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Volumn 27, Issue 5, 2015, Pages 476-482

Update on the pathogenesis and treatment of the antiphospholipid syndrome

Author keywords

Antiphospholipid antibodies; Antiphospholipid syndrome; Pathogenesis; Treatment

Indexed keywords

ANTIVITAMIN K; BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CELL RECEPTOR; ECULIZUMAB; PHOSPHOLIPID ANTIBODY; RITUXIMAB;

EID: 84942581213     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000200     Document Type: Review
Times cited : (31)

References (42)
  • 1
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (aps
    • Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295-306.
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3
  • 2
    • 84922593999 scopus 로고    scopus 로고
    • 14th international congress on antiphospholipid antibodies task force. Report on antiphospholipid syndrome laboratory diagnostics and trends
    • This study from the latest International Task Force discusses available evidence on the laboratory assays to detect antiphospholipid antibodies, focusing on both criteria and novel tests
    • Bertolaccini ML, Amengual O, Andreoli L, et al. 14th International Congress on antiphospholipid antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends. Autoimmun Rev 2014; 13:917-930. This study from the latest International Task Force discusses available evidence on the laboratory assays to detect antiphospholipid antibodies, focusing on both criteria and novel tests.
    • (2014) Autoimmun Rev , vol.13 , pp. 917-930
    • Bertolaccini, M.L.1    Amengual, O.2    Andreoli, L.3
  • 3
    • 84925141086 scopus 로고    scopus 로고
    • The relevance of ' noncriteria' clinical manifestations of antiphospholipid syndrome: 14th international congress on antiphospholipid antibodies t echnical task force report on antiphospholipid syndrome clinical features
    • This study from the latest International Task Force offers an update on the manifestations that are increasingly recognized as part of the clinical spectrum of APS, but are still not included in the classification criteria
    • Abreu MM, Danowski A, Wahl DG, et al. The relevance of ' noncriteria' clinical manifestations of antiphospholipid syndrome: 14th International Congress on antiphospholipid antibodies T echnical Task Force Report on antiphospholipid syndrome clinical features. Autoimmun Rev 2015; 14:401-414. This study from the latest International Task Force offers an update on the manifestations that are increasingly recognized as part of the clinical spectrum of APS, but are still not included in the classification criteria.
    • (2015) Autoimmun Rev , vol.14 , pp. 401-414
    • Abreu, M.M.1    Danowski, A.2    Wahl, D.G.3
  • 4
    • 84896702818 scopus 로고    scopus 로고
    • New tests to detect antiphospholipid antibodies: Antidomain i beta-2-glycoprotein-i antibodies
    • Chighizola CB, Gerosa M, Meroni PL. New tests to detect antiphospholipid antibodies: antidomain I beta-2-glycoprotein-I antibodies. Curr Rheumatol Rep 2014; 16:402-409. 5.
    • (2014) Curr Rheumatol Rep , vol.16 , pp. 402-409
    • Chighizola, C.B.1    Gerosa, M.2    Meroni, P.L.3
  • 5
    • 84901705578 scopus 로고    scopus 로고
    • A noncomplement-fixing antibody to b2 glycoprotein i as a novel therapy for antiphospholipid syndrome
    • This in-vivo study further highlights the pathogenicity of antibodies targeting domain I of b2GPI In addition, a monoclonal antibody against domain I not able to activate complement is presented for the first time as a potential th erapeutic tool in thrombotic and obstetric manifestations
    • Agostinis C, Durigutto P, Sblattero D, et al. A noncomplement-fixing antibody to b2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Blood 201 4; 123:3478-3487. This in-vivo study further highlights the pathogenicity of antibodies targeting domain I of b2GPI. In addition, a monoclonal antibody against domain I not able to activate complement is presented for the first time as a potential th erapeutic tool in thrombotic and obstetric manifestations. 6.
    • (2014) Blood , vol.123 , pp. 3478-3487
    • Agostinis, C.1    Durigutto, P.2    Sblattero, D.3
  • 6
    • 84908476494 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells specific for b2-glycoprotein-i domain-i, attenuate experimental antiphosphol ipid syndrome
    • Tolerogenic dendritic cells specific for domain I of b2GPI are suggested as a novel therapeutic approach for APS
    • Zandman-Goddard G, Pierangeli SS, Gertel S, Blank M. Tolerogenic dendritic cells specific for b2-glycoprotein-I Domain-I, attenuate experimental antiphosphol ipid syndrome. J Autoimmun 2014; 54:72-80. Tolerogenic dendritic cells specific for domain I of b2GPI are suggested as a novel therapeutic approach for APS. 7.
