Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways

Journal of Immunology

Volumn 184, Issue 12, 2010, Pages 6622-6628

  Lambrianides, Anastasia ^a,b   Carroll, Christopher J ^a   Pierangeli, Silvia S ^d   Pericleous, Charis ^a,b   Branch, Ware ^e   Rice, Jurhee ^c   Latchman, David S ^a   Townsend, Paul ^c   Isenberg, David A ^b   Rahman, Anisur ^b   Giles, Ian P ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d University of Texas Medical Branch School of Medicine   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; CELL EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPID ANTIBODY; THROMBOPLASTIN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL LINE; CLINICAL ARTICLE; EXTRACT; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; MONOCYTE; MORBIDITY; PREGNANCY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOSIS; UPREGULATION; ADULT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; PREGNANCY COMPLICATION; WESTERN BLOTTING;

ADULT; ANTIPHOSPHOLIPID SYNDROME; BLOTTING, WESTERN; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MONOCYTES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PREGNANCY; PREGNANCY COMPLICATIONS; SIGNAL TRANSDUCTION; THROMBOPLASTIN; TOLL-LIKE RECEPTOR 4;

EID: 77953624768     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902765     Document Type: Article

References (37)

1. Hughes, G. R., N. N. Harris, and A. E. Gharavi. 1986. The anticardiolipin syndrome. J. Rheumatol. 13: 486-489.
2. Miyakis, S., M. D. Lockshin, T. Atsumi, D. W. Branch, R. L. Brey, R. Cervera, R. H. Derksen, P. G. de Groot, T. Koike, P. L. Meroni, et al. 2006. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4: 295-306.
3. Petri, M. 2002. Classification and epidemiology of the antiphospholipid syndrome. In The Antiphospholipid Syndrome II: Autoimmune Thrombosis, 2nd Ed. R. A. Asherson, R. Cervera, J.-C. Piette, and Y. Shoenfeld, eds. Elsevier Science, Amsterdam, p. 11-20.
4. Rai, R., and L. Regan. 2002. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet. Gynecol. 100: 1354.
5. Schulman, S., E. Svenungsson, S. Granqvist; Duration of Anticoagulation Study Group. 1998. Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Am. J. Med. 104: 332-338.
6. Lynch, A., R. Marlar, J. Murphy, G. Davila, M. Santos, J. Rutledge, and W. Emlen. 1994. Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective study. Ann. Intern. Med. 120: 470-475.
7. Cervera, R., J. C. Piette, J. Font, M. A. Khamashta, Y. Shoenfeld, M. T. Camps, S. Jacobsen, G. Lakos, A. Tincani, I. Kontopoulou-Griva, et al; Euro-Phospholipid Project Group. 2002. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 46: 1019-1027.
8. Pierangeli, S. S., M. Colden-Stanfield, X. Liu, J. H. Barker, G. L. Anderson, and E. N. Harris. 1999. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99: 1997-2002.
9. Vega-Ostertag, M., E. N. Harris, and S. S. Pierangeli. 2003. Phosphorylation of p38MAPK is involved in antiphospholipid antibody mediated platelet activation. Arthritis Rheum. 48: S161.
10. López-Pedrera, C., P. Buendía, M. J. Cuadrado, E. Siendones, M. A. Aguirre, N. Barbarroja, C. Montiel-Duarte, A. Torres, M. Khamashta, and F. Velasco. 2006. Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum. 54: 301-311. (Pubitemid 43122214)
11. Cervera, R., M. A. Khamashta, Y. Shoenfeld, M. T. Camps, S. Jacobsen, E. Kiss, M. M. Zeher, A. Tincani, I. Kontopoulou-Griva, M. Galeazzi, et al. 2009. Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicenter prospective study of 1,000 patients. Ann. Rheum. Dis. 68: 1428-1432.
12. Quenby, S., R. G. Farquharson, F. Dawood, A. M. Hughes, and J. Topping. 2005. Recurrent miscarriage and long-term thrombosis risk: a case-control study. Hum. Reprod. 20: 1729-1732.
13. Cuadrado, M. J., C. López-Pedrera, M. A. Khamashta, M. T. Camps, F. Tinahones, A. Torres, G. R. Hughes, and F. Velasco. 1997. Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis Rheum. 40: 834-841.
14. Dobado-Berrios, P. M., C. López-Pedrera, F. Velasco, M. A. Aguirre, A. Torres, and M. J. Cuadrado. 1999. Increased levels of tissue factor mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome. Thromb. Haemost. 82: 1578-1582.
15. Reverter, J. C., D. Tàssies, J. Font, M. A. Khamashta, K. Ichikawa, R. Cervera, G. Escolar, G. R. Hughes, M. Ingelmo, and A. Ordinas. 1998. Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes. Arthritis Rheum. 41: 1420-1427.
