메뉴 건너뛰기




Volumn 46, Issue 10, 2014, Pages 1908-1916

Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats

Author keywords

Antiapoptotic signaling; Brain ischemia; Exercise; Motor function; Oxidative stress defense; Quercetin

Indexed keywords

ANTIOXIDANT; NEUROPROTECTIVE AGENT; QUERCETIN;

EID: 84914683088     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000310     Document Type: Article
Times cited : (41)

References (43)
  • 1
    • 79961210488 scopus 로고    scopus 로고
    • Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion
    • Ahmad A, Khan MM, Hoda MN, et al. Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion. Neurochem Res. 2011; 36(8):1360-71.
    • (2011) Neurochem Res. , vol.36 , Issue.8 , pp. 1360-1371
    • Ahmad, A.1    Khan, M.M.2    Hoda, M.N.3
  • 2
    • 84859393557 scopus 로고    scopus 로고
    • Neuroprotective agents in brain injury: A partial failure?
    • Barreto GE, Gonzalez J, Capani F, Morales L. Neuroprotective agents in brain injury: a partial failure? Int J Neurosci. 2012;122(5):223-6.
    • (2012) Int J Neurosci. , vol.122 , Issue.5 , pp. 223-226
    • Barreto, G.E.1    Gonzalez, J.2    Capani, F.3    Morales, L.4
  • 3
    • 77957974182 scopus 로고    scopus 로고
    • Targets for neural repair therapies after stroke
    • Carmichael ST. Targets for neural repair therapies after stroke. Stroke. 2010;41(10 Suppl):S124-6.
    • (2010) Stroke , vol.41 , Issue.10 , pp. S124-S126
    • Carmichael, S.T.1
  • 4
    • 81355138837 scopus 로고    scopus 로고
    • Insulinlike growth factor 1 signaling for brain recovery and exercise ability in brain ischemic rats
    • Chang HC, Yang YR, Wang PS, Kuo CH, Wang RY. Insulinlike growth factor 1 signaling for brain recovery and exercise ability in brain ischemic rats. Med Sci Sports Exerc. 2011;43(12): 2274-80.
    • (2011) Med Sci Sports Exerc. , vol.43 , Issue.12 , pp. 2274-2280
    • Chang, H.C.1    Yang, Y.R.2    Wang, P.S.3    Kuo, C.H.4    Wang, R.Y.5
  • 5
    • 70349782113 scopus 로고    scopus 로고
    • Effects of treadmill training on motor performance and extracellular glutamate level in striatum in rats with or without transient middle cerebral artery occlusion
    • Chang HC, Yang YR, Wang SG, Wang RY. Effects of treadmill training on motor performance and extracellular glutamate level in striatum in rats with or without transient middle cerebral artery occlusion. Behav Brain Res. 2009;205(2):450-5.
    • (2009) Behav Brain Res. , vol.205 , Issue.2 , pp. 450-455
    • Chang, H.C.1    Yang, Y.R.2    Wang, S.G.3    Wang, R.Y.4
  • 6
    • 0022545394 scopus 로고
    • A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction
    • Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke. 1986;17(4):738-43.
    • (1986) Stroke , vol.17 , Issue.4 , pp. 738-743
    • Chen, S.T.1    Hsu, C.Y.2    Hogan, E.L.3    Maricq, H.4    Balentine, J.D.5
  • 8
    • 0346099205 scopus 로고    scopus 로고
    • Motor balance and coordination training enhances functional outcome in rat with transient middle cerebral artery occlusion
    • Ding Y, Li J, Lai Q, et al. Motor balance and coordination training enhances functional outcome in rat with transient middle cerebral artery occlusion. Neuroscience. 2004;123(3):667-74.
    • (2004) Neuroscience , vol.123 , Issue.3 , pp. 667-674
    • Ding, Y.1    Li, J.2    Lai, Q.3
  • 9
    • 12244283706 scopus 로고    scopus 로고
    • Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. Saboten
    • Dok-Go H, Lee KH, Kim HJ, et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003;965(1-2):130-6.
    • (2003) Brain Res. , vol.965 , Issue.1-2 , pp. 130-136
    • Dok-Go, H.1    Lee, K.H.2    Kim, H.J.3
  • 10
    • 77954577365 scopus 로고    scopus 로고
    • Flavonoid transport across RBE4 cells: A blood-brain barrier model
    • Faria A, Pestana D, Teixeira D, et al. Flavonoid transport across RBE4 cells: a blood-brain barrier model. Cell Mol Biol Lett. 2010;15(2):234-41.
    • (2010) Cell Mol Biol Lett. , vol.15 , Issue.2 , pp. 234-241
    • Faria, A.1    Pestana, D.2    Teixeira, D.3