    • (2014) J Autoimmun , vol.54 , pp. 72-80
    • Zandman-Goddard, G.1    Pierangeli, S.S.2    Gertel, S.3    Blank, M.4
  • 7
    • 84928773743 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: Antibodies to domain 1 of b2-glycoprotein 1 correctly classify patients at risk
    • In this study, positivity for anti-domain I antibodies consistently confirmed at 12 we eks identifies patients at highest risk of developing thromboembolic events
    • Pengo V, Ruffatti A, Tonello M, et al. Antiphospholipid syndrome: antibodies to domain 1 of b2-glycoprotein 1 correctly classify patients at risk. J Thromb Haemost 2015. doi: 10.1111/jth.12865. In this study, positivity for anti-domain I antibodies consistently confirmed at 12 we eks identifies patients at highest risk of developing thromboembolic events.
    • (2015) J Thromb Haemost
    • Pengo, V.1    Ruffatti, A.2    Tonello, M.3
  • 8
    • 84938099968 scopus 로고    scopus 로고
    • Antiphospholipid antibody profiling: The detection of igg antibodies against b2glycoprotein i domain 1 and 4/5 offers better clinical characterization
    • (in press
    • Andreoli L, Chighizola CB, Nalli C, et al. Antiphospholipid antibody profiling: the detection of IgG antibodies against b2glycoprotein I domain 1 and 4/5 offers better clinical characterization. Arthritis Rheumatol 2015. doi: 10.1002/art.39187 (in press).
    • (2015) Arthritis Rheumatol
    • Andreoli, L.1    Chighizola, C.B.2    Nalli, C.3
  • 9
    • 84925490713 scopus 로고    scopus 로고
    • Immunoreactivity and avidity of igg a ntib2-glycoprotein i antibodies from patients with autoimmune diseases to different peptide clusters of b2-glycoprotein i
    • Artenjak A, Locatelli I, Brelih H, et al. Immunoreactivity and avidity of IgG a ntib2-glycoprotein I antibodies from patients with autoimmune diseases to different peptide clusters of b2-glycoprotein I. Immunol Res 2015; 61:35-44.
    • (2015) Immunol Res , vol.61 , pp. 35-44
    • Artenjak, A.1    Locatelli, I.2    Brelih, H.3
  • 10
    • 84899102723 scopus 로고    scopus 로고
    • Antiphospholipid syndrome in 2014: More clinical manifestations novel pathogenic players and emerging biomarkers
    • Meroni PL, Chighizola CB, Rovelli F, Gerosa M. Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers. Arthritis Res Ther 2014; 209:1-14.
    • (2014) Arthritis Res Ther , vol.209 , pp. 1-14
    • Meroni, P.L.1    Chighizola, C.B.2    Rovelli, F.3    Gerosa, M.4
  • 11
    • 84922410809 scopus 로고    scopus 로고
    • B 2-glycoprotein i, lipopolysaccharide and endothelial tlr4: Three players in the two hit theory for antiphospholipid-mediated thrombosis
    • This in-vitro study provides novel insights into TLR4 engagement by b2GPI; noteworthy, this interaction appears not to be LPS-dependent in endothelial cells
    • Raschi E, Chighizola CB, Grossi C, et al. b 2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for antiphospholipid-mediated thrombosis. J Autoimmun 2014; 55:42-50. This in-vitro study provides novel insights into TLR4 engagement by b2GPI; noteworthy, this interaction appears not to be LPS-dependent in endothelial cells.
    • (2014) J Autoimmun , vol.55 , pp. 42-50
    • Raschi, E.1    Chighizola, C.B.2    Grossi, C.3
  • 12
    • 84925581582 scopus 로고    scopus 로고
    • Role of toll-like receptors 2 and 4 in mediating endothelial dysfunction and arte rial remodeling in primary arterial antiphospholipid syndrome
    • Benhamou Y, Bellien J, Armengol G, et al. Role of Toll-like Receptors 2 and 4 in mediating endothelial dysfunction and arte rial remodeling in primary arterial antiphospholipid syndrome. Arthritis Rheumatol 2014; 66:3210-3220.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 3210-3220
    • Benhamou, Y.1    Bellien, J.2    Armengol, G.3
  • 13
    • 84901193062 scopus 로고    scopus 로고
    • Nf-kb is activated from endosomal compartm ents in antiphospholipid antibodies-treated human monocytes
    • Brandt KJ, Fickentscher C, Boehlen F, et al. NF-kB is activated from endosomal compartm ents in antiphospholipid antibodies-treated human monocytes. J Thromb Haemost 2014; 12:779-791.