16. Kornberg, A., M. Blank, S. Kaufman, and Y. Shoenfeld. 1994. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J. Immunol. 153: 1328-1332. (Pubitemid 24228525)
17. Bohgaki, M., T. Atsumi, Y. Yamashita, S. Yasuda, Y. Sakai, A. Furusaki, T. Bohgaki, O. Amengual, Y. Amasaki, and T. Koike. 2004. The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti- beta2Glycoprotein I antibodies. Int. Immunol. 16: 1633-1641.
18. Vega-Ostertag, M., K. Casper, R. Swerlick, D. Ferrara, E. N. Harris, and S. S. Pierangeli. 2005. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum. 52: 1545-1554.
19. Raschi, E., C. Testoni, D. Bosisio, M. O. Borghi, T. Koike, A. Mantovani, and P. L. Meroni. 2003. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 101: 3495-3500.
20. Pierangeli, S. S., M. E. Vega-Ostertag, E. Raschi, X. Liu, Z. Romay-Penabad, V. De Micheli, M. Galli, M. Moia, A. Tincani, M. O. Borghi, et al. 2007. Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies. Ann. Rheum. Dis. 66: 1327-1333.
21. Sorice, M., A. Longo, A. Capozzi, T. Garofalo, R. Misasi, C. Alessandri, F. Conti, B. Buttari, R. Riganò, E. Ortona, and G. Valesini. 2007. Anti-beta2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts. Arthritis Rheum. 56: 2687-2697.
22. Satta, N., S. Dunoyer-Geindre, G. Reber, R. J. Fish, F. Boehlen, E. K. Kruithof, and P. de Moerloose. 2007. The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies. Blood 109: 1507-1514. (Pubitemid 46239583)
23. López-Pedrera, C., M. J. Cuadrado, V. Herández, P. Buendïa, M. A. Aguirre, N. Barbarroja, L. A. Torres, J. M. Villalba, F. Velasco, and M. Khamashta. 2008. Proteomic analysis in monocytes of antiphospholipid syndrome patients: deregulation of proteins related to the development of thrombosis. Arthritis Rheum. 58: 2835-2844.
24. Giles, I., N. Lambrianides, N. Pattni, D. Faulkes, D. Latchman, P. Chen, S. Pierangeli, D. Isenberg, and A. Rahman. 2006. Arginine residues are important in determining the binding of human monoclonal antiphospholipid antibodies to clinically relevant antigens. J. Immunol. 177: 1729-1736. (Pubitemid 44092509)
25. Sundström, C., and K. Nilsson. 1976. Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int. J. Cancer 17: 565-577.
26. Cuadrado, M. J., P. Buendía, F. Velasco, M. A. Aguirre, N. Barbarroja, L. A. Torres, M. Khamashta, and C. López-Pedrera. 2006. Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome. J. Thromb. Haemost. 4: 2461-2469.
27. Redecha, P., C. W. Franzke, W. Ruf, N. Mackman, and G. Girardi. 2008. Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J. Clin. Invest. 118: 3453-3461.
28. Redecha, P., R. Tilley, M. Tencati, J. E. Salmon, D. Kirchhofer, N. Mackman, and G. Girardi. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110: 2423-2431. (Pubitemid 47523163)
29. Coats, S. R., R. A. Reife, B. W. Bainbridge, T. T. Pham, and R. P. Darveau. 2003. Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells. Infect. Immun. 71: 6799-6807.
30. Somerville, J. E. J., Jr., L. Cassiano, B. Bainbridge, M. D. Cunningham, and R. P. Darveau. 1996. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J. Clin. Invest. 97: 359-365.
31. Re, F., and J. L. Strominger. 2003. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J. Immunol. 171: 5272-5276.
32. Giannakopoulos, B., F. Passam, S. Rahgozar, and S. A. Krilis. 2007. Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 109: 422-430.
33. Oku, K., T. Atsumi, M. Bohgaki, O. Amengual, H. Kataoka, T. Horita, S. Yasuda, and T. Koike. 2009. Complement activation in patients with primary antiphospholipid syndrome. Ann. Rheum. Dis. 68: 1030-1035.
34. Girardi, G., J. Berman, P. Redecha, L. Spruce, J. M. Thurman, D. Kraus, T. J. Hollmann, P. Casali, M. C. Caroll, R. A. Wetsel, et al. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J. Clin. Invest. 112: 1644-1654.
35. Vega-Ostertag, M. E., and S. S. Pierangeli. 2007. Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets. Curr. Rheumatol. Rep. 9: 190-197.
36. Fischetti, F., P. Durigutto, V. Pellis, A. Debeus, P. Macor, R. Bulla, F. Bossi, F. Ziller, D. Sblattero, P. Meroni, and F. Tedesco. 2005. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood 106: 2340-2346. (Pubitemid 41510805)
37. Salmon, J. E., G. Girardi, and V. M. Holers. 2003. Activation of complement mediates antiphospholipid antibody-induced pregnancy loss. Lupus 12: 535-538.