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Volumn 3, Issue 8, 2012, Pages 981-996

Peptide therapeutics: Its all in the delivery

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; HEXYL INSULIN MONOCONJUGATE 2; INFLUENZA VACCINE; INSULIN; INSULIN ASPART; LINAGLIPTIN; LIRAGLUTIDE; NASULIN; ORACAL; OSTORA; OXYNTOMODULIN; OXYTOCIN; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PEPTIDE YY [3-36]; PLACEBO; RECOMBINANT HUMAN INSULIN; SALCATONIN; SAXAGLIPTIN; SITAGLIPTIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; PEPTIDE;

EID: 84865511133     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.12.79     Document Type: Review
Times cited : (29)

References (70)
  • 2
    • 27644485390 scopus 로고    scopus 로고
    • The impact of hormone physiology on clinical practice with reference to two papers spanning 40 years of endocrinology
    • DOI 10.1136/adc.2004.069682
    • Hindmarsh PC. The impact of hormone physiology on clinical practice with reference to two papers spanning 40 years of endocrinology. Arch. Dis. Child. 90(11), 1144-1147 (2005). (Pubitemid 41565274)
    • (2005) Archives of Disease in Childhood , vol.90 , Issue.11 , pp. 1144-1147
    • Hindmarsh, P.C.1
  • 3
    • 0042333459 scopus 로고    scopus 로고
    • Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure
    • DOI 10.1016/S8756-3282(03)00202-3
    • Frolik CA, Black EC, Cain RL et al. Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. Bone 33(3), 372-379 (2003). (Pubitemid 37103254)
    • (2003) Bone , vol.33 , Issue.3 , pp. 372-379
    • Frolik, C.A.1    Black, E.C.2    Cain, R.L.3    Satterwhite, J.H.4    Brown-Augsburger, P.L.5    Sato, M.6    Hock, J.M.7
  • 4
    • 65949123793 scopus 로고    scopus 로고
    • Effects of Type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism
    • Basu A, Man CD, Basu R, Toffolo G, Cobelli C, Rizza RA. Effects of Type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism. Diabetes Care 32(5), 866-872 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 866-872
    • Basu, A.1    Man, C.D.2    Basu, R.3    Toffolo, G.4    Cobelli, C.5    Rizza, R.A.6
  • 5
    • 18144368866 scopus 로고    scopus 로고
    • Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin
    • DOI 10.2337/diacare.28.5.1077
    • Rave K, Bott S, Heinemann L et al. Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin. Diabetes Care 28(5), 1077-1082 (2005). (Pubitemid 40616616)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1077-1082
    • Rave, K.1    Bott, S.2    Heinemann, L.3    Sha, S.4    Becker, R.H.A.5    Willavize, S.A.6    Heise, T.7
  • 6
    • 78851472325 scopus 로고    scopus 로고
    • Comparative pharmacodynamic and pharmacokinetic characteristics of subcutaneous insulin glulisine and insulin aspart prior to a standard meal in obese subjects with Type 2 diabetes
    • Bolli GB, Luzio S, Marzotti S et al. Comparative pharmacodynamic and pharmacokinetic characteristics of subcutaneous insulin glulisine and insulin aspart prior to a standard meal in obese subjects with Type 2 diabetes. Diabetes Obes. Metab. 13(3), 251-257 (2011).
    • (2011) Diabetes Obes. Metab. , vol.13 , Issue.3 , pp. 251-257
    • Bolli, G.B.1    Luzio, S.2    Marzotti, S.3
  • 7
    • 49249136821 scopus 로고    scopus 로고
    • A novel insulin formulation with a more rapid onset of action
    • Steiner S, Hompesch M, Pohl R et al. A novel insulin formulation with a more rapid onset of action. Diabetologia 51(9), 1602-1606 (2008).