    • (2014) J Thromb Haemost , vol.12 , pp. 779-791
    • Brandt, K.J.1    Fickentscher, C.2    Boehlen, F.3
  • 14
    • 82755176786 scopus 로고    scopus 로고
    • Interaction of b2-glycoprotein i with lipopolysaccha ride leads to toll-like receptor 4 (tlr4)-dependent activation of macrophages
    • Laplante P, Amireault P, Subang R, et al. Interaction of b2-glycoprotein I with lipopolysaccha ride leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages. J Biol Chem 2011; 286:42494-42503.
    • (2011) J Biol Chem , vol.286 , pp. 42494-42503
    • Laplante, P.1    Amireault, P.2    Subang, R.3
  • 15
    • 84919884264 scopus 로고    scopus 로고
    • The role of the gut microbiota in the pathogenesis of antiphospholipid syndrome
    • Ruff WE, Vieira SM, Kriegel MA. The Role of the gut microbiota in the pathogenesis of antiphospholipid syndrome. Curr Rheumatol Rep 2015; 472:1-10.
    • (2015) Curr Rheumatol Rep , vol.472 , pp. 1-10
    • Ruff, W.E.1    Vieira, S.M.2    Kriegel, M.A.3
  • 16
    • 84883058074 scopus 로고    scopus 로고
    • The nf-kb specific inhibitor dhmeq prevents thrombus formation in a mouse model of antiphospholipid syndrome
    • Nishimura M, Nii T, Trimova G, et al. The NF-kB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome. J Nephropathol 2013; 2:114-121.
    • (2013) J Nephropathol , vol.2 , pp. 114-121
    • Nishimura, M.1    Nii, T.2    Trimova, G.3
  • 17
    • 77953624768 scopus 로고    scopus 로고
    • Effects of polyclonal igg derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways
    • Lambrianides A, Carroll CJ, Pierangeli SS, et al. Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways. J Immunol 2010; 184:6 622-6628.
    • (2010) J Immunol , vol.184 , pp. 6622-6628
    • Lambrianides, A.1    Carroll, C.J.2    Pierangeli, S.S.3
  • 18
    • 84926971910 scopus 로고    scopus 로고
    • Purified igg from patients with obstetric but not igg from nonobstetric antiphospholipid syndrome inhibit trophoblast invasion
    • This study suggests that antibodies purified from patients with thrombotic versus pure obstetric clinical manifestations may elicit different in-vitro biological effects in trophoblast cells
    • Poulton K, Ripoll VM, Pericleous C, et al. Purified IgG from patients with obstetric but not IgG from nonobstetric antiphospholipid syndrome inhibit trophoblast invasion. Am J Reprod Immunol 2014; 73:390-401. This study suggests that antibodies purified from patients with thrombotic versus pure obstetric clinical manifestations may elicit different in-vitro biological effects in trophoblast cells.
    • (2014) Am J Reprod Immunol , vol.73 , pp. 390-401
    • Poulton, K.1    Ripoll, V.M.2    Pericleous, C.3
  • 19
    • 84904581191 scopus 로고    scopus 로고
    • Inhibition of the mtorc pathway in the antiphospholipid syndrome
    • The in-vitro and in-vivo experiments presented in this study support the involve ment of mTOR pathway in the APS, proposing sirolimus-A mTOR inhibitor-As a potential pharmacological tool in patients undergoing renal transplantation
    • Can aud G, Bienaimé F, Tabarin F, et al. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N Engl J Med 2014; 371:303-312. The in-vitro and in-vivo experiments presented in this study support the involve ment of mTOR pathway in the APS, proposing sirolimus-A mTOR inhibitor-As a potential pharmacological tool in patients undergoing renal transplantation.
    • (2014) N Engl J Med , vol.371 , pp. 303-312
    • Can aud, G.1    Bienaimé, F.2    Tabarin, F.3
  • 20
    • 84908073165 scopus 로고    scopus 로고
    • Inhibition of the mtorc pathway in the antiphospholipid syndrome
    • Van Laecke S, Nagler EV, Vanholder R. Inhibition of the mTORC Pathway in the antiphospholipid syndrome. N Engl J Med 2014; 371:1553.
