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Volumn 11, Issue , 2015, Pages 2405-2414

Intractable and highly active relapsing multiple sclerosis – Role of alemtuzumab

Author keywords

Alemtuzumab; CD52; Idiopathic thrombocytopenic purpura; Monoclonal antibody; Multiple sclerosis

Indexed keywords

ALEMTUZUMAB; BETA1A INTERFERON; FINGOLIMOD; MITOXANTRONE; NATALIZUMAB;

EID: 84942317156     PISSN: None     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/ndt.s90473     Document Type: Review
Times cited : (10)

References (55)
  • 1
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis – the plaque and its pathogenesis
    • Frohman EM, Racke MK, Raine CS. Multiple sclerosis – the plaque and its pathogenesis. N Engl J Med. 2006;354:942–955.
    • (2006) N Engl J Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 2
    • 84906097087 scopus 로고    scopus 로고
    • Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: A comparative study
    • Brickshawana A, Hinson SR, Romero MF, et al. Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study. Lancet Neurol. 2014;13:795–806.
    • (2014) Lancet Neurol , vol.13 , pp. 795-806
    • Brickshawana, A.1    Hinson, S.R.2    Romero, M.F.3
  • 3
    • 0018942701 scopus 로고
    • Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients
    • Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain. 1980;103:281–300.
    • (1980) Brain , vol.103 , pp. 281-300
    • Confavreux, C.1    Aimard, G.2    Devic, M.3
  • 4
    • 77952118055 scopus 로고    scopus 로고
    • Accessed August 1, 2015
    • European Medicines Agency. Gilenya Summary of Product Characteristics; 2011. Available from http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002202/WC500104528.pdf. Accessed August 1, 2015.
    • (2011) Gilenya Summary of Product Characteristics
  • 5
    • 84878794457 scopus 로고    scopus 로고
    • How does fingolimod (Gilenya((R))) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis?
    • Fazekas F, Bajenaru O, Berger T, et al. How does fingolimod (gilenya((R))) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis? Front Neurol. 2013;4:10.
    • (2013) Front Neurol , vol.4 , pp. 10
    • Fazekas, F.1    Bajenaru, O.2    Berger, T.3
  • 6
    • 85027946124 scopus 로고    scopus 로고
    • FREEDOMS study group. Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: Subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study
    • Devonshire V, Havrdova E, Radue EW, et al; FREEDOMS study group. Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study. Lancet Neurol. 2012;11:420–428.
    • (2012) Lancet Neurol , vol.11 , pp. 420-428
    • Devonshire, V.1    Havrdova, E.2    Radue, E.W.3
  • 7
    • 40149098173 scopus 로고    scopus 로고
    • Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis
    • Hirst CL, Pace A, Pickersgill TP, et al. Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis. J Neurol. 2008;255:231–238.
    • (2008) J Neurol , vol.255 , pp. 231-238
    • Hirst, C.L.1    Pace, A.2    Pickersgill, T.P.3
  • 8
    • 84925431283 scopus 로고    scopus 로고
    • Effectiveness of natalizumab in patients with highly active relapsing remitting multiple sclerosis
    • Cobo-Calvo Á, Bau L, Matas E, et al. Effectiveness of natalizumab in patients with highly active relapsing remitting multiple sclerosis. Eur Neurol. 2015;73:220–229.
    • (2015) Eur Neurol , vol.73 , pp. 220-229
    • Cobo-Calvo, Á.1    Bau, L.2    Matas, E.3
  • 9
    • 21444439605 scopus 로고    scopus 로고
    • Use of low-dose mitozantrone to treat aggressive multiple sclerosis: A single-centre open-label study using patient self-assessment and clinical measures of multiple sclerosis status
    • Ostberg A, Pittas F, Taylor B. Use of low-dose mitozantrone to treat aggressive multiple sclerosis: a single-centre open-label study using patient self-assessment and clinical measures of multiple sclerosis status. Intern Med J. 2005;35:382–387.
    • (2005) Intern Med J , vol.35 , pp. 382-387
    • Ostberg, A.1    Pittas, F.2    Taylor, B.3
  • 10
    • 0345601517 scopus 로고    scopus 로고
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet. 1998;352:1498–1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 11
    • 0027418515 scopus 로고
    • Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group
    • IFNB Multiple Sclerosis Study Group. Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology. 1993;43(4):655–661.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 12
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol. 1996;39:285–294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 13
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology. 1995;45(7):1277–1285.
