메뉴 건너뛰기




Volumn 27, Issue 5, 2015, Pages 468-475

Update on the immunobiology of Sjögren's syndrome

Author keywords

B cell; Genetic association; IFN; Sj gren's syndrome

Indexed keywords

B CELL ACTIVATING FACTOR; GAMMA INTERFERON; INTERLEUKIN 17; INTERFERON;

EID: 84942591193     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000195     Document Type: Review
Times cited : (57)

References (50)
  • 1
    • 84924428174 scopus 로고    scopus 로고
    • Incident cases of primary sjogren's syndrome during a 5-year period in stockholm county: A descriptive study of the patients and their characteristics
    • This is the first prospective, population-based study looking at the incidence rate of pSS. The authors reported an incidence rate of 3.1 cases per 100 000 personyears. Interestingly, the prevalence of autoantibodies in this cohort of incident cases is lower than previously reported, and severe extraglandular manifestations are less frequent than in prevalent pSS
    • Kvarnstrom M, Ottosson V, Nordmark B, Wahren-Herlenius M. Incident cases of primary Sjogren's syndrome during a 5-year period in Stockholm County: a descriptive study of the patients and their characteristics. Scand J Rheumat ol 2015; 44:135-142. This is the first prospective, population-based study looking at the incidence rate of pSS. The authors reported an incidence rate of 3.1 cases per 100 000 personyears. Interestingly, the prevalence of autoantibodies in this cohort of incident cases is lower than previously reported, and severe extraglandular manifestations are less frequent than in prevalent pSS.
    • (2015) Scand J Rheumatol , vol.44 , pp. 135-142
    • Kvarnstrom, M.1    Ottosson, V.2    Nordmark, B.3    Wahren-Herlenius, M.4
  • 2
    • 33644530664 scopus 로고    scopus 로고
    • Activation of ifn p athways and plasmacytoid dendritic cell recruitment in target organs of primary sjogren's syndrome
    • Gottenberg JE, Cagnard N, Lucchesi C, et al. Activation of IFN p athways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc Natl Acad Sci U S A 2006; 103:2770-2775.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2770-2775
    • Gottenberg, J.E.1    Cagnard, N.2    Lucchesi, C.3
  • 3
    • 84875958991 scopus 로고    scopus 로고
    • Prevalence of interferon type i signature in cd14 monocytes of patients with sjogren's syndrome and association with disease activity and baff gene expression
    • This study shows that an I FN signature is present in up to 60% of pSS patients and that it is associated with higher disease activity and the presence of autoantibodies, highlighting the importance of the type I IFN system in pSS pathogenesis
    • Brkic Z, Maria NI, van Helden-Meeuwsen CG, et al. Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression. Ann Rheum Dis 2013; 72:728-735. This study shows that an I FN signature is present in up to 60% of pSS patients and that it is associated with higher disease activity and the presence of autoantibodies, highlighting the importance of the type I IFN system in pSS pathogenesis.
    • (2013) Ann Rheum Dis , vol.72 , pp. 728-735
    • Brkic, Z.1    Maria, N.I.2    Van Helden-Meeuwsen, C.G.3
  • 4
    • 17244372491 scopus 로고    scopus 로고
    • Activation of the type i interferon system in primary sjogren's syndrome: A possible etiopathogenic mechanism
    • Bave U, Nordmark G, Lovgren T, et al. Activation of the type I interferon system in primary Sjogren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum 2005; 52:1185-1195.
    • (2005) Arthritis Rheum , vol.52 , pp. 1185-1195
    • Bave, U.1    Nordmark, G.2    Lovgren, T.3
  • 5
    • 84865704333 scopus 로고    scopus 로고
    • Il-17: A new actor in ifn-driven systemic autoimmune diseases
    • Ambrosi A, Espi nosa A, Wahren-Herlenius M. IL-17: a new actor in IFN-driven systemic autoimmune diseases. Eur J Immunol 2012; 42:2274-2284.