    • (2008) Diabetologia , vol.51 , Issue.9 , pp. 1602-1606
    • Steiner, S.1    Hompesch, M.2    Pohl, R.3
  • 8
    • 64749102777 scopus 로고    scopus 로고
    • First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in Type 2 diabetic subjects after bariatric surgery
    • Salinari S, Bertuzzi A, Asnaghi S, Guidone C, Manco M, Mingrone G. First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in Type 2 diabetic subjects after bariatric surgery. Diabetes Care 32(3), 375-380 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.3 , pp. 375-380
    • Salinari, S.1    Bertuzzi, A.2    Asnaghi, S.3    Guidone, C.4    Manco, M.5    Mingrone, G.6
  • 9
    • 0023226183 scopus 로고
    • Pulsatility of insulin and glucagon release: Physiological significance and pharmacological implications
    • Lefèbvre PJ, Paolisso G, Scheen AJ, Henquin JC. Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications. Diabetologia 30(7), 443-452 (1987). (Pubitemid 17139070)
    • (1987) Diabetologia , vol.30 , Issue.7 , pp. 443-452
    • Lefebvre, P.J.1    Paolisso, G.2    Scheen, A.J.3    Henquin, J.C.4
  • 10
    • 78651070550 scopus 로고    scopus 로고
    • Treatment pharmacokinetics and pharmacodynamics of different modes of insulin pump delivery. A randomized, controlled study comparing subcutaneous and intravenous administration of insulin aspart
    • Ihlo CA, Lauritzen T, Sturist J, Skyggebjerg O, Christiansen JS, Larsen T. Treatment pharmacokinetics and pharmacodynamics of different modes of insulin pump delivery. A randomized, controlled study comparing subcutaneous and intravenous administration of insulin aspart. Diabetic Med. 28(2), 230-236 (2011).
    • (2011) Diabetic Med. , vol.28 , Issue.2 , pp. 230-236
    • Ihlo, C.A.1    Lauritzen, T.2    Sturist, J.3    Skyggebjerg, O.4    Christiansen, J.S.5    Larsen, T.6
  • 11
    • 0036411713 scopus 로고    scopus 로고
    • The role of lymphatic transport in enhancing oral protein and peptide drug delivery
    • DOI 10.1081/DDC-120014573
    • Wasan KM. The role of lymphatic transport in enhancing oral protein and peptide drug delivery. Drug Dev. Ind. Pharm. 28(9), 1047-1058 (2002). (Pubitemid 35278830)
    • (2002) Drug Development and Industrial Pharmacy , vol.28 , Issue.9 , pp. 1047-1058
    • Wasan, K.M.1
  • 13
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs
    • Hamman JH, Enslin GM, Kotze AF. Oral delivery of peptide drugs. Biodrugs 19(3), 165-177 (2005).
    • (2005) Biodrugs , vol.19 , Issue.3 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 14
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • Aungst BJ. Intestinal permeation enhancers. J. Pharm. Sci. 89(4), 429-442 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , Issue.4 , pp. 429-442
    • Aungst, B.J.1
  • 15
    • 27744448891 scopus 로고    scopus 로고
    • Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers
    • DOI 10.1016/j.farmac.2005.08.008, PII S0014827X05001874
    • Sharma P, Varma MVS, Chawla HPS, Panchagnula R. Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers. Il Farmaco 60(11-12), 884-893 (2005). (Pubitemid 41586262)
    • (2005) Farmaco , vol.60 , Issue.11-12 , pp. 884-893
    • Sharma, P.1    Varma, M.V.S.2    Chawla, H.P.S.3    Panchagnula, R.4
  • 16
    • 84864144366 scopus 로고    scopus 로고
    • Nighttime dosing with an oral calcitonin tablet significantly reduces plasma CTx-1
    • Mehta N, Erickson K, Stern W et al. Nighttime dosing with an oral calcitonin tablet significantly reduces plasma CTx-1. J. Bone Miner. Res. 24 (Suppl. 1), (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , Issue.1 SUPPL.
    • Mehta, N.1    Erickson, K.2    Stern, W.3
  • 17
    • 84864127997 scopus 로고    scopus 로고
    • A Phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The ORACAL trial
    • doi:10.1002/jbmr.1602, In Press
    • Binkley N, Bolognese M, Sidorowicz-Bialynicka A et al. A Phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the ORACAL trial. J. Bone Miner. Res. doi:10.1002/jbmr.1602 (2012) (In Press).
    • (2012) J. Bone Miner. Res.
    • Binkley, N.1    Bolognese, M.2    Sidorowicz-Bialynicka, A.3
  • 18
    • 52949084000 scopus 로고    scopus 로고
    • Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteroporosis with oral calcitonin
    • Karsdal MA, Byrjalsen I, Riis BJ, Christiansen C. Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteroporosis with oral calcitonin. BMC Clin. Pharmacol. 8 (12) (2008).
