Discovery and development of the χ-conopeptide class of analgesic peptides

Toxicon

Volumn 59, Issue 4, 2012, Pages 524-528

  Lewis, Richard J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Allosteric Inhibition; Cone snail; Norepinephrine transporter; Pain; Venom peptide

Indexed keywords

ANALGESIC AGENT; CHI CONOPEPTIDE; CHI CONOPEPTIDE MRIA; CONANTOKIN G; CONTULAKIN G; MORPHINE; NORADRENALIN TRANSPORTER; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN MVIIA; UNCLASSIFIED DRUG; XEN 2174;

ALLODYNIA; BINDING AFFINITY; CHRONIC PAIN; CONUS MARMOREUS; CONUS SNAIL; CRYSTAL STRUCTURE; DRUG DOSE ESCALATION; DRUG MEGADOSE; HUMAN; NEUROPATHIC PAIN; NONHUMAN; PHARMACOPHORE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CHRONIC PAIN; CONOTOXINS; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PEPTIDES; PROTEIN CONFORMATION; RATS;

GASTROPODA; RATTUS;

EID: 84857049157     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.07.012     Document Type: Review

References (13)

1. Brust A., Palant E., Croker D.E., Colless B., Drinkwater R., Patterson B., Schroeder C.I., Wilson D., Nielsen C.K., Smith M.T., Alewood D., Alewood P.F., Lewis R.J. χ-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 2009, 52:6991-7002.
2. Davis J., Jones A., Lewis R.J. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides 2009, 30:1222-1227.
3. Freeman R. The treatment of neuropathic pain. CNS Spectr. 2005, 10:698-706.
4. Goddard A.W., Ball S.G., Martinez J., Robinson M.J., Yang C.R., Russell J.M., Shekhar A. Current perspectives of the roles of the central norepinephrine system in anxiety and depression. Depress Anxiety 2010, 27:339-350.
5. Lewis R.J., Garcia M.L. Therapeutic potential of venom peptides. Nat. Rev. Drug Discov. 2003, 2:790-802.
6. Milne T.J., Abbenante G., Tyndall J.D., Halliday J., Lewis R.J. Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. J. Biol. Chem. 2003, 278:31105-31110.
7. Nilsson K.P., Lovelace E.S., Caesar C.E., Tynngard N., Alewood P.F., Johansson H.M., Sharpe I.A., Lewis R.J., Daly N.L., Craik D.J. Solution structure of χ-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers 2005, 80:815-823.
8. Paczkowski F.A., Sharpe I.A., Dutertre S., Lewis R.J. χ-Conopeptide and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. J. Biol. Chem. 2007, 282:17837-17844.
9. 1-adrenoceptor and noradrenaline transporter. Nat. Neurosci. 2001, 4:902-907.
10. + dependence, and structure-activity relationship. J. Biol. Chem. 2003, 278:40317-40323.
11. Singh S.K., Yamashita A., Gouaux E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 2007, 448:952-956.
12. Terlau H., Olivera B.M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol. Rev. 2004, 84:41-68.
13. Wang C.I., Lewis R.J. Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity. Biochem Pharmacol 2010, 79:1083-1091.