  • 11
    • 84867864631 scopus 로고    scopus 로고
    • Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
    • Galindo P, Gonzalez-Manzano S, Zarzuelo MJ, et al. Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats. Food Funct. 2012;3(6):643-50.
    • (2012) Food Funct. , vol.3 , Issue.6 , pp. 643-650
    • Galindo, P.1    Gonzalez-Manzano, S.2    Zarzuelo, M.J.3
  • 12
    • 38149131289 scopus 로고    scopus 로고
    • Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    • Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008;87(1):142-9.
    • (2008) Am J Clin Nutr. , vol.87 , Issue.1 , pp. 142-149
    • Gomez-Cabrera, M.C.1    Domenech, E.2    Romagnoli, M.3
  • 13
    • 36148992160 scopus 로고    scopus 로고
    • Hormetic effects of regular exercise in aging: Correlation with oxidative stress
    • Goto S, Naito H, Kaneko T, Chung HY, Radak Z. Hormetic effects of regular exercise in aging: correlation with oxidative stress. Appl Physiol Nutr Metab. 2007;32(5):948-53.
    • (2007) Appl Physiol Nutr Metab. , vol.32 , Issue.5 , pp. 948-953
    • Goto, S.1    Naito, H.2    Kaneko, T.3    Chung, H.Y.4    Radak, Z.5
  • 14
    • 1942517481 scopus 로고    scopus 로고
    • PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis
    • Hirai K, Hayashi T, Chan PH, et al. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain Res Mol Brain Res. 2004;124(1):51-61.
    • (2004) Brain Res Mol Brain Res. , vol.124 , Issue.1 , pp. 51-61
    • Hirai, K.1    Hayashi, T.2    Chan, P.H.3
  • 15
    • 45849117586 scopus 로고    scopus 로고
    • Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo
    • Hu P, Wang M, Chen WH, et al. Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2008; 378(1):43-51.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol. , vol.378 , Issue.1 , pp. 43-51
    • Hu, P.1    Wang, M.2    Chen, W.H.3
  • 16
    • 0036961980 scopus 로고    scopus 로고
    • Selenium-induced alteration of lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat
    • Islam F, Zia S, Sayeed I, Zafar KS, Ahmad AS. Selenium-induced alteration of lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat. Biol Trace Elem Res. 2002;90(1-3):203-14.
    • (2002) Biol Trace Elem Res. , vol.90 , Issue.1-3 , pp. 203-214
    • Islam, F.1    Zia, S.2    Sayeed, I.3    Zafar, K.S.4    Ahmad, A.S.5
  • 17
    • 84874547093 scopus 로고    scopus 로고
    • Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats
    • Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U, Mohanakumar KP. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. 2013;236:136-48.
    • (2013) Neuroscience , vol.236 , pp. 136-148
    • Karuppagounder, S.S.1    Madathil, S.K.2    Pandey, M.3    Haobam, R.4    Rajamma, U.5    Mohanakumar, K.P.6
  • 18
    • 69449089391 scopus 로고    scopus 로고
    • Rutin protects the neural damage induced by transient focal ischemia in rats
    • Khan MM, Ahmad A, Ishrat T, et al. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res. 2009;1292:123-35.
    • (2009) Brain Res. , vol.1292 , pp. 123-135
    • Khan, M.M.1    Ahmad, A.2    Ishrat, T.3
  • 19
    • 67949112601 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
    • Kimura R, Okouchi M, Fujioka H, et al. Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience. 2009;162(4):1212-9.
    • (2009) Neuroscience , vol.162 , Issue.4 , pp. 1212-1219
    • Kimura, R.1    Okouchi, M.2    Fujioka, H.3
  • 20
    • 79959560081 scopus 로고    scopus 로고
    • Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats
    • discussion 9
    • Lee JK, Kwak HJ, Piao MS, Jang JW, Kim SH, Kim HS. Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats. Acta Neurochir (Wien). 2011;153(6):1321-9; discussion 9.
    • (2011) Acta Neurochir (Wien) , vol.153 , Issue.6 , pp. 1321-1329
    • Lee, J.K.1    Kwak, H.J.2    Piao, M.S.3    Jang, J.W.4    Kim, S.H.5    Kim, H.S.6
  • 21
    • 84856558818 scopus 로고    scopus 로고
    • Effects of rehabilitative training and anti-inflammatory treatment on functional recovery and cellular reorganization following stroke