    • (2012) Eur J Immunol , vol.42 , pp. 2274-2284
    • Ambrosi, A.1    Espi nosa, A.2    Wahren-Herlenius, M.3
  • 6
    • 68149179247 scopus 로고    scopus 로고
    • Loss of the lu pus autoantigen ro52/trim21 induces tissue inflammation and systemic autoimmunity by disregulating the il-23-th17 pathway
    • Espinosa A, Dardalhon V, Brauner S, et al. Loss of the lu pus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med 2009; 206:1661-1671.
    • (2009) J Exp Med , vol.206 , pp. 1661-1671
    • Espinosa, A.1    Dardalhon, V.2    Brauner, S.3
  • 8
    • 84887116043 scopus 로고    scopus 로고
    • Variants at multiple loci implicated in bo th innate and adaptive immune responses are associated with sjogren's syndrome
    • One of the first two GWAS performed in pSS. Importantly, this study finds associations between pSS and polymorphisms in gen es involved in IFN and B cell responses, strengthening the idea that genetic susceptibility related to these two immune-related pathways plays an important role in pSS pathogenesis
    • Lessard CJ, Li H, Adrianto I, et al. Variants at multiple loci implicated in bo th innate and adaptive immune responses are associated with Sjogren's syndrome. Nat Genet 2013; 45:1284-1292. One of the first two GWAS performed in pSS. Importantly, this study finds associations between pSS and polymorphisms in gen es involved in IFN and B cell responses, strengthening the idea that genetic susceptibility related to these two immune-related pathways plays an important role in pSS pathogenesis.
    • (2013) Nat Genet , vol.45 , pp. 1284-1292
    • Lessard, C.J.1    Li, H.2    Adrianto, I.3
  • 9
    • 84903184518 scopus 로고    scopus 로고
    • Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility
    • Kallionpaa H, Elo LL, Laajala E, et al. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes 2014; 63:2402-2414.
    • (2014) Diabetes , vol.63 , pp. 2402-2414
    • Kallionpaa, H.1    Elo, L.L.2    Laajala, E.3
  • 10
    • 84897017107 scopus 로고    scopus 로고
    • Ebv and other viruses as triggers of tertiary lymphoid structures in primary sjogren's syndrome
    • Comprehensive review looking at the current evidence supporting a role for viruses in pSS initiation/persistence In p a rticular, the authors reflected on the possible link between viral infections, the formation of ectopic lymphoid structures, and the development/maintenance of autoimmune responses in target organs
    • Lucchesi D, Pitzalis C, Bombardieri M. EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjogren's syndrome. Expert Rev Clin Immunol 2014; 10:445-455. Comprehensive review looking at the current evidence supporting a role for viruses in pSS initiation/persistence. In p a rticular, the authors reflected on the possible link between viral infections, the formation of ectopic lymphoid structures, and the development/maintenance of autoimmune responses in target organs.
    • (2014) Expert Rev Clin Immunol , vol.10 , pp. 445-455
    • Lucchesi, D.1    Pitzalis, C.2    Bombardieri, M.3
  • 11
    • 84866534641 scopus 로고    scopus 로고
    • Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in c57bl/6 mice
    • Important study supporting a ro le for viral infections in pSS pathogenesis. The authors demonstrated that administration of adenovirus to the salivary glands of mice led to features of pSS, including formation of ectopic lymphoid structures in the glands, production of autoantibodies, and reduced salivary flow
    • Bombardieri M, Barone F, Lucchesi D, et al. Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice. J Immunol 2012; 189:3767-3776. Important study supporting a ro le for viral infections in pSS pathogenesis. The authors demonstrated that administration of adenovirus to the salivary glands of mice led to features of pSS, including formation of ectopic lymphoid structures in the glands, production of autoantibodies, and reduced salivary flow.
