Genetic ablation of CD38 protects against Western diet-induced exercise intolerance and metabolic inflexibility

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Chiang, Shian Huey ^a   Harrington, W Wallace ^a   Luo, Guizhen ^a   Milliken, Naphtali O ^a   Ulrich, John C ^a   Chen, Jing ^a   Rajpal, Deepak K ^a   Qian, Ying ^a   Carpenter, Tiffany ^a   Murray, Rusty ^a   Geske, RobertS ^a   Stimpson, Stephen A ^a   Kramer, Henning F ^a   Haffner, Curt D ^a   Becherer, J David ^a   Preugschat, Frank ^a   Billin, Andrew N ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; EXERCISE TOLERANCE; GENE EXPRESSION; HYPERGLYCEMIA; HYPERINSULINEMIA; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PHYSICAL CAPACITY; PROTEIN FUNCTION; TISSUE LEVEL; TREADMILL EXERCISE; WESTERN DIET; WILD TYPE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; GENETICS; KNOCKOUT MOUSE; METABOLIC DISORDER; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SKELETAL MUSCLE;

ADP-RIBOSYL CYCLASE; ANIMALS; ANTIGENS, CD38; CYCLIC ADP-RIBOSE; DIET, WESTERN; MALE; METABOLIC DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; NAD; OXIDATION-REDUCTION; PHYSICAL CONDITIONING, ANIMAL;

EID: 84942645673     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134927     Document Type: Article

References (35)

