Anxiogenic potential of ciprofloxacin and norfloxacin in rats

Singapore Medical Journal

Volumn 48, Issue 11, 2007, Pages 1028-1032

  Sen, S ^a   Jaiswal, A K ^b   Yanpallewar, S ^a   Acharya, S B ^a,c  

^a BANARAS HINDU UNIVERSITY   (India)

^b Tilak Dhari College   (India)

^c SGRR Institute of Medical and Health Sciences   (India)

Author keywords

Anxiogenic effects; Ciprofloxacin; Fluoroquinolone; Norfloxacin; Rat

Indexed keywords

CIPROFLOXACIN; NORFLOXACIN; ANTIINFECTIVE AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEEDING BEHAVIOR; FEMALE; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; RAT; SOCIAL INTERACTION; ANIMAL; CHEMICALLY INDUCED DISORDER; EXPLORATORY BEHAVIOR; FEAR; ORAL DRUG ADMINISTRATION; PSYCHOLOGICAL ASPECT; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANXIETY; CIPROFLOXACIN; EXPLORATORY BEHAVIOR; FEAR; FEEDING BEHAVIOR; FEMALE; MALE; MAZE LEARNING; NORFLOXACIN; RATS; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT;

EID: 38449103833     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Halkin H. Adverse effects of fluoroquinolones. Rev Inf Dis 1988; 10(suppl 1):S258-61.
2. Christ W. Central nervous system toxicity of quinolones: human and animal findings. J Antimicrob Chemother 1990; 26 Suppl B: 219-25.
3. Yasuda H, Yoshida A, Masuda, Y, et al. [Levofloxacin-induced neurological adverse effects such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients]. Nippon Ronen Igakkai Zasshi 1999; 36:213-7. Japanese.
4. Prabhu S, Rewari S. A comparative study of anxiogenic effects of fluoroquinolones in rats. Indian J Physiol Pharmacol 1998; 42:135-8.
5. Erden B F, Ulak G, Yildiz F, et al. Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice. Pharmacol Biochem Behav 2001; 68:435-41.
6. Thiel R, Metzner S, Gericke C, Rahm U, Stahlmann R. Effects of fluoroquinolones on the locomotor activity in rats. Arch Toxicol 2001; 75:36-41.
7. Bronstein PM. Open-field behaviour of the rat as a function of age: Cross-sectional and longitudinal investigations. J Comp Physiol Psychol 1972; 80: 335-341.
8. Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986; 24:525-9.
9. Shepherd JK, Grewal SS, Fletcher A, Bill DJ, Dourish CT. Behavioural and pharmacological characterisation of the elevated "zero maze" as an animal model of anxiety. Psychopharmacology (Berl) 1994; 116:56-64.
10. Johnston AL, Baldwin HA, File SE. Measures of anxiety and stress in the rat following chronic treatment with yohimbine. J Psychopharmacol 1988; 2:33-38.
11. Bodnoff SR, Suranji-Cadotte B, Aitken DH, Quirion R, Meaney MJ. The effects of chronic antidepressant treatment on an animal model of anxiety. Psychopharmacology (Berl) 1988; 95:298-302.
12. Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill, 1962.
13. Treit D. Animal models for the study of anti-anxiety agents: a review. Neurosci Biobehav Rev 1985; 9:203-22.
14. File SE. Animal models for predicting clinical efficacy of anxiolytic drugs: social behaviour. Neuropsychobiology 1985; 13:55-62.
15. File SE. How good is social interaction as a test of anxiety? In: Simon P, Soubrié P, Widlocher D, eds. Selected Models of Anxiety, Depression and Psychosis. Basel: Karger, 1988: 151-66.
16. Lister RG. Ethologically-based animal models of anxiety disorders. Pharmacol Ther 1990; 46:321-40.
17. Pellow S, Chopin P, File SE, Brieley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985; 14:149-67.
18. File SE. Animals Animal models of different anxiety states. In: Biggio G, Sanna E, Serra M, Costa E, eds. GABA Receptor and Anxiety: From Neurobiology to Treatment. New York: Lippincott Williams & Wilkins, 1995: 93-113.
19. Bhattacharya SK, Satyan KS. Experimental methods for evaluation of psychotropic agents in rodents: I - Anti-anxiety agents. Indian J Exp Biol 1997; 35:565-75.
20. Kawakami J, Yamamoto K, Asanuma A, et al. Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo. Toxicol Appl Pharmacol 1997; 145:246-54.
21. Davis M, Rainnie D, Cassell M. Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 1994; 17:208-14.
22. Unseld E, Ziegler G, Gemerhardt A, Janssen U, Koltz U. Possible interaction of fluoroquinolones with the benzodiazepine-GABAA-receptor complex. Br J Clin Pharmacol 1990; 30:63-70.
23. Akahane K, Tsutomi Y, Kimura Y, Kitano Y. Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor binding. Chemotherapy 1994; 40:412-7.
24. Imanishi T, Akahane K, Akaike N. Attenuated inhibition by levofloxacin, l-isomer of ofloxacin, on GABA response in the dissociated rat hippocampal neurons. Neurosci Lett 1995; 193:81-4.
25. Enginar N, Ero?lu L. The effect of ofloxacin and ciprofloxacin on pentylenetetrazol-induced convulsions in mice. Pharmacol Biochem Behav 1991; 39:587-9.
26. Dodd PR, Davies LP, Watson WE, et al. Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS. Pharmacol Toxicol 1988; 64:404-11.
27. Schmuck G, Schürmann A, Schlüter G. Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model. Antimicrob Agents Chemother 1998; 42:1831-6.
28. Williams PD, Helton DR. The proconvulsive activity of quinolone antibiotics in an animal model. Toxicol Lett 1991; 58:23-8.
29. Nakamura M, Abe S, Goto Y, et al. In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. Epilepsy Res 1994; 17:249-56.
30. De Sarro G, Nava F, Calapai G, De Sarro A. Effects of some excitatory amino acid antagonists and drugs enhancing gammaaminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice. Antimicrob Agents Chemother 1997; 41:427-34.