    • (2014) N Engl J Med , vol.371 , pp. 1553
    • Van Laecke, S.1    Nagler, E.V.2    Vanholder, R.3
  • 21
    • 84908664176 scopus 로고    scopus 로고
    • Complement c5-inhibitor rev576 (coversin) ameliorates in-vivo effects o f antiphospholipid antibodies
    • Romay-Penabad Z,Carrera Marin A,Willis R,et al. Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects o f antiphospholipid antibodies Lupus, 2014, 23, 1324-1326.
    • (2014) Lupus , vol.23 , pp. 1324-1326
    • Romay-Penabad, Z.1    Carrera Marin, A.2    Willis, R.3
  • 22
    • 84908671635 scopus 로고    scopus 로고
    • New oral anticoagulants in thrombotic antiphospholipid syndrome
    • Chighizola CB, Moia M, Meroni PL. New oral anticoagulants in thrombotic antiphospholipid syndrome. Lupus 2014; 23:1279-1282.
    • (2014) Lupus , vol.23 , pp. 1279-1282
    • Chighizola, C.B.1    Moia, M.2    Meroni, P.L.3
  • 23
    • 84928625226 scopus 로고    scopus 로고
    • The use of rivaroxaban in patients with antiphospholipid syndrome: A series of 12 cases
    • Son M, Wypasek E, Celinska-Lowenhoff M, Undas A. The use of rivaroxaban in patients with antiphospholipid syndrome: a series of 12 cases. Thromb Res 2015; 135:1035-1036.
    • (2015) Thromb Res , vol.135 , pp. 1035-1036
    • Son, M.1    Wypasek, E.2    Celinska-Lowenhoff, M.3    Undas, A.4
  • 24
    • 84908550562 scopus 로고    scopus 로고
    • Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: A case series of three patients
    • Schaefer JK, McBane RD, Black DF, et al. Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: a case series of three patients. Thromb Haemost 2014; 112:947-950. 25.
    • (2014) Thromb Haemost , vol.112 , pp. 947-950
    • Schaefer, J.K.1    McBane, R.D.2    Black, D.F.3
  • 25
    • 84896544929 scopus 로고    scopus 로고
    • 14th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends
    • This report from the latest International Task Force extensively reviews all the therapeutic options-from the established to the cutting edge ones-that might be considered in the management of patients with antiphospholipid antibodies
    • Erkan D, Aguiar CL, Andrade D, et al. 14th International Congress on Antiphospholipid Antibodies Task Force Report on antiphospholipid syndrome treatment trends. Autoimmun Rev 2014; 13:685-696. This report from the latest International Task Force extensively reviews all the therapeutic options-from the established to the cutting edge ones-that might be considered in the management of patients with antiphospholipid antibodies.
    • (2014) Autoimmun Rev , vol.13 , pp. 685-696
    • Erkan, D.1    Aguiar, C.L.2    Andrade, D.3
  • 26
    • 84917728306 scopus 로고    scopus 로고
    • Efficacy of eculizumab in a patient with immunoadsorption-dependent catastrophic antiphospholipid syndrome
    • Kronbichler A, Frank R, Kirschfink M, et al. Efficacy of eculizumab in a patient with immunoadsorption-dependent catastrophic antiphospholipid syndrome. Medicine (Baltimore) 2014; 93:e143.
    • (2014) Medicine (Baltimore , vol.93 , pp. e143
    • Kronbichler, A.1    Frank, R.2    Kirschfink, M.3
  • 27
    • 84895064562 scopus 로고    scopus 로고
    • Eculizumab prevents recurrent antiphospholipid antibody syndrome and enables successful renal transplantation
    • Lonze BE, Zachary AA, Magro CM, et al. Eculizumab prevents recurrent antiphospholipid antibody syndrome and enables successful renal transplantation. Am J Transplant 2014; 14:459-465.
    • (2014) Am J Transplant , vol.14 , pp. 459-465
    • Lonze, B.E.1    Zachary, A.A.2    Magro, C.M.3
  • 28
    • 84925140284 scopus 로고    scopus 로고
    • The european registry on obstetric antiphospholipid syndrome (euroaps): A survey of 247 consecutive cases
    • Alij otas-Reig J, Ferrer-Oliveras R, Ruffatti A, et al. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a survey of 247 consecutive cases. Autoimmun Rev 2015; 14:387-395.