    • (2008) BMC Clin. Pharmacol. , vol.8 , Issue.12
    • Karsdal, M.A.1    Byrjalsen, I.2    Riis, B.J.3    Christiansen, C.4
  • 19
    • 63849211819 scopus 로고    scopus 로고
    • Influence of food intake on the bioavailability and efficacy of oral calcitonin
    • Karsdal MA, Byrjalsen I, Azira M et al. Influence of food intake on the bioavailability and efficacy of oral calcitonin. Br. J. Clin. Pharmacol. 67(4), 413-420 (2009).
    • (2009) Br. J. Clin. Pharmacol. , vol.67 , Issue.4 , pp. 413-420
    • Karsdal, M.A.1    Byrjalsen, I.2    Azira, M.3
  • 20
    • 58149327054 scopus 로고    scopus 로고
    • Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of salmon calcitonin
    • Karsdal MA, Byrjalsen I, Riis BJ, Christiansen C. Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of salmon calcitonin. BMC Clin. Pharmacol. 8 (5) (2008).
    • (2008) BMC Clin. Pharmacol. , vol.8 , Issue.5
    • Karsdal, M.A.1    Byrjalsen, I.2    Riis, B.J.3    Christiansen, C.4
  • 21
    • 77956061331 scopus 로고    scopus 로고
    • Oral insulin: A comparison with subcutaneous regular human insulin in patients with Type 2 diabetes
    • Kapitza C, Zijlstra E, Heinemann L, Castelli MC, Riley G, Heise T. Oral insulin: a comparison with subcutaneous regular human insulin in patients with Type 2 diabetes. Diabetes Care 33(6), 1288-1290 (2010).
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1288-1290
    • Kapitza, C.1    Zijlstra, E.2    Heinemann, L.3    Castelli, M.C.4    Riley, G.5    Heise, T.6
  • 22
    • 0347316399 scopus 로고    scopus 로고
    • Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: Results from a phase I/II clinical trial
    • DOI 10.1016/j.metabol.2003.07.021
    • Clement S, Dandona P, Still JG, Kosutic G. Oral modified insulin (HIM2) in patients with Type 1 diabetes mellitus: results from a phase I/II clinical trial. Metabolism 53(1), 54-58 (2004). (Pubitemid 38071936)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.1 , pp. 54-58
    • Clement, S.1    Dandona, P.2    Still, J.G.3    Kosutic, G.4
  • 23
    • 77958084962 scopus 로고    scopus 로고
    • A dose range finding study of novel oral insulin (IN-105) under fed conditions in Type 2 diabetes mellitus subjects
    • Khedkar A, Iyer H, Anand A et al. A dose range finding study of novel oral insulin (IN-105) under fed conditions in Type 2 diabetes mellitus subjects. Diabetes Obes. Metab. 12(8), 659-664 (2010).
    • (2010) Diabetes Obes. Metab. , vol.12 , Issue.8 , pp. 659-664
    • Khedkar, A.1    Iyer, H.2    Anand, A.3
  • 24
    • 84856687434 scopus 로고    scopus 로고
    • Are all estrogens created equal? A review of oral vs. transdermal therapy
    • Goodman MP. Are all estrogens created equal? A review of oral vs. transdermal therapy. J. Womens Health 21(2), 161-169 (2012).
    • (2012) J. Womens Health , vol.21 , Issue.2 , pp. 161-169
    • Goodman, M.P.1
  • 25
    • 79954416467 scopus 로고    scopus 로고
    • Transdermal delivery of proteins
    • Kalluri H, Banga AK. Transdermal delivery of proteins. AAPS PharmSciTech 12(1), 431-441 (2011).