    • (1995) Neurology. , vol.45 , Issue.7 , pp. 1277-1285
  • 14
    • 84919794431 scopus 로고    scopus 로고
    • Clinical management of multiple sclerosis and neuromyelitis optica with therapeutic monoclonal antibodies: Approved therapies and emerging candidates
    • Dubey D, Kieseier BC, Hartung HP, Hemmer B, Miller-Little WA, Stuve O. Clinical management of multiple sclerosis and neuromyelitis optica with therapeutic monoclonal antibodies: approved therapies and emerging candidates. Expert Rev Clin Immunol. 2015;11:93–108.
    • (2015) Expert Rev Clin Immunol , vol.11 , pp. 93-108
    • Dubey, D.1    Kieseier, B.C.2    Hartung, H.P.3    Hemmer, B.4    Miller-Little, W.A.5    Stuve, O.6
  • 15
    • 0034765991 scopus 로고    scopus 로고
    • The CD52 antigen and development of the CAMPATH antibodies
    • Hale G. The CD52 antigen and development of the CAMPATH antibodies. Cytotherapy. 2001;3:137–143.
    • (2001) Cytotherapy , vol.3 , pp. 137-143
    • Hale, G.1
  • 16
    • 0029912735 scopus 로고    scopus 로고
    • Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils
    • Elsner J, Hochstetter R, Spiekermann K, Kapp A. Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils. Blood. 1996;88:4684–4693.
    • (1996) Blood , vol.88 , pp. 4684-4693
    • Elsner, J.1    Hochstetter, R.2    Spiekermann, K.3    Kapp, A.4
  • 17
    • 0027462047 scopus 로고
    • The glycosylphosphatidylinositol-anchored lymphocyte antigen CDw52 is associated with the epididymal maturation of human spermatozoa
    • Hale G, Rye PD, Warford A, Lauder I, Brito-Babapulle A. The glycosylphosphatidylinositol-anchored lymphocyte antigen CDw52 is associated with the epididymal maturation of human spermatozoa. J Reprod Immunol. 1993;23:189–205.
    • (1993) J Reprod Immunol , vol.23 , pp. 189-205
    • Hale, G.1    Rye, P.D.2    Warford, A.3    Lauder, I.4    Brito-Babapulle, A.5
  • 18
    • 0032535279 scopus 로고    scopus 로고
    • Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection
    • Hale G, Zhang MJ, Bunjes D, et al. Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection. Blood. 1998;92: 4581–4590.
    • (1998) Blood , vol.92 , pp. 4581-4590
    • Hale, G.1    Zhang, M.J.2    Bunjes, D.3
  • 19
    • 9444257631 scopus 로고    scopus 로고
    • Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission
    • Oakhill A, Pamphilon DH, Potter MN, et al. Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission. Br J Haematol. 1996;94:574–578.
    • (1996) Br J Haematol , vol.94 , pp. 574-578
    • Oakhill, A.1    Pamphilon, D.H.2    Potter, M.N.3
  • 20
    • 0034759325 scopus 로고    scopus 로고
    • Manufacture and quality control of CAMPATH-1 antibodies for clinical trials
    • Phillips J, Drumm A, Harrison P, et al. Manufacture and quality control of CAMPATH-1 antibodies for clinical trials. Cytotherapy. 2001;3:233–242.
    • (2001) Cytotherapy , vol.3 , pp. 233-242
    • Phillips, J.1    Drumm, A.2    Harrison, P.3
  • 21
    • 84904020925 scopus 로고    scopus 로고
    • Alemtuzumab: The advantages and challenges of a novel therapy in MS
    • Menge T, Stuve O, Kieseier BC, Hartung HP. Alemtuzumab: the advantages and challenges of a novel therapy in MS. Neurology. 2014; 83:87–97.
    • (2014) Neurology , vol.83 , pp. 87-97
    • Menge, T.1    Stuve, O.2    Kieseier, B.C.3    Hartung, H.P.4
  • 22
    • 31444453579 scopus 로고    scopus 로고
    • Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
    • Mone AP, Cheney C, Banks AL, et al. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia. 2006;20: 272–279.
    • (2006) Leukemia , vol.20 , pp. 272-279
    • Mone, A.P.1    Cheney, C.2    Banks, A.L.3
  • 24
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells
    • Rowan W, Tite J, Topley P, Brett SJ. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells. Immunology. 1998;95:427–436.
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3    Brett, S.J.4
  • 25
    • 19444377855 scopus 로고    scopus 로고
    • Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    • Nuckel H, Frey UH, Roth A, Duhrsen U, Siffert W. Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity. Eur J Pharmacol. 2005;514:217–224.