    • (2012) J Immunol , vol.189 , pp. 3767-3776
    • Bombardieri, M.1    Barone, F.2    Lucchesi, D.3
  • 12
    • 84885747649 scopus 로고    scopus 로고
    • Innate immune signaling induces interleukin-7 production from sali vary gland cells and accelerates the development of primary sjogren's syndrome in a mouse model
    • Study linking an initial virally induced innate immune response to the development of adaptive immune responses and disease acce leration in a mouse model of pSS
    • Jin JO, Shinohara Y, Yu Q. Innate immune signaling induces interleukin-7 production from sali vary gland cells and accelerates the development of primary Sjogren's syndrome in a mouse model. PLoS One 2013; 8:e77605. Study linking an initial virally induced innate immune response to the development of adaptive immune responses and disease acce leration in a mouse model of pSS.
    • (2013) PLoS One , vol.8 , pp. e77605
    • Jin, J.O.1    Shinohara, Y.2    Yu, Q.3
  • 13
    • 84903393902 scopus 로고    scopus 로고
    • Implication of Epstein-Barr virus infection in disease-specific autoreactive b cell activation in ectopic lymphoid structures of sjogren 's syndrome
    • This study shows that there may be a particular connection between persistent viral infections (such as EBV) and the presence of ectopic lymphoid structures and autoantibody produc tion in pSS patients
    • Croia C, Astorri E, Murray-Brown W, et al. Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjogren 's syndrome. Arthritis Rheumatol 2014; 66:2545-2557. This study shows that there may be a particular connection between persistent viral infections (such as EBV) and the presence of ectopic lymphoid structures and autoantibody produc tion in pSS patients.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2545-2557
    • Croia, C.1    Astorri, E.2    Murray-Brown, W.3
  • 14
    • 0242663585 scopus 로고    scopus 로고
    • Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with sjogren's syndrome
    • Salomonsson S,Jonsson MV,Skarstein K,et al. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome Ar thritis Rheum 2003 48 3187-3201.
    • (2003) Ar Thritis Rheum , vol.48 , pp. 3187-3201
    • Salomonsson, S.1    Jonsson, M.V.2    Skarstein, K.3
  • 15
    • 84863605611 scopus 로고    scopus 로고
    • Selective localization of t helper subsets in labial salivary glands from primary sjogren's syndrome patients
    • Maehara T, Moriyama M, Hayashida JN, et al. Selective localization of T helper subsets in labial salivary glands from primary Sjogren's syndrome patients. Cl in Exp Immunol 2012; 169:89-99.
    • (2012) Cl in Exp Immunol , vol.169 , pp. 89-99
    • Maehara, T.1    Moriyama, M.2    Hayashida, J.N.3
  • 16
    • 84930011390 scopus 로고    scopus 로고
    • The histopathology of labial salivary glands in primary sjogren's syndrome: Focusing on follicular helper t cells in the inflamm atory infiltrates
    • Szabo K, Papp G, Dezso B, Zeher M. The histopathology of labial salivary glands in primary Sjogren's syndrome: focusing on follicular helper T cells in the inflamm atory infiltrates. Mediators Inflamm 2014; 2014:631787.
    • (2014) Mediators Inflamm , vol.2014 , pp. 631787
    • Szabo, K.1    Papp, G.2    Dezso, B.3    Zeher, M.4
  • 17
    • 84902477298 scopus 로고    scopus 로고
    • Cd4+cxcr5+ follicular helper t cells in salivary gland promote b cells maturation in patients with primary s jogren's syndrome
    • Jin L, Yu D, Li X, et al. CD4+CXCR5+ follicular helper T cells in salivary gland promote B cells maturation in patients with primary S jogren's syndrome. Int J Clin Exp Pathol 2014; 7:1988-1996.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 1988-1996
    • Jin, L.1    Yu, D.2    Li, X.3
  • 18
    • 84860918960 scopus 로고    scopus 로고
    • Association between genetic variants in the tumour necrosis factor/lymphotoxin alpha/lymphotoxin beta locus and primary sjogren's syndrome in scandinavian samples
    • Bolstad AI, Le Hellard S, Kristjansdottir G, et al. Association between genetic variants in the tumour necrosis factor/lymphotoxin alpha/lymphotoxin beta locus and primary Sjogren's syndrome in Scandinavian samples. Ann Rheu m Dis 2012; 71:981-988.
