Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes

Journal of Functional Foods

Volumn 18, Issue , 2015, Pages 598-607

  Hernández Mijares, Antonio ^a,b,c,d   Bañuls, Celia ^a,b,c   Rovira Llopis, Susana ^a,b,c   Álvarez, Ángeles ^d   Orden, Samuel ^d   Rubio Puchol, Olalla ^b   Víctor, Víctor M ^a,b,c,d   Rocha, Milagros ^a,b,c,d  

^a Foundation for the Promotion of Healthcare Biomedical Research in the Valencian Community (FISABIO)   (Spain)

^b HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^c Instituto Universitario IVI INCLIVA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Endothelial function; Inflammation; Inositol; Oxidative stress; Type 2 diabetes

Indexed keywords

EID: 84942522354     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.08.025     Document Type: Article

References (39)

1. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2012, 35:S64-S71.
2. Bates S.H., Jones R.B., Bailey C.J. Insulin-like effect of pinitol. British Journal of Pharmacology 2000, 130:1944-1948.
3. Beckman J.A., Creager M.A., Libby P. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA: The Journal of the American Medical Association 2002, 287:2570-2581.
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-820.
5. Cheang K.I., Baillargeon J.P., Essah P.A., Ostlund R.E., Apridonize T., Islam L., Nestler J.E. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism: Clinical and Experimental 2008, 57:1390-1397.
6. Dang N.T., Mukai R., Yoshida K., Ashida H. D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL/6 mice. Bioscience, Biotechnology, and Biochemistry 2010, 74:1062-1067.
7. Davis A., Christiansen M., Horowitz J.F., Klein S., Hellerstein M.K., Ostlund R.E. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 2000, 23:1000-1005.
8. De Pablo C., Orden S., Apostolova N., Blanquer A., Esplugues J.V., Alvarez A. Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation. AIDS (London, England) 2010, 24:1259-1266.
9. Geethan P.K., Prince P.S. Antihyperlipidemic effect of D-pinitol on streptozotocin-induced diabetic Wistar rats. Journal of Biochemical and Molecular Toxicology 2008, 22:220-224.
10. Giordano D., Corrado F., Santamaria A., Quattrone S., Pintaudi B., D'Anna R. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study. Menopause (New York, N.Y.) 2011, 18:102-104.
11. Hernández-Mijares A., Bañuls C., Peris J.E., Monzó N., Jover A., Bellod L., Victor V.M., Rocha M. A single acute dose of pinitol from a naturally-occurring food ingredient decreases hyperglycaemia and circulating insulin levels in healthy subjects. Food Chemistry 2013, 141:1267-1272.
12. Hernández-Mijares A., Rocha M., Apostolova N., Borras C., Jover A., Bañuls C., Sola E., Victor V.M. Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients. Free Radical Biology & Medicine 2011, 50:1215-1221.
13. Johnstone M.T., Creager S.J., Scales K.M., Cusco J.A., Lee B.K., Creager M.A. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993, 88:2510-2516.
14. Jude E.B., Douglas J.T., Anderson S.G., Young M.J., Boulton A.J. Circulating cellular adhesion molecules ICAM-1, VCAM-1, P- and E-selectin in the prediction of cardiovascular disease in diabetes mellitus. European Journal of Internal Medicine 2002, 13:185-189.
15. Kim H.J., Park K.S., Lee S.K., Min K.W., Han K.A., Kim Y.K., Ku B.J. Effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in patients with type 2 diabetes mellitus. Annals of Nutrition & Metabolism 2012, 60:1-5.
16. Kim J.I., Kim J.C., Kang M.J., Lee M.S., Kim J.J., Cha I.J. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: A randomized controlled study. European Journal of Clinical Nutrition 2005, 59:456-458.
17. Kim M.J., Yoo K.H., Kim J.H., Seo Y.T., Ha B.W., Kho J.H., Shin Y.G., Chung C.H. Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes. Diabetes Research and Clinical Practice 2007, 77:S247-S251.
18. Kumar S., Boulton A.J., Beck-Nielsen H., Berthezene F., Muggeo M., Persson B., Spinas G.A., Donoghue S., Lettis S., Stewart-Long P. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group. Diabetologia 1996, 39:701-709.