    • (2011) AAPS PharmSciTech , vol.12 , Issue.1 , pp. 431-441
    • Kalluri, H.1    Banga, A.K.2
  • 26
    • 55749108348 scopus 로고    scopus 로고
    • Transdermal drug delivery
    • Prausnitz MR, Langer R. Transdermal drug delivery. Nat. Biotechnol. 26(11), 1261-1268 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , Issue.11 , pp. 1261-1268
    • Prausnitz, M.R.1    Langer, R.2
  • 27
    • 53549096557 scopus 로고    scopus 로고
    • Altea Therapeutics Transdermal PassPort™ system: Freedom from insulin injections for superior diabetes management
    • Furness G Ed.. ONdrugDelivery Ltd, Newtimber, UK
    • Patel YR. Altea Therapeutics Transdermal PassPort™ system: freedom from insulin injections for superior diabetes management. In: Drug Delivery in Diabetes: Making Effective Treatment Tolerable. Furness G (Ed.). ONdrugDelivery Ltd, Newtimber, UK, 4-7 (2006).
    • (2006) Drug Delivery in Diabetes: Making Effective Treatment Tolerable. , pp. 4-7
    • Patel, Y.R.1
  • 28
    • 85157076413 scopus 로고    scopus 로고
    • Repetitive rapid delivery of pharmacologically-active hPTH 1-34 across human skin without injection
    • Montreal, Canada, 12-16 September
    • Shalom SI, Kenan Y, Matsumoto T, Neer R. Repetitive rapid delivery of pharmacologically-active hPTH 1-34 across human skin without injection. Presented at: 30th ASMBR Annual Meeting. Montreal, Canada, 12-16 September 2008.
    • (2008) 30th ASMBR Annual Meeting.
    • Shalom, S.I.1    Kenan, Y.2    Matsumoto, T.3    Neer, R.4
  • 29
    • 78651225870 scopus 로고    scopus 로고
    • Parathyroid hormone (1-34)-coated microneedle patch system: Clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis
    • Daddona PE, Matriano JA, Mandema J, Maa Y-F. Parathyroid hormone (1-34)-coated microneedle patch system: clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis. Pharm. Res. 28(1), 159-165 (2011).
    • (2011) Pharm. Res. , vol.28 , Issue.1 , pp. 159-165
    • Daddona, P.E.1    Matriano, J.A.2    Mandema, J.3    Maa, Y.-F.4
  • 32
    • 77952741221 scopus 로고    scopus 로고
    • Intranasal insulin: From nose to brain
    • Henkin RI. Intranasal insulin: from nose to brain. Nutrition 26(6), 624-633 (2010).
    • (2010) Nutrition , vol.26 , Issue.6 , pp. 624-633
    • Henkin, R.I.1
  • 33
    • 70349556669 scopus 로고    scopus 로고
    • Nasal delivery of high molecular weight drugs
    • Ozsoy Y, Gungor S, Cevher E. Nasal delivery of high molecular weight drugs. Molecules 14, 3754-3779 (2009).
    • (2009) Molecules , vol.14 , pp. 3754-3779
    • Ozsoy, Y.1    Gungor, S.2    Cevher, E.3
  • 34
    • 33645295252 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intranasal insulin administered to patients with Type 1 diabetes: A preliminary study
    • Leary AC, Stote RM, Cussen K, O'Brien J, Leary WP, Buckley B. Pharmacokinetics and pharmacodynamics of intranasal insulin administered to patients with Type 1 diabetes: a preliminary study. Diabetes Technol. Ther. 8(1), 81-88 (2006).
    • (2006) Diabetes Technol. Ther. , vol.8 , Issue.1 , pp. 81-88
    • Leary, A.C.1    Stote, R.M.2    Cussen, K.3    O'Brien, J.4    Leary, W.P.5    Buckley, B.6
  • 35
    • 67649140570 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intranasal insulin spray (Nasulin™) administered to healthy male volunteers: Influence of the nasal cycle
    • Leary AC, Dowling M, Cussen K, O'Brien J, Stote RM. Pharmacokinetics and pharmacodynamics of intranasal insulin spray (Nasulin™) administered to healthy male volunteers: influence of the nasal cycle. J. Diabetes Sci. Technol. 2(6), 1054-1060 (2008).
    • (2008) J. Diabetes Sci. Technol. , vol.2 , Issue.6 , pp. 1054-1060
    • Leary, A.C.1    Dowling, M.2    Cussen, K.3    O'Brien, J.4    Stote, R.M.5
  • 36
    • 71549161443 scopus 로고    scopus 로고
    • Inhaled insulin - Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action
    • Henkin RI. Inhaled insulin - intrapulmonary, intranasal, and other routes of administration: mechanisms of action. Nutrition 26(1), 33-39 (2010).