    • (2012) Ann Rheu M Dis , vol.71 , pp. 981-988
    • Bolstad, A.I.1    Le Hellard, S.2    Kristjansdottir, G.3
  • 19
    • 84899981675 scopus 로고    scopus 로고
    • Genetic associations to germinal centre formation in primary sjogren's syndrome
    • This study identifies genetic variations that are selectively associated with the presence of ectopic lymphoid structures in the salivary glands of pSS patients, supporting the idea that individuals with such histopathologic characteristics may represent a d istinct disease phenotype
    • Reksten TR, Johnsen SJ, Jonsson MV, et al. Genetic associations to germinal centre formation in primary Sjogren's syndrome. Ann Rheum Dis 2014; 73:1253-1258. Thi s study identifies genetic variations that are selectively associated with the presence of ectopic lymphoid structures in the salivary glands of pSS patients, supporting the idea that individuals with such histopathologic characteristics may represent a d istinct disease phenotype.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1253-1258
    • Reksten, T.R.1    Johnsen, S.J.2    Jonsson, M.V.3
  • 20
    • 79959799977 scopus 로고    scopus 로고
    • Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary sjogren's syndrome
    • Important study showing that the presence of germinal center-like structures in salivary glands is a useful and highly predictive marker for lymphoma development in pSS patients
    • Theander E, Vasaitis L, Baecklund E, et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome. Ann Rheum Dis 2011; 70:1363-1368. Important study showing that the presence of germinal center-like structures in salivary glands is a useful and highly predictive marker for lymphoma development in pSS patients.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1363-1368
    • Theander, E.1    Vasaitis, L.2    Baecklund, E.3
  • 21
    • 0035152101 scopus 로고    scopus 로고
    • Ectopic expression of the b cellattracting chemokine bca-1 (cxcl13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like s tructures in sjogren's syndrome
    • Amft N, Curnow SJ, Scheel-Toellner D, et al. Ectopic expression of the B cellattracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like s tructures in Sjogren's syndrome. Arthritis Rheum 2001; 44:2633-2641.
    • (2001) Arthritis Rheum , vol.44 , pp. 2633-2641
    • Amft, N.1    Curnow, S.J.2    Scheel-Toellner, D.3
  • 22
    • 44449140526 scopus 로고    scopus 로고
    • Cxcl13, ccl21, and cxcl12 expression in salivary glands of patients with sjogre n's syndrome and malt lymphoma: Association with reactive and malignant areas of lymphoid organization
    • Barone F, Bombardieri M, Rosado MM, et al. CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogre n's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol 2008; 180:5130-5140.
    • (2008) J Immunol , vol.180 , pp. 5130-5140
    • Barone, F.1    Bombardieri, M.2    Rosado, M.M.3
  • 23
    • 84855350256 scopus 로고    scopus 로고
    • Potential involveme nt of il-22 and il-22-producing cells in the inflamed salivary glands of patients with sjogren's syndrome
    • Ciccia F, Guggino G, Rizzo A, et al. Potential involveme nt of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's syndrome. Ann Rheum Dis 2012; 71:295-301.
    • (2012) Ann Rheum Dis , vol.71 , pp. 295-301
    • Ciccia, F.1    Guggino, G.2    Rizzo, A.3
  • 24
    • 84901264968 scopus 로고    scopus 로고
    • Differentiati on of follicular helper t cells by salivary gland epithelial cells in primary sjogren's syndrome
    • Gong YZ, Nititham J, Taylor K, et al. Differentiati on of follicular helper T cells by salivary gland epithelial cells in primary Sjogren's syndrome. J Autoimmun 2014; 51:57-66.
    • (2014) J Autoimmun , vol.51 , pp. 57-66
    • Gong, Y.Z.1    Nititham, J.2    Taylor, K.3
  • 25
    • 44849084239 scopus 로고    scopus 로고
    • Viruses induce high expression of baff by salivary gland epithelial cells through tlr-And type-i ifn-dependent and-independent pathways
    • Ittah M, Miceli-Richard C,Gottenberg JE, et al. Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR-And type-I IFN-dependent and-independent pathways. Eur J Immunol 2008; 38:1058-1064.