    • (2005) Eur J Pharmacol , vol.514 , pp. 217-224
    • Nuckel, H.1    Frey, U.H.2    Roth, A.3    Duhrsen, U.4    Siffert, W.5
  • 26
    • 0035525772 scopus 로고    scopus 로고
    • Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation
    • Jones DT, Ganeshaguru K, Virchis AE, et al. Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. Blood. 2001;98:2800–2807.
    • (2001) Blood , vol.98 , pp. 2800-2807
    • Jones, D.T.1    Ganeshaguru, K.2    Virchis, A.E.3
  • 27
    • 77957044257 scopus 로고    scopus 로고
    • Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity
    • Jones JL, Anderson JM, Phuah CL, et al. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain. 2010;133:2232–2247.
    • (2010) Brain , vol.133 , pp. 2232-2247
    • Jones, J.L.1    Erson, J.M.2    Phuah, C.L.3
  • 28
    • 84873690365 scopus 로고    scopus 로고
    • Clinical relevance of differential lymphocyte recovery after alemtuzumab therapy for multiple sclerosis
    • Cossburn MD, Harding K, Ingram G, et al. Clinical relevance of differential lymphocyte recovery after alemtuzumab therapy for multiple sclerosis. Neurology. 2013;80:55–61.
    • (2013) Neurology , vol.80 , pp. 55-61
    • Cossburn, M.D.1    Harding, K.2    Ingram, G.3
  • 29
    • 84921047834 scopus 로고    scopus 로고
    • Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use
    • Havrdova E, Horakova D, Kovarova I. Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use. Ther Adv Neurol Disord. 2015;8:31–45.
    • (2015) Ther Adv Neurol Disord , vol.8 , pp. 31-45
    • Havrdova, E.1    Horakova, D.2    Kovarova, I.3
  • 30
    • 84928168073 scopus 로고    scopus 로고
    • Alemtuzumab for the treatment of multiple sclerosis
    • Willis MD, Robertson NP. Alemtuzumab for the treatment of multiple sclerosis. Ther Clin Risk Manag. 2015;11:525–534.
    • (2015) Ther Clin Risk Manag , vol.11 , pp. 525-534
    • Willis, M.D.1    Robertson, N.P.2
  • 31
    • 57449094932 scopus 로고    scopus 로고
    • Pharmacokinetics of alemtuzumab and the relevance in clinical practice
    • Elter T, Molnar I, Kuhlmann J, Hallek M, Wendtner C. Pharmacokinetics of alemtuzumab and the relevance in clinical practice. Leuk Lymphoma. 2008;49:2256–2262.
    • (2008) Leuk Lymphoma , vol.49 , pp. 2256-2262
    • Elter, T.1    Molnar, I.2    Kuhlmann, J.3    Hallek, M.4    Wendtner, C.5
  • 32
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs. Interferon beta-1a in early multiple sclerosis
    • CAMMS223 Trial Investigators; Coles AJ, Compston DA, Selmaj KW, et al. Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N Engl J Med. 2008;359:1786–1801.
    • (2008) N Engl J Med , vol.359 , pp. 1786-1801
    • Coles, A.J.1    Compston, D.A.2    Selmaj, K.W.3
  • 33
    • 84869492471 scopus 로고    scopus 로고
    • CARE-MS I investigators. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled phase 3 trial
    • Cohen JA, Coles AJ, Arnold DL, et al; CARE-MS I investigators. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet. 2012;380:1819–1828.
    • (2012) Lancet , vol.380 , pp. 1819-1828
    • Cohen, J.A.1    Coles, A.J.2    Arnold, D.L.3
  • 34
    • 84869507357 scopus 로고    scopus 로고
    • CARE-MS II investigators. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: A randomised controlled phase 3 trial
    • Coles AJ, Twyman CL, Arnold DL, et al; CARE-MS II investigators. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet. 2012;380:1829–1839.
    • (2012) Lancet , vol.380 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.L.2    Arnold, D.L.3
  • 35
    • 84860780657 scopus 로고    scopus 로고
    • Alemtuzumab more effective than interferon beta-1a at 5-year follow-up of CAMMS223 clinical trial
    • Coles AJ, Fox E, Vladic A, et al. Alemtuzumab more effective than interferon beta-1a at 5-year follow-up of CAMMS223 clinical trial. Neurology. 2012;78:1069–1078.
    • (2012) Neurology , vol.78 , pp. 1069-1078
    • Coles, A.J.1    Fox, E.2    Vladic, A.3
  • 36
    • 84921319094 scopus 로고    scopus 로고
    • Alemtuzumab treatment of multiple sclerosis: Long-term safety and efficacy
    • Tuohy O, Costelloe L, Hill-Cawthorne G, et al. Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. J Neurol Neurosurg Psychiatry. 2015;86:208–215.