19. Larner J., Allan G., Kessler C., Reamer P., Gunn R., Huang L.C. Phosphoinositol glycan derived mediators and insulin resistance. Prospects for diagnosis and therapy. Journal of Basic and Clinical Physiology and Pharmacology 1998, 9:127-137.
20. Larner J., Brautigan D.L., Thorner M.O. D-chiro-inositol glycans in insulin signaling and insulin resistance. Molecular Medicine 2010, 16:543-552.
21. Lu Z.X., Walker K.Z., Muir J.G., Mascara T., O'Dea K. Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects. American Journal of Clinical Nutrition 2000, 71:1123-1128.
22. Lu Z.X., Walker K.Z., Muir J.G., O'Dea K. Arabinoxylan fibre improves metabolic control in people with type II diabetes. European Journal of Clinical Nutrition 2004, 58:621-628.
23. McDonnell C.M., Donath S.M., Vidmar S.I., Werther G.A., Cameron F.J. A novel approach to continuous glucose analysis utilizing glycemic variation. Diabetes Technology & Therapeutics 2005, 7:253-263.
24. Minozzi M., Nordio M., Pajalich R. The combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. European Review for Medical and Pharmacological Sciences 2013, 17:537-540.
25. Nascimento N.R., Lessa L.M., Kerntopf M.R., Sousa C.M., Alves R.S., Queiroz M.G., Price J., Heimark D.B., Larner J., Du X., Brownlee M., Gow A., Davis C., Fonteles M.C. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:218-223.
26. Nestler J.E., Jakubowicz D.J., Reamer P., Gunn R.D., Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. The New England Journal of Medicine 1999, 340:1314-1320.
27. Rosenblat M., Volkova N., Paland N., Aviram M. Triglyceride accumulation in macrophages upregulates paraoxonase 2 (PON2) expression via ROS-mediated JNK/c-Jun signaling pathway activation. Biofactors (Oxford, England) 2012, 38:458-469.
28. Rovira-Llopis S., Rocha M., Falcon R., de Pablo C., Alvarez A., Jover A., Hernandez-Mijares A., Victor V.M. Is myeloperoxidase a key component in the ROS-induced vascular damage related to nephropathy in type 2 diabetes?. Antioxidants & Redox Signaling 2013, 19:1452-1458.
29. Saltiel A.R., Olefsky J.M. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 1996, 45:1661-1669.
30. Sivakumar S., Palsamy P., Subramanian S.P. Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats. Free Radical Research 2010, 44:668-678.
31. Sivakumar S., Palsamy P., Subramanian S.P. Impact of D-pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats. Chemico-Biological Interactions 2010, 188:237-245.
32. Sivakumar S., Subramanian S.P. Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats. European Journal of Pharmacology 2009, 622:65-70.
33. Steinberg H.O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A.D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. The Journal of Clinical Investigation 1997, 100:1230-1239.
34. Stratton I.M., Adler A.I., Neil H.A., Matthews D.R., Manley S.E., Cull C.A., Hadden D., Turner R.C., Holman R.R. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ (Clinical Research Ed.) 2000, 321:405-412.
35. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The New England Journal of Medicine 1993, 329:977-986. The Diabetes Control and Complications Trial Research Group.
36. Victor V.M., Rocha M., Solá E., Bañuls C., Garcia-Malpartida K., Hernández-Mijares A. Oxidative stress, endothelial dysfunction and atherosclerosis. Current Pharmaceutical Design 2009, 15:2988-3002.
37. Wang L., Gill R., Pedersen T.L., Higgins L.J., Newman J.W., Rutledge J.C. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation. Journal of Lipid Research 2009, 50:204-213.
38. Wang L., Sapuri-Butti A.R., Aung H.H., Parikh A.N., Rutledge J.C. Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. American Journal of Physiology, Heart and Circulatory Physiology 2008, 295:H237-H244.
39. Yaniv Z., Dafni A., Friedman J., Palevitch D. Plants used for the treatment of diabetes in Israel. Journal of Ethnopharmacology 1987, 19:145-151.