    • (2008) Eur J Immunol , vol.38 , pp. 1058-1064
    • Ittah, M.1    Miceli-Richard Cgottenberg, J.E.2
  • 26
    • 84925780736 scopus 로고    scopus 로고
    • Direct infection of primary salivary gland epithelial cells by humant lymphotropic virus type i in patients with sjogren's syndrome
    • Nakamura H, Takahashi Y, Yamamoto-Fukuda T, et al. Direct infection of primary salivary gland epithelial cells by humanT lymphotropic virus type I in patients with Sjogren's syndrome. Arthritis Rheumatol 2015; 67:1096-1106.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1096-1106
    • Nakamura, H.1    Takahashi, Y.2    Yamamoto-Fukuda, T.3
  • 27
    • 0036231050 scopus 로고    scopus 로고
    • Expression of the b cellattracting chemokine cxcl13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease sjogren's syndrome
    • Salomonsson S, Larsson P, Tengner P, et al. Expression of the B cellattracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjogren's syndrome. Scand J Immunol 2002; 55:336-342.
    • (2002) Scand J Immunol , vol.55 , pp. 336-342
    • Salomonsson, S.1    Larsson, P.2    Tengner, P.3
  • 28
    • 84897569619 scopus 로고    scopus 로고
    • Targeting the splicing of mRNA in autoimmune diseases: Baff inhibition in sjogren's syndrome as a proof of concept
    • Roescher N, Vosters JL, Alsaleh G, et al. Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjogren's syndrome as a proof of concept. Mol Ther 2014; 22:821-827.
    • (2014) Mol Ther , vol.22 , pp. 821-827
    • Roescher, N.1    Vosters, J.L.2    Alsaleh, G.3
  • 29
    • 84904241886 scopus 로고    scopus 로고
    • Ductal epithelial expression of ro52 correlates with inflammation in salivary gl ands of patients with primary sjogren's syndrome
    • Aqrawi LA, Kvarnstrom M, Brokstad KA, et al. Ductal epithelial expression of Ro52 correlates with inflammation in salivary gl ands of patients with primary Sjogren's syndrome. Clin Exp Immunol 2014; 177:244-252.
    • (2014) Clin Exp Immunol , vol.177 , pp. 244-252
    • Aqrawi, L.A.1    Kvarnstrom, M.2    Brokstad, K.A.3
  • 30
    • 84922391089 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in primary sjogren's syndrome: Resu lts of the beliss open-label phase II study
    • First phase II clinical trial investigating the efficacy and safety of belimumab, a BAFF-blocking antibody, in the treatment of pSS. The primary end-point w as achieved in 60% of patients, indicating that targeting BAFF may be a promising therapeutic strategy in pSS that warrants larger randomized controlled trials
    • Mariette X,Seror R,Quartuccio L,et al. Efficacy and safety of belimumab in primary Sjogren's syndrome: resu lts of the BELISS open-label phase II study Ann Rheum Dis 2015 74 526-531. First phase II clinical trial investigating the efficacy and safety of belimumab, a BAFF-blocking antibody, in the treatment of pSS. The primary end-point w as achieved in 60% of patients, indicating that targeting BAFF may be a promising therapeutic strategy in pSS that warrants larger randomized controlled trials.
    • (2015) Ann Rheum Dis , vol.74 , pp. 526-531
    • Mariette, X.1    Seror, R.2    Quartuccio, L.3
  • 31
    • 84938758949 scopus 로고    scopus 로고
    • Treatmen t with belimumab restores b cell subsets and their expression of b cell activating factor receptor in patients with primary sjogren's syndrome
    • Pontarini E, Fabris M, Quartuccio L, et al. Treatmen t with belimumab restores B cell subsets and their expression of B cell activating factor receptor in patients with primary Sjogren's syndrome. Rheumatology (Oxford) 2015.