    • (2015) Autoimmun Rev , vol.14 , pp. 387-395
    • Alijotas-Reig, J.1    Ferrer-Oliveras, R.2    Ruffatti, A.3
  • 29
    • 84911468310 scopus 로고    scopus 로고
    • Update on the current recommendations and outcomes in pregnant women with antiphospholipid syndrome
    • This recent review covers the everyday therapeutic approaches to pregnant women with antiphospholipid antibodies
    • Chighizola CB, Gerosa M, Trespidi L, et al. Update on the current recommendations and outcomes in pregnant women with antiphospholipid syndrome. Expert Rev Clin Immunol 2014; 10:1505-1517. This recent review covers the everyday therapeutic approaches to pregnant women with antiphospholipid antibodies.
    • (2014) Expert Rev Clin Immunol , vol.10 , pp. 1505-1517
    • Chighizola, C.B.1    Gerosa, M.2    Trespidi, L.3
  • 30
    • 84893089265 scopus 로고    scopus 로고
    • Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: The noh-Aps observational study
    • Bouvier S, Cochery-Nouvellon E, Lavigne-Lissalde G, et al. Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study. Blood 2014; 123:404-413.
    • (2014) Blood , vol.123 , pp. 404-413
    • Bouvier, S.1    Cochery-Nouvellon, E.2    Lavigne-Lissalde, G.3
  • 31
    • 84908528863 scopus 로고    scopus 로고
    • Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity
    • This retrospective cohort study identifies additional treatments as the only predictor of favourable pregnancy outcome among women with triple antiphospholipid antibody-positivity and a history of thrombosis
    • Ruffatti A, Salvan E, Del Ross T, et al. Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. Thromb Haemost 2014; 1 12: 727-735. This retrospective cohort study identifies additional treatments as the only predictor of favourable pregnancy outcome among women with triple antiphospholipid antibody-positivity and a history of thrombosis.
    • (2014) Thromb Haemost , vol.112 , pp. 727-735
    • Ruffatti, A.1    Salvan, E.2    Del Ross, T.3
  • 32
    • 84904724731 scopus 로고    scopus 로고
    • Combination therapy with anticoagulants corticosteroids and intravenous immunoglobulin for women with severe obstetric antiphospholipid syndrome
    • This case series supports the efficacy of intravenous immunoglobulins on top of standard treatment in the therapeutic management of women with refractory obstetric APS
    • Watanabe N, Yamaguchi K, Motomura K, et al. Combination therapy with anticoagulants, corticosteroids and intravenous immunoglobulin for women with severe obstetric antiphospholipid syndrome. Clin Exp Rheumatol 2014; 32:299-3 00. This case series supports the efficacy of intravenous immunoglobulins on top of standard treatment in the therapeutic management of women with refractory obstetric APS.
    • (2014) Clin Exp Rheumatol , vol.32 , pp. 299-300
    • Watanabe, N.1    Yamaguchi, K.2    Motomura, K.3
  • 33
    • 84933670410 scopus 로고    scopus 로고
    • The efficacy of hydroxychloroquine for obstetrical outcome in antiphospholipid syndrome: Data from a european multicenter retrospective study
    • This multi-centre retrospective study proposes HCQ as a novel eff ective tool in the management of refractory obstetric APS
    • Mekinian A, Lazzaroni MG, Kuzenko A, et al. The efficacy of hydroxychloroquine for obstetrical outcome in antiphospholipid syndrome: data from a European multicenter retrospective study. Autoimmun Rev 2015; 1-5. This multi-centre retrospective study proposes HCQ as a novel eff ective tool in the management of refractory obstetric APS.
    • Autoimmun Rev , vol.2015 , pp. 1-5
    • Mekinian, A.1    Lazzaroni, M.G.2    Kuzenko, A.3
  • 34
    • 84902107289 scopus 로고    scopus 로고
    • Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies
    • Marchetti T, Ruffatti A, Wuillemin C, et al. Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies. J Thromb Haemost 2014; 12:910-920.
    • (2014) J Thromb Haemost , vol.12 , pp. 910-920
    • Marchetti, T.1    Ruffatti, A.2    Wuillemin, C.3
  • 35
    • 84892438423 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function
    • Albert CR, Schlesinger WJ, Viall CA, et al. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function. Am J Reprod Immunol 2013; 71:154-164.
