In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases

International Journal of Pharmaceutics

Volumn 252, Issue 1-2, 2003, Pages 187-196

  Guggi, Davide ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Calcitonin delivery; Chitosan derivatives; Enzymatic degradation; Protective effect

Indexed keywords

BOWMAN BIRK INHIBITOR; CHITOSAN; CHYMOTRYPSIN; CHYMOTRYPSIN INHIBITOR; CYANAMIDE; ELASTASE; ELASTASE INHIBITOR; ELASTATINAL; SALCATONIN; SERINE PROTEINASE; TRYPSIN INHIBITOR;

ARTICLE; CONCENTRATION (PARAMETERS); COVALENT BOND; DEGRADATION KINETICS; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG INHIBITION; ENZYMATIC DEGRADATION; ENZYME ASSAY; ENZYME SUBSTRATE; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE FLUID; POLYMERIZATION; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BIOTRANSFORMATION; CALCITONIN; CATTLE; DRUG EVALUATION, PRECLINICAL; EXCIPIENTS; INTESTINES; MOLECULAR SEQUENCE DATA; POLYMERS; SERINE ENDOPEPTIDASES;

EID: 0037452427     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00631-2     Document Type: Article

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