    • (2015) J Neurol Neurosurg Psychiatry , vol.86 , pp. 208-215
    • Tuohy, O.1    Costelloe, L.2    Hill-Cawthorne, G.3
  • 37
    • 84864119671 scopus 로고    scopus 로고
    • Subcutaneous administration of alemtuzumab in patients with highly active multiple sclerosis
    • Perumal JS, Foo F, Cook P, Khan O. Subcutaneous administration of alemtuzumab in patients with highly active multiple sclerosis. Mult Scler. 2012;18:1197–1199.
    • (2012) Mult Scler , vol.18 , pp. 1197-1199
    • Perumal, J.S.1    Foo, F.2    Cook, P.3    Khan, O.4
  • 38
    • 84939973524 scopus 로고    scopus 로고
    • Alemtuzumab as rescue therapy in a cohort of 16 aggressive multiple sclerosis patients previously treated by Mitoxantrone: An observational study
    • Le PE, Deburghgraeve V, Lester MA, Cardiet I, Leray E, Edan G. Alemtuzumab as rescue therapy in a cohort of 16 aggressive multiple sclerosis patients previously treated by Mitoxantrone: an observational study. J Neurol. 2015;262:1024–1034.
    • (2015) J Neurol , vol.262 , pp. 1024-1034
    • Le, P.E.1    Deburghgraeve, V.2    Lester, M.A.3    Cardiet, I.4    Leray, E.5    Edan, G.6
  • 39
    • 67349250932 scopus 로고    scopus 로고
    • AFFIRM and SENTINEL Investigators. The efficacy of natalizumab in patients with relapsing multiple sclerosis: Subgroup analyses of AFFIRM and SENTINEL
    • Hutchinson M, Kappos L, Calabresi PA, et al; AFFIRM and SENTINEL Investigators. The efficacy of natalizumab in patients with relapsing multiple sclerosis: subgroup analyses of AFFIRM and SENTINEL. J Neurol. 2009;256:405–415.
    • (2009) J Neurol , vol.256 , pp. 405-415
    • Hutchinson, M.1    Kappos, L.2    Calabresi, P.A.3
  • 40
    • 84939817991 scopus 로고    scopus 로고
    • Efficacy of fingolimod in patients with highly active relapsing-remitting multiple sclerosis
    • Epub, August 24
    • Derfuss T, Bergvall NK, Sfikas N, Tomic DL. Efficacy of fingolimod in patients with highly active relapsing-remitting multiple sclerosis. Curr Med Res Opin. Epub 2015 August 24.
    • (2015) Curr Med Res Opin
    • Derfuss, T.1    Bergvall, N.K.2    Sfikas, N.3    Tomic, D.L.4
  • 41
    • 84899070305 scopus 로고    scopus 로고
    • Effect of daclizumab high-yield process in patients with highly active relapsing-remitting multiple sclerosis
    • Giovannoni G, Radue EW, Havrdova E, et al. Effect of daclizumab high-yield process in patients with highly active relapsing-remitting multiple sclerosis. J Neurol. 2014;261:316–323.
    • (2014) J Neurol , vol.261 , pp. 316-323
    • Giovannoni, G.1    Radue, E.W.2    Havrdova, E.3
  • 42
    • 17044391471 scopus 로고    scopus 로고
    • Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-beta
    • Correale J, Rush C, Amengual A, Goicochea MT. Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-beta. J Neuroimmunol. 2005;162:173–183.
    • (2005) J Neuroimmunol , vol.162 , pp. 173-183
    • Correale, J.1    Rush, C.2    Amengual, A.3    Goicochea, M.T.4
  • 43
    • 33745285962 scopus 로고    scopus 로고
    • Management of worsening multiple sclerosis with mitoxantrone: A review
    • Fox EJ. Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther. 2006;28:461–474.
    • (2006) Clin Ther , vol.28 , pp. 461-474
    • Fox, E.J.1
  • 44
    • 20144368500 scopus 로고    scopus 로고
    • Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: Impact on disease activity and quality of life
    • Saccardi R, Mancardi GL, Solari A, et al. Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood. 2005;105:2601–2607.