    • (2013) Am J Reprod Immunol , vol.71 , pp. 154-164
    • Albert, C.R.1    Schlesinger, W.J.2    Viall, C.A.3
  • 36
    • 84893113042 scopus 로고    scopus 로고
    • Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity
    • Ota K, Dambaeva S, Han AR, et al. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod 2014; 29:208-219. 37.
    • (2014) Hum Reprod , vol.29 , pp. 208-219
    • Ota, K.1    Dambaeva, S.2    Han, A.R.3
  • 37
    • 84922791456 scopus 로고    scopus 로고
    • Vitamin D reverses apl-induced inflammation and lmwh-induced sflt-1 release by human trophoblast
    • This in-vitro study shows that vitamin D treatment attenuates the inflammatory response induced by antiphospholipid antibodies in trophoblast cells
    • Gysler SM, Mulla MJ, Stuhlman M, et al. Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast. Am J Reprod Immunol 2014; 73:242-250. This in-vitro study shows that vitamin D treatment attenuates the inflammatory response induced by antiphospholipid antibodies in trophoblast cells.
    • (2014) Am J Reprod Immunol , vol.73 , pp. 242-250
    • Gysler, S.M.1    Mulla, M.J.2    Stuhlman, M.3
  • 38
    • 84921026907 scopus 로고    scopus 로고
    • Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies
    • According to this recent meta-Analysis, low-dose aspirin exerts a protective antithrombotic effect among asymptomatic antiphospholipid antibody patients and women with obstetric APS
    • Arnaud L, Mathian A, Devilliers H, et al. Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies. Autoimmun Rev 2015; 14:192-200. According to this recent meta-Analysis, low-dose aspirin exerts a protective antithrombotic effect among asymptomatic antiphospholipid antibody patients and women with obstetric APS.
    • (2015) Autoimmun Rev , vol.14 , pp. 192-200
    • Arnaud, L.1    Mathian, A.2    Devilliers, H.3
  • 39
    • 84899916939 scopus 로고    scopus 로고
    • A prospective open-label pilot s tudy of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients
    • This ex-vivo study reports the reduction of the serum levels of several proinflamma tory and pro-thrombotic parameters by fluvastatin
    • Erkan D, Willis R, Murthy VL, et al. A prospective open-label pilot s tudy of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients. Ann Rheum Dis 2014; 73:1176-1180. This ex-vivo study reports the reduction of the serum levels of several proinflamma tory and pro-thrombotic parameters by fluvastatin.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1176-1180
    • Erkan, D.1    Willis, R.2    Murthy, V.L.3
  • 40
    • 84925346049 scopus 로고    scopus 로고
    • Iga anticardiolipin and iga antib2 glycoprotein i antibody positivity determined by fluorescence enzyme immunoassay in pri Mary antiphospholipid syndrome
    • Mattia E, Ruffatti A, Tonello M, et al. IgA anticardiolipin and IgA antib2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in pri mary antiphospholipid syndrome. Clin Chem Lab Med 2014; 52:1329-1333.
    • (2014) Clin Chem Lab Med , vol.52 , pp. 1329-1333
    • Mattia, E.1    Ruffatti, A.2    Tonello, M.3
  • 41
    • 84899554236 scopus 로고    scopus 로고
    • Isolated iga anti b2 glycoprotein i antibodies in patients with clinical criteri a for antiphospholipid syndrome
    • Ruiz-Garcá R, Serrano M, Martínez-Flores JÁ, et al. Isolated IgA anti b2 glycoprotein I antibodies in patients with clinical criteri a for antiphospholipid syndrome. J Immunol Res 2014. doi: 10.1155/2014/704395.
    • (2014) J Immunol Res
    • Ruiz-Garcá, R.1    Serrano, M.2    Martínez-Flores, J.A.3
  • 42
    • 84918547537 scopus 로고    scopus 로고
    • Antibodies to domain i of b-2-glycoprotein i and iga antiphospholipid antibodies in patients with 'seronegative ' antiphospholipid syndrome
    • Cousins L, Pericleous C, Khamashta M, et al. Antibodies to domain I of b-2-glycoprotein I and IgA antiphospholipid antibodies in patients with 'seronegative ' antiphospholipid syndrome. Ann Rheum Dis 2015; 74:317-319.
    • (2015) Ann Rheum Dis , vol.74 , pp. 317-319
    • Cousins, L.1    Pericleous, C.2    Khamashta, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.