi, M.3
  • 46
    • 0036224782 scopus 로고    scopus 로고
    • Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients
    • Mohr S., Xi X., Tang J., Kern T.S. Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes 2002, 51:1172-1179.
    • (2002) Diabetes , vol.51 , pp. 1172-1179
    • Mohr, S.1    Xi, X.2    Tang, J.3    Kern, T.S.4
  • 47
    • 0037459043 scopus 로고    scopus 로고
    • Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9
    • Moon S.K., Cho G.O., Jung S.Y., Gal S.W., Kwon T.K., Lee Y.C., Madamanchi N.R., Kim C.H. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem. Biophys. Res. Commun. 2003, 301:1069-1078.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 1069-1078
    • Moon, S.K.1    Cho, G.O.2    Jung, S.Y.3    Gal, S.W.4    Kwon, T.K.5    Lee, Y.C.6    Madamanchi, N.R.7    Kim, C.H.8
  • 48
    • 0033104066 scopus 로고    scopus 로고
    • Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains
    • Nagelhus E.A., Horio Y., Inanobe A., Fujita A., Haug F.M., Nielsen S., Kurachi Y., Ottersen O.P. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 1999, 26:47-54.
    • (1999) Glia , vol.26 , pp. 47-54
    • Nagelhus, E.A.1    Horio, Y.2    Inanobe, A.3    Fujita, A.4    Haug, F.M.5    Nielsen, S.6    Kurachi, Y.7    Ottersen, O.P.8
  • 49
    • 0032053965 scopus 로고    scopus 로고
    • Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes
    • Nagelhus E.A., Veruki M.L., Torp R., Haug F.M., Laake J.H., Nielsen S., Ottersen O.P. Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes. J.Neurosci. 1998, 18:2506-2519.
    • (1998) J.Neurosci. , vol.18 , pp. 2506-2519
    • Nagelhus, E.A.1    Veruki, M.L.2    Torp, R.3    Haug, F.M.4    Laake, J.H.5    Nielsen, S.6    Ottersen, O.P.7
  • 50
    • 79960730016 scopus 로고    scopus 로고
    • Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death
    • Nakayama M., Aihara M., Chen Y.N., Araie M., Tomita-Yokotani K., Iwashina T. Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death. Mol. Vis. 2011, 17:1784-1793.
    • (2011) Mol. Vis. , vol.17 , pp. 1784-1793
    • Nakayama, M.1    Aihara, M.2    Chen, Y.N.3    Araie, M.4    Tomita-Yokotani, K.5    Iwashina, T.6
  • 51
    • 0030032832 scopus 로고    scopus 로고
    • Acid effl{ligature}ux from retinal glial cells generated by sodium bicarbonate cotransport
    • Newman E.A. Acid effl{ligature}ux from retinal glial cells generated by sodium bicarbonate cotransport. J.Neurosci. 1996, 16:159-168.
    • (1996) J.Neurosci. , vol.16 , pp. 159-168
    • Newman, E.A.1
  • 52
    • 0030201340 scopus 로고    scopus 로고
    • The Müller cell: a functional element of the retina
    • Newman E.A., Reichenbach A. The Müller cell: a functional element of the retina. Trends Neurosci. 1996, 19:307-317.
    • (1996) Trends Neurosci. , vol.19 , pp. 307-317
    • Newman, E.A.1    Reichenbach, A.2
  • 54
    • 0141594635 scopus 로고    scopus 로고
    • Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina
    • Park S.H., Park J.W., Park S.J., Kim K.Y., Chung J.W., Chun M.H., Oh S.J. Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia 2003, 46:1260-1268.
    • (2003) Diabetologia , vol.46 , pp. 1260-1268
    • Park, S.H.1    Park, J.W.2    Park, S.J.3    Kim, K.Y.4    Chung, J.W.5    Chun, M.H.6    Oh, S.J.7
  • 55
    • 34248146559 scopus 로고    scopus 로고
    • Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection
    • Sharma V., Mishra M., Ghosh S., Tewari R., Basu A., Seth P., Sen E. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain Res. Bull. 2007, 73:55-63.
    • (2007) Brain Res. Bull. , vol.73 , pp. 55-63
    • Sharma, V.1    Mishra, M.2    Ghosh, S.3    Tewari, R.4    Basu, A.5    Seth, P.6    Sen, E.7
  • 56
    • 84867094327 scopus 로고    scopus 로고
    • European consortium for the early treatment of diabetic retinopathy (EUROCONDOR).Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications
    • Simó R., Hernández C. European consortium for the early treatment of diabetic retinopathy (EUROCONDOR).Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications. Br. J. Ophthalmol. 2012, 96:1285-1290.
    • (2012) Br. J. Ophthalmol. , vol.96 , pp. 1285-1290
    • Simó, R.1    Hernández, C.2
  • 57
    • 38349008651 scopus 로고    scopus 로고
    • The interactions of flavonoids within neuronal signalling pathways
    • Spencer J.P. The interactions of flavonoids within neuronal signalling pathways. Genes. Nutr. 2007, 2:257-273.
    • (2007) Genes. Nutr. , vol.2 , pp. 257-273
    • Spencer, J.P.1
  • 58
    • 84883231913 scopus 로고    scopus 로고
    • Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications
    • Stem M.S., Gardner T.W. Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. Curr. Med. Chem. 2013, 20:3241-3250.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 3241-3250
    • Stem, M.S.1    Gardner, T.W.2
  • 59
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352:837-853. UK Prospective Diabetes Study (UKPDS) Group.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 63
    • 84855389514 scopus 로고    scopus 로고
    • Diabetic retinopathy and damage to mitochondrial structure and transport machinery
    • Zhong Q., Kowluru R.A. Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Invest. Ophthalmol. Vis. Sci. 2011, 52:8739-8746.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 8739-8746
    • Zhong, Q.1    Kowluru, R.A.2
  • 64
    • 84874721465 scopus 로고    scopus 로고
    • Effect of Quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD)
    • Zhuang P., Shen Y., Lin B.Q., Zhang W.Y., Chiou G.C. Effect of Quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD). Yan KeXueBao 2011, 26:23-29.
    • (2011) Yan KeXueBao , vol.26 , pp. 23-29
    • Zhuang, P.1    Shen, Y.2    Lin, B.Q.3    Zhang, W.Y.4    Chiou, G.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.