In-vitro and in-vivo studies of cefpirom using bile salts as absorption enhancers

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 12, 2003, Pages 1601-1606

  Mrestani, Yahya ^a   Bretschneider, Beate ^a   Härtl, Albert ^b   Neubert, Reinhard H H ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOLYTE; BILE SALT; BUFFER; CEFPIROME; CEPHALOSPORIN DERIVATIVE; CHOLIC ACID; DEHYDROCHOLIC ACID; DEOXYCHOLATE SODIUM; GLUCOSE; OCTANOL; TAURODEOXYCHOLIC ACID;

ADSORPTION; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL MEMBRANE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG TRANSPORT; DRUG URINE LEVEL; EXCIPIENT COMPATIBILITY; EXPERIMENTAL MODEL; FEMALE; GUINEA PIG; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LIPID MEMBRANE; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; RABBIT; SMALL INTESTINE;

ANIMALS; AREA UNDER CURVE; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCOSE; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; RABBITS;

EID: 0346098043     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357022214     Document Type: Article

References (27)

1. Arai, S., Kobayashi, S., Hayashi, S. (1987) In vitro antimicrobial activity of cefpirome, a new cephalosporin with broad antimicrobial spectrum. Jpn J. Antibiot 40: 969-982
2. Auterhoff, H., Knabe, J., Höltje, H. D. (1991) Lehrbuch der Pharmazeutischen Chemie. Vol. 12, Wiss. Verl., Stuttgart, pp 51-58
3. Bretschneider, B. (1999) Charakterisierung und Beeinflussung des intestinalen Cephalosporintransportes. Doctoral Thesis, Martin Luther University Halle-Wittenberg, Halle
4. Bretschneider, B., Brandsch, M., Neubert, R. (1999) Intestinal transport of β-lactam antibiotics: Analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm. Res. 16: 55-61
5. +-activated D-glucose transport systems in guinea pig jejunal brush border membrane. J. Biol. Chem. 261: 6168-6176
6. Burdett, K., Lauterbach, F. (1994) Gastric fundic inhibition of sugar transport across the intestinal mucosa of guinea pig. Eur. J. Physiol. 426: 491-498
7. Feldman, S., Salvino, M., Gibaldi, M. (1970) Physiological surface-active agents and drug absorption VII: Effect of sodium deoxycholate on phenol red absorption in the rat. J. Pharm. Sci. 59: 705-707
8. Fuchs, P. C., Jones, R. N., Barry, A. L. (1985) Evaluation of the in vitro activity of BMY-28142, a new broad spectrum cephalosporin. Antimicrob. Agents Chemother. 27: 679-682
9. Grass, G. M., Sweetana, S. A. (1998) In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharm. Res. 5: 372-376
10. Guarini, S., Ferrari, W. (1985) Sodium deoxycholate promotes the absorption of heparin administered orally, probably by acting on gastrointestinal mucosa in rat. Experienta 41: 350-352
11. Heinzel, G., Woloszcak, R., Thomann, P. (1993) TOPFIT 2.0 Pharmacokinetic and Pharmacodynamic Data Analysis for the PC. Gustav Fischer Verlag, Stuttgart
12. Horrevorts, A. M. (1987) In vitro activity of new antimicrobial agents Pseudomonas aeruginosa isolates from cystic fibrosis patients. Eur. J. Clin. Microbiol. 6: 323-324
13. Kakemi, K., Sezaki, H., Muranishi, S., Tsujimura, Y. (1969) Absorption and excretion of drug. XL. Enhancement of the rectal absorption of pharmaceutical amines with lauryl sulfate and saccharinate anions. Chem. Pharm. Bull. 17: 1641-1650
14. Lee, C. P., De Vrueh, R. L. A., Smith, P. L. (1996) Transport of a prodrug of acyclovir, L-Val-acyclovir, via the oligopeptide transporter. Proc. Int. Symp. Control. Release. Bioact. Mater. 23: 47-48
15. Moses, A. C. (1988) Nasal absorption of insulin. Pharm. Weekbl. Sci. 10: 45-46
16. Mrestani, Y., Neubert, R., Härtl, A., Wohlrab, J. (1997) Determination of cephalosporins in urine and bile by capillary zone electrophoresis. Anal. Chim. Acta 349: 207-213
17. Mrestani, Y., Neubert, R., Munk, A., Wiese, M. (1998) Determination of dissociation constants of cephalosporins by capillary electrophoresis. J. Chromatogr. A 803: 273-278
18. Neubert, R., Fürst, W. (1989) In vitro-Untersuchungen des Arzneistofftransports. Pharm. Zeit 18: 112-124
19. Nishihata, B. T., Lee, C. S., Rytting, J. H., Higuchi, T. (1987) The synergistic effects of concurrent administration to rats of EDTA and sodium salicylate on the rectal absorption of sodiumcefoxitin and the effect of inhibitors. J. Pharm. Pharmacol. 39: 180-184
20. Sancho, C. V., Fabra, C. S., Gomez, M. V., Bengochea, M., Martin, V. A. (1995) Experimental studies on the influence of surfactants on intestinal absorption of drugs. Drug Res. 45: 595-601
21. Schoenfield, L. J., Lachim, J. M. (1981) Chenodeoxycholic acid for dissolution of gallstones: The national cooperative gallstone study. Ann. Intern. Med. 95: 257-282
22. Smith, P. L., Eddy, E. P., Lee, C. P., Wilson, G. (1996) Exploitation of the intestinal oligopeptide transporter to enhance drug absorption. Drug Deliv. 3: 117-123
23. Tacnet, F., Lauthier, F., Ripoche, P. (1993) Mechanisms of zinc transport into pig small intestine brush-border membrane vesicles. J. Physiol. 465: 57-72
24. Then, R. L., Angehrn, P. (1985) Ways to overcome cephalosporinase-mediated beta lactam resistance in Enterobacter cloacae. Chemiotherapia IV(1): 83-98
25. Van Hoogdalem, E. J., De Boer, A. G., Breimer, D. D. (1989) Intestinal drug absorption enhancement: An overview. Pharmacol. Ther. 44: 407-443
26. Van Krimpen, P. C., Van Bennekom, W. P., Bult, A. (1987) Penicillins and cephalosporins. Physicochemical properties and analysis in pharmaceutical and biological matrices. Pharm. Weekbl. Sci. 9: 1-23
27. Widemann, B., Tolxdorff-Neutzing, R. M. (1993) Mechanisms of resistance to beta lactam antibiotics. Chemiotherapia IV(1): 24-27