    • (2010) Nutrition , vol.26 , Issue.1 , pp. 33-39
    • Henkin, R.I.1
  • 37
    • 0025000586 scopus 로고
    • Alkaline phosphatase and dipeptidylpeptidase IV staining of tissue components of skeletal muscle: A comparative study
    • Grim M, Carlson BM. Alkaline phosphatase and dipeptidyldipeptidase IV staining of tissue components of skeletal muscle: a comparative study. J. Histochem. Cytochem. 38(12), 1907-1912 (1990). (Pubitemid 20382408)
    • (1990) Journal of Histochemistry and Cytochemistry , vol.38 , Issue.12 , pp. 1907-1912
    • Grim, M.1    Carlson, B.M.2
  • 38
    • 0024461541 scopus 로고
    • Peptidase enzymes of the pulmonary vascular surface
    • Ryan JW. Peptidase enzymes of the pulmonary vascular surface. Am. J. Physiol. Lung Cell Mol. Biol. 257(2), L53-L60 (1989).
    • (1989) Am. J. Physiol. Lung Cell Mol. Biol. , vol.257 , Issue.2
    • Ryan, J.W.1
  • 39
    • 1042291852 scopus 로고    scopus 로고
    • Concept, strategies, and feasibility of noninvasive insulin delivery
    • DOI 10.2337/diacare.27.1.239
    • Cefalu WT. Concept, strategies, and feasibility of noninvasive insulin delivery. Diabetes Care 27(1), 239-246 (2004). (Pubitemid 38196739)
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 239-246
    • Cefalu, W.T.1
  • 40
    • 64549117379 scopus 로고    scopus 로고
    • Systematic treatment by inhalation of macromolecules - Principles, problems, and examples
    • Siekmeier R, Scheuch G. Systematic treatment by inhalation of macromolecules - principles, problems, and examples. J. Physiol. Pharmacol. 59(Suppl. 6), 53-79 (2008).
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.6 SUPPL. , pp. 53-79
    • Siekmeier, R.1    Scheuch, G.2
  • 41
    • 34548412091 scopus 로고    scopus 로고
    • Coverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes
    • DOI 10.2337/dc07-0478
    • Rave K, Heise T, Pfützner A, Boss AH. Coverage of postprandial blood glucose excursions with inhaled Technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with Type 2 diabetes. Diabetes Care 30(9), 2307-2308 (2007). (Pubitemid 47359038)
    • (2007) Diabetes Care , vol.30 , Issue.9 , pp. 2307-2308
    • Rave, K.1    Heise, T.2    Pfutzner, A.3    Boss, A.H.4
  • 42
    • 49449090136 scopus 로고    scopus 로고
    • Inhaled Technosphere insulin in comparison to subcutaneous regular human insulin: Time action profile and variability in subjects with Type 2 diabetes
    • Rave K, Heise T, Heinemann L, Boss AH. Inhaled Technosphere insulin in comparison to subcutaneous regular human insulin: time action profile and variability in subjects with Type 2 diabetes. J. Diabetes Sci. Technol. 2(2), 205-212 (2008).
    • (2008) J. Diabetes Sci. Technol. , vol.2 , Issue.2 , pp. 205-212
    • Rave, K.1    Heise, T.2    Heinemann, L.3    Boss, A.H.4
  • 43
    • 7744226683 scopus 로고    scopus 로고
    • Current status of the development of inhaled insulin
    • Heinemann L, Heise T. Current status of the development of inhaled insulin. Br. J. Diabetes Vasc. Dis. 4(5), 295-301 (2004). (Pubitemid 39462106)
    • (2004) British Journal of Diabetes and Vascular Disease , vol.4 , Issue.5 , pp. 295-301
    • Heinemann, L.1
  • 44
    • 77950791696 scopus 로고    scopus 로고
    • Comparative efficacy and safety of AFRESA™ and a rapid-acting analog both given with glargine in subjects with T1DM in a 52-week study
    • New Orleans, LA, USA, 5-7 June
    • Bergenstal RM, Kapsner PL, Rendell MS et al. Comparative efficacy and safety of AFRESA™ and a rapid-acting analog both given with glargine in subjects with T1DM in a 52-week study. Presented at: American Diabetes Association's 69th Scientific Sessions. New Orleans, LA, USA, 5-7 June 2009.
