Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone

Pain

Volumn 156, Issue 2, 2015, Pages 328-334

  Hughes, Sam ^a   Hickey, Louise ^a   Donaldson, Lucy F ^b   Lumb, Bridget M ^a,b   Pickering, Anthony E ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Descending control; Intrathecal noradrenergic reuptake inhibitor; Neuropathic pain; Noradrenaline; Spontaneous pain

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; PRAZOSIN; PROPRANOLOL; REBOXETINE; YOHIMBINE; ADRENERGIC RECEPTOR AFFECTING AGENT; MORPHOLINE DERIVATIVE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONDITIONING; CONTROLLED STUDY; EVOKED RESPONSE; MALE; NERVE INJURY; NERVE TRANSECTION; NEUROPATHIC PAIN; NONHUMAN; NORADRENERGIC SYSTEM; PHENOTYPE; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; TIBIAL NERVE; ADRENERGIC NERVE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL INHIBITION; NEURALGIA; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ADRENERGIC NEURONS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; INJECTIONS, SPINAL; MALE; MORPHOLINES; NEURAL INHIBITION; NEURALGIA; NOREPINEPHRINE; RATS; RATS, WISTAR;

EID: 84942603223     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/01.j.pain.0000460313.73358.31     Document Type: Article

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