    • (2015) Rheumatology (Oxford
    • Pontarini, E.1    Fabris, M.2    Quartuccio, L.3
  • 32
    • 84875684077 scopus 로고    scopus 로고
    • Blys upregulation in sjogren's syndrome associated with lymphoproliferative disorders, higher essdai score and b-cell clonal expansion in the salivary glands
    • Quartuccio L, Salvin S, Fabris M, e t al. BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands. Rheumatology (Oxford) 2013; 52:276-281.
    • (2013) Rheumatology (Oxford , vol.52 , pp. 276-281
    • Quartuccio, L.1    Salvin, S.2    Fabris, M.3
  • 33
    • 84878118827 scopus 로고    scopus 로고
    • Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary sjogren's syndrome data at enrollment in the p rospective assess cohort
    • Gottenberg JE, Seror R, Miceli-Richard C, et al. Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary Sjogren's syndrome. Data at enrollment in the p rospective ASSESS cohort. PLoS One 2013; 8:e59868.
    • (2013) PLoS One , vol.8 , pp. e59868
    • Gottenberg, J.E.1    Seror, R.2    Miceli-Richard, C.3
  • 34
    • 79952280367 scopus 로고    scopus 로고
    • Association of ebf1 fam167a(c8orf13)-blk and tnfsf4 gene variants with primary sjogren's syndrome
    • Nordmark G, Kristjansdottir G, Theander E, et al. Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome. Genes Immun 2011; 12:100-109.
    • (2011) Genes Immun , vol.12 , pp. 100-109
    • Nordmark, G.1    Kristjansdottir, G.2    Theander, E.3
  • 35
    • 84887085183 scopus 로고    scopus 로고
    • A genome-wide association study in han Chinese identifies a susceptibility locus for primary sjogren's syndrome at 7q11.23
    • One of the first two GWAS performed in pSS. This study confirms in a Han Chinese population genetic associations previously reported in European populations in the HLA locus as well as in loci including STAT4 and TNFAIP3. It al so identifies a new susceptibility locus, GTF2IRD1-GTF2I
    • Li Y, Zhang K, Chen H, et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23. Nat Genet 2013; 45:1361-1365. One of the first two GWAS performed in pSS. This study confirms in a Han Chinese population genetic associations previously reported in European populations in the HLA locus as well as in loci including STAT4 and TNFAIP3. It al so identifies a new susceptibility locus, GTF2IRD1-GTF2I.
    • (2013) Nat Genet , vol.45 , pp. 1361-1365
    • Li, Y.1    Zhang, K.2    Chen, H.3
  • 36
    • 84892848904 scopus 로고    scopus 로고
    • Germline and somatic genetic variations of tnfaip3 in lymphoma complicating primary sjogren's syndrome
    • This study shows that mutations in TNFAIP3, which encodes a key regulator of NF-kB activation,areassociatedwithprogressiontowardlymphomadevelopment inasubstantial proportion of pSS patients, suggesting a pos sible mechanismfor progression from autoimmunity to lymphomagenesis in the context of chronic B cell activation in pSS
    • Nocturne G, Boudaoud S, Miceli-Richard C, et al. Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome. Blood 2013; 122:4068-4076. This study shows that mutations in TNFAIP3, which encodes a key regulator of NF-kB activation,areassociatedwithprogressiontowardlymphomadevelopment inasubstantial proportion of pSS patients, suggesting a pos sible mechanismfor progression from autoimmunity to lymphomagenesis in the context of chronic B cell activation in pSS.
    • (2013) Blood , vol.122 , pp. 4068-4076
    • Nocturne, G.1    Boudaoud, S.2    Miceli-Richard, C.3
  • 37
    • 84912035224 scopus 로고    scopus 로고
    • Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with sjogren's syndrome
    • Maier-Moore JS, KoelschKA, Smith K, et al. Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjogren's syndrome. Arthritis Rheumatol 2014; 66:3445-3456.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 3445-3456
    • Maier-Moore, J.S.1    Koelsch, K.A.2    Smith, K.3
  • 38
    • 84920494935 scopus 로고    scopus 로고
    • Ig gene analy sis reveals altered selective pressures on ig-producing cells in parotid glands of primary sjogren's syndrome patients
    • Hamza N, Hershberg U, Kallenberg CG, et al. Ig gene analy sis reveals altered selective pressures on Ig-producing cells in parotid glands of primary Sjogren's syndrome patients. J Immunol 2015; 194:514-521.