    • Liebigt S, Schlegel N, Oberland J, Witte OW, Redecker C, Keiner S. Effects of rehabilitative training and anti-inflammatory treatment on functional recovery and cellular reorganization following stroke. Exp Neurol. 2012;233(2):776-82.
    • (2012) Exp Neurol. , vol.233 , Issue.2 , pp. 776-782
    • Liebigt, S.1    Schlegel, N.2    Oberland, J.3    Witte, O.W.4    Redecker, C.5    Keiner, S.6
  • 22
    • 84886501298 scopus 로고    scopus 로고
    • Influence of inflammation on poststroke plasticity
    • Liguz-Lecznar M, Kossut M. Influence of inflammation on poststroke plasticity. Neural Plast. 2013:258582.
    • (2013) Neural Plast. , pp. 258582
    • Liguz-Lecznar, M.1    Kossut, M.2
  • 23
    • 84887194572 scopus 로고    scopus 로고
    • Physical activity and the brain: A review of this dynamic, bi-directional relationship
    • Loprinzi PD, Herod SM, Cardinal BJ, Noakes TD. Physical activity and the brain: a review of this dynamic, bi-directional relationship. Brain Res 2013. 1539;95-104.
    • (2013) Brain Res , vol.1539 , pp. 95-104
    • Loprinzi, P.D.1    Herod, S.M.2    Cardinal, B.J.3    Noakes, T.D.4
  • 24
    • 78651458683 scopus 로고    scopus 로고
    • The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats
    • Matsuda F, Sakakima H, Yoshida Y. The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. Acta Physiol (Oxf). 2011;201(2):275-87.
    • (2011) Acta Physiol (Oxf) , vol.201 , Issue.2 , pp. 275-287
    • Matsuda, F.1    Sakakima, H.2    Yoshida, Y.3
  • 25
    • 0026795049 scopus 로고
    • Middle cerebral artery occlusion in rats: A neurological and pathological evaluation of a reproducible model
    • discussion 6-7
    • Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992;31(1):100-6; discussion 6-7.
    • (1992) Neurosurgery. , vol.31 , Issue.1 , pp. 100-106
    • Menzies, S.A.1    Hoff, J.T.2    Betz, A.L.3
  • 26
    • 79957941516 scopus 로고    scopus 로고
    • A study of the relative importance of the peroxiredoxin-, catalase-, and glutathionedependent systems in neural peroxide metabolism
    • Mitozo PA, de Souza LF, Loch-Neckel G, et al. A study of the relative importance of the peroxiredoxin-, catalase-, and glutathionedependent systems in neural peroxide metabolism. Free Radic Biol Med. 2011;51(1):69-77.
    • (2011) Free Radic Biol Med. , vol.51 , Issue.1 , pp. 69-77
    • Mitozo, P.A.1    De Souza, L.F.2    Loch-Neckel, G.3
  • 27
    • 0021154323 scopus 로고
    • Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy
    • Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller DJ. Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy. Biochem Pharmacol. 1984;33(11):1801-7.
    • (1984) Biochem Pharmacol. , vol.33 , Issue.11 , pp. 1801-1807
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.J.5
  • 28
    • 84971652209 scopus 로고    scopus 로고
    • The rat brain in stereotaxic coordinates
    • San Diego: Harcourt Brace Jovanovich; 6th ed
    • Paxinos G, Watson C. The rat brain in stereotaxic coordinates. In. Plates and Figures. San Diego: Harcourt Brace Jovanovich; 6th ed; 2007. pp. 11-30.
    • (2007) Plates and Figures , pp. 11-30
    • Paxinos, G.1    Watson, C.2
  • 30
    • 0025060236 scopus 로고
    • Hyperbaric oxygen increases survival following carotid ligation in gerbils
    • Reitan JA, Kien ND, Thorup S, Corkill G. Hyperbaric oxygen increases survival following carotid ligation in gerbils. Stroke. 1990;21(1):119-23.
    • (1990) Stroke , vol.21 , Issue.1 , pp. 119-123
    • Reitan, J.A.1    Kien, N.D.2    Thorup, S.3    Corkill, G.4
  • 31
    • 84866881016 scopus 로고    scopus 로고
    • Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion
    • Sakakima H, Khan M, Dhammu TS, et al. Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2012; 30(5):383-96.
    • (2012) Restor Neurol Neurosci. , vol.30 , Issue.5 , pp. 383-396
    • Sakakima, H.1    Khan, M.2    Dhammu, T.S.3
  • 32
    • 56649112931 scopus 로고    scopus 로고
    • The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia
    • Song YS, Narasimhan P, Kim GS, Jung JE, Park EH, Chan PH. The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2008;28(12):1917-26.
    • (2008) J Cereb Blood Flow Metab. , vol.28 , Issue.12 , pp. 1917-1926
    • Song, Y.S.1    Narasimhan, P.2    Kim, G.S.3    Jung, J.E.4    Park, E.H.5    Chan, P.H.6
  • 34
    • 13244249799 scopus 로고    scopus 로고
    • Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death
    • Taylor JM, Ali U, Iannello RC, Hertzog P, Crack PJ. Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J Neurochem. 2005;92(2):283-93.
    • (2005) J Neurochem. , vol.92 , Issue.2 , pp. 283-293
    • Taylor, J.M.1    Ali, U.2    Iannello, R.C.3    Hertzog, P.4    Crack, P.J.5
  • 35
    • 0035856860 scopus 로고    scopus 로고
    • Protective effects of treadmill training on infarction in rats
    • Wang RY, Yang YR, Yu SM. Protective effects of treadmill training on infarction in rats. Brain Res. 2001;922(1):140-3.
    • (2001) Brain Res. , vol.922 , Issue.1 , pp. 140-143
    • Wang, R.Y.1    Yang, Y.R.2    Yu, S.M.3
  • 36
    • 84855469557 scopus 로고    scopus 로고
    • Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione
    • Wilkins HM, Marquardt K, Lash LH, Linseman DA. Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. Free Radic Biol Med. 2012; 52(2):410-9.
    • (2012) Free Radic Biol Med. , vol.52 , Issue.2 , pp. 410-419
    • Wilkins, H.M.1    Marquardt, K.2    Lash, L.H.3    Linseman, D.A.4
  • 37
    • 0042864426 scopus 로고    scopus 로고
    • Treadmill training effects on neurological outcome after middle cerebral artery occlusion in rats
    • Yang YR, Wang RY, Wang PS, Yu SM. Treadmill training effects on neurological outcome after middle cerebral artery occlusion in rats. Can J Neurol Sci. 2003;30(3):252-8.
    • (2003) Can J Neurol Sci. , vol.30 , Issue.3 , pp. 252-258
    • Yang, Y.R.1    Wang, R.Y.2    Wang, P.S.3    Yu, S.M.4
  • 38
    • 84871432763 scopus 로고    scopus 로고
    • Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
    • Yao RQ, Qi DS, Yu HL, Liu J, Yang LH, Wu XX. Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res. 2012;37(12):2777-86.
    • (2012) Neurochem Res. , vol.37 , Issue.12 , pp. 2777-2786
    • Yao, R.Q.1    Qi, D.S.2    Yu, H.L.3    Liu, J.4    Yang, L.H.5    Wu, X.X.6
  • 39
    • 74249099539 scopus 로고    scopus 로고
    • Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltagedependent sodium channels in hippocampal CA1 pyramidal neurons
    • Yao Y, Han DD, Zhang T, Yang Z. Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltagedependent sodium channels in hippocampal CA1 pyramidal neurons. Phytother Res. 2010;24(1):136-40.
    • (2010) Phytother Res. , vol.24 , Issue.1 , pp. 136-140
    • Yao, Y.1    Han, D.D.2    Zhang, T.3    Yang, Z.4
  • 41
    • 81255135741 scopus 로고    scopus 로고
    • Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway
    • Zeng KW, Wang XM, Ko H, Kwon HC, Cha JW, Yang HO. Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway. Eur J Pharmacol. 2011;672(1-3):45-55.
    • (2011) Eur J Pharmacol. , vol.672 , Issue.1-3 , pp. 45-55
    • Zeng, K.W.1    Wang, X.M.2    Ko, H.3    Kwon, H.C.4    Cha, J.W.5    Yang, H.O.6
  • 42
    • 84862782562 scopus 로고    scopus 로고
    • Exercise induces mitochondrial biogenesis after brain ischemia in rats
    • Zhang Q, Wu Y, Zhang P, et al. Exercise induces mitochondrial biogenesis after brain ischemia in rats. Neuroscience. 2012; 205:10-7.
    • (2012) Neuroscience , vol.205 , pp. 10-17
    • Zhang, Q.1    Wu, Y.2    Zhang, P.3
  • 43
    • 84878475974 scopus 로고    scopus 로고
    • Early exercise protects the blood-brain barrier from ischemic brain injury via the regulation of MMP-9 and occludin in rats
    • Zhang Y, Zhang P, Shen X, et al. Early exercise protects the blood-brain barrier from ischemic brain injury via the regulation of MMP-9 and occludin in rats. Int J Mol Sci. 2013;14(6):11096-112.
    • (2013) Int J Mol Sci. , vol.14 , Issue.6 , pp. 11096-11112
    • Zhang, Y.1    Zhang, P.2    Shen, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.