Ciprofloxacin-induced neurotoxicity: Evaluation of possible underlying mechanisms

Toxicology Mechanisms and Methods

Volumn 25, Issue 5, 2015, Pages 374-381

  Ilgin, Sinem ^a   Can, Ozgur Devrim ^b   Atli, Ozlem ^a   Ucel, Umut Irfan ^b   Sener, Erol ^a   Guven, Ilkay ^a  

^a ANADOLU UNIVERSITY   (Turkey)

^b Department of Pharmacology ^*  (Turkey)

Author keywords

Anxiety; ciprofloxacin; depression; fluoroquinolone; oxidative stress

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENALIN; ANTIOXIDANT; CATALASE; CIPROFLOXACIN; DOPAMINE; GLUTAMIC ACID; GLUTATHIONE; MALONALDEHYDE; NEUROTRANSMITTER; NORADRENALIN; SUPEROXIDE DISMUTASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BRAIN HOMOGENATE; CIPROFLOXACIN INDUCED NEUROTOXICITY; CONTROLLED STUDY; DEPRESSION; ELEVATED PLUS MAZE TEST; FEMALE; FORCED SWIM TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOCOMOTION; MOTOR COORDINATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; ANIMAL; ANIMAL BEHAVIOR; BRAIN; DRUG EFFECTS; ENZYMOLOGY; MAZE TEST; METABOLISM; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; PSYCHOLOGY; ROTAROD TEST; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; BEHAVIOR, ANIMAL; BRAIN; CIPROFLOXACIN; FEMALE; MAZE LEARNING; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; NEUROTRANSMITTER AGENTS; OXIDATIVE STRESS; RATS, WISTAR; ROTAROD PERFORMANCE TEST;

EID: 84942303441     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2015.1026008     Document Type: Article

References (51)