1. Grahnert A, Klein C, Schilling E, Wehrhahn J, Hauschildt S. Review: NAD+: a modulator of immune functions. Innate immunity. 2011;17(2):212-33. Epub 2010/04/15. doi: 10.1177/1753425910361989 PMID: 20388721
2. Houtkooper RH, Canto C, Wanders RJ, Auwerx J. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocrine reviews. 2010;31(2):194-223. Epub 2009/12/17. doi: 10.1210/er.2009-0026 PMID: 20007326
3. Ying W. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxidants & redox signaling. 2008;10(2):179-206. Epub 2007/11/21.
4. Hipkiss AR. Error-protein metabolism and ageing. Biogerontology. 2009;10(4):523-9. Epub 2008/10/17. doi: 10.1007/s10522-008-9188-9 PMID: 18923917
5. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, et al. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007;130(6):1095-107. Epub 2007/09/25. PMID: 17889652
6. Imai S. Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS letters. 2011;585(11):1657-62. Epub 2011/05/10. doi: 10.1016/j.febslet.2011.04.060 PMID: 21550345
7. Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell metabolism. 2011;13(4):461-8. Epub 2011/04/05. doi: 10.1016/j.cmet.2011.03.004 PMID: 21459330
8. Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell metabolism. 2012;15(6):838-47. Epub 2012/06/12. doi: 10.1016/j.cmet.2012.04.022 PMID: 22682224
9. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD (+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism. 2011;14(4):528-36. Epub 2011/10/11. doi: 10.1016/j.cmet.2011.08.014 PMID: 21982712
10. Malavasi F, Deaglio S, Funaro A, Ferrero E, Horenstein AL, Ortolan E, et al. Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiological reviews. 2008;88(3):841-86. Epub 2008/07/16. doi: 10.1152/physrev. 00035.2007 PMID: 18626062
11. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, et al. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2007;21(13):3629-39. Epub 2007/06/23.
12. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, et al. Flavonoid apigenin is an inhibitor of the NAD+aseCD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013;62(4):1084-93. Epub 2012/11/23. doi: 10.2337/db12-1139 PMID: 23172919
13. Barbieri E, Sestili P. Reactive oxygen species in skeletal muscle signaling. Journal of signal transduction. 2012;2012:982794. Epub 2011/12/17. doi: 10.1155/2012/982794 PMID: 22175016
14. Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, et al. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. The Biochemical journal. 2011;433(3):505-14. Epub 2010/11/04. doi: 10.1042/BJ20100791 PMID: 21044047
15. Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin MA, Morio B, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. The Journal of clinical investigation. 2008;118(2):789-800. Epub 2008/01/12. doi: 10.1172/JCI32601 PMID: 18188455
16. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, et al. Genetic control of obesity and gut micro-biota composition in response to high-fat, high-sucrose diet in mice. Cell metabolism. 2013;17(1):141-52. Epub 2013/01/15. doi: 10.1016/j.cmet.2012.12.007 PMID: 23312289
17. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes. 1988;37(9):1163-7. Epub 1988/09/01. PMID: 3044882
18. Johnson JD, Ford EL, Bernal-Mizrachi E, Kusser KL, Luciani DS, Han Z, et al. Suppressed insulin signaling and increased apoptosis in CD38-null islets. Diabetes. 2006;55(10):2737-46. Epub 2006/09/28. PMID: 17003338
19. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacological research: the official journal of the Italian Pharmacological Society. 2006;53(6):482-91. Epub 2006/04/29.
20. Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Ryden M, et al. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes. 2005;54(11):3190-7. Epub 2005/10/27. PMID: 16249444
21. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK{varepsilon} and TBK1. eLife. 2013;2:e01119. Epub 2013/12/26. doi: 10.7554/eLife.01119 PMID: 24368730
22. Corpeleijn E, Saris WH, Blaak EE. Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obesity reviews: an official journal of the International Association for the Study of Obesity. 2009;10(2):178-93. Epub 2009/02/12.
23. Kelley DE. Skeletal muscle fat oxidation: timing and flexibility are everything. The Journal of clinical investigation. 2005;115(7):1699-702. Epub 2005/07/12. PMID: 16007246
24. Storlien L, Oakes ND, Kelley DE. Metabolic flexibility. The Proceedings of the Nutrition Society. 2004;63(2):363-8. Epub 2004/08/06. PMID: 15294056
25. Vieira DC, Tibana RA, Tajra V, Nascimento Dda C, De Farias DL, Silva Ade O, et al. Decreased functional capacity and muscle strength in elderly women with metabolic syndrome. Clinical interventions in aging. 2013;8:1377-86. Epub 2013/10/22. doi: 10.2147/CIA. S50333 PMID: 24143083
26. Wagner GR, Payne RM. Mitochondrial acetylation and diseases of aging. Journal of aging research. 2011;2011:234875. Epub 2011/03/26. doi: 10.4061/2011/234875 PMID: 21437190
27. Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays in biochemistry. 2012;52:23-35. Epub 2012/06/20. doi: 10.1042/bse0520023 PMID: 22708561
28. Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harbor symposia on quantitative biology. 2011;76:81-90. Epub 2011/11/25. doi: 10.1101/sqb.2011.76.010629 PMID: 22114328
29. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annual review of pathology. 2010;5:253-95. Epub 2010/01/19. doi: 10.1146/annurev. pathol.4.110807.092250 PMID: 20078221
30. Li M, Ren D, Iseki M, Takaki S, Rui L. Differential role of SH2-B and APS in regulating energy and glucose homeostasis. Endocrinology. 2006;147(5):2163-70. Epub 2006/02/04. PMID: 16455776
31. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4(2):249-64. Epub 2003/08/20. PMID: 12925520
32. Dai M, Wang P, Boyd AD, Kostov G, Athey B, Jones EG, et al. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic acids research. 2005;33(20):e175. Epub 2005/11/15. PMID: 16284200
33. Kauffmann A, Gentleman R, Huber W. arrayQualityMetrics-a bioconductor package for quality assessment of microarray data. Bioinformatics. 2009;25(3):415-6. Epub 2008/12/25. doi: 10.1093/bioinformatics/btn647 PMID: 19106121
34. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in micro-array experiments. Statistical applications in genetics and molecular biology. 2004;3: Article3. Epub 2006/05/02.
35. Klipper-Aurbach Y, Wasserman M, Braunspiegel-Weintrob N, Borstein D, Peleg S, Assa S, et al. Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Medical hypotheses. 1995;45(5):486-90. Epub 1995/11/01. PMID: 8748093