Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Pienaar, Ilse S ^a,b   Gartside, Sarah E ^c   Sharma, Puneet ^a   De Paola, Vincenzo ^a   Gretenkord, Sabine ^c   Withers, Dominic ^a   Elson, Joanna L ^c,d   Dexter, David T ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NORTHUMBRIA UNIVERSITY   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Cholinergic; Deep brain stimulation; DREADD; Parkinson's disease; Pedunculopontine nucleus

Indexed keywords

CLOZAPINE N OXIDE; DESIGNER DRUG; PROTEIN C FOS; CHOLINERGIC RECEPTOR STIMULATING AGENT;

AKINESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY POSTURE; CELL POPULATION; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DISEASE MODEL; DRUG MECHANISM; FORELIMB; FUNCTION TEST; GAIT; IN VIVO STUDY; MALE; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NERVE CELL STIMULATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROMODULATION; NONHUMAN; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PHARMACOGENETICS; PROTEIN EXPRESSION; RAT; SENSORIMOTOR INTEGRATION; SYMPTOM; UPREGULATION; ANIMAL; BRAIN DEPTH STIMULATION; DRUG EFFECTS; LONG EVANS RAT; METABOLISM; PROCEDURES; TRANSGENIC RAT;

ANIMALS; CHOLINERGIC AGENTS; CHOLINERGIC NEURONS; DEEP BRAIN STIMULATION; DISEASE MODELS, ANIMAL; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PHARMACOGENETICS; RATS, LONG-EVANS; RATS, TRANSGENIC;

EID: 84942292827     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0044-5     Document Type: Article

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