1. Abdel-Zaher AO, Afify AHM, Kamel SM, et al. (2012). Involvement of glutamate, oxidative stress and inducible nitric oxide synthase in the convulsant activity of ciprofloxacin in mice. Eur J Pharmacol 685: 30-7
2. Ahmed AI, van der Heijden FM, van den Berkmortel H, Kramers K. (2011). A man who wanted to commit suicide by hanging himself: an adverse effect of ciprofloxacin. Gen Hosp Psychiatry 33: 82.e5-7
3. Al-Ghamdi SM. (2002). Reversible encephalopathy and delirium in patients with chronic renal failure who had received ciprofloxacin. Saudi J Kidney Dis Transpl 13: 163-70
4. Arafa NM, Abdel-Rahman M, El-khadragy MF, Kassab RB. (2013). Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters. Neurochem Res 38: 174-85
5. Azar S, Ramjiani A, Van Gerpen JA. (2005). Ciprofloxacin-induced chorea. Mov Disord 20: 513-14
6. Bhalerao S, Talsky A, Hansen K, et al. (2006). Ciprofloxacin-induced manic episode. Psychosomatics 47: 539-40
7. Can OD, Demir Ozkay U, Kaplancikli ZA, Ozturk Y. (2009). Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice. Arch Pharm Res 32: 1293-9
8. Can OD, Ozkay UD. (2012). Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/benzodiazepine receptors in its pharmacological activity. Phytother Res 26: 1695-700
9. Can OD, Ozkay UD, Ozturk N, Ozturk Y. (2010). Effects of hawthorn seed and pulp extracts on the central nervous system. Pharm Biol 48: 924-31
10. Can OD, Ozturk Y, Ozkay UD. (2011). Effects of insulin and St. John's Wort treatments on anxiety, locomotory activity, depression, and active learning parameters of streptozotocin-diabetic rats. Planta Med 77: 1970-6
11. Castrén E, Rantamäki T. (2010). The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev Neurobiol 70: 289-97
12. Channa HM, Ashfaq M, Bangash R, et al. (2008). Preventive role of zinc chloride against toxicity of ciprofloxacin on the growing cartilage of Wistar Albino rat litter. J Ayub Med Coll Abbottabad 20: 77-81
13. Channa MA, Ashfaq M, Jokhio AL, et al. (2012). Effects of ciprofloxacin and zinc chloride in adult albino rat and pre-natal conceptus. J Ayub Med Coll Abbottabad 24: 55-8
14. Cryan JF, Markou A, Lucki I. (2002). Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23: 238-45
15. De Sarro A, Naccari F, De Sarro G. (1999). Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects. Int J Antimicrob Agents 12: 239-44
16. Denysenko L, Nicolson SE. (2011). Cefoxitin and ciprofloxacin neurotoxicity and catatonia in a patient on hemodialysis. Psychosomatics 52: 379-83
17. El-Naga RN, Ahmed HI, Abd Al Haleem EN. (2014). Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: impact on oxidative stress, inflammation, apoptosis and monoamine levels. Neurotoxicology 44C: 48-57
18. Garabadu D, Krishnamurthy S. (2014). Asparagus racemosus attenuates anxiety-like behavior in experimental animal models. Cell Mol Neurobiol 34: 511-21
19. Gardiner J, Barton D, Overall R, Marc J. (2009). Neurotrophic support and oxidative stress: converging effects in the normal and diseased nervous system. Neuroscientist 15: 47-61
20. Grassi L, Biancosino B, Pavanati M, et al. (2001). Depression or hypoactive delirium? A report of ciprofloxacin-induced mental disorder in a patient with chronic obstructive pulmonary disease. Psychother Psychosom 70: 58-9
21. Green CR, Corsi-Travali S, Neumeister A. (2013). The role of BDNFTrkB signaling in the pathogenesis of PTSD. J Depress Anxiety S4(006): 1-13
22. Gurbay A, Gonthier B, Daveloose D, et al. (2001). Microsomal metabolism of ciprofloxacin generates free radicals. Free Radic Biol Med 30: 1118-21
23. Halliwell RF, Davey PG, Lambert JJ. (1995). A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and ionotropic glutamate receptors. Neuropharmacology 34: 1615-24
24. Hicks LA, Taylor Jr TH, Hunkler RJ. (2013). U.S. outpatient antibiotic prescribing, 2010. N Engl J Med 368: 1461-2
25. Hincal F, Gürbay A, Favier A. (2003). Biphasic response of ciprofloxacin in human fibroblast cell cultures. Nonlinearity Biol Toxicol Med 1: 481-92
26. Jacobson-Pick S, Audet MC, McQuaid RJ, et al. (2013). Social agonistic distress in male and female mice: changes of behavior and brain monoamine functioning in relation to acute and chronic challenges. PLoS One 8: e60133
27. Kaita KD, Assy N, Gauthier T, et al. (1998). The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. Hepatology 27: 533-6
28. Kim SH, Jeong SH, Kim JW, et al. (2009). A case of hemiballism as a rare side effect of ciprofloxacin in a patient with liver cirrhosis. Chemotherapy 55: 207-10
29. Koponen E, Rantamaki T, Voikar V, et al. (2005). Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol 25: 973-80
30. LaSalvia EA, Domek GJ, Gitlin DF. (2010). Fluoroquinolone-induced suicidal ideation. Gen Hosp Psychiatry 32: 108-10
31. Lunn G, Hellwig LC, eds. (1998). Handbook of derivatization reactions for HPLC, amino acids. New Jersey, USA: Wiley
32. Maes M, Galecki P, Chang YS, Berk M. (2011). A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 35: 676-92
33. McManus MJ, Murphy MP, Franklin JL. (2014). Mitochondria-derived reactive oxygen species mediate caspase-dependent and-independent neuronal deaths. Mol Cell Neurosci 63C: 13-23
34. Merzoug S, Toumi ML, Tahraoui A. (2014). Quercetin mitigates Adriamycin-induced anxiety-and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats. Naunyn Schmiedebergs Arch Pharmacol 387:921-33
35. Nakamura T, Fukuda H, Morita Y, et al. (2003). Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system. J Toxicol Sci 28: 35-45
36. Naora K, Ichikawa N, Hirano H, Iwamoto K. (1999). Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure. J Pharm Pharmacol 51: 609-16
37. Nduka SO, Okonta MJ, Esimone CO. (2013). Effects of Zingiber officinale on the plasma pharmacokinetics and lung penetrations of ciprofloxacin and isoniazid. Am J Ther 20: 507-13
38. Ng F, Berk M, Dean O, Bush AI. (2008). Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 11: 851-76
39. Pencea V, Bingaman KD, Wiegand SJ, Luskin MB. (2001). Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 21: 6706-17
40. Pesarico AP, Sampaio TB, Stangherlin EC, et al. (2014). The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems. Prog Neuropsychopharmacol Biol Psychiatry 54C: 179-86
41. Prabhu S, Rewari S. (1998). A comparative study of anxiogenic effects of fluoroquinolones in rats. Indian J Physiol Pharmacol 42: 135-8
42. Qin P, Liu R. (2013). Oxidative stress response of two fluoroquinolones with catalase and erythrocytes: a combined molecular and cellular study. J Hazard Mater 252-253: 321-9
43. Rollof J, Vinge E. (1993). Neurologic adverse effects during concomitant treatment with ciprofloxacin, NSAIDS, and chloroquine: possible drug interaction. Ann Pharmacother 27: 1058-9
44. Saraçoʇlu A, Temel HE, Ergun B, Colak O. (2009). Oxidative stress-mediated myocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats. Drug Chem Toxicol 32: 238-42
45. Sen S, Jaiswal AK, Yanpallewar S, Acharya SB. (2007). Anxiogenic potential of ciprofloxacin and norfloxacin in rats. Singapore Med J 48: 1028-32
46. Shahzad N, Ahmad J, Khan W, et al. (2014). Interactions of atenolol with alprazolam/escitalopram on anxiety, depression and oxidative stress. Pharmacol Biochem Behav 117: 79-84
47. Stahlmann R, Lode H. (1999). Toxicity of quinolones. Drugs 58: 37-42
48. Stangherlin EC, Nogueira CW. (2014). Diphenyl ditelluride induces anxiogenic-like behavior in rats by reducing glutamate uptake. Biol Trace Elem Res 158: 392-8
49. Strzelec JS, Kubik-Bogucka E, Czarnecka E. (1999). Influence of fluoroquinolones on the central action of ethanol. Pol J Pharmacol 51: 71-8
50. Talla V, Veerareddy P. (2011). Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients. J Young Pharm 3: 304-9
51. Zanoli P, Rivasi M, Zavatti M, et al. (2005). New insight in the neuropharmacological activity of Humulus lupulus L. J Ethnopharmacol 102: 102-6