    • (2015) J Immunol , vol.194 , pp. 514-521
    • Hamza, N.1    Hershberg, U.2    Kallenberg, C.G.3
  • 39
    • 84886552636 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab treatment in early primary sjogren's syndrome: A prospective, multicenter, follow-up study
    • Carubbi F, Cipriani P, Marrelli A, et al. Efficacy and safety of rituximab treatment in early primary Sjogren's syndrome: a prospective, multicenter, follow-up study. Arthritis Res Ther 2013; 15:R172.
    • (2013) Arthritis Res Ther , vol.15 , pp. R172
    • Carubbi, F.1    Cipriani, P.2    Marrelli, A.3
  • 40
    • 84877611272 scopus 로고    scopus 로고
    • Efficacy of rituximab in systemic manifestations of primary sjogren's syndrome: Results in 78 patients of the autoimmune and rituximab registry
    • Gottenberg JE,Cinquetti G,Larroche C,et al. Efficacy of rituximab in systemic manifestations of primary Sjogren's syndrome: results in 78 patients of the AutoImmune and Rituximab registry. Ann Rheum Dis 2013 72 1026-1031.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1026-1031
    • Gottenberg, J.E.1    Cinquetti, G.2    Larroche, C.3
  • 41
    • 84894243056 scopus 로고    scopus 로고
    • Treatment of primary sjogren syndrome with rituximab: A randomized trial
    • Double-blind rand omized controlled trial of B cell depletion therapy (Rituximab) in pSS.Nosignificant improvement insymptomsor disease activitywas found6months after treatment, highlighting the need to target additional pathways related to pSS pathogenesis in order to ach ieve satisfactory treatment of pSS
    • Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, et al. Treatment of primary Sjogren syndrome with rituximab: a randomized trial. Ann Intern Med 2014; 160:233-242. Double-blind rand omized controlled trial of B cell depletion therapy (Rituximab) in pSS.Nosignificant improvement insymptomsor disease activitywas found6months after treatment, highlighting the need to target additional pathways related to pSS pathogenesis in order to ach ieve satisfactory treatment of pSS.
    • (2014) Ann Intern Med , vol.160 , pp. 233-242
    • Devauchelle-Pensec, V.1    Mariette, X.2    Jousse-Joulin, S.3
  • 42
    • 84902290218 scopus 로고    scopus 로고
    • Abatacept treatment reduces disease activity in early primary sjogren's syndrome (open-label proof of concept asap study
    • Small proof-of-concept clinical trial showing that blocking T cell costimulation (Abatacept) may be useful in the treatment of pSS. Disease activity as well as RF and IgG levels decreased during and a fter treatment, while fatigue and quality of life reported by patients improved
    • Meiners PM, Vissink A, Kroese FG, et al. Abatacept treatment reduces disease activity in early primary Sjogren's syndrome (open-label proof of concept ASAP study). Ann Rheum Dis 2014; 73:1393-1396. Small proof-of-concept clinical trial showing that blocking T cell costimulation (Abatacept) may be useful in the treatment of pSS. Disease activity as well as RF and IgG levels decreased during and a fter treatment, while fatigue and quality of life reported by patients improved.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1393-1396
    • Meiners, P.M.1    Vissink, A.2    Kroese, F.G.3
  • 43
    • 84867907920 scopus 로고    scopus 로고
    • Precise probes of type II interferon activity define the origin of interferon signature s in target tissues in rheumatic diseases
    • Hall JC, Casciola-Rosen L, Berger AE, et al. Precise probes of type II interferon activity define the origin of interferon signature s in target tissues in rheumatic diseases. Proc Natl Acad Sci U S A 2012; 109:17609-17614.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17609-17614
    • Hall, J.C.1    Casciola-Rosen, L.2    Berger, A.E.3
  • 44
    • 84872076298 scopus 로고    scopus 로고
    • Il-17-producing cd4-cd8-t cells are expanded in the periph eral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary sjogren's syndrome
    • Alunno A, Bistoni O, Bartoloni E, et al. IL-17-producing CD4-CD8-T cells are expanded in the periph eral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren's syndrome. Ann Rheum Dis 2013; 72:286-292.