    • (2009) American Diabetes Association's 69th Scientific Sessions.
    • Bergenstal, R.M.1    Kapsner, P.L.2    Rendell, M.S.3
  • 45
    • 85157193619 scopus 로고    scopus 로고
    • Reduced incidence and frequency of hypoglycemia in an integrated analysis from clinical trials of subjects with Type 2 diabetes using prandial inhaled Technosphere® insulin
    • Boston, MA, USA, 21-25 April
    • Lorber D, Howard CP, Ren H, Rossiter A, Boss AH. Reduced incidence and frequency of hypoglycemia in an integrated analysis from clinical trials of subjects with Type 2 diabetes using prandial inhaled Technosphere® insulin. Presented at: AACE 19th Annual Meeting and Clinical Congress. Boston, MA, USA, 21-25 April 2010.
    • (2010) AACE 19th Annual Meeting and Clinical Congress.
    • Lorber, D.1    Howard, C.P.2    Ren, H.3    Rossiter, A.4    Boss, A.H.5
  • 46
    • 85157274201 scopus 로고    scopus 로고
    • A1C and hypoglycemia in patients with Type 2 diabetes mellitus incorporating prandial inhaled Technosphere insulin into their usual antihyperglycemic regimen vs continuing their usual antihyperglycemic regimen
    • Orlando, FL, USA, 25-29 June
    • Raskin P, Phillips MD, Rossiter A, Boss AH, Richardson PC. A1C and hypoglycemia in patients with Type 2 diabetes mellitus incorporating prandial inhaled Technosphere insulin into their usual antihyperglycemic regimen vs continuing their usual antihyperglycemic regimen. Presented at: American Diabetes Association's 70th Scientific Sessions. Orlando, FL, USA, 25-29 June 2010.
    • (2010) American Diabetes Association's 70th Scientific Sessions.
    • Raskin, P.1    Phillips, M.D.2    Rossiter, A.3    Boss, A.H.4    Richardson, P.C.5
  • 47
    • 77953839066 scopus 로고    scopus 로고
    • Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for Type 2 diabetes: A multicentre randomised trial
    • Rosenstock J, Lorber DL, Gnudi L et al. Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for Type 2 diabetes: a multicentre randomised trial. Lancet 375(9733), 2244-2253 (2010).
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2244-2253
    • Rosenstock, J.1    Lorber, D.L.2    Gnudi, L.3
  • 48
    • 70349440796 scopus 로고    scopus 로고
    • Efficacy and safety of AIR inhaled insulin compared to insulin lispro in patients with Type 1 diabetes mellitus in a 6-month, randomized, noninferiority trial
    • Comulada AL, Renard E, Nakano M et al. Efficacy and safety of AIR inhaled insulin compared to insulin lispro in patients with Type 1 diabetes mellitus in a 6-month, randomized, noninferiority trial. Diabetes Technol. Ther. 11(Suppl. 2), S17-S25 (2009).
    • (2009) Diabetes Technol. Ther. , vol.11 , Issue.2 SUPPL.
    • Comulada, A.L.1    Renard, E.2    Nakano, M.3
  • 49
    • 70349456479 scopus 로고    scopus 로고
    • Two-year efficacy and safety of AIR inhaled insulin inpatients with Type 1 diabetes: An open-label randomized controlled trial
    • Garg SK, Mathieu C, Rais N et al. Two-year efficacy and safety of AIR inhaled insulin inpatients with Type 1 diabetes: an open-label randomized controlled trial. Diabetes Technol. Ther. 11(Suppl. 2), S5-S16 (2009).
    • (2009) Diabetes Technol. Ther. , vol.11 , Issue.2 SUPPL.
    • Garg, S.K.1    Mathieu, C.2    Rais, N.3
  • 51
    • 62449219273 scopus 로고    scopus 로고
    • Treatment safety and efficacy of inhaled insulin (AERx iDMS1) compared with subcutaneous insulin therapy in patients with Type 1 diabetes: 1-year data from a randomized, parallel group trial
    • Moses RG, Bartley P, Lunt H et al. Treatment safety and efficacy of inhaled insulin (AERx iDMS1) compared with subcutaneous insulin therapy in patients with Type 1 diabetes: 1-year data from a randomized, parallel group trial. Diabetic Med. 26(3), 260-267 (2009).