    • (2005) Blood , vol.105 , pp. 2601-2607
    • Saccardi, R.1    Mancardi, G.L.2    Solari, A.3
  • 45
    • 84924368416 scopus 로고    scopus 로고
    • ASTIMS Haemato-Neurological Collaborative Group, On behalf of the Autoimmune Disease Working Party (ADWP) of the European Group for Blood and Marrow Transplantation (EBMT); ASTIMS Haemato-Neurological Collaborative Group On behalf of the Autoimmune Disease Working Party ADWP of the European Group for Blood and Marrow Transplantation EBMT. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A phase II trial
    • Mancardi GL, Sormani MP, Gualandi F, et al; ASTIMS Haemato-Neurological Collaborative Group, On behalf of the Autoimmune Disease Working Party (ADWP) of the European Group for Blood and Marrow Transplantation (EBMT); ASTIMS Haemato-Neurological Collaborative Group On behalf of the Autoimmune Disease Working Party ADWP of the European Group for Blood and Marrow Transplantation EBMT. Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial. Neurology. 2015;84: 981–988.
    • (2015) Neurology , vol.84 , pp. 981-988
    • Mancardi, G.L.1    Sormani, M.P.2    Gualandi, F.3
  • 46
    • 84864310045 scopus 로고    scopus 로고
    • Complications of autologous hematopoietic stem cell transplantation for patients with autoimmune diseases
    • Daikeler T, Tichelli A, Passweg J. Complications of autologous hematopoietic stem cell transplantation for patients with autoimmune diseases. Pediatr Res. 2012;71:439–444.
    • (2012) Pediatr Res , vol.71 , pp. 439-444
    • Daikeler, T.1    Tichelli, A.2    Passweg, J.3
  • 47
    • 0020591822 scopus 로고
    • Removal of T cells from bone marrow for transplantation: A monoclonal antilymphocyte antibody that fixes human complement
    • Hale G, Bright S, Chumbley G, et al. Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 1983;62:873–882.
    • (1983) Blood , vol.62 , pp. 873-882
    • Hale, G.1    Bright, S.2    Chumbley, G.3
  • 48
    • 0028290250 scopus 로고
    • T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease
    • Jacobs P, Wood L, Fullard L, Waldmann H, Hale G. T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease. Bone Marrow Transplant. 1994;13:763–769.
    • (1994) Bone Marrow Transplant , vol.13 , pp. 763-769
    • Jacobs, P.1    Wood, L.2    Fullard, L.3    Waldmann, H.4    Hale, G.5
  • 49
    • 68849084141 scopus 로고    scopus 로고
    • IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)
    • Jones JL, Phuah CL, Cox AL, et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest. 2009;119:2052–2061.
    • (2009) J Clin Invest , vol.119 , pp. 2052-2061
    • Jones, J.L.1    Phuah, C.L.2    Cox, A.L.3
  • 50
    • 83455210452 scopus 로고    scopus 로고
    • A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
    • Cuker A, Coles AJ, Sullivan H, et al. A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis. Blood. 2011;118:6299–6305.
    • (2011) Blood , vol.118 , pp. 6299-6305
    • Cuker, A.1    Coles, A.J.2    Sullivan, H.3
  • 51
    • 84866686643 scopus 로고    scopus 로고
    • Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing-remitting multiple sclerosis
    • Meyer D, Coles A, Oyuela P, Purvis A, Margolin DH. Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing-remitting multiple sclerosis. Mult Scler Relat Disord. 2013;2:60–63.
    • (2013) Mult Scler Relat Disord , vol.2 , pp. 60-63
    • Meyer, D.1    Coles, A.2    Oyuela, P.3    Purvis, A.4    Margolin, D.H.5
  • 52
    • 84942355013 scopus 로고    scopus 로고
    • August 1
    • LEMTRADA REMS program overview. Available from https://www.lemtradarems.com/Docs/Pdf/LEMTRADA_REMS_Program_Overview.pdf. Accessed August 1, 2015.
    • (2015)
  • 53
    • 84942355014 scopus 로고    scopus 로고
    • August 1, 2015
    • FDA Approves Lemtrada™ (alemtuzumab) for Relapsing MS – UPDATE; 2014. Available from http://www.nationalmssociety.org/About-the-Society/News/FDA-Approves-Lemtrada%E2%84%A2-(alemtuzumab)-for-Relapsing. Accessed August 1, 2015.
    • (2014)
  • 54
    • 84942355015 scopus 로고    scopus 로고
    • August 1, 2015
    • Disease Modification; 2015. Available from http://www.nationalmssociety.org/For-Professionals/Clinical-Care/Managing-MS/Disease-Modification#section-1. Accessed August 1, 2015.
    • (2015)
  • 55
    • 84942355016 scopus 로고    scopus 로고
    • August 1
    • Genzyme Details Market Potential of Alemtuzumab for MS; 2014. Available from http://www.worldpharmanews.com/genzyme/1529-genzyme-details-market-potential-of-alemtuzumab-for-ms. Accessed August 1, 2015.
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.