Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 77, Issue 3 SUPPL., 2007, Pages

  Kim, Mi Jin ^a   Yoo, Kwang Ha ^b   Kim, Ji Hoon ^a   Seo, Young Tak ^a   Ha, Byung Wook ^a   Kho, Jang Hyun ^c   Shin, Young Goo ^c   Chung, Choon Hee ^c  

^a Hong ik Hospital   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Adipocytokine; Diabetes mellitus; Pinitol

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ADIPONECTIN; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; C PEPTIDE; C REACTIVE PROTEIN; FATTY ACID; GLIMEPIRIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN SENSITIZING AGENT; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PINITOL; SULFONYLUREA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; DIABETES MELLITUS; DIABETIC PATIENT; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HUMAN; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RADIOIMMUNOASSAY; SIDE EFFECT; TREATMENT OUTCOME; WEIGHT GAIN;

ADIPONECTIN; AGED; BLOOD GLUCOSE; C-REACTIVE PROTEIN; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; FATTY ACIDS, NONESTERIFIED; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INOSITOL; LEPTIN; MALE; MIDDLE AGED;

EID: 34547700332     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2007.01.066     Document Type: Article

References (27)

1. Kelly K.L., Mato J.M., Merida I., and Jarrett L. Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 6404-6407
2. Larner J., Allan G., Kessler C., Reamer P., Gunn R., and Cuang L. Phosphoinositol glycan derived mediators and insulin resistance: prospects for diagnosis and therapy. J. Basic Clin. Physiol. Pharmacol. 9 (1988) 127-137
3. Fonteles M.C., Huang L.C., and Larner J. Infusion of pH 2.0 d-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycemia. Diabetologia 39 (1996) 731-734
4. Ortmeyer H.K., Huang L.C., Zhang L., Hansen B.C., and Larner L. Chiroinositol deficiency and insulin resistance. II. Acute effects of d-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistance rhesus monkeys. Endocrinology 132 (1993) 646-651
5. Ortmeyer H.K., Larner J., and Hansen B.C. Effects of d-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys. Obes. Res. 3 (1995) S605-S608
6. Davis A., Christiansen M., Horowitz J.F., Klein S., Hellerstein M.K., and Ostlund Jr. R.E. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 23 (2000) 1000-1005
7. Romero G., and Larner J. Insulin mediators and the mechanism of insulin action. Adv. Pharmacol. 24 (1993) 21-50
8. Low M.G., and Saltiel A.R. Structural and functional roles of glycosylphosphatidylinositol in membrane. Science 239 (1988) 268-275
9. Larner J., Huang L.C., Schwartz C.F., Oswald A.S., Shen T.Y., Kinter M., et al. Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and d-chiroinositol. Biochem. Biophys. Res. Commun. 151 (1988) 1416-1426
10. Kennington A.S., Hill C.R., Craig J., Bogardus C., Raz I., Ortmeyer H.K., et al. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 323 (1990) 373-378
11. Ostlund Jr. R.E., McGill J.B., Herskowitz I., Kipnis D.M., Santiago J.V., and Sherman W.R. d-chiro-inositol metabolism in diabetic mellitus. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 9988-9992
12. Nestler J.E., Jakubowicz D.J., Reamer P., Gunn R.D., and Allan G. Ovulatory and metabolic effects of ds-chiro-inositol in the polycystic ovary disease. N. Engl. J. Med. 340 (1999) 1314-1320
13. DeFronzo R.A., Tobin J.D., and Andres R. The glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237 (1979) E214-E223
14. Katz A., Nambi S.S., Mather K., Baron A.D., Follmann D.A., Sullivan G., et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 85 (2000) 2402-2410
15. Henry R.R. Thiazolidinedione. Endocrinol. Metab. Clin. North Am. 26 (1997) 553-573
16. Kumar S., Boulton A.J., Beck-Nielsen H., Berthezene F., Muggeo M., Persson B., et al., Troglitazone Study Group. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Diabetologia 39 (1996) 701-709
17. Maeda K., Okubo K., Ahimomura I., Funahashi T., Matsuzawa Y., and Matsubara K. cDNA cloning and expression of a novel adipose-specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem. Biophys. Res. Commun. 221 (1996) 286-289
18. Scherer P.E., Williams S., Fogliano M., Baldini G., and Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270 (1995) 26746-26749
19. Hu E., Liang P., and Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 18 (1996) 10697-10703
20. Takahashi M., Arita Y., Yamagata K., Matsukawa Y., Okutomi K., M Horie M., et al. Genomic structure and mutations in adipose-specific gene, adiponectin. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 861-868
21. Shapiro L., and Scherer P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 12 (1998) 335-338
22. Statnick M.A., BeaversS L.S., Conner L.J., Corominola H., Johnson D., Hammond C.D., et al. Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes. Int. J. Exp. Diabetes Res. 1 (2000) 81-88
23. Yokota T., Oritani K., Takahashi I., Ishikana J., Matsuyama A., Ouchi N., et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the function of macrophages. Blood 96 (2000) 1723-1732
24. Berg A.H., Combs T.P., Du X., Brownlee M., and P. Scherer P. The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action. Nature Med. 7 (2001) 947-953
25. Emilsson V., Liu Y.L., Cawthorne M.A., Morton N.M., and Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islet and direct inhibitory action in insulin secretion. Diabetes 46 (1997) 313-316
26. + channels in pancreatic β-cells. Diabetes 46 (1997) 1087-1093
27. Randle P.J., Garland P.B., Hales C.N., and Newsholme E.S. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbance of diabetes mellitus. Lancet 13 (1963) 785-789