    • (2009) Diabetic Med. , vol.26 , Issue.3 , pp. 260-267
    • Moses, R.G.1    Bartley, P.2    Lunt, H.3
  • 53
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and cell function in type 2 diabetes: A parallel-group study
    • DOI 10.1016/S0140-6736(02)07952-7
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in Type 2 diabetes: a parallel-group study. Lancet 359(9309), 824-830 (2002). (Pubitemid 34233752)
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 54
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • DOI 10.1210/jc.2002-021053
    • Vilsbøll T, Agersø H, Krarup T, Holst. JJ. Similar elimination rates of glucagon-like peptide-1 in obese Type 2 diabetic patients and healthy subjects. J. Clin. Endocrinol. Metab. 88(1), 220-224 (2003). (Pubitemid 36115169)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.1 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 55
    • 77956301808 scopus 로고    scopus 로고
    • Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
    • Vrang N, Larsen PJ. Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides. Prog. Neurobiol. 92(3), 442-462 (2010).
    • (2010) Prog. Neurobiol. , vol.92 , Issue.3 , pp. 442-462
    • Vrang, N.1    Larsen, P.J.2
  • 56
    • 70350148542 scopus 로고    scopus 로고
    • Evaluation of novel particles as an inhalation system for GLP-1
    • Leone-Bay A, Grant M, Greene S et al. Evaluation of novel particles as an inhalation system for GLP-1. Diabetes Obes. Metab. 11(11), 1050-1059 (2009).
    • (2009) Diabetes Obes. Metab. , vol.11 , Issue.11 , pp. 1050-1059
    • Leone-Bay, A.1    Grant, M.2    Greene, S.3
  • 57
    • 77954887591 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of inhaled GLP-1 (MKC253): Proof of concept studies in healthy normal volunteers and in patients with Type 2 diabetes
    • Marino MT, Costello D, Baughman R et al. Pharmacokinetics and pharmacodynamics of inhaled GLP-1 (MKC253): proof of concept studies in healthy normal volunteers and in patients with Type 2 diabetes. Clin. Pharmacol. Ther. 88(2), 243-250 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.88 , Issue.2 , pp. 243-250
    • Marino, M.T.1    Costello, D.2    Baughman, R.3
  • 59
    • 34250635159 scopus 로고    scopus 로고
    • GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting
    • DOI 10.2967/jnumed.106.038679
    • Körner M, Stöckli M, Waser B, Reubi JC. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J. Nuclear Med. 48(5), 736-743 (2007). (Pubitemid 47604973)
    • (2007) Journal of Nuclear Medicine , vol.48 , Issue.5 , pp. 736-743
    • Korner, M.1    Stockli, M.2    Waser, B.3    Reubi, J.C.4
  • 60
    • 78049440734 scopus 로고    scopus 로고
    • Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy males
    • Steinert RE, Poller B, Castelli MC, Drewe J, Beglinger C. Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy males. Am. J. Clin. Nutr. 92(4), 810-817 (2010).
    • (2010) Am. J. Clin. Nutr. , vol.92 , Issue.4 , pp. 810-817
    • Steinert, R.E.1    Poller, B.2    Castelli, M.C.3    Drewe, J.4    Beglinger, C.5
  • 61
    • 56449126449 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: A proof-of-concept study in healthy subjects
    • Beglinger C, Poller B, Arbit E et al. Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: a proof-of-concept study in healthy subjects. Clin. Pharmacol. Ther. 84(4), 469-474 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , Issue.4 , pp. 469-474
    • Beglinger, C.1    Poller, B.2    Arbit, E.3
  • 62
    • 85157086109 scopus 로고    scopus 로고
    • Mimicking endogenous peptide secretion by inhalation
    • Bloomington, IN, USA, 7-12 June
    • Leone-Bay A. Mimicking endogenous peptide secretion by inhalation. Presented at: 21st American Peptide Symposium Peptides: Breaking Away'. Bloomington, IN, USA, 7-12 June 2009.
    • (2009) 21st American Peptide Symposium Peptides: Breaking Away'
    • Leone-Bay, A.1


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