    • (2013) Ann Rheum Dis , vol.72 , pp. 286-292
    • Alunno, A.1    Bistoni, O.2    Bartoloni, E.3
  • 45
    • 84901285092 scopus 로고    scopus 로고
    • Cd4(-)cd8(-) t-cells in primary sjogren's syndrome: Association with the extent of glandular involvement
    • Alunno A, Carubbi F, Bistoni O, et al. CD4(-)CD8(-) T-cells in primary Sjogren's syndrome: association with the extent of glandular involvement. J Autoimmun 2014; 51:38-43.
    • (2014) J Autoimmun , vol.51 , pp. 38-43
    • Alunno, A.1    Carubbi, F.2    Bistoni, O.3
  • 46
    • 84898924344 scopus 로고    scopus 로고
    • Clinical parameter and t h17 related to lymphocytes infiltrating degree of labial salivary gland in primary sjogren's syndrome
    • Fei Y, Zhang W, Lin D, et al. Clinical parameter and T h17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjogren's syndrome. Clin Rheumatol 2014; 33:523-529.
    • (2014) Clin Rheumatol , vol.33 , pp. 523-529
    • Fei, Y.1    Zhang, W.2    Lin, D.3
  • 47
    • 70349244787 scopus 로고    scopus 로고
    • Systemic and local interleukin-17 and linked cytokines associated with sjogren's syndrome immunopathogenesis
    • Katsifis GE, Rekka S, Moutsopoulos NM, et al. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am J Pathol 2009; 175:1167-1177.
    • (2009) Am J Pathol , vol.175 , pp. 1167-1177
    • Katsifis, G.E.1    Rekka, S.2    Moutsopoulos, N.M.3
  • 48
    • 84934998034 scopus 로고    scopus 로고
    • Th17 cells play a critical role in the development of experimental sjogren's syndrome
    • Lin X, Rui K, Deng J, et al. Th17 cells play a critical role in the development of experimental Sjogren's syndrome. Ann Rheum Dis 2015; 74:1302-1310.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1302-1310
    • Lin, X.1    Rui, K.2    Deng, J.3
  • 49
    • 84919665375 scopus 로고    scopus 로고
    • A crucial role of rorgammat in the development of spontaneous sialadenitis-like sjogren's syndrome
    • Iizuka M, Tsuboi H, Matsuo N, et al. A crucial role of RORgammat in the development of spontaneous Sialadenitis-like Sjogren's syndrome. J Immunol 2015; 194:56-67.
    • (2015) J Immunol , vol.194 , pp. 56-67
    • Iizuka, M.1    Tsuboi, H.2    Matsuo, N.3
  • 50
    • 84882999456 scopus 로고    scopus 로고
    • Ncr3/nkp30 contributes to pathogenesis in primarysjogren'ssyndrome
    • This study identifies an association between a polymorphism in the NCR3 locus and susceptibility to pSS, and shows that elevated levels of the NCR3-encoded NK cell-Activating receptor in pSS patients correlate with enhanced se cretion of IFNg by NK cells. These new findings support a role for NK cells in pSS that warrants further investigation
    • Rusakiewicz S,Nocturne G,Lazure T,et al NCR3/NKp30 contributes to pathogenesis in primarySjogren'ssyndrome.Sci TranslMe d2013 5 196-196. This study identifies an association between a polymorphism in the NCR3 locus and susceptibility to pSS, and shows that elevated levels of the NCR3-encoded NK cell-Activating receptor in pSS patients correlate with enhanced se cretion of IFNg by NK cells. These new findings support a role for NK cells in pSS that warrants further investigation.
    • (2013) Sci Transl Med , vol.5 , pp. 196-196
    • Rusakiewicz, S.1    Nocturne, G